Amino acid dipepetide frequency for Tyzzerella sp. An114

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.055AlaAla: 4.055 ± 0.105	0.769AlaCys: 0.769 ± 0.031	3.48AlaAsp: 3.48 ± 0.068	4.566AlaGlu: 4.566 ± 0.087	2.761AlaPhe: 2.761 ± 0.053	4.493AlaGly: 4.493 ± 0.112	0.737AlaHis: 0.737 ± 0.029	5.144AlaIle: 5.144 ± 0.093	4.783AlaLys: 4.783 ± 0.08	5.514AlaLeu: 5.514 ± 0.088	1.8AlaMet: 1.8 ± 0.051	2.418AlaAsn: 2.418 ± 0.063	1.552AlaPro: 1.552 ± 0.049	1.551AlaGln: 1.551 ± 0.042	1.895AlaArg: 1.895 ± 0.062	3.251AlaSer: 3.251 ± 0.068	2.896AlaThr: 2.896 ± 0.069	5.677AlaVal: 5.677 ± 0.097	0.352AlaTrp: 0.352 ± 0.024	2.173AlaTyr: 2.173 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.789CysAla: 0.789 ± 0.036	0.262CysCys: 0.262 ± 0.019	0.957CysAsp: 0.957 ± 0.035	0.944CysGlu: 0.944 ± 0.037	0.584CysPhe: 0.584 ± 0.026	1.326CysGly: 1.326 ± 0.053	0.24CysHis: 0.24 ± 0.016	1.252CysIle: 1.252 ± 0.042	0.964CysLys: 0.964 ± 0.039	0.927CysLeu: 0.927 ± 0.034	0.318CysMet: 0.318 ± 0.02	0.732CysAsn: 0.732 ± 0.03	0.507CysPro: 0.507 ± 0.029	0.275CysGln: 0.275 ± 0.015	0.412CysArg: 0.412 ± 0.022	0.799CysSer: 0.799 ± 0.038	0.655CysThr: 0.655 ± 0.031	0.906CysVal: 0.906 ± 0.031	0.084CysTrp: 0.084 ± 0.012	0.478CysTyr: 0.478 ± 0.032	0.0CysXaa: 0.0 ± 0.0
Asp	2.994AspAla: 2.994 ± 0.059	0.822AspCys: 0.822 ± 0.029	3.634AspAsp: 3.634 ± 0.098	5.331AspGlu: 5.331 ± 0.095	3.286AspPhe: 3.286 ± 0.074	3.637AspGly: 3.637 ± 0.086	0.533AspHis: 0.533 ± 0.032	7.155AspIle: 7.155 ± 0.11	4.864AspLys: 4.864 ± 0.081	3.635AspLeu: 3.635 ± 0.075	1.958AspMet: 1.958 ± 0.055	3.393AspAsn: 3.393 ± 0.065	1.254AspPro: 1.254 ± 0.044	0.625AspGln: 0.625 ± 0.029	1.982AspArg: 1.982 ± 0.049	2.978AspSer: 2.978 ± 0.071	3.434AspThr: 3.434 ± 0.072	4.131AspVal: 4.131 ± 0.073	0.478AspTrp: 0.478 ± 0.028	2.937AspTyr: 2.937 ± 0.069	0.0AspXaa: 0.0 ± 0.0
Glu	4.424GluAla: 4.424 ± 0.092	0.827GluCys: 0.827 ± 0.035	3.914GluAsp: 3.914 ± 0.076	6.22GluGlu: 6.22 ± 0.112	3.111GluPhe: 3.111 ± 0.066	4.68GluGly: 4.68 ± 0.085	0.909GluHis: 0.909 ± 0.037	7.196GluIle: 7.196 ± 0.099	8.44GluLys: 8.44 ± 0.124	6.008GluLeu: 6.008 ± 0.088	2.161GluMet: 2.161 ± 0.053	6.699GluAsn: 6.699 ± 0.119	1.715GluPro: 1.715 ± 0.051	1.918GluGln: 1.918 ± 0.059	2.864GluArg: 2.864 ± 0.069	3.489GluSer: 3.489 ± 0.072	3.853GluThr: 3.853 ± 0.071	4.249GluVal: 4.249 ± 0.082	0.575GluTrp: 0.575 ± 0.03	3.552GluTyr: 3.552 ± 0.075	0.0GluXaa: 0.0 ± 0.0
