Amino acid dipepetide frequency for Flavobacterium faecale

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.024AlaAla: 5.024 ± 0.096	0.547AlaCys: 0.547 ± 0.033	3.514AlaAsp: 3.514 ± 0.055	3.797AlaGlu: 3.797 ± 0.068	3.314AlaPhe: 3.314 ± 0.061	4.482AlaGly: 4.482 ± 0.107	1.026AlaHis: 1.026 ± 0.028	5.79AlaIle: 5.79 ± 0.075	5.045AlaLys: 5.045 ± 0.071	6.197AlaLeu: 6.197 ± 0.079	1.655AlaMet: 1.655 ± 0.045	3.84AlaAsn: 3.84 ± 0.073	2.083AlaPro: 2.083 ± 0.059	2.67AlaGln: 2.67 ± 0.051	1.947AlaArg: 1.947 ± 0.04	4.45AlaSer: 4.45 ± 0.082	4.751AlaThr: 4.751 ± 0.162	4.734AlaVal: 4.734 ± 0.062	0.619AlaTrp: 0.619 ± 0.024	2.374AlaTyr: 2.374 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.461CysAla: 0.461 ± 0.02	0.108CysCys: 0.108 ± 0.009	0.454CysAsp: 0.454 ± 0.037	0.448CysGlu: 0.448 ± 0.025	0.419CysPhe: 0.419 ± 0.021	0.601CysGly: 0.601 ± 0.033	0.197CysHis: 0.197 ± 0.013	0.578CysIle: 0.578 ± 0.021	0.489CysLys: 0.489 ± 0.02	0.702CysLeu: 0.702 ± 0.024	0.151CysMet: 0.151 ± 0.011	0.413CysAsn: 0.413 ± 0.02	0.323CysPro: 0.323 ± 0.021	0.229CysGln: 0.229 ± 0.014	0.214CysArg: 0.214 ± 0.014	0.629CysSer: 0.629 ± 0.03	0.516CysThr: 0.516 ± 0.024	0.43CysVal: 0.43 ± 0.02	0.078CysTrp: 0.078 ± 0.009	0.321CysTyr: 0.321 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.787AspAla: 3.787 ± 0.064	0.428AspCys: 0.428 ± 0.019	2.658AspAsp: 2.658 ± 0.062	3.274AspGlu: 3.274 ± 0.059	3.57AspPhe: 3.57 ± 0.06	3.688AspGly: 3.688 ± 0.086	0.858AspHis: 0.858 ± 0.03	4.043AspIle: 4.043 ± 0.068	4.251AspLys: 4.251 ± 0.065	5.353AspLeu: 5.353 ± 0.07	1.067AspMet: 1.067 ± 0.026	3.199AspAsn: 3.199 ± 0.062	1.732AspPro: 1.732 ± 0.052	1.715AspGln: 1.715 ± 0.04	1.787AspArg: 1.787 ± 0.036	3.101AspSer: 3.101 ± 0.051	2.611AspThr: 2.611 ± 0.072	3.309AspVal: 3.309 ± 0.053	0.743AspTrp: 0.743 ± 0.026	2.684AspTyr: 2.684 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.168GluAla: 4.168 ± 0.075	0.341GluCys: 0.341 ± 0.02	3.046GluAsp: 3.046 ± 0.056	3.991GluGlu: 3.991 ± 0.076	2.761GluPhe: 2.761 ± 0.048	3.445GluGly: 3.445 ± 0.065	0.999GluHis: 0.999 ± 0.029	5.288GluIle: 5.288 ± 0.072	5.752GluLys: 5.752 ± 0.098	5.738GluLeu: 5.738 ± 0.083	1.545GluMet: 1.545 ± 0.04	4.377GluAsn: 4.377 ± 0.065	1.392GluPro: 1.392 ± 0.032	2.193GluGln: 2.193 ± 0.055	2.142GluArg: 2.142 ± 0.047	3.283GluSer: 3.283 ± 0.055	3.365GluThr: 3.365 ± 0.051	4.051GluVal: 4.051 ± 0.06	0.618GluTrp: 0.618 ± 0.022	