Amino acid dipepetide frequency for Candidatus Viridilinea mediisalina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.343AlaAla: 15.343 ± 0.161	1.149AlaCys: 1.149 ± 0.031	5.335AlaAsp: 5.335 ± 0.06	7.322AlaGlu: 7.322 ± 0.091	3.424AlaPhe: 3.424 ± 0.052	8.415AlaGly: 8.415 ± 0.091	2.686AlaHis: 2.686 ± 0.051	5.547AlaIle: 5.547 ± 0.058	2.1AlaLys: 2.1 ± 0.048	15.61AlaLeu: 15.61 ± 0.144	2.524AlaMet: 2.524 ± 0.041	3.17AlaAsn: 3.17 ± 0.047	6.132AlaPro: 6.132 ± 0.101	5.787AlaGln: 5.787 ± 0.075	7.7AlaArg: 7.7 ± 0.094	5.61AlaSer: 5.61 ± 0.068	7.227AlaThr: 7.227 ± 0.093	7.121AlaVal: 7.121 ± 0.064	1.908AlaTrp: 1.908 ± 0.041	2.876AlaTyr: 2.876 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.016CysAla: 1.016 ± 0.031	0.146CysCys: 0.146 ± 0.01	0.496CysAsp: 0.496 ± 0.018	0.428CysGlu: 0.428 ± 0.019	0.333CysPhe: 0.333 ± 0.014	0.86CysGly: 0.86 ± 0.03	0.26CysHis: 0.26 ± 0.014	0.408CysIle: 0.408 ± 0.015	0.175CysLys: 0.175 ± 0.012	0.83CysLeu: 0.83 ± 0.023	0.162CysMet: 0.162 ± 0.01	0.266CysAsn: 0.266 ± 0.013	0.494CysPro: 0.494 ± 0.02	0.315CysGln: 0.315 ± 0.015	0.604CysArg: 0.604 ± 0.022	0.574CysSer: 0.574 ± 0.024	0.478CysThr: 0.478 ± 0.018	0.537CysVal: 0.537 ± 0.018	0.17CysTrp: 0.17 ± 0.022	0.305CysTyr: 0.305 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.601AspAla: 5.601 ± 0.079	0.383AspCys: 0.383 ± 0.019	2.841AspAsp: 2.841 ± 0.051	3.577AspGlu: 3.577 ± 0.055	1.614AspPhe: 1.614 ± 0.034	4.242AspGly: 4.242 ± 0.089	1.187AspHis: 1.187 ± 0.028	1.903AspIle: 1.903 ± 0.036	0.831AspLys: 0.831 ± 0.03	6.396AspLeu: 6.396 ± 0.072	0.862AspMet: 0.862 ± 0.027	1.146AspAsn: 1.146 ± 0.052	3.532AspPro: 3.532 ± 0.069	2.313AspGln: 2.313 ± 0.037	3.046AspArg: 3.046 ± 0.054	1.926AspSer: 1.926 ± 0.038	2.214AspThr: 2.214 ± 0.047	3.242AspVal: 3.242 ± 0.05	0.789AspTrp: 0.789 ± 0.022	1.52AspTyr: 1.52 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	7.397GluAla: 7.397 ± 0.095	0.331GluCys: 0.331 ± 0.013	2.293GluAsp: 2.293 ± 0.045	3.305GluGlu: 3.305 ± 0.069	1.513GluPhe: 1.513 ± 0.031	3.836GluGly: 3.836 ± 0.058	1.659GluHis: 1.659 ± 0.033	2.515GluIle: 2.515 ± 0.046	1.064GluLys: 1.064 ± 0.038	7.697GluLeu: 7.697 ± 0.085	1.15GluMet: 1.15 ± 0.029	1.063GluAsn: 1.063 ± 0.029	3.108GluPro: 3.108 ± 0.067	4.093GluGln: 4.093 ± 0.071	6.198GluArg: 6.198 ± 0.076	2.03GluSer: 2.03 ± 0.036	2.624GluThr: 2.624 ± 0.045	4.349GluVal: 4.349 ± 0.055	0.711GluTrp: 0.711 ± 0.023	