Phe	2.8PheAla: 2.8 ± 0.058	0.736PheCys: 0.736 ± 0.029	3.225PheAsp: 3.225 ± 0.076	3.442PheGlu: 3.442 ± 0.073	2.101PhePhe: 2.101 ± 0.057	3.187PheGly: 3.187 ± 0.062	0.554PheHis: 0.554 ± 0.03	4.58PheIle: 4.58 ± 0.102	3.399PheLys: 3.399 ± 0.078	3.332PheLeu: 3.332 ± 0.078	1.455PheMet: 1.455 ± 0.041	2.537PheAsn: 2.537 ± 0.06	1.244PhePro: 1.244 ± 0.042	0.936PheGln: 0.936 ± 0.035	1.337PheArg: 1.337 ± 0.041	3.286PheSer: 3.286 ± 0.08	2.449PheThr: 2.449 ± 0.063	3.274PheVal: 3.274 ± 0.075	0.286PheTrp: 0.286 ± 0.021	1.862PheTyr: 1.862 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.275GlyAla: 4.275 ± 0.092	1.028GlyCys: 1.028 ± 0.045	3.537GlyAsp: 3.537 ± 0.076	4.668GlyGlu: 4.668 ± 0.085	3.227GlyPhe: 3.227 ± 0.072	4.801GlyGly: 4.801 ± 0.11	1.066GlyHis: 1.066 ± 0.037	6.93GlyIle: 6.93 ± 0.109	5.755GlyLys: 5.755 ± 0.093	5.051GlyLeu: 5.051 ± 0.087	2.01GlyMet: 2.01 ± 0.052	3.442GlyAsn: 3.442 ± 0.071	1.103GlyPro: 1.103 ± 0.041	1.544GlyGln: 1.544 ± 0.041	2.32GlyArg: 2.32 ± 0.053	3.903GlySer: 3.903 ± 0.077	4.034GlyThr: 4.034 ± 0.083	4.934GlyVal: 4.934 ± 0.086	0.544GlyTrp: 0.544 ± 0.027	3.054GlyTyr: 3.054 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	0.652HisAla: 0.652 ± 0.029	0.252HisCys: 0.252 ± 0.018	0.698HisAsp: 0.698 ± 0.032	0.815HisGlu: 0.815 ± 0.033	0.662HisPhe: 0.662 ± 0.027	0.865HisGly: 0.865 ± 0.035	0.301HisHis: 0.301 ± 0.031	1.451HisIle: 1.451 ± 0.041	0.98HisLys: 0.98 ± 0.042	0.902HisLeu: 0.902 ± 0.031	0.373HisMet: 0.373 ± 0.016	0.763HisAsn: 0.763 ± 0.033	0.585HisPro: 0.585 ± 0.032	0.289HisGln: 0.289 ± 0.02	0.532HisArg: 0.532 ± 0.028	0.868HisSer: 0.868 ± 0.031	0.777HisThr: 0.777 ± 0.036	0.696HisVal: 0.696 ± 0.029	0.109HisTrp: 0.109 ± 0.012	0.601HisTyr: 0.601 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.729IleAla: 5.729 ± 0.106	1.439IleCys: 1.439 ± 0.043	6.007IleAsp: 6.007 ± 0.099	7.303IleGlu: 7.303 ± 0.099	4.477IlePhe: 4.477 ± 0.09	5.592IleGly: 5.592 ± 0.1	1.179IleHis: 1.179 ± 0.037	8.917IleIle: 8.917 ± 0.147	7.95IleLys: 7.95 ± 0.12	7.897IleLeu: 7.897 ± 0.12	2.605IleMet: 2.605 ± 0.065	5.574IleAsn: 5.574 ± 0.094	3.443IlePro: 3.443 ± 0.069	2.041IleGln: 2.041 ± 0.046	2.941IleArg: 2.941 ± 0.067	6.742IleSer: 6.742 ± 0.098	5.238IleThr: 5.238 ± 0.085	6.143IleVal: 6.143 ± 0.096	0.574IleTrp: 0.574 ± 0.031	3.679IleTyr: 3.679 ± 0.068	0.0IleXaa: 0.0 ± 0.0
