Amino acid dipepetide frequency for Roseomonas rhizosphaerae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	25.823AlaAla: 25.823 ± 0.275	1.31AlaCys: 1.31 ± 0.036	6.29AlaAsp: 6.29 ± 0.078	10.379AlaGlu: 10.379 ± 0.117	4.433AlaPhe: 4.433 ± 0.053	14.135AlaGly: 14.135 ± 0.14	2.461AlaHis: 2.461 ± 0.039	5.368AlaIle: 5.368 ± 0.061	2.505AlaLys: 2.505 ± 0.057	18.665AlaLeu: 18.665 ± 0.203	4.227AlaMet: 4.227 ± 0.054	2.33AlaAsn: 2.33 ± 0.043	8.644AlaPro: 8.644 ± 0.108	4.495AlaGln: 4.495 ± 0.061	13.006AlaArg: 13.006 ± 0.134	5.863AlaSer: 5.863 ± 0.064	6.296AlaThr: 6.296 ± 0.072	10.013AlaVal: 10.013 ± 0.097	2.061AlaTrp: 2.061 ± 0.044	2.274AlaTyr: 2.274 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.216CysAla: 1.216 ± 0.034	0.126CysCys: 0.126 ± 0.01	0.47CysAsp: 0.47 ± 0.018	0.361CysGlu: 0.361 ± 0.017	0.306CysPhe: 0.306 ± 0.016	0.938CysGly: 0.938 ± 0.028	0.217CysHis: 0.217 ± 0.014	0.32CysIle: 0.32 ± 0.015	0.105CysLys: 0.105 ± 0.009	0.854CysLeu: 0.854 ± 0.023	0.125CysMet: 0.125 ± 0.009	0.165CysAsn: 0.165 ± 0.011	0.51CysPro: 0.51 ± 0.018	0.227CysGln: 0.227 ± 0.012	0.707CysArg: 0.707 ± 0.022	0.354CysSer: 0.354 ± 0.018	0.376CysThr: 0.376 ± 0.017	0.597CysVal: 0.597 ± 0.021	0.126CysTrp: 0.126 ± 0.009	0.158CysTyr: 0.158 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	6.704AspAla: 6.704 ± 0.079	0.399AspCys: 0.399 ± 0.016	2.046AspAsp: 2.046 ± 0.048	2.631AspGlu: 2.631 ± 0.045	1.742AspPhe: 1.742 ± 0.046	4.786AspGly: 4.786 ± 0.062	1.055AspHis: 1.055 ± 0.029	2.055AspIle: 2.055 ± 0.04	0.884AspLys: 0.884 ± 0.026	5.091AspLeu: 5.091 ± 0.063	1.143AspMet: 1.143 ± 0.029	0.812AspAsn: 0.812 ± 0.026	3.65AspPro: 3.65 ± 0.053	1.192AspGln: 1.192 ± 0.027	3.981AspArg: 3.981 ± 0.05	1.812AspSer: 1.812 ± 0.04	2.152AspThr: 2.152 ± 0.043	3.181AspVal: 3.181 ± 0.053	0.935AspTrp: 0.935 ± 0.027	1.066AspTyr: 1.066 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	10.541GluAla: 10.541 ± 0.12	0.331GluCys: 0.331 ± 0.016	2.534GluAsp: 2.534 ± 0.052	3.614GluGlu: 3.614 ± 0.058	1.436GluPhe: 1.436 ± 0.035	5.72GluGly: 5.72 ± 0.08	1.163GluHis: 1.163 ± 0.03	2.646GluIle: 2.646 ± 0.05	1.541GluLys: 1.541 ± 0.043	5.184GluLeu: 5.184 ± 0.068	1.555GluMet: 1.555 ± 0.033	1.135GluAsn: 1.135 ± 0.034	3.019GluPro: 3.019 ± 0.055	2.002GluGln: 2.002 ± 0.04	5.524GluArg: 5.524 ± 0.069	2.052GluSer: 2.052 ± 0.043	2.889GluThr: 2.889 ± 0.049	4.035GluVal: 4.035 ± 0.058	0.799GluTrp: 0.799 ± 