1.204GluTyr: 1.204 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.953PheAla: 3.953 ± 0.053	0.377PheCys: 0.377 ± 0.017	2.02PheAsp: 2.02 ± 0.032	1.727PheGlu: 1.727 ± 0.033	1.428PhePhe: 1.428 ± 0.034	2.95PheGly: 2.95 ± 0.05	0.712PheHis: 0.712 ± 0.022	1.61PheIle: 1.61 ± 0.038	0.624PheLys: 0.624 ± 0.022	3.065PheLeu: 3.065 ± 0.054	0.669PheMet: 0.669 ± 0.021	1.071PheAsn: 1.071 ± 0.027	1.49PhePro: 1.49 ± 0.039	1.189PheGln: 1.189 ± 0.027	1.907PheArg: 1.907 ± 0.038	2.125PheSer: 2.125 ± 0.046	2.094PheThr: 2.094 ± 0.045	2.639PheVal: 2.639 ± 0.046	0.588PheTrp: 0.588 ± 0.02	1.047PheTyr: 1.047 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	7.617GlyAla: 7.617 ± 0.084	0.79GlyCys: 0.79 ± 0.028	3.67GlyAsp: 3.67 ± 0.067	4.143GlyGlu: 4.143 ± 0.061	2.765GlyPhe: 2.765 ± 0.049	6.044GlyGly: 6.044 ± 0.092	1.711GlyHis: 1.711 ± 0.036	3.808GlyIle: 3.808 ± 0.06	1.891GlyLys: 1.891 ± 0.046	8.637GlyLeu: 8.637 ± 0.095	2.172GlyMet: 2.172 ± 0.039	2.312GlyAsn: 2.312 ± 0.064	3.335GlyPro: 3.335 ± 0.06	3.583GlyGln: 3.583 ± 0.048	5.304GlyArg: 5.304 ± 0.07	4.356GlySer: 4.356 ± 0.069	4.16GlyThr: 4.16 ± 0.074	5.553GlyVal: 5.553 ± 0.071	1.34GlyTrp: 1.34 ± 0.031	2.334GlyTyr: 2.334 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.772HisAla: 2.772 ± 0.048	0.252HisCys: 0.252 ± 0.017	1.325HisAsp: 1.325 ± 0.033	1.504HisGlu: 1.504 ± 0.032	0.833HisPhe: 0.833 ± 0.027	2.0HisGly: 2.0 ± 0.036	0.721HisHis: 0.721 ± 0.023	1.043HisIle: 1.043 ± 0.029	0.417HisLys: 0.417 ± 0.017	2.506HisLeu: 2.506 ± 0.048	0.471HisMet: 0.471 ± 0.017	0.678HisAsn: 0.678 ± 0.022	1.584HisPro: 1.584 ± 0.033	0.977HisGln: 0.977 ± 0.027	1.273HisArg: 1.273 ± 0.03	1.103HisSer: 1.103 ± 0.026	1.286HisThr: 1.286 ± 0.033	1.648HisVal: 1.648 ± 0.032	0.387HisTrp: 0.387 ± 0.016	0.828HisTyr: 0.828 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.031IleAla: 6.031 ± 0.066	0.532IleCys: 0.532 ± 0.018	2.609IleAsp: 2.609 ± 0.043	3.347IleGlu: 3.347 ± 0.055	2.072IlePhe: 2.072 ± 0.04	4.029IleGly: 4.029 ± 0.062	1.059IleHis: 1.059 ± 0.025	2.756IleIle: 2.756 ± 0.052	1.151IleLys: 1.151 ± 0.032	4.592IleLeu: 4.592 ± 0.069	0.931IleMet: 0.931 ± 0.022	1.709IleAsn: 1.709 ± 0.034	2.453IlePro: 2.453 ± 0.041	1.616IleGln: 1.616 ± 0.036	2.713IleArg: 2.713 ± 0.046	2.864IleSer: 2.864 ± 0.056	3.083IleThr: 3.083 ± 0.057	3.788IleVal: 3.788 ± 0.054	0.71IleTrp: 0.71 ± 0.023	1.561IleTyr: 1.561 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	