Amino acid dipepetide frequency for Bifidobacterium vespertilionis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.924AlaAla: 14.924 ± 0.206	1.116AlaCys: 1.116 ± 0.044	8.073AlaAsp: 8.073 ± 0.127	6.11AlaGlu: 6.11 ± 0.118	3.86AlaPhe: 3.86 ± 0.08	9.931AlaGly: 9.931 ± 0.137	2.215AlaHis: 2.215 ± 0.05	6.033AlaIle: 6.033 ± 0.09	4.606AlaLys: 4.606 ± 0.101	10.885AlaLeu: 10.885 ± 0.143	3.329AlaMet: 3.329 ± 0.075	3.472AlaAsn: 3.472 ± 0.071	4.633AlaPro: 4.633 ± 0.103	4.191AlaGln: 4.191 ± 0.094	6.857AlaArg: 6.857 ± 0.131	6.653AlaSer: 6.653 ± 0.101	6.226AlaThr: 6.226 ± 0.105	8.967AlaVal: 8.967 ± 0.135	1.544AlaTrp: 1.544 ± 0.047	2.802AlaTyr: 2.802 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	1.151CysAla: 1.151 ± 0.04	0.125CysCys: 0.125 ± 0.012	0.591CysAsp: 0.591 ± 0.033	0.487CysGlu: 0.487 ± 0.027	0.322CysPhe: 0.322 ± 0.019	1.003CysGly: 1.003 ± 0.037	0.174CysHis: 0.174 ± 0.013	0.394CysIle: 0.394 ± 0.023	0.205CysLys: 0.205 ± 0.017	0.795CysLeu: 0.795 ± 0.033	0.252CysMet: 0.252 ± 0.016	0.234CysAsn: 0.234 ± 0.017	0.46CysPro: 0.46 ± 0.026	0.213CysGln: 0.213 ± 0.017	0.587CysArg: 0.587 ± 0.031	0.505CysSer: 0.505 ± 0.025	0.515CysThr: 0.515 ± 0.025	0.814CysVal: 0.814 ± 0.034	0.14CysTrp: 0.14 ± 0.014	0.223CysTyr: 0.223 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	8.11AspAla: 8.11 ± 0.128	0.554AspCys: 0.554 ± 0.028	4.695AspAsp: 4.695 ± 0.099	4.574AspGlu: 4.574 ± 0.075	2.263AspPhe: 2.263 ± 0.055	6.617AspGly: 6.617 ± 0.124	1.435AspHis: 1.435 ± 0.042	2.76AspIle: 2.76 ± 0.062	2.071AspLys: 2.071 ± 0.063	5.62AspLeu: 5.62 ± 0.086	1.508AspMet: 1.508 ± 0.045	1.594AspAsn: 1.594 ± 0.048	4.052AspPro: 4.052 ± 0.071	1.939AspGln: 1.939 ± 0.056	4.407AspArg: 4.407 ± 0.093	3.162AspSer: 3.162 ± 0.067	2.946AspThr: 2.946 ± 0.069	5.301AspVal: 5.301 ± 0.084	1.112AspTrp: 1.112 ± 0.044	2.012AspTyr: 2.012 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	6.197GluAla: 6.197 ± 0.098	0.433GluCys: 0.433 ± 0.026	3.189GluAsp: 3.189 ± 0.076	2.977GluGlu: 2.977 ± 0.076	1.695GluPhe: 1.695 ± 0.047	3.908GluGly: 3.908 ± 0.068	1.564GluHis: 1.564 ± 0.046	2.598GluIle: 2.598 ± 0.057	1.791GluLys: 1.791 ± 0.055	5.092GluLeu: 5.092 ± 0.079	1.298GluMet: 1.298 ± 0.039	1.631GluAsn: 1.631 ± 0.052	2.852GluPro: 2.852 ± 0.069	2.187GluGln: 2.187 ± 0.063	4.466GluArg: 4.466 ± 0.091	3.284GluSer: 3.284 ± 0.056	3.219GluThr: 3.219 ± 0.071	3.498GluVal: 3.498 ± 0.071	0.75GluTrp: 0.75 ± 0.027	1.622GluTyr: 1.622 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	4.148PheAla: 4.148 ± 0.075	0.381PheCys: 0.381 ± 0.023	2.689PheAsp: 2.689 ± 0.054	1.811PheGlu: 1.811 ± 0.046	1.165PhePhe: 1.165 ± 0.041	3.317PheGly: 3.317 ± 0.067	0.733PheHis: 0.733 ± 0.032	1.556PheIle: 1.556 ± 0.049	1.026PheLys: 1.026 ± 0.037	2.825PheLeu: 2.825 ± 0.068	0.833PheMet: 0.833 ± 0.031	1.193PheAsn: 1.193 ± 0.039	1.436PhePro: 1.436 ± 0.041	0.924PheGln: 0.924 ± 0.033	1.919PheArg: 1.919 ± 0.056	2.093PheSer: 2.093 ± 0.057	2.307PheThr: 2.307 ± 0.055	2.626PheVal: 2.626 ± 0.062	0.458PheTrp: 0.458 ± 0.027	0.887PheTyr: 0.887 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	8.167GlyAla: