Amino acid dipepetide frequency for Bacteroidales bacterium KHT7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.357AlaAla: 5.357 ± 0.1	1.022AlaCys: 1.022 ± 0.036	4.683AlaAsp: 4.683 ± 0.07	5.03AlaGlu: 5.03 ± 0.075	3.272AlaPhe: 3.272 ± 0.08	4.627AlaGly: 4.627 ± 0.081	1.216AlaHis: 1.216 ± 0.035	4.66AlaIle: 4.66 ± 0.08	4.915AlaLys: 4.915 ± 0.074	6.075AlaLeu: 6.075 ± 0.088	2.014AlaMet: 2.014 ± 0.048	3.477AlaAsn: 3.477 ± 0.06	2.084AlaPro: 2.084 ± 0.057	2.795AlaGln: 2.795 ± 0.061	2.756AlaArg: 2.756 ± 0.054	4.527AlaSer: 4.527 ± 0.076	3.812AlaThr: 3.812 ± 0.071	4.792AlaVal: 4.792 ± 0.085	0.767AlaTrp: 0.767 ± 0.024	2.9AlaTyr: 2.9 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.97CysAla: 0.97 ± 0.029	0.313CysCys: 0.313 ± 0.019	0.825CysAsp: 0.825 ± 0.026	0.855CysGlu: 0.855 ± 0.034	0.744CysPhe: 0.744 ± 0.026	1.254CysGly: 1.254 ± 0.035	0.339CysHis: 0.339 ± 0.017	1.139CysIle: 1.139 ± 0.035	1.006CysLys: 1.006 ± 0.038	1.207CysLeu: 1.207 ± 0.034	0.407CysMet: 0.407 ± 0.018	0.864CysAsn: 0.864 ± 0.034	0.577CysPro: 0.577 ± 0.026	0.408CysGln: 0.408 ± 0.019	0.659CysArg: 0.659 ± 0.026	1.044CysSer: 1.044 ± 0.032	0.812CysThr: 0.812 ± 0.029	0.985CysVal: 0.985 ± 0.032	0.198CysTrp: 0.198 ± 0.012	0.747CysTyr: 0.747 ± 0.029	0.0CysXaa: 0.0 ± 0.0
Asp	4.4AspAla: 4.4 ± 0.065	0.883AspCys: 0.883 ± 0.032	3.429AspAsp: 3.429 ± 0.067	4.494AspGlu: 4.494 ± 0.077	3.328AspPhe: 3.328 ± 0.057	4.743AspGly: 4.743 ± 0.074	0.733AspHis: 0.733 ± 0.025	4.336AspIle: 4.336 ± 0.07	4.324AspLys: 4.324 ± 0.072	4.153AspLeu: 4.153 ± 0.067	1.73AspMet: 1.73 ± 0.047	3.305AspAsn: 3.305 ± 0.072	1.535AspPro: 1.535 ± 0.041	1.025AspGln: 1.025 ± 0.032	2.242AspArg: 2.242 ± 0.052	3.659AspSer: 3.659 ± 0.06	2.607AspThr: 2.607 ± 0.055	4.111AspVal: 4.111 ± 0.068	0.859AspTrp: 0.859 ± 0.025	3.024AspTyr: 3.024 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	4.469GluAla: 4.469 ± 0.083	0.838GluCys: 0.838 ± 0.027	3.285GluAsp: 3.285 ± 0.062	4.32GluGlu: 4.32 ± 0.081	2.612GluPhe: 2.612 ± 0.057	3.899GluGly: 3.899 ± 0.051	1.265GluHis: 1.265 ± 0.037	4.376GluIle: 4.376 ± 0.07	5.319GluLys: 5.319 ± 0.082	5.414GluLeu: 5.414 ± 0.074	1.916GluMet: 1.916 ± 0.044	3.796GluAsn: 3.796 ± 0.063	1.799GluPro: 1.799 ± 0.046	2.407GluGln: 2.407 ± 0.046	2.999GluArg: 2.999 ± 0.056	3.344GluSer: 3.344 ± 0.057	3.11GluThr: 3.11 ± 0.055	3.817GluVal: 3.817 ± 0.064	0.89GluTrp: 0.89 ± 0.03	2.908GluTyr: 2.908 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.408PheAla: 3.408 ± 0.064	0.985PheCys: 0.985 ± 0.029	3.225PheAsp: 3.225 ± 0.064	2.71PheGlu: 2.71 ± 0.056	2.347PhePhe: 2.347 ± 0.055	3.568PheGly: 3.568 ± 0.059	0.796PheHis: 0.796 ± 0.027	2.995PheIle: 2.995 ± 0.06	2.759PheLys: 2.759 ± 0.051	3.663PheLeu: 3.663 ± 0.058	1.273PheMet: 1.273 ± 0.033	2.596PheAsn: 2.596 ± 0.061	1.488PhePro: 1.488 ± 0.04	1.081PheGln: 1.081 ± 0.035	2.042PheArg: 2.042 ± 0.041	3.584PheSer: 3.584 ± 0.064	2.568PheThr: 2.568 ± 0.044	3.474PheVal: 3.474 ± 0.068	0.591PheTrp: 0.591 ± 0.025	2.178PheTyr: 2.178 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.442GlyAla: 4.442 ± 0.078	1.288GlyCys: 1.288 ± 0.044	3.731GlyAsp: 3.731 ± 0.064	3.961GlyGlu: 3.961 ± 0.063	3.305GlyPhe: 3.305 ± 0.06	4.831GlyGly: 4.831 ± 0.083	1.199GlyHis: 1.199 ± 0.033	5.099GlyIle: 5.099 ± 0.08	5.628GlyLys: 5.628 ± 0.076	5.343GlyLeu: 5.343 ± 0.082	2.031GlyMet: 2.031 ± 0.048	3.724GlyAsn: 3.724 ± 0.061	1.147GlyPro: 1.147 ± 0.03	1.852GlyGln: 1.852 ± 0.038	2.738GlyArg: 2.738 ± 0.051	3.993GlySer: 3.993 ± 0.08	4.025GlyThr: 4.025 ± 0.069	4.609GlyVal: 4.609 ± 0.072	0.988GlyTrp: 0.988 ± 0.036	3.291GlyTyr: 3.291 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	0.99HisAla: 0.99 ± 0.031	0.31HisCys: 0.31 ± 0.018	1.022HisAsp: 1.022 ± 0.031	0.977HisGlu: 0.977 ± 0.03	1.077HisPhe: 1.077 ± 0.035	1.256HisGly: 1.256 ± 0.036	0.476HisHis: 0.476 ± 0.027	1.387HisIle: 1.387 ± 0.036	1.169HisLys: 1.169 ± 0.036	1.633HisLeu: 1.633 ± 0.041	0.349HisMet: 0.349 ± 0.019	1.078HisAsn: 1.078 ± 0.033	0.889HisPro: 0.889 ± 0.029	0.588HisGln: 0.588 ± 0.025	0.816HisArg: 0.816 ± 0.031	1.188HisSer: 1.188 ± 0.03	0.936HisThr: 0.936 ± 0.028	0.99HisVal: 0.99 ± 0.029	0.216HisTrp: 0.216 ± 0.014	0.891HisTyr: 0.891 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.086IleAla: 5.086 ± 0.083	1.118IleCys: 1.118 ± 0.034	4.723IleAsp: 4.723 ± 0.062	4.564IleGlu: 4.564 ± 0.073	2.945IlePhe: 2.945 ± 0.061	4.573IleGly: 4.573 ± 0.077	1.186IleHis: 1.186 ± 0.031	4.7IleIle: 4.7 ± 0.08	4.635IleLys: 4.635 ± 0.065	5.434IleLeu: 5.434 ± 0.099	1.601IleMet: 1.601 ± 0.039	3.585IleAsn: 3.585 ± 0.061	2.902IlePro: 2.902 ± 0.055	1.926IleGln: 1.926 ± 0.04	2.964IleArg: 2.964 ± 0.056	4.78IleSer: 4.78 ± 0.068	3.951IleThr: 3.951 ± 0.073	4.852IleVal: 4.852 ± 0.079	0.681IleTrp: 0.681 ± 0.027	2.591IleTyr: 2.591 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	5.263LysAla: 5.263 ± 0.086	0.833LysCys: 0.833 ± 0.028	4.288LysAsp: 4.288 ± 0.073	5.115LysGlu: 5.115 ± 0.083	2.792LysPhe: 2.792 ± 0.056	4.436LysGly: 4.436 ± 0.059	1.386LysHis: 1.386 ± 0.04	4.974LysIle: 4.974 ± 0.071	6.024LysLys: 6.024 ± 0.092	5.355LysLeu: 5.355 ± 0.067	2.513LysMet: 2.513 ± 0.051	4.374LysAsn: 4.374 ± 0.071	2.391LysPro: 2.391 ± 0.053	2.571LysGln: 2.571 ± 0.05	3.03LysArg: 3.03 ± 0.054	4.186LysSer: 4.186 ± 0.066	3.703LysThr: 3.703 ± 0.056	4.649LysVal: 4.649 ± 0.075	0.908LysTrp: 0.908 ± 0.03	3.343LysTyr: 3.343 ± 0.062	0.0LysXaa: 0.0 ± 0.0
Leu	6.126LeuAla: 6.126 ± 0.08	1.483LeuCys: 1.483 ± 0.041	4.69LeuAsp: 4.69 ± 0.078	4.48LeuGlu: 4.48 ± 0.068	4.148LeuPhe: 4.148 ± 0.074	5.264LeuGly: 5.264 ± 0.085	1.605LeuHis: 1.605 ± 0.044	4.874LeuIle: 4.874 ± 0.081	6.335LeuLys: 6.335 ± 0.086	7.648LeuLeu: 7.648 ± 0.127	2.368LeuMet: 2.368 ± 0.057	4.573LeuAsn: 4.573 ± 0.078	3.458LeuPro: 3.458 ± 0.053	2.851LeuGln: 2.851 ± 0.056	3.711LeuArg: 3.711 ± 0.057	5.995LeuSer: 5.995 ± 0.079	4.866LeuThr: 4.866 ± 0.071	4.95LeuVal: 4.95 ± 0.083	0.966LeuTrp: 0.966 ± 0.03	3.613LeuTyr: 3.613 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.21MetAla: 2.21 ± 0.055	0.396MetCys: 0.396 ± 0.015	1.34MetAsp: 1.34 ± 0.036	1.442MetGlu: 1.442 ± 0.035	1.426MetPhe: 1.426 ± 0.059	1.707MetGly: 1.707 ± 0.046	0.531MetHis: 0.531 ± 0.021	1.658MetIle: 1.658 ± 0.042	2.453MetLys: 2.453 ± 0.048	2.625MetLeu: 2.625 ± 0.051	0.879MetMet: 0.879 ± 0.031	1.627MetAsn: 1.627 ± 0.039	1.289MetPro: 1.289 ± 0.029	1.094MetGln: 1.094 ± 0.031	1.407MetArg: 1.407 ± 0.033	1.729MetSer: 1.729 ± 0.043	1.511MetThr: 1.511 ± 0.037	1.639MetVal: 1.639 ± 0.042	0.307MetTrp: 0.307 ± 0.017	0.96MetTyr: 0.96 ± 0.032	0.001MetXaa: 0.001 ± 0.001
Asn	3.831AsnAla: 3.831 ± 0.064	0.797AsnCys: 0.797 ± 0.031	3.135AsnAsp: 3.135 ± 0.06	3.173AsnGlu: 3.173 ± 0.058	2.498AsnPhe: 2.498 ± 0.046	4.493AsnGly: 4.493 ± 0.089	0.964AsnHis: 0.964 ± 0.03	4.371AsnIle: 4.371 ± 0.076	3.589AsnLys: 3.589 ± 0.063	4.462AsnLeu: 4.462 ± 0.078	1.508AsnMet: 1.508 ± 0.041	3.083AsnAsn: 3.083 ± 0.075	2.504AsnPro: 2.504 ± 0.046	1.484AsnGln: 1.484 ± 0.041	2.35AsnArg: 2.35 ± 0.041	3.348AsnSer: 3.348 ± 0.074	2.942AsnThr: 2.942 ± 0.073	3.825AsnVal: 3.825 ± 0.068	0.734AsnTrp: 0.734 ± 0.027	2.55AsnTyr: 2.55 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	2.351ProAla: 2.351 ± 0.053	0.398ProCys: 0.398 ± 0.02	2.328ProAsp: 