0.025	0.802GluTyr: 0.802 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.285PheAla: 4.285 ± 0.059	0.354PheCys: 0.354 ± 0.016	1.926PheAsp: 1.926 ± 0.038	1.679PheGlu: 1.679 ± 0.038	1.096PhePhe: 1.096 ± 0.029	3.524PheGly: 3.524 ± 0.058	0.71PheHis: 0.71 ± 0.023	1.203PheIle: 1.203 ± 0.033	0.492PheLys: 0.492 ± 0.02	3.404PheLeu: 3.404 ± 0.052	0.621PheMet: 0.621 ± 0.023	0.778PheAsn: 0.778 ± 0.023	1.62PhePro: 1.62 ± 0.035	0.908PheGln: 0.908 ± 0.024	2.542PheArg: 2.542 ± 0.041	1.74PheSer: 1.74 ± 0.036	1.751PheThr: 1.751 ± 0.036	2.165PheVal: 2.165 ± 0.051	0.516PheTrp: 0.516 ± 0.019	0.626PheTyr: 0.626 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	12.423GlyAla: 12.423 ± 0.105	0.91GlyCys: 0.91 ± 0.024	3.73GlyAsp: 3.73 ± 0.06	5.166GlyGlu: 5.166 ± 0.06	3.664GlyPhe: 3.664 ± 0.06	9.331GlyGly: 9.331 ± 0.101	2.218GlyHis: 2.218 ± 0.046	4.12GlyIle: 4.12 ± 0.061	2.188GlyLys: 2.188 ± 0.049	11.09GlyLeu: 11.09 ± 0.108	2.848GlyMet: 2.848 ± 0.049	1.912GlyAsn: 1.912 ± 0.044	4.754GlyPro: 4.754 ± 0.059	3.465GlyGln: 3.465 ± 0.055	8.29GlyArg: 8.29 ± 0.087	4.295GlySer: 4.295 ± 0.06	4.998GlyThr: 4.998 ± 0.07	6.286GlyVal: 6.286 ± 0.074	1.822GlyTrp: 1.822 ± 0.044	1.991GlyTyr: 1.991 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.906HisAla: 2.906 ± 0.051	0.214HisCys: 0.214 ± 0.012	1.129HisAsp: 1.129 ± 0.027	0.946HisGlu: 0.946 ± 0.026	0.736HisPhe: 0.736 ± 0.026	2.241HisGly: 2.241 ± 0.047	0.581HisHis: 0.581 ± 0.022	0.677HisIle: 0.677 ± 0.023	0.284HisLys: 0.284 ± 0.016	2.254HisLeu: 2.254 ± 0.038	0.407HisMet: 0.407 ± 0.02	0.41HisAsn: 0.41 ± 0.019	1.576HisPro: 1.576 ± 0.035	0.571HisGln: 0.571 ± 0.023	1.662HisArg: 1.662 ± 0.039	0.796HisSer: 0.796 ± 0.027	0.788HisThr: 0.788 ± 0.027	1.499HisVal: 1.499 ± 0.035	0.358HisTrp: 0.358 ± 0.019	0.502HisTyr: 0.502 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.976IleAla: 5.976 ± 0.068	0.339IleCys: 0.339 ± 0.016	2.163IleAsp: 2.163 ± 0.045	2.402IleGlu: 2.402 ± 0.05	1.031IlePhe: 1.031 ± 0.028	4.292IleGly: 4.292 ± 0.063	0.783IleHis: 0.783 ± 0.024	1.346IleIle: 1.346 ± 0.032	0.641IleLys: 0.641 ± 0.024	3.807IleLeu: 3.807 ± 0.057	0.68IleMet: 0.68 ± 0.022	0.885IleAsn: 0.885 ± 0.028	2.176IlePro: 2.176 ± 0.042	0.998IleGln: 0.998 ± 0.027	3.065IleArg: 3.065 ± 0.051	1.796IleSer: 1.796 ± 0.042	1.942IleThr: 1.942 ± 0.038	2.731IleVal: 2.731 ± 0.046	0.451IleTrp: 0.451 ± 0.016	0.729IleTyr: 0.729 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	