2.002LysAla: 2.002 ± 0.044	0.103LysCys: 0.103 ± 0.008	0.886LysAsp: 0.886 ± 0.031	1.069LysGlu: 1.069 ± 0.029	0.529LysPhe: 0.529 ± 0.022	1.413LysGly: 1.413 ± 0.033	0.512LysHis: 0.512 ± 0.017	1.021LysIle: 1.021 ± 0.033	0.57LysLys: 0.57 ± 0.025	2.417LysLeu: 2.417 ± 0.051	0.416LysMet: 0.416 ± 0.017	0.532LysAsn: 0.532 ± 0.02	1.288LysPro: 1.288 ± 0.032	1.031LysGln: 1.031 ± 0.03	1.568LysArg: 1.568 ± 0.037	0.934LysSer: 0.934 ± 0.027	1.096LysThr: 1.096 ± 0.033	1.361LysVal: 1.361 ± 0.038	0.195LysTrp: 0.195 ± 0.012	0.458LysTyr: 0.458 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	15.212LeuAla: 15.212 ± 0.145	1.1LeuCys: 1.1 ± 0.032	5.971LeuAsp: 5.971 ± 0.065	6.577LeuGlu: 6.577 ± 0.076	3.748LeuPhe: 3.748 ± 0.055	8.873LeuGly: 8.873 ± 0.094	2.807LeuHis: 2.807 ± 0.051	5.969LeuIle: 5.969 ± 0.08	2.291LeuLys: 2.291 ± 0.046	15.056LeuLeu: 15.056 ± 0.151	2.347LeuMet: 2.347 ± 0.047	3.249LeuAsn: 3.249 ± 0.047	7.214LeuPro: 7.214 ± 0.077	4.421LeuGln: 4.421 ± 0.058	9.617LeuArg: 9.617 ± 0.106	6.22LeuSer: 6.22 ± 0.068	6.509LeuThr: 6.509 ± 0.079	8.82LeuVal: 8.82 ± 0.074	1.596LeuTrp: 1.596 ± 0.043	2.568LeuTyr: 2.568 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.443MetAla: 2.443 ± 0.043	0.127MetCys: 0.127 ± 0.009	0.773MetAsp: 0.773 ± 0.027	0.898MetGlu: 0.898 ± 0.025	0.55MetPhe: 0.55 ± 0.02	1.526MetGly: 1.526 ± 0.033	0.52MetHis: 0.52 ± 0.018	1.098MetIle: 1.098 ± 0.029	0.487MetLys: 0.487 ± 0.018	3.086MetLeu: 3.086 ± 0.041	0.428MetMet: 0.428 ± 0.022	0.582MetAsn: 0.582 ± 0.02	1.472MetPro: 1.472 ± 0.034	1.005MetGln: 1.005 ± 0.025	1.743MetArg: 1.743 ± 0.039	1.299MetSer: 1.299 ± 0.034	1.185MetThr: 1.185 ± 0.03	1.618MetVal: 1.618 ± 0.035	0.179MetTrp: 0.179 ± 0.011	0.286MetTyr: 0.286 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.841AsnAla: 2.841 ± 0.047	0.221AsnCys: 0.221 ± 0.011	1.539AsnAsp: 1.539 ± 0.048	1.591AsnGlu: 1.591 ± 0.034	0.97AsnPhe: 0.97 ± 0.031	2.267AsnGly: 2.267 ± 0.064	0.652AsnHis: 0.652 ± 0.019	1.319AsnIle: 1.319 ± 0.03	0.491AsnLys: 0.491 ± 0.021	3.431AsnLeu: 3.431 ± 0.049	0.489AsnMet: 0.489 ± 0.019	0.986AsnAsn: 0.986 ± 0.049	2.115AsnPro: 2.115 ± 0.045	1.356AsnGln: 1.356 ± 0.031	1.833AsnArg: 1.833 ± 0.04	1.397AsnSer: 1.397 ± 0.036	1.388AsnThr: 1.388 ± 0.038	1.811AsnVal: 1.811 ± 0.039	0.413AsnTrp: 0.413 ± 0.019	0.828AsnTyr: 0.828 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.542ProAla: 6.542 ± 0.099	