2.328 ± 0.054	2.904ProGlu: 2.904 ± 0.056	1.671ProPhe: 1.671 ± 0.033	1.849ProGly: 1.849 ± 0.045	0.604ProHis: 0.604 ± 0.026	2.118ProIle: 2.118 ± 0.043	2.177ProLys: 2.177 ± 0.047	2.763ProLeu: 2.763 ± 0.054	0.967ProMet: 0.967 ± 0.027	1.847ProAsn: 1.847 ± 0.048	0.688ProPro: 0.688 ± 0.025	1.278ProGln: 1.278 ± 0.038	1.173ProArg: 1.173 ± 0.033	2.317ProSer: 2.317 ± 0.052	1.939ProThr: 1.939 ± 0.05	2.564ProVal: 2.564 ± 0.055	0.44ProTrp: 0.44 ± 0.019	1.659ProTyr: 1.659 ± 0.039	0.001ProXaa: 0.001 ± 0.001
Gln	1.94GlnAla: 1.94 ± 0.04	0.357GlnCys: 0.357 ± 0.019	1.39GlnAsp: 1.39 ± 0.037	1.754GlnGlu: 1.754 ± 0.049	1.438GlnPhe: 1.438 ± 0.036	1.76GlnGly: 1.76 ± 0.037	0.656GlnHis: 0.656 ± 0.023	2.358GlnIle: 2.358 ± 0.049	2.669GlnLys: 2.669 ± 0.049	2.884GlnLeu: 2.884 ± 0.055	1.146GlnMet: 1.146 ± 0.032	2.016GlnAsn: 2.016 ± 0.049	1.084GlnPro: 1.084 ± 0.032	1.47GlnGln: 1.47 ± 0.044	1.457GlnArg: 1.457 ± 0.042	1.823GlnSer: 1.823 ± 0.038	1.903GlnThr: 1.903 ± 0.043	1.749GlnVal: 1.749 ± 0.039	0.403GlnTrp: 0.403 ± 0.022	1.446GlnTyr: 1.446 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	2.49ArgAla: 2.49 ± 0.044	0.603ArgCys: 0.603 ± 0.024	2.173ArgAsp: 2.173 ± 0.045	2.623ArgGlu: 2.623 ± 0.052	2.11ArgPhe: 2.11 ± 0.048	2.327ArgGly: 2.327 ± 0.049	0.877ArgHis: 0.877 ± 0.03	3.317ArgIle: 3.317 ± 0.053	3.308ArgLys: 3.308 ± 0.059	4.024ArgLeu: 4.024 ± 0.069	1.399ArgMet: 1.399 ± 0.041	2.606ArgAsn: 2.606 ± 0.056	1.337ArgPro: 1.337 ± 0.036	1.652ArgGln: 1.652 ± 0.04	2.127ArgArg: 2.127 ± 0.06	2.168ArgSer: 2.168 ± 0.048	2.216ArgThr: 2.216 ± 0.044	2.487ArgVal: 2.487 ± 0.04	0.602ArgTrp: 0.602 ± 0.022	2.111ArgTyr: 2.111 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.736SerAla: 4.736 ± 0.084	0.944SerCys: 0.944 ± 0.03	3.816SerAsp: 3.816 ± 0.057	3.88SerGlu: 3.88 ± 0.063	3.23SerPhe: 3.23 ± 0.059	4.582SerGly: 4.582 ± 0.077	1.208SerHis: 1.208 ± 0.034	4.373SerIle: 4.373 ± 0.082	4.01SerLys: 4.01 ± 0.06	5.88SerLeu: 5.88 ± 0.088	1.552SerMet: 1.552 ± 0.035	3.337SerAsn: 3.337 ± 0.072	2.071SerPro: 2.071 ± 0.044	1.898SerGln: 1.898 ± 0.049	2.584SerArg: 2.584 ± 0.046	4.101SerSer: 4.101 ± 0.084	3.371SerThr: 3.371 ± 0.064	4.804SerVal: 4.804 ± 0.084	0.733SerTrp: 0.733 ± 0.026	2.799SerTyr: 2.799 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	4.007ThrAla: 4.007 ± 0.067	0.643ThrCys: 0.643 ± 0.025	3.399ThrAsp: 3.399 ± 0.053	3.182ThrGlu: 3.182 ± 0.053	2.643ThrPhe: 