2.838LysAla: 2.838 ± 0.055	0.084LysCys: 0.084 ± 0.008	0.942LysAsp: 0.942 ± 0.028	0.977LysGlu: 0.977 ± 0.032	0.473LysPhe: 0.473 ± 0.023	1.814LysGly: 1.814 ± 0.042	0.344LysHis: 0.344 ± 0.018	0.751LysIle: 0.751 ± 0.029	0.562LysLys: 0.562 ± 0.028	2.146LysLeu: 2.146 ± 0.049	0.424LysMet: 0.424 ± 0.018	0.389LysAsn: 0.389 ± 0.019	1.392LysPro: 1.392 ± 0.036	0.608LysGln: 0.608 ± 0.021	1.632LysArg: 1.632 ± 0.038	0.925LysSer: 0.925 ± 0.028	0.918LysThr: 0.918 ± 0.025	1.653LysVal: 1.653 ± 0.044	0.213LysTrp: 0.213 ± 0.014	0.316LysTyr: 0.316 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	18.562LeuAla: 18.562 ± 0.183	1.017LeuCys: 1.017 ± 0.027	5.797LeuAsp: 5.797 ± 0.068	6.19LeuGlu: 6.19 ± 0.081	3.296LeuPhe: 3.296 ± 0.059	10.257LeuGly: 10.257 ± 0.114	2.212LeuHis: 2.212 ± 0.04	3.517LeuIle: 3.517 ± 0.05	2.256LeuLys: 2.256 ± 0.048	12.911LeuLeu: 12.911 ± 0.163	2.299LeuMet: 2.299 ± 0.044	2.036LeuAsn: 2.036 ± 0.044	7.89LeuPro: 7.89 ± 0.095	2.698LeuGln: 2.698 ± 0.049	10.456LeuArg: 10.456 ± 0.119	5.915LeuSer: 5.915 ± 0.075	4.842LeuThr: 4.842 ± 0.06	7.949LeuVal: 7.949 ± 0.09	1.46LeuTrp: 1.46 ± 0.039	1.794LeuTyr: 1.794 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.733MetAla: 3.733 ± 0.05	0.123MetCys: 0.123 ± 0.009	1.077MetAsp: 1.077 ± 0.027	1.185MetGlu: 1.185 ± 0.03	0.571MetPhe: 0.571 ± 0.02	1.904MetGly: 1.904 ± 0.042	0.375MetHis: 0.375 ± 0.018	0.877MetIle: 0.877 ± 0.026	0.557MetLys: 0.557 ± 0.02	2.805MetLeu: 2.805 ± 0.044	0.592MetMet: 0.592 ± 0.021	0.581MetAsn: 0.581 ± 0.019	1.841MetPro: 1.841 ± 0.034	0.813MetGln: 0.813 ± 0.023	2.027MetArg: 2.027 ± 0.039	1.345MetSer: 1.345 ± 0.034	1.572MetThr: 1.572 ± 0.035	1.715MetVal: 1.715 ± 0.038	0.2MetTrp: 0.2 ± 0.012	0.251MetTyr: 0.251 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.714AsnAla: 2.714 ± 0.041	0.173AsnCys: 0.173 ± 0.011	0.935AsnAsp: 0.935 ± 0.031	0.82AsnGlu: 0.82 ± 0.028	0.63AsnPhe: 0.63 ± 0.023	1.789AsnGly: 1.789 ± 0.042	0.413AsnHis: 0.413 ± 0.018	0.902AsnIle: 0.902 ± 0.025	0.413AsnLys: 0.413 ± 0.017	2.151AsnLeu: 2.151 ± 0.042	0.459AsnMet: 0.459 ± 0.019	0.52AsnAsn: 0.52 ± 0.02	1.605AsnPro: 1.605 ± 0.038	0.552AsnGln: 0.552 ± 0.022	1.635AsnArg: 1.635 ± 0.03	0.828AsnSer: 0.828 ± 0.026	1.006AsnThr: 1.006 ± 0.029	1.358AsnVal: 1.358 ± 0.032	0.323AsnTrp: 0.323 ± 0.017	0.451AsnTyr: 0.451 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	9.854ProAla: 9.854 ± 