0.403ProCys: 0.403 ± 0.018	3.492ProAsp: 3.492 ± 0.051	3.946ProGlu: 3.946 ± 0.064	1.995ProPhe: 1.995 ± 0.042	3.949ProGly: 3.949 ± 0.071	1.35ProHis: 1.35 ± 0.029	2.678ProIle: 2.678 ± 0.049	1.08ProLys: 1.08 ± 0.031	6.676ProLeu: 6.676 ± 0.079	1.084ProMet: 1.084 ± 0.028	1.791ProAsn: 1.791 ± 0.042	4.371ProPro: 4.371 ± 0.101	2.453ProGln: 2.453 ± 0.043	3.285ProArg: 3.285 ± 0.056	3.322ProSer: 3.322 ± 0.057	4.016ProThr: 4.016 ± 0.094	3.871ProVal: 3.871 ± 0.055	0.819ProTrp: 0.819 ± 0.022	1.334ProTyr: 1.334 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	5.86GlnAla: 5.86 ± 0.076	0.275GlnCys: 0.275 ± 0.013	1.41GlnAsp: 1.41 ± 0.032	2.095GlnGlu: 2.095 ± 0.04	1.146GlnPhe: 1.146 ± 0.029	3.046GlnGly: 3.046 ± 0.049	1.285GlnHis: 1.285 ± 0.032	2.7GlnIle: 2.7 ± 0.043	0.751GlnLys: 0.751 ± 0.03	5.462GlnLeu: 5.462 ± 0.069	0.945GlnMet: 0.945 ± 0.025	0.904GlnAsn: 0.904 ± 0.028	2.939GlnPro: 2.939 ± 0.047	2.829GlnGln: 2.829 ± 0.058	4.555GlnArg: 4.555 ± 0.061	2.146GlnSer: 2.146 ± 0.043	2.299GlnThr: 2.299 ± 0.043	3.386GlnVal: 3.386 ± 0.051	0.554GlnTrp: 0.554 ± 0.019	0.786GlnTyr: 0.786 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	7.246ArgAla: 7.246 ± 0.089	0.691ArgCys: 0.691 ± 0.024	3.679ArgAsp: 3.679 ± 0.055	4.622ArgGlu: 4.622 ± 0.058	2.721ArgPhe: 2.721 ± 0.04	4.619ArgGly: 4.619 ± 0.061	1.724ArgHis: 1.724 ± 0.037	3.969ArgIle: 3.969 ± 0.051	1.513ArgLys: 1.513 ± 0.039	8.618ArgLeu: 8.618 ± 0.09	1.977ArgMet: 1.977 ± 0.042	2.024ArgAsn: 2.024 ± 0.034	3.812ArgPro: 3.812 ± 0.055	3.361ArgGln: 3.361 ± 0.055	5.741ArgArg: 5.741 ± 0.092	3.96ArgSer: 3.96 ± 0.061	3.617ArgThr: 3.617 ± 0.05	4.861ArgVal: 4.861 ± 0.062	1.292ArgTrp: 1.292 ± 0.027	2.411ArgTyr: 2.411 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.608SerAla: 5.608 ± 0.077	0.43SerCys: 0.43 ± 0.018	2.942SerAsp: 2.942 ± 0.051	2.961SerGlu: 2.961 ± 0.048	2.224SerPhe: 2.224 ± 0.046	4.686SerGly: 4.686 ± 0.081	1.187SerHis: 1.187 ± 0.024	2.601SerIle: 2.601 ± 0.043	0.997SerLys: 0.997 ± 0.03	6.037SerLeu: 6.037 ± 0.07	1.163SerMet: 1.163 ± 0.025	1.618SerAsn: 1.618 ± 0.04	3.048SerPro: 3.048 ± 0.058	2.065SerGln: 2.065 ± 0.041	3.018SerArg: 3.018 ± 0.052	3.326SerSer: 3.326 ± 0.065	2.672SerThr: 2.672 ± 0.051	3.343SerVal: 3.343 ± 0.049	0.704SerTrp: 0.704 ± 0.023	1.606SerTyr: 1.606 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.692ThrAla: 5.692 ± 0.09	0.525ThrCys: 0.525 ± 0.023	2.241ThrAsp: 2.241 ± 