2.292GluTyr: 2.292 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.122PheAla: 3.122 ± 0.051	0.468PheCys: 0.468 ± 0.021	3.355PheAsp: 3.355 ± 0.053	3.571PheGlu: 3.571 ± 0.057	2.699PhePhe: 2.699 ± 0.065	3.549PheGly: 3.549 ± 0.065	0.835PheHis: 0.835 ± 0.027	3.798PheIle: 3.798 ± 0.065	3.775PheLys: 3.775 ± 0.065	4.604PheLeu: 4.604 ± 0.078	1.221PheMet: 1.221 ± 0.036	3.021PheAsn: 3.021 ± 0.055	1.692PhePro: 1.692 ± 0.039	1.621PheGln: 1.621 ± 0.034	1.541PheArg: 1.541 ± 0.035	4.046PheSer: 4.046 ± 0.073	3.247PheThr: 3.247 ± 0.057	3.233PheVal: 3.233 ± 0.052	0.544PheTrp: 0.544 ± 0.026	2.26PheTyr: 2.26 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.31GlyAla: 4.31 ± 0.082	0.575GlyCys: 0.575 ± 0.032	3.181GlyAsp: 3.181 ± 0.054	3.15GlyGlu: 3.15 ± 0.059	3.653GlyPhe: 3.653 ± 0.063	4.384GlyGly: 4.384 ± 0.092	1.089GlyHis: 1.089 ± 0.03	5.497GlyIle: 5.497 ± 0.072	5.137GlyLys: 5.137 ± 0.067	5.669GlyLeu: 5.669 ± 0.087	1.605GlyMet: 1.605 ± 0.039	3.624GlyAsn: 3.624 ± 0.087	1.356GlyPro: 1.356 ± 0.037	2.096GlyGln: 2.096 ± 0.042	1.987GlyArg: 1.987 ± 0.044	4.137GlySer: 4.137 ± 0.071	4.425GlyThr: 4.425 ± 0.125	4.284GlyVal: 4.284 ± 0.065	0.693GlyTrp: 0.693 ± 0.024	2.953GlyTyr: 2.953 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	0.965HisAla: 0.965 ± 0.029	0.175HisCys: 0.175 ± 0.012	0.849HisAsp: 0.849 ± 0.026	0.888HisGlu: 0.888 ± 0.029	1.206HisPhe: 1.206 ± 0.03	0.98HisGly: 0.98 ± 0.03	0.431HisHis: 0.431 ± 0.024	1.209HisIle: 1.209 ± 0.035	1.09HisLys: 1.09 ± 0.035	1.63HisLeu: 1.63 ± 0.042	0.286HisMet: 0.286 ± 0.014	0.937HisAsn: 0.937 ± 0.029	0.805HisPro: 0.805 ± 0.029	0.716HisGln: 0.716 ± 0.027	0.592HisArg: 0.592 ± 0.024	1.067HisSer: 1.067 ± 0.028	0.892HisThr: 0.892 ± 0.025	0.839HisVal: 0.839 ± 0.027	0.201HisTrp: 0.201 ± 0.013	0.822HisTyr: 0.822 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.044IleAla: 6.044 ± 0.093	0.727IleCys: 0.727 ± 0.034	4.725IleAsp: 4.725 ± 0.069	5.443IleGlu: 5.443 ± 0.083	3.514IlePhe: 3.514 ± 0.062	5.05IleGly: 5.05 ± 0.078	1.309IleHis: 1.309 ± 0.039	5.972IleIle: 5.972 ± 0.088	5.964IleLys: 5.964 ± 0.071	6.94IleLeu: 6.94 ± 0.088	1.502IleMet: 1.502 ± 0.039	4.567IleAsn: 4.567 ± 0.07	3.163IlePro: 3.163 ± 0.063	2.784IleGln: 2.784 ± 0.047	2.426IleArg: 2.426 ± 0.045	5.445IleSer: 5.445 ± 0.081	5.024IleThr: 5.024 ± 0.074	5.005IleVal: 5.005 ± 0.065	0.672IleTrp: 0.672 ± 0.026	2.691IleTyr: 2.691 