Lys	4.884LysAla: 4.884 ± 0.098	0.886LysCys: 0.886 ± 0.038	5.051LysAsp: 5.051 ± 0.084	7.512LysGlu: 7.512 ± 0.105	3.043LysPhe: 3.043 ± 0.061	5.157LysGly: 5.157 ± 0.074	1.044LysHis: 1.044 ± 0.04	7.411LysIle: 7.411 ± 0.112	7.616LysLys: 7.616 ± 0.107	5.97LysLeu: 5.97 ± 0.089	2.47LysMet: 2.47 ± 0.062	6.483LysAsn: 6.483 ± 0.124	2.135LysPro: 2.135 ± 0.058	1.851LysGln: 1.851 ± 0.051	3.146LysArg: 3.146 ± 0.069	4.974LysSer: 4.974 ± 0.105	4.623LysThr: 4.623 ± 0.075	4.724LysVal: 4.724 ± 0.09	0.57LysTrp: 0.57 ± 0.025	4.12LysTyr: 4.12 ± 0.078	0.0LysXaa: 0.0 ± 0.0
Leu	4.593LeuAla: 4.593 ± 0.085	1.157LeuCys: 1.157 ± 0.04	4.342LeuAsp: 4.342 ± 0.083	5.375LeuGlu: 5.375 ± 0.086	3.586LeuPhe: 3.586 ± 0.076	5.272LeuGly: 5.272 ± 0.079	1.019LeuHis: 1.019 ± 0.037	6.312LeuIle: 6.312 ± 0.107	7.236LeuLys: 7.236 ± 0.111	6.071LeuLeu: 6.071 ± 0.108	2.306LeuMet: 2.306 ± 0.055	4.421LeuAsn: 4.421 ± 0.08	2.676LeuPro: 2.676 ± 0.064	1.824LeuGln: 1.824 ± 0.046	2.916LeuArg: 2.916 ± 0.064	6.057LeuSer: 6.057 ± 0.094	4.026LeuThr: 4.026 ± 0.078	4.398LeuVal: 4.398 ± 0.081	0.595LeuTrp: 0.595 ± 0.029	3.078LeuTyr: 3.078 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	2.158MetAla: 2.158 ± 0.051	0.358MetCys: 0.358 ± 0.019	1.59MetAsp: 1.59 ± 0.039	2.274MetGlu: 2.274 ± 0.062	1.122MetPhe: 1.122 ± 0.039	2.331MetGly: 2.331 ± 0.062	0.326MetHis: 0.326 ± 0.017	2.22MetIle: 2.22 ± 0.05	2.497MetLys: 2.497 ± 0.055	2.22MetLeu: 2.22 ± 0.057	0.69MetMet: 0.69 ± 0.034	1.722MetAsn: 1.722 ± 0.045	1.032MetPro: 1.032 ± 0.038	0.647MetGln: 0.647 ± 0.026	1.041MetArg: 1.041 ± 0.032	1.879MetSer: 1.879 ± 0.051	1.563MetThr: 1.563 ± 0.038	1.712MetVal: 1.712 ± 0.043	0.174MetTrp: 0.174 ± 0.015	1.069MetTyr: 1.069 ± 0.035	0.0MetXaa: 0.0 ± 0.0
Asn	3.038AsnAla: 3.038 ± 0.065	0.837AsnCys: 0.837 ± 0.036	3.301AsnAsp: 3.301 ± 0.072	4.173AsnGlu: 4.173 ± 0.082	2.639AsnPhe: 2.639 ± 0.063	4.039AsnGly: 4.039 ± 0.082	0.767AsnHis: 0.767 ± 0.031	7.388AsnIle: 7.388 ± 0.114	4.483AsnLys: 4.483 ± 0.101	4.186AsnLeu: 4.186 ± 0.07	1.824AsnMet: 1.824 ± 0.047	3.776AsnAsn: 3.776 ± 0.098	2.264AsnPro: 2.264 ± 0.057	1.18AsnGln: 1.18 ± 0.037	1.88AsnArg: 1.88 ± 0.047	3.965AsnSer: 3.965 ± 0.098	3.367AsnThr: 3.367 ± 0.073	3.852AsnVal: 3.852 ± 0.071	0.415AsnTrp: 0.415 ± 0.025	2.373AsnTyr: 2.373 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	1.696ProAla: 1.696 ± 0.055	0.375ProCys: 0.375 ± 0.019	1.885ProAsp: 1.885 ± 0.06	2.863ProGlu: 2.863 ± 0.067	1.578ProPhe: 1.578 ± 0.049	1.565ProGly: 1.565 ± 0.045	0.45ProHis: 0.45 ± 0.025	2.369ProIle: 2.369 ± 0.066	2.157ProLys: 2.157 ± 0.052	2.33ProLeu: 2.33 ± 0.053	0.733ProMet: 0.733 ± 0.029	1.434ProAsn: 1.434 ± 0.05	0.721ProPro: 0.721 ± 0.033	0.816ProGln: 0.816 ± 0.032	0.774ProArg: 0.774 ± 0.036	1.936ProSer: 1.936 ± 0.053	1.378ProThr: 1.378 ± 0.053	2.712ProVal: 2.712 ± 0.06	0.21ProTrp: 0.21 ± 0.016	1.272ProTyr: 1.272 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	1.385GlnAla: 1.385 ± 0.034	0.258GlnCys: 0.258 ± 0.017	0.995GlnAsp: 0.995 ± 0.032	1.553GlnGlu: 1.553 ± 0.052	0.9GlnPhe: 0.9 ± 0.033	1.442GlnGly: 1.442 ± 0.046	0.324GlnHis: 0.324 ± 0.022	2.098GlnIle: 2.098 ± 0.047	2.051GlnLys: 2.051 ± 0.053	1.951GlnLeu: 1.951 ± 0.049	0.62GlnMet: 0.62 ± 0.027	1.483GlnAsn: 1.483 ± 0.042	0.595GlnPro: 0.595 ± 0.03	0.683GlnGln: 0.683 ± 0.036	0.979GlnArg: 0.979 ± 0.041	1.394GlnSer: 1.394 ± 0.044	1.184GlnThr: 1.184 ± 0.039	1.259GlnVal: 1.259 ± 0.04	0.195GlnTrp: 0.195 ± 0.016	1.031GlnTyr: 1.031 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	1.984ArgAla: 1.984 ± 0.045	0.422ArgCys: 0.422 ± 0.025	1.88ArgAsp: 1.88 ± 0.053	2.922ArgGlu: 2.922 ± 0.067	1.557ArgPhe: 1.557 ± 0.049	2.113ArgGly: 2.113 ± 0.056	0.493ArgHis: 0.493 ± 0.025	3.189ArgIle: 3.189 ± 0.067	3.032ArgLys: 3.032 ± 0.072	2.891ArgLeu: 2.891 ± 0.072	0.988ArgMet: 0.988 ± 0.036	2.103ArgAsn: 2.103 ± 0.048	1.003ArgPro: 1.003 ± 0.038	0.989ArgGln: 0.989 ± 0.039	1.456ArgArg: 1.456 ± 0.053	1.597ArgSer: 1.597 ± 0.047	1.703ArgThr: 1.703 ± 0.043	2.133ArgVal: 2.133 ± 0.059	0.235ArgTrp: 0.235 ± 0.018	1.482ArgTyr: 1.482 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	3.74SerAla: 3.74 ± 0.082	0.74SerCys: 0.74 ± 0.035	3.966SerAsp: 3.966 ± 0.083	4.673SerGlu: 4.673 ± 0.078	3.046SerPhe: 3.046 ± 0.067	4.745SerGly: 4.745 ± 0.079	0.885SerHis: 0.885 ± 0.034	5.792SerIle: 5.792 ± 0.104	4.842SerLys: 4.842 ± 0.084	5.059SerLeu: 5.059 ± 0.092	1.681SerMet: 1.681 ± 0.045	3.297SerAsn: 3.297 ± 0.077	1.731SerPro: 1.731 ± 0.047	1.639SerGln: 1.639 ± 0.049	2.12SerArg: 2.12 ± 0.051	4.067SerSer: 4.067 ± 0.093	3.005SerThr: 3.005 ± 0.072	4.606SerVal: 4.606 ± 0.089	0.414SerTrp: 0.414 ± 0.027	2.51SerTyr: 2.51 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	3.899ThrAla: 3.899 ± 0.078	0.453ThrCys: 0.453 ± 0.025	3.356ThrAsp: 3.356 ± 0.07	4.177ThrGlu: 