0.053	2.487ThrGlu: 2.487 ± 0.053	1.905ThrPhe: 1.905 ± 0.041	4.013ThrGly: 4.013 ± 0.076	1.148ThrHis: 1.148 ± 0.027	3.355ThrIle: 3.355 ± 0.06	1.035ThrLys: 1.035 ± 0.027	7.379ThrLeu: 7.379 ± 0.085	1.296ThrMet: 1.296 ± 0.03	1.697ThrAsn: 1.697 ± 0.045	4.315ThrPro: 4.315 ± 0.098	2.07ThrGln: 2.07 ± 0.038	3.388ThrArg: 3.388 ± 0.055	3.247ThrSer: 3.247 ± 0.058	3.734ThrThr: 3.734 ± 0.084	3.838ThrVal: 3.838 ± 0.071	0.903ThrTrp: 0.903 ± 0.025	1.442ThrTyr: 1.442 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.407ValAla: 9.407 ± 0.107	0.627ValCys: 0.627 ± 0.018	3.464ValAsp: 3.464 ± 0.053	4.267ValGlu: 4.267 ± 0.062	2.108ValPhe: 2.108 ± 0.037	5.529ValGly: 5.529 ± 0.06	1.281ValHis: 1.281 ± 0.031	3.551ValIle: 3.551 ± 0.055	1.237ValLys: 1.237 ± 0.034	7.552ValLeu: 7.552 ± 0.085	1.413ValMet: 1.413 ± 0.036	1.875ValAsn: 1.875 ± 0.039	3.673ValPro: 3.673 ± 0.053	2.774ValGln: 2.774 ± 0.046	5.397ValArg: 5.397 ± 0.058	3.691ValSer: 3.691 ± 0.057	3.939ValThr: 3.939 ± 0.076	6.072ValVal: 6.072 ± 0.075	0.966ValTrp: 0.966 ± 0.025	1.687ValTyr: 1.687 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.51TrpAla: 1.51 ± 0.032	0.15TrpCys: 0.15 ± 0.01	0.651TrpAsp: 0.651 ± 0.023	0.792TrpGlu: 0.792 ± 0.022	0.504TrpPhe: 0.504 ± 0.019	1.036TrpGly: 1.036 ± 0.037	0.42TrpHis: 0.42 ± 0.015	0.613TrpIle: 0.613 ± 0.02	0.279TrpLys: 0.279 ± 0.015	2.146TrpLeu: 2.146 ± 0.045	0.357TrpMet: 0.357 ± 0.016	0.441TrpAsn: 0.441 ± 0.019	0.755TrpPro: 0.755 ± 0.024	0.911TrpGln: 0.911 ± 0.024	1.36TrpArg: 1.36 ± 0.037	0.773TrpSer: 0.773 ± 0.025	0.593TrpThr: 0.593 ± 0.024	0.914TrpVal: 0.914 ± 0.024	0.295TrpTrp: 0.295 ± 0.016	0.46TrpTyr: 0.46 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.893TyrAla: 2.893 ± 0.042	0.244TyrCys: 0.244 ± 0.013	1.532TyrAsp: 1.532 ± 0.041	1.48TyrGlu: 1.48 ± 0.03	0.9TyrPhe: 0.9 ± 0.028	2.189TyrGly: 2.189 ± 0.042	0.726TyrHis: 0.726 ± 0.022	1.141TyrIle: 1.141 ± 0.031	0.417TyrLys: 0.417 ± 0.019	2.975TyrLeu: 2.975 ± 0.042	0.448TyrMet: 0.448 ± 0.018	0.826TyrAsn: 0.826 ± 0.024	1.327TyrPro: 1.327 ± 0.031	1.224TyrGln: 1.224 ± 0.029	2.21TyrArg: 2.21 ± 0.039	1.331TyrSer: 1.331 ± 0.032	1.499TyrThr: 1.499 ± 0.029	1.737TyrVal: 1.737 ± 0.036	0.442TyrTrp: 0.442 ± 0.018	0.784TyrTyr: 0.784 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4287 proteins (1557175 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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