Amino acid dipepetide frequency for Alteromonadaceae bacterium 2753L.S.0a.02

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.753AlaAla: 8.753 ± 0.121	1.149AlaCys: 1.149 ± 0.028	4.668AlaAsp: 4.668 ± 0.067	5.821AlaGlu: 5.821 ± 0.067	3.435AlaPhe: 3.435 ± 0.05	6.489AlaGly: 6.489 ± 0.076	1.754AlaHis: 1.754 ± 0.036	5.629AlaIle: 5.629 ± 0.064	3.977AlaLys: 3.977 ± 0.058	9.825AlaLeu: 9.825 ± 0.105	2.388AlaMet: 2.388 ± 0.046	3.876AlaAsn: 3.876 ± 0.059	3.295AlaPro: 3.295 ± 0.053	3.905AlaGln: 3.905 ± 0.054	4.267AlaArg: 4.267 ± 0.055	6.054AlaSer: 6.054 ± 0.074	4.848AlaThr: 4.848 ± 0.063	6.185AlaVal: 6.185 ± 0.064	1.178AlaTrp: 1.178 ± 0.028	2.595AlaTyr: 2.595 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.966CysAla: 0.966 ± 0.027	0.201CysCys: 0.201 ± 0.011	0.705CysAsp: 0.705 ± 0.021	0.772CysGlu: 0.772 ± 0.023	0.483CysPhe: 0.483 ± 0.017	1.002CysGly: 1.002 ± 0.027	0.405CysHis: 0.405 ± 0.027	0.609CysIle: 0.609 ± 0.02	0.418CysLys: 0.418 ± 0.017	1.042CysLeu: 1.042 ± 0.025	0.222CysMet: 0.222 ± 0.011	0.508CysAsn: 0.508 ± 0.02	0.436CysPro: 0.436 ± 0.017	0.358CysGln: 0.358 ± 0.013	0.548CysArg: 0.548 ± 0.018	0.869CysSer: 0.869 ± 0.024	0.493CysThr: 0.493 ± 0.016	0.776CysVal: 0.776 ± 0.024	0.173CysTrp: 0.173 ± 0.011	0.35CysTyr: 0.35 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.037AspAla: 5.037 ± 0.065	0.621AspCys: 0.621 ± 0.02	3.195AspAsp: 3.195 ± 0.069	3.607AspGlu: 3.607 ± 0.054	2.528AspPhe: 2.528 ± 0.042	4.144AspGly: 4.144 ± 0.095	1.074AspHis: 1.074 ± 0.026	3.842AspIle: 3.842 ± 0.057	2.634AspLys: 2.634 ± 0.047	5.316AspLeu: 5.316 ± 0.062	1.137AspMet: 1.137 ± 0.026	2.559AspAsn: 2.559 ± 0.066	2.394AspPro: 2.394 ± 0.049	1.884AspGln: 1.884 ± 0.031	2.464AspArg: 2.464 ± 0.035	3.701AspSer: 3.701 ± 0.068	3.074AspThr: 3.074 ± 0.063	3.676AspVal: 3.676 ± 0.055	0.944AspTrp: 0.944 ± 0.026	2.26AspTyr: 2.26 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	5.297GluAla: 5.297 ± 0.067	0.536GluCys: 0.536 ± 0.02	2.943GluAsp: 2.943 ± 0.041	3.303GluGlu: 3.303 ± 0.058	2.698GluPhe: 2.698 ± 0.041	3.483GluGly: 3.483 ± 0.048	1.434GluHis: 1.434 ± 0.032	4.032GluIle: 4.032 ± 0.049	3.377GluLys: 3.377 ± 0.054	6.847GluLeu: 6.847 ± 0.081	1.439GluMet: 1.439 ± 0.028	3.146GluAsn: 3.146 ± 0.045	2.298GluPro: 2.298 ± 0.037	3.408GluGln: 3.408 ± 0.049	3.305GluArg: 3.305 ± 0.05	3.887GluSer: 3.887 ± 0.053	3.371GluThr: 3.371 ± 0.047	3.816GluVal: 3.816 ± 0.057	