4.177 ± 0.082	2.34ThrPhe: 2.34 ± 0.057	4.473ThrGly: 4.473 ± 0.089	0.713ThrHis: 0.713 ± 0.029	4.633ThrIle: 4.633 ± 0.076	3.603ThrLys: 3.603 ± 0.067	4.304ThrLeu: 4.304 ± 0.071	1.377ThrMet: 1.377 ± 0.04	2.572ThrAsn: 2.572 ± 0.071	2.03ThrPro: 2.03 ± 0.053	1.169ThrGln: 1.169 ± 0.037	1.613ThrArg: 1.613 ± 0.047	3.073ThrSer: 3.073 ± 0.072	2.941ThrThr: 2.941 ± 0.075	4.863ThrVal: 4.863 ± 0.082	0.344ThrTrp: 0.344 ± 0.023	1.963ThrTyr: 1.963 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	4.158ValAla: 4.158 ± 0.089	1.042ValCys: 1.042 ± 0.035	3.96ValAsp: 3.96 ± 0.073	4.484ValGlu: 4.484 ± 0.078	3.546ValPhe: 3.546 ± 0.076	4.083ValGly: 4.083 ± 0.083	0.897ValHis: 0.897 ± 0.032	6.447ValIle: 6.447 ± 0.099	5.201ValLys: 5.201 ± 0.084	5.68ValLeu: 5.68 ± 0.095	1.938ValMet: 1.938 ± 0.046	3.541ValAsn: 3.541 ± 0.072	2.333ValPro: 2.333 ± 0.053	1.373ValGln: 1.373 ± 0.039	2.148ValArg: 2.148 ± 0.056	5.079ValSer: 5.079 ± 0.083	3.952ValThr: 3.952 ± 0.097	4.882ValVal: 4.882 ± 0.091	0.446ValTrp: 0.446 ± 0.021	2.827ValTyr: 2.827 ± 0.065	0.0ValXaa: 0.0 ± 0.0
Trp	0.401TrpAla: 0.401 ± 0.026	0.087TrpCys: 0.087 ± 0.011	0.466TrpAsp: 0.466 ± 0.023	0.472TrpGlu: 0.472 ± 0.024	0.337TrpPhe: 0.337 ± 0.022	0.559TrpGly: 0.559 ± 0.027	0.132TrpHis: 0.132 ± 0.013	0.589TrpIle: 0.589 ± 0.031	0.529TrpLys: 0.529 ± 0.029	0.629TrpLeu: 0.629 ± 0.03	0.134TrpMet: 0.134 ± 0.013	0.502TrpAsn: 0.502 ± 0.027	0.116TrpPro: 0.116 ± 0.012	0.239TrpGln: 0.239 ± 0.018	0.244TrpArg: 0.244 ± 0.018	0.414TrpSer: 0.414 ± 0.024	0.339TrpThr: 0.339 ± 0.025	0.39TrpVal: 0.39 ± 0.021	0.076TrpTrp: 0.076 ± 0.011	0.333TrpTyr: 0.333 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.209TyrAla: 2.209 ± 0.059	0.658TyrCys: 0.658 ± 0.026	2.819TyrAsp: 2.819 ± 0.071	3.039TyrGlu: 3.039 ± 0.066	2.121TyrPhe: 2.121 ± 0.057	2.866TyrGly: 2.866 ± 0.06	0.605TyrHis: 0.605 ± 0.028	4.395TyrIle: 4.395 ± 0.093	3.285TyrLys: 3.285 ± 0.075	2.701TyrLeu: 2.701 ± 0.057	1.183TyrMet: 1.183 ± 0.045	2.854TyrAsn: 2.854 ± 0.064	1.216TyrPro: 1.216 ± 0.045	0.793TyrGln: 0.793 ± 0.033	1.575TyrArg: 1.575 ± 0.046	2.809TyrSer: 2.809 ± 0.058	2.477TyrThr: 2.477 ± 0.056	2.479TyrVal: 2.479 ± 0.057	0.309TyrTrp: 0.309 ± 0.02	2.01TyrTyr: 2.01 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2549 proteins (804866 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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