0.115	0.398ProCys: 0.398 ± 0.016	3.579ProAsp: 3.579 ± 0.053	4.935ProGlu: 4.935 ± 0.061	1.998ProPhe: 1.998 ± 0.036	6.997ProGly: 6.997 ± 0.074	1.27ProHis: 1.27 ± 0.03	1.785ProIle: 1.785 ± 0.037	1.035ProLys: 1.035 ± 0.031	6.297ProLeu: 6.297 ± 0.077	1.352ProMet: 1.352 ± 0.03	1.167ProAsn: 1.167 ± 0.033	4.778ProPro: 4.778 ± 0.103	1.786ProGln: 1.786 ± 0.034	4.708ProArg: 4.708 ± 0.062	2.644ProSer: 2.644 ± 0.051	2.32ProThr: 2.32 ± 0.05	4.85ProVal: 4.85 ± 0.061	0.934ProTrp: 0.934 ± 0.026	1.089ProTyr: 1.089 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.983GlnAla: 4.983 ± 0.064	0.183GlnCys: 0.183 ± 0.012	1.531GlnAsp: 1.531 ± 0.031	1.693GlnGlu: 1.693 ± 0.037	0.792GlnPhe: 0.792 ± 0.024	3.046GlnGly: 3.046 ± 0.044	0.622GlnHis: 0.622 ± 0.021	1.266GlnIle: 1.266 ± 0.031	0.689GlnLys: 0.689 ± 0.028	2.64GlnLeu: 2.64 ± 0.04	0.731GlnMet: 0.731 ± 0.023	0.611GlnAsn: 0.611 ± 0.024	2.099GlnPro: 2.099 ± 0.036	1.14GlnGln: 1.14 ± 0.038	2.665GlnArg: 2.665 ± 0.056	1.329GlnSer: 1.329 ± 0.031	1.183GlnThr: 1.183 ± 0.033	2.278GlnVal: 2.278 ± 0.039	0.372GlnTrp: 0.372 ± 0.017	0.421GlnTyr: 0.421 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	11.81ArgAla: 11.81 ± 0.109	0.655ArgCys: 0.655 ± 0.022	4.232ArgAsp: 4.232 ± 0.057	4.99ArgGlu: 4.99 ± 0.066	3.074ArgPhe: 3.074 ± 0.05	6.686ArgGly: 6.686 ± 0.08	2.248ArgHis: 2.248 ± 0.044	3.766ArgIle: 3.766 ± 0.058	1.583ArgLys: 1.583 ± 0.037	10.64ArgLeu: 10.64 ± 0.104	2.19ArgMet: 2.19 ± 0.043	1.77ArgAsn: 1.77 ± 0.037	5.365ArgPro: 5.365 ± 0.08	3.171ArgGln: 3.171 ± 0.06	8.396ArgArg: 8.396 ± 0.098	3.266ArgSer: 3.266 ± 0.053	3.223ArgThr: 3.223 ± 0.047	5.567ArgVal: 5.567 ± 0.072	1.308ArgTrp: 1.308 ± 0.032	1.48ArgTyr: 1.48 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	5.765SerAla: 5.765 ± 0.064	0.4SerCys: 0.4 ± 0.017	1.901SerAsp: 1.901 ± 0.039	2.001SerGlu: 2.001 ± 0.041	1.788SerPhe: 1.788 ± 0.038	5.042SerGly: 5.042 ± 0.058	0.925SerHis: 0.925 ± 0.028	1.842SerIle: 1.842 ± 0.038	0.77SerLys: 0.77 ± 0.026	5.062SerLeu: 5.062 ± 0.071	1.04SerMet: 1.04 ± 0.032	0.87SerAsn: 0.87 ± 0.029	2.89SerPro: 2.89 ± 0.048	1.232SerGln: 1.232 ± 0.028	3.465SerArg: 3.465 ± 0.051	2.041SerSer: 2.041 ± 0.042	2.105SerThr: 2.105 ± 0.039	3.174SerVal: 3.174 ± 0.047	0.715SerTrp: 0.715 ± 0.023	0.937SerTyr: 0.937 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.094ThrAla: 6.094 ± 0.062	0.325ThrCys: 0.325 ± 0.018	2.198ThrAsp: 2.198 ± 0.04	2.476ThrGlu: 