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	5.119LysAla: 5.119 ± 0.073	0.38LysCys: 0.38 ± 0.016	4.389LysAsp: 4.389 ± 0.066	5.773LysGlu: 5.773 ± 0.094	2.982LysPhe: 2.982 ± 0.054	4.696LysGly: 4.696 ± 0.062	1.172LysHis: 1.172 ± 0.031	6.69LysIle: 6.69 ± 0.09	7.055LysLys: 7.055 ± 0.106	6.471LysLeu: 6.471 ± 0.084	2.347LysMet: 2.347 ± 0.043	5.62LysAsn: 5.62 ± 0.083	2.399LysPro: 2.399 ± 0.048	2.734LysGln: 2.734 ± 0.055	2.442LysArg: 2.442 ± 0.056	4.898LysSer: 4.898 ± 0.078	4.921LysThr: 4.921 ± 0.07	4.897LysVal: 4.897 ± 0.068	0.869LysTrp: 0.869 ± 0.028	3.097LysTyr: 3.097 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	6.028LeuAla: 6.028 ± 0.08	0.717LeuCys: 0.717 ± 0.026	4.77LeuAsp: 4.77 ± 0.075	5.679LeuGlu: 5.679 ± 0.086	5.109LeuPhe: 5.109 ± 0.081	5.79LeuGly: 5.79 ± 0.076	1.522LeuHis: 1.522 ± 0.039	6.557LeuIle: 6.557 ± 0.09	7.465LeuLys: 7.465 ± 0.097	8.713LeuLeu: 8.713 ± 0.137	2.017LeuMet: 2.017 ± 0.048	5.569LeuAsn: 5.569 ± 0.078	3.478LeuPro: 3.478 ± 0.054	3.337LeuGln: 3.337 ± 0.054	2.898LeuArg: 2.898 ± 0.052	6.508LeuSer: 6.508 ± 0.072	5.309LeuThr: 5.309 ± 0.084	5.415LeuVal: 5.415 ± 0.074	0.773LeuTrp: 0.773 ± 0.025	3.241LeuTyr: 3.241 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	1.573MetAla: 1.573 ± 0.04	0.135MetCys: 0.135 ± 0.009	1.162MetAsp: 1.162 ± 0.034	1.354MetGlu: 1.354 ± 0.037	0.862MetPhe: 0.862 ± 0.031	1.468MetGly: 1.468 ± 0.037	0.403MetHis: 0.403 ± 0.018	1.645MetIle: 1.645 ± 0.038	2.267MetLys: 2.267 ± 0.041	1.878MetLeu: 1.878 ± 0.039	0.616MetMet: 0.616 ± 0.025	1.388MetAsn: 1.388 ± 0.03	0.847MetPro: 0.847 ± 0.028	0.844MetGln: 0.844 ± 0.026	0.821MetArg: 0.821 ± 0.027	1.442MetSer: 1.442 ± 0.035	1.269MetThr: 1.269 ± 0.034	1.419MetVal: 1.419 ± 0.04	0.174MetTrp: 0.174 ± 0.013	0.766MetTyr: 0.766 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	4.049AsnAla: 4.049 ± 0.083	0.548AsnCys: 0.548 ± 0.04	3.283AsnAsp: 3.283 ± 0.055	3.594AsnGlu: 3.594 ± 0.059	3.255AsnPhe: 3.255 ± 0.063	4.241AsnGly: 4.241 ± 0.089	1.041AsnHis: 1.041 ± 0.029	4.564AsnIle: 4.564 ± 0.07	4.619AsnLys: 4.619 ± 0.068	5.577AsnLeu: 5.577 ± 0.075	1.237AsnMet: 1.237 ± 0.035	3.975AsnAsn: 3.975 ± 0.088	2.835AsnPro: 2.835 ± 0.053	2.339AsnGln: 2.339 ± 0.044	2.038AsnArg: 2.038 ± 0.047	4.216AsnSer: 4.216 ± 0.079	3.779AsnThr: 3.779 ± 0.084	3.615AsnVal: 3.615 ± 0.081	0.797AsnTrp: 0.797 ± 0.023	2.92AsnTyr: 2.92 ± 0.062	0.0AsnXaa: 0.0 ± 0.0
Pro	2.292ProAla: 2.292 ± 0.107	0.168ProCys: 0.168 ± 0.013	1.913ProAsp: 1.913 ± 0.046	2.574ProGlu: 2.574 ± 0.05	1.977ProPhe: 1.977 ± 0.048	1.735ProGly: 1.735 ± 0.044	0.566ProHis: 0.566 ± 0.023	2.727ProIle: 2.727 ± 0.05	2.568ProLys: 2.568 ± 0.05	2.925ProLeu: 2.925 ± 0.047	0.697ProMet: 0.697 ± 0.021	2.351ProAsn: 2.351 ± 0.052	0.751ProPro: 0.751 ± 0.029	1.088ProGln: 1.088 ± 0.023	0.824ProArg: 0.824 ± 0.027	2.215ProSer: 2.215 ± 0.054	2.357ProThr: 2.357 ± 0.072	2.399ProVal: 2.399 ± 0.069	0.346ProTrp: 0.346 ± 0.016	1.413ProTyr: 1.413 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.187GlnAla: 2.187 ± 0.049	0.189GlnCys: 0.189 ± 0.011	1.709GlnAsp: 1.709 ± 0.04	2.233GlnGlu: 2.233 ± 0.045	1.812GlnPhe: 1.812 ± 0.041	1.899GlnGly: 1.899 ± 0.048	0.589GlnHis: 0.589 ± 0.022	2.803GlnIle: 2.803 ± 0.05	3.17GlnLys: 3.17 ± 0.062	3.591GlnLeu: 3.591 ± 0.065	0.846GlnMet: 0.846 ± 0.027	2.476GlnAsn: 2.476 ± 0.041	1.079GlnPro: 1.079 ± 0.034	1.447GlnGln: 1.447 ± 0.037	1.114GlnArg: 1.114 ± 0.031	2.119GlnSer: 2.119 ± 0.04	2.104GlnThr: 2.104 ± 0.036	2.062GlnVal: 2.062 ± 0.042	0.417GlnTrp: 0.417 ± 0.019	1.429GlnTyr: 1.429 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.01ArgAla: 2.01 ± 0.048	0.188ArgCys: 0.188 ± 0.013	1.624ArgAsp: 1.624 ± 0.037	1.895ArgGlu: 1.895 ± 0.041	1.792ArgPhe: 1.792 ± 0.038	1.752ArgGly: 1.752 ± 0.039	0.501ArgHis: 0.501 ± 0.021	2.646ArgIle: 2.646 ± 0.054	2.617ArgLys: 2.617 ± 0.049	2.886ArgLeu: 2.886 ± 0.056	0.877ArgMet: 0.877 ± 0.024	1.989ArgAsn: 1.989 ± 0.045	1.068ArgPro: 1.068 ± 0.028	0.993ArgGln: 0.993 ± 0.03	1.081ArgArg: 1.081 ± 0.033	1.836ArgSer: 1.836 ± 0.044	1.877ArgThr: 1.877 ± 0.04	1.917ArgVal: 1.917 ± 0.043	0.376ArgTrp: 0.376 ± 0.018	1.409ArgTyr: 1.409 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	4.004SerAla: 4.004 ± 0.066	0.686SerCys: 0.686 ± 0.025	3.431SerAsp: 3.431 ± 0.052	3.441SerGlu: 3.441 ± 0.064	3.848SerPhe: 3.848 ± 0.062	4.508SerGly: 4.508 ± 0.095	1.11SerHis: 1.11 ± 0.031	5.411SerIle: 5.411 ± 0.073	5.102SerLys: 5.102 ± 0.073	5.937SerLeu: 5.937 ± 0.082	1.308SerMet: 1.308 ± 0.032	4.318SerAsn: 4.318 ± 0.078	2.217SerPro: 2.217 ± 0.048	2.298SerGln: 2.298 ± 0.043	2.109SerArg: 2.109 ± 0.042	4.686SerSer: 4.686 ± 0.09	4.102SerThr: 4.102 ± 0.084	4.056SerVal: 4.056 ± 0.059	0.733SerTrp: 0.733 ± 0.026	2.863SerTyr: 2.863 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	4.801ThrAla: 4.801 ± 0.147	0.36ThrCys: 0.36 ± 0.027	3.41ThrAsp: 