2.643 ± 0.053	3.783ThrGly: 3.783 ± 0.062	0.936ThrHis: 0.936 ± 0.031	4.087ThrIle: 4.087 ± 0.073	3.267ThrLys: 3.267 ± 0.056	5.047ThrLeu: 5.047 ± 0.074	1.303ThrMet: 1.303 ± 0.037	2.716ThrAsn: 2.716 ± 0.069	2.342ThrPro: 2.342 ± 0.046	1.554ThrGln: 1.554 ± 0.039	1.954ThrArg: 1.954 ± 0.041	3.641ThrSer: 3.641 ± 0.087	3.267ThrThr: 3.267 ± 0.068	3.925ThrVal: 3.925 ± 0.078	0.59ThrTrp: 0.59 ± 0.025	2.259ThrTyr: 2.259 ± 0.044	0.001ThrXaa: 0.001 ± 0.001
Val	4.977ValAla: 4.977 ± 0.084	1.175ValCys: 1.175 ± 0.035	3.883ValAsp: 3.883 ± 0.06	4.249ValGlu: 4.249 ± 0.055	3.059ValPhe: 3.059 ± 0.06	4.308ValGly: 4.308 ± 0.078	1.05ValHis: 1.05 ± 0.035	4.2ValIle: 4.2 ± 0.074	4.607ValLys: 4.607 ± 0.063	5.635ValLeu: 5.635 ± 0.086	1.715ValMet: 1.715 ± 0.041	3.406ValAsn: 3.406 ± 0.055	2.487ValPro: 2.487 ± 0.051	1.902ValGln: 1.902 ± 0.041	2.963ValArg: 2.963 ± 0.047	4.682ValSer: 4.682 ± 0.067	3.809ValThr: 3.809 ± 0.08	5.077ValVal: 5.077 ± 0.078	0.74ValTrp: 0.74 ± 0.026	2.715ValTyr: 2.715 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.823TrpAla: 0.823 ± 0.027	0.221TrpCys: 0.221 ± 0.016	0.673TrpAsp: 0.673 ± 0.026	0.669TrpGlu: 0.669 ± 0.023	0.575TrpPhe: 0.575 ± 0.024	0.918TrpGly: 0.918 ± 0.033	0.357TrpHis: 0.357 ± 0.019	0.79TrpIle: 0.79 ± 0.029	0.895TrpLys: 0.895 ± 0.03	1.113TrpLeu: 1.113 ± 0.037	0.415TrpMet: 0.415 ± 0.02	0.817TrpAsn: 0.817 ± 0.029	0.257TrpPro: 0.257 ± 0.015	0.505TrpGln: 0.505 ± 0.025	0.545TrpArg: 0.545 ± 0.024	0.744TrpSer: 0.744 ± 0.024	0.677TrpThr: 0.677 ± 0.026	0.656TrpVal: 0.656 ± 0.025	0.216TrpTrp: 0.216 ± 0.016	0.554TrpTyr: 0.554 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.904TyrAla: 2.904 ± 0.06	0.742TyrCys: 0.742 ± 0.027	2.876TyrAsp: 2.876 ± 0.056	2.402TyrGlu: 2.402 ± 0.049	2.109TyrPhe: 2.109 ± 0.046	3.044TyrGly: 3.044 ± 0.066	0.855TyrHis: 0.855 ± 0.031	2.988TyrIle: 2.988 ± 0.053	3.045TyrLys: 3.045 ± 0.049	3.648TyrLeu: 3.648 ± 0.062	1.146TyrMet: 1.146 ± 0.032	2.814TyrAsn: 2.814 ± 0.053	1.711TyrPro: 1.711 ± 0.044	1.362TyrGln: 1.362 ± 0.037	2.041TyrArg: 2.041 ± 0.039	3.052TyrSer: 3.052 ± 0.055	2.525TyrThr: 2.525 ± 0.054	2.685TyrVal: 2.685 ± 0.054	0.592TyrTrp: 0.592 ± 0.025	2.2TyrTyr: 2.2 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.007XaaXaa: 0.007 ± 0.004

Statistics based on 3157 proteins (1128700 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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