2.476 ± 0.042	1.414ThrPhe: 1.414 ± 0.033	4.869ThrGly: 4.869 ± 0.071	0.925ThrHis: 0.925 ± 0.03	1.831ThrIle: 1.831 ± 0.038	0.731ThrLys: 0.731 ± 0.025	5.943ThrLeu: 5.943 ± 0.072	0.969ThrMet: 0.969 ± 0.03	0.861ThrAsn: 0.861 ± 0.026	3.534ThrPro: 3.534 ± 0.048	1.232ThrGln: 1.232 ± 0.032	3.406ThrArg: 3.406 ± 0.052	1.863ThrSer: 1.863 ± 0.037	2.264ThrThr: 2.264 ± 0.046	3.704ThrVal: 3.704 ± 0.055	0.523ThrTrp: 0.523 ± 0.02	0.91ThrTyr: 0.91 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	10.386ValAla: 10.386 ± 0.111	0.554ValCys: 0.554 ± 0.021	3.132ValAsp: 3.132 ± 0.052	4.475ValGlu: 4.475 ± 0.059	2.353ValPhe: 2.353 ± 0.04	5.236ValGly: 5.236 ± 0.064	1.263ValHis: 1.263 ± 0.033	2.888ValIle: 2.888 ± 0.058	1.482ValLys: 1.482 ± 0.041	8.587ValLeu: 8.587 ± 0.088	1.759ValMet: 1.759 ± 0.038	1.643ValAsn: 1.643 ± 0.043	4.587ValPro: 4.587 ± 0.058	2.041ValGln: 2.041 ± 0.035	5.134ValArg: 5.134 ± 0.07	3.494ValSer: 3.494 ± 0.05	3.944ValThr: 3.944 ± 0.06	6.084ValVal: 6.084 ± 0.079	0.893ValTrp: 0.893 ± 0.026	1.029ValTyr: 1.029 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.556TrpAla: 1.556 ± 0.036	0.163TrpCys: 0.163 ± 0.011	0.643TrpAsp: 0.643 ± 0.022	0.658TrpGlu: 0.658 ± 0.022	0.509TrpPhe: 0.509 ± 0.021	1.105TrpGly: 1.105 ± 0.03	0.385TrpHis: 0.385 ± 0.018	0.503TrpIle: 0.503 ± 0.019	0.356TrpLys: 0.356 ± 0.017	1.984TrpLeu: 1.984 ± 0.046	0.382TrpMet: 0.382 ± 0.018	0.388TrpAsn: 0.388 ± 0.017	0.895TrpPro: 0.895 ± 0.023	0.605TrpGln: 0.605 ± 0.021	1.575TrpArg: 1.575 ± 0.034	0.77TrpSer: 0.77 ± 0.027	0.685TrpThr: 0.685 ± 0.022	0.881TrpVal: 0.881 ± 0.028	0.252TrpTrp: 0.252 ± 0.014	0.258TrpTyr: 0.258 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.411TyrAla: 2.411 ± 0.041	0.197TyrCys: 0.197 ± 0.012	1.062TyrAsp: 1.062 ± 0.03	0.944TyrGlu: 0.944 ± 0.028	0.597TyrPhe: 0.597 ± 0.021	1.792TyrGly: 1.792 ± 0.036	0.368TyrHis: 0.368 ± 0.016	0.571TyrIle: 0.571 ± 0.021	0.326TyrLys: 0.326 ± 0.017	1.839TyrLeu: 1.839 ± 0.04	0.338TyrMet: 0.338 ± 0.017	0.417TyrAsn: 0.417 ± 0.018	0.951TyrPro: 0.951 ± 0.026	0.537TyrGln: 0.537 ± 0.019	1.544TyrArg: 1.544 ± 0.032	0.837TyrSer: 0.837 ± 0.027	0.816TyrThr: 0.816 ± 0.027	1.243TyrVal: 1.243 ± 0.028	0.292TyrTrp: 0.292 ± 0.015	0.424TyrTyr: 0.424 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4203 proteins (1364214 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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