3.41 ± 0.067	3.299ThrGlu: 3.299 ± 0.053	3.173ThrPhe: 3.173 ± 0.062	4.202ThrGly: 4.202 ± 0.099	1.01ThrHis: 1.01 ± 0.029	5.471ThrIle: 5.471 ± 0.095	4.192ThrLys: 4.192 ± 0.052	5.446ThrLeu: 5.446 ± 0.086	1.028ThrMet: 1.028 ± 0.033	3.819ThrAsn: 3.819 ± 0.102	2.605ThrPro: 2.605 ± 0.11	2.015ThrGln: 2.015 ± 0.042	1.536ThrArg: 1.536 ± 0.037	3.96ThrSer: 3.96 ± 0.084	4.482ThrThr: 4.482 ± 0.121	4.445ThrVal: 4.445 ± 0.125	0.576ThrTrp: 0.576 ± 0.027	2.43ThrTyr: 2.43 ± 0.064	0.0ThrXaa: 0.0 ± 0.0
Val	4.785ValAla: 4.785 ± 0.07	0.553ValCys: 0.553 ± 0.023	3.507ValAsp: 3.507 ± 0.058	3.58ValGlu: 3.58 ± 0.059	3.205ValPhe: 3.205 ± 0.054	4.08ValGly: 4.08 ± 0.053	0.951ValHis: 0.951 ± 0.026	4.784ValIle: 4.784 ± 0.058	4.452ValLys: 4.452 ± 0.07	5.974ValLeu: 5.974 ± 0.068	1.298ValMet: 1.298 ± 0.034	3.644ValAsn: 3.644 ± 0.062	2.306ValPro: 2.306 ± 0.052	2.066ValGln: 2.066 ± 0.038	2.012ValArg: 2.012 ± 0.048	4.546ValSer: 4.546 ± 0.073	4.067ValThr: 4.067 ± 0.134	4.583ValVal: 4.583 ± 0.063	0.602ValTrp: 0.602 ± 0.023	2.425ValTyr: 2.425 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.617TrpAla: 0.617 ± 0.022	0.096TrpCys: 0.096 ± 0.008	0.588TrpAsp: 0.588 ± 0.023	0.648TrpGlu: 0.648 ± 0.024	0.559TrpPhe: 0.559 ± 0.023	0.67TrpGly: 0.67 ± 0.027	0.243TrpHis: 0.243 ± 0.013	0.737TrpIle: 0.737 ± 0.027	0.833TrpLys: 0.833 ± 0.026	0.88TrpLeu: 0.88 ± 0.031	0.296TrpMet: 0.296 ± 0.015	0.753TrpAsn: 0.753 ± 0.027	0.233TrpPro: 0.233 ± 0.017	0.412TrpGln: 0.412 ± 0.018	0.356TrpArg: 0.356 ± 0.019	0.712TrpSer: 0.712 ± 0.026	0.665TrpThr: 0.665 ± 0.03	0.582TrpVal: 0.582 ± 0.025	0.148TrpTrp: 0.148 ± 0.008	0.432TrpTyr: 0.432 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.514TyrAla: 2.514 ± 0.049	0.372TyrCys: 0.372 ± 0.02	2.291TyrAsp: 2.291 ± 0.043	2.155TyrGlu: 2.155 ± 0.042	2.493TyrPhe: 2.493 ± 0.054	2.583TyrGly: 2.583 ± 0.048	0.729TyrHis: 0.729 ± 0.026	2.757TyrIle: 2.757 ± 0.048	3.107TyrLys: 3.107 ± 0.056	3.785TyrLeu: 3.785 ± 0.069	0.735TyrMet: 0.735 ± 0.028	2.642TyrAsn: 2.642 ± 0.056	1.52TyrPro: 1.52 ± 0.035	1.677TyrGln: 1.677 ± 0.04	1.466TyrArg: 1.466 ± 0.038	2.875TyrSer: 2.875 ± 0.065	2.494TyrThr: 2.494 ± 0.059	2.143TyrVal: 2.143 ± 0.046	0.483TyrTrp: 0.483 ± 0.02	1.864TyrTyr: 1.864 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3658 proteins (1287814 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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