0.78GluTrp: 0.78 ± 0.021	2.011GluTyr: 2.011 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.519PheAla: 3.519 ± 0.052	0.577PheCys: 0.577 ± 0.019	2.799PheAsp: 2.799 ± 0.043	2.618PheGlu: 2.618 ± 0.043	1.805PhePhe: 1.805 ± 0.043	3.151PheGly: 3.151 ± 0.056	0.812PheHis: 0.812 ± 0.02	2.431PheIle: 2.431 ± 0.038	1.84PheLys: 1.84 ± 0.035	3.522PheLeu: 3.522 ± 0.056	0.871PheMet: 0.871 ± 0.025	2.09PheAsn: 2.09 ± 0.04	1.538PhePro: 1.538 ± 0.027	1.331PheGln: 1.331 ± 0.023	1.719PheArg: 1.719 ± 0.033	3.365PheSer: 3.365 ± 0.044	2.422PheThr: 2.422 ± 0.043	2.899PheVal: 2.899 ± 0.05	0.589PheTrp: 0.589 ± 0.018	1.469PheTyr: 1.469 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	5.572GlyAla: 5.572 ± 0.062	0.875GlyCys: 0.875 ± 0.026	4.424GlyAsp: 4.424 ± 0.075	4.673GlyGlu: 4.673 ± 0.057	3.296GlyPhe: 3.296 ± 0.046	5.431GlyGly: 5.431 ± 0.118	1.429GlyHis: 1.429 ± 0.029	4.374GlyIle: 4.374 ± 0.057	3.469GlyLys: 3.469 ± 0.054	6.729GlyLeu: 6.729 ± 0.082	1.747GlyMet: 1.747 ± 0.033	3.17GlyAsn: 3.17 ± 0.065	1.866GlyPro: 1.866 ± 0.038	2.271GlyGln: 2.271 ± 0.042	3.297GlyArg: 3.297 ± 0.049	4.799GlySer: 4.799 ± 0.092	3.584GlyThr: 3.584 ± 0.066	5.43GlyVal: 5.43 ± 0.069	1.093GlyTrp: 1.093 ± 0.03	2.554GlyTyr: 2.554 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.694HisAla: 1.694 ± 0.033	0.357HisCys: 0.357 ± 0.016	1.079HisAsp: 1.079 ± 0.027	1.165HisGlu: 1.165 ± 0.027	1.031HisPhe: 1.031 ± 0.024	1.475HisGly: 1.475 ± 0.033	0.632HisHis: 0.632 ± 0.019	1.3HisIle: 1.3 ± 0.027	0.997HisLys: 0.997 ± 0.023	2.217HisLeu: 2.217 ± 0.036	0.459HisMet: 0.459 ± 0.019	0.971HisAsn: 0.971 ± 0.027	1.169HisPro: 1.169 ± 0.027	0.996HisGln: 0.996 ± 0.027	1.191HisArg: 1.191 ± 0.027	1.479HisSer: 1.479 ± 0.03	1.183HisThr: 1.183 ± 0.025	1.145HisVal: 1.145 ± 0.027	0.396HisTrp: 0.396 ± 0.015	0.891HisTyr: 0.891 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.092IleAla: 6.092 ± 0.066	0.649IleCys: 0.649 ± 0.019	3.904IleAsp: 3.904 ± 0.06	3.973IleGlu: 3.973 ± 0.056	2.234IlePhe: 2.234 ± 0.042	3.91IleGly: 3.91 ± 0.058	1.254IleHis: 1.254 ± 0.028	2.977IleIle: 2.977 ± 0.048	2.671IleLys: 2.671 ± 0.042	4.782IleLeu: 4.782 ± 0.062	1.032IleMet: 1.032 ± 0.024	2.925IleAsn: 2.925 ± 0.041	2.619IlePro: 2.619 ± 0.041	1.979IleGln: 1.979 ± 0.034	2.817IleArg: 2.817 ± 0.044	4.498IleSer: 4.498 ± 0.058	3.639IleThr: 3.639 ± 0.053	3.816IleVal: 3.816 ± 0.062	0.626IleTrp: 0.626 ± 0.019	1.788IleTyr: 1.788 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.938LysAla: 3.938 ± 0.06	0.318LysCys: 0.318 ± 0.014	2.146LysAsp: 2.146 ± 0.035	2.364LysGlu: 2.364 ± 0.041	1.558LysPhe: 1.558 ± 0.033	2.588LysGly: 2.588 ± 0.043	1.153LysHis: 1.153 ± 0.028	3.027LysIle: 3.027 ± 0.048	2.597LysLys: 2.597 ± 0.053	4.879LysLeu: 4.879 ± 0.066	1.043LysMet: 1.043 ± 0.025	2.389LysAsn: 2.389 ± 0.039	2.283LysPro: 2.283 ± 0.041	2.268LysGln: 2.268 ± 0.044	2.55LysArg: 2.55 ± 0.039	3.01LysSer: 3.01 ± 0.049	2.807LysThr: 2.807 ± 0.046	3.012LysVal: 3.012 ± 0.046	0.49LysTrp: 0.49 ± 0.018	1.425LysTyr: 1.425 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	10.103LeuAla: 10.103 ± 0.103	1.18LeuCys: 1.18 ± 0.03	5.639LeuAsp: 5.639 ± 0.074	6.345LeuGlu: 6.345 ± 0.075	3.979LeuPhe: 3.979 ± 0.061	6.95LeuGly: 6.95 ± 0.076	2.168LeuHis: 2.168 ± 0.036	5.505LeuIle: 5.505 ± 0.063	4.863LeuLys: 4.863 ± 0.06	10.719LeuLeu: 10.719 ± 0.118	2.188LeuMet: 2.188 ± 0.035	4.536LeuAsn: 4.536 ± 0.049	4.768LeuPro: 4.768 ± 0.055	4.726LeuGln: 4.726 ± 0.073	5.113LeuArg: 5.113 ± 0.072	7.614LeuSer: 7.614 ± 0.073	5.225LeuThr: 5.225 ± 0.06	6.891LeuVal: 6.891 ± 0.08	1.201LeuTrp: 1.201 ± 0.027	2.783LeuTyr: 2.783 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.209MetAla: 2.209 ± 0.043	0.207MetCys: 0.207 ± 0.012	1.126MetAsp: 1.126 ± 0.026	1.211MetGlu: 1.211 ± 0.03	0.763MetPhe: 0.763 ± 0.021	1.527MetGly: 1.527 ± 0.032	0.503MetHis: 0.503 ± 0.017	1.131MetIle: 1.131 ± 0.027	1.139MetLys: 1.139 ± 0.028	2.285MetLeu: 2.285 ± 0.038	0.502MetMet: 0.502 ± 0.017	0.959MetAsn: 0.959 ± 0.021	1.07MetPro: 1.07 ± 0.024	1.011MetGln: 1.011 ± 0.022	1.199MetArg: 1.199 ± 0.031	1.6MetSer: 1.6 ± 0.031	1.131MetThr: 1.131 ± 0.031	1.511MetVal: 1.511 ± 0.029	0.191MetTrp: 0.191 ± 0.011	0.48MetTyr: 0.48 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	4.008AsnAla: 4.008 ± 0.061	0.528AsnCys: 0.528 ± 0.019	2.446AsnAsp: 2.446 ± 0.053	2.444AsnGlu: 2.444 ± 0.038	1.897AsnPhe: 1.897 ± 0.036	3.303AsnGly: 3.303 ± 0.073	0.959AsnHis: 0.959 ± 0.024	2.874AsnIle: 2.874 ± 0.047	1.966AsnLys: 1.966 ± 0.041	4.388AsnLeu: 4.388 ± 0.051	0.917AsnMet: 0.917 ± 0.02	2.326AsnAsn: 2.326 ± 0.051	2.374AsnPro: 2.374 ± 0.045	1.78AsnGln: 1.78 ± 0.034	2.33AsnArg: 2.33 ± 0.037	3.258AsnSer: 3.258 ± 0.055	2.754AsnThr: 2.754 ± 0.052	2.542AsnVal: 2.542 ± 0.05	0.769AsnTrp: 0.769 ± 0.022	1.728AsnTyr: 1.728 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	3.549ProAla: 3.549 ± 0.055	0.347ProCys: 0.347 ± 0.016	2.654ProAsp: 2.654 ± 0.046	3.417ProGlu: 3.417 ± 0.045	1.662ProPhe: 1.662 ± 0.032	3.072ProGly: 3.072 ± 0.039	0.872ProHis: 0.872 ± 0.022	2.151ProIle: 2.151 ± 0.041	1.803ProLys: 1.803 ± 0.037	4.287ProLeu: 4.287 ± 0.068	0.847ProMet: 0.847 ± 0.023	1.839ProAsn: 1.839 ± 0.034	1.58ProPro: 1.58 ± 0.039	1.965ProGln: 1.965 ± 0.038	1.654ProArg: 1.654 ± 0.033	2.716ProSer: 2.716 ± 0.038	2.129ProThr: 2.129 ± 0.055	3.227ProVal: 3.227 ± 0.049	0.582ProTrp: 0.582 ± 0.021	1.261ProTyr: 1.261 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.089GlnAla: 4.089 ± 0.06	0.421GlnCys: 0.421 ± 0.018	1.742GlnAsp: 1.742 ± 0.031	2.245GlnGlu: 2.245 ± 0.042	1.666GlnPhe: 1.666 ± 0.029	2.74GlnGly: 2.74 ± 0.044	1.143GlnHis: 1.143 ± 0.028	2.357GlnIle: 2.357 ± 0.041	2.109GlnLys: 2.109 ± 0.039	5.014GlnLeu: 5.014 ± 0.066	0.979GlnMet: 0.979 ± 0.027	1.893GlnAsn: 1.893 ± 0.039	1.774GlnPro: 1.774 ± 0.036	2.926GlnGln: 2.926 ± 0.061	2.513GlnArg: 2.513 ± 0.044	2.68GlnSer: 2.68 ± 0.041	2.219GlnThr: 2.219 ± 0.038	2.811GlnVal: 2.811 ± 0.042	0.658GlnTrp: 0.658 ± 0.022	1.261GlnTyr: 1.261 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	4.045ArgAla: 4.045 ± 0.059	0.543ArgCys: 0.543 ± 0.018	2.927ArgAsp: 2.927 ± 0.047	3.395ArgGlu: 3.395 ± 0.053	2.325ArgPhe: 2.325 ± 0.036	3.039ArgGly: 3.039 ± 0.048	1.116ArgHis: 1.116 ± 0.025	3.105ArgIle: 3.105 ± 0.043	2.423ArgLys: 2.423 ± 0.042	5.24ArgLeu: 5.24 ± 0.067	1.178ArgMet: 1.178 ± 0.026	2.181ArgAsn: 2.181 ± 0.033	1.737ArgPro: 1.737 ± 0.031	2.069ArgGln: 2.069 ± 0.038	2.569ArgArg: 2.569 ± 0.042	3.01ArgSer: 3.01 ± 0.043	2.202ArgThr: 2.202 ± 0.038	3.53ArgVal: 3.53 ± 0.05	0.81ArgTrp: 0.81 ± 0.021	1.981ArgTyr: 1.981 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.088SerAla: 6.088 ± 0.068	0.831SerCys: 0.831 ± 0.025	4.356SerAsp: 4.356 ± 0.062	4.346SerGlu: 4.346 ± 0.053	2.856SerPhe: 2.856 ± 0.038	5.942SerGly: 5.942 ± 0.088	1.56SerHis: 1.56 ± 0.035	3.673SerIle: 3.673 ± 0.058	2.81SerLys: 2.81 ± 0.042	7.02SerLeu: 7.02 ± 0.077	1.372SerMet: 1.372 ± 0.031	3.131SerAsn: 3.131 ± 0.062	2.813SerPro: 2.813 ± 0.044	2.86SerGln: 2.86 ± 0.043	3.249SerArg: 3.249 ± 0.05	7.455SerSer: 7.455 ± 0.361	3.466SerThr: 3.466 ± 0.069	4.743SerVal: 4.743 ± 0.064	0.979SerTrp: 0.979 ± 0.027	2.27SerTyr: 2.27 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	5.012ThrAla: 5.012 ± 0.076	0.561ThrCys: 0.561 ± 0.019	2.819ThrAsp: 2.819 ± 0.065	3.115ThrGlu: 3.115 ± 0.047	2.055ThrPhe: 2.055 ± 0.041	4.181ThrGly: 4.181 ± 0.066	1.123ThrHis: 1.123 ± 0.025	2.918ThrIle: 2.918 ± 0.053	1.898ThrLys: 1.898 ± 0.04	6.377ThrLeu: 6.377 ± 0.075	0.945ThrMet: 0.945 ± 0.023	2.009ThrAsn: 2.009 ± 0.04	2.991ThrPro: 2.991 ± 0.063	2.405ThrGln: 2.405 ± 0.038	2.61ThrArg: 2.61 ± 0.04	3.624ThrSer: 3.624 ± 0.067	3.032ThrThr: 3.032 ± 0.056	3.86ThrVal: 3.86 ± 0.052	0.717ThrTrp: 0.717 ± 0.025	1.516ThrTyr: 1.516 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	6.681ValAla: 6.681 ± 0.069	0.857ValCys: 0.857 ± 0.022	4.011ValAsp: 4.011 ± 0.052	4.178ValGlu: 4.178 ± 0.052	2.933ValPhe: 2.933 ± 0.046	4.422ValGly: 4.422 ± 0.057	1.3ValHis: 1.3 ± 0.027	4.022ValIle: 4.022 ± 0.054	3.012ValLys: 3.012 ± 0.052	6.83ValLeu: 6.83 ± 0.078	1.555ValMet: 1.555 ± 0.03	3.106ValAsn: 3.106 ± 0.045	2.69ValPro: 2.69 ± 0.046	2.297ValGln: 2.297 ± 0.037	3.152ValArg: 3.152 ± 0.046	4.962ValSer: 4.962 ± 0.054	3.857ValThr: 3.857 ± 0.057	5.258ValVal: 5.258 ± 0.07	0.83ValTrp: 0.83 ± 0.025	2.03ValTyr: 2.03 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.94TrpAla: 0.94 ± 0.026	0.152TrpCys: 0.152 ± 0.009	0.673TrpAsp: 0.673 ± 0.023	0.663TrpGlu: 0.663 ± 0.021	0.584TrpPhe: 0.584 ± 0.017	0.933TrpGly: 0.933 ± 0.025	0.36TrpHis: 0.36 ± 0.016	0.641TrpIle: 0.641 ± 0.022	0.496TrpLys: 0.496 ± 0.018	1.726TrpLeu: 1.726 ± 0.038	0.336TrpMet: 0.336 ± 0.014	0.627TrpAsn: 0.627 ± 0.019	0.58TrpPro: 0.58 ± 0.019	1.107TrpGln: 1.107 ± 0.033	0.859TrpArg: 0.859 ± 0.024	0.871TrpSer: 0.871 ± 0.029	0.565TrpThr: 0.565 ± 0.022	0.953TrpVal: 0.953 ± 0.025	0.218TrpTrp: 0.218 ± 0.013	0.477TrpTyr: 0.477 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.5TyrAla: 2.5 ± 0.045	0.428TyrCys: 0.428 ± 0.017	1.834TyrAsp: 1.834 ± 0.05	1.754TyrGlu: 1.754 ± 0.035	1.579TyrPhe: 1.579 ± 0.032	2.3TyrGly: 2.3 ± 0.043	0.776TyrHis: 0.776 ± 0.02	1.587TyrIle: 1.587 ± 0.028	1.345TyrLys: 1.345 ± 0.03	3.455TyrLeu: 3.455 ± 0.049	0.595TyrMet: 0.595 ± 0.02	1.35TyrAsn: 1.35 ± 0.035	1.341TyrPro: 1.341 ± 0.03	1.694TyrGln: 1.694 ± 0.033	2.019TyrArg: 2.019 ± 0.04	2.368TyrSer: 2.368 ± 0.047	1.766TyrThr: 1.766 ± 0.042	1.903TyrVal: 1.903 ± 0.037	0.537TyrTrp: 0.537 ± 0.017	1.184TyrTyr: 1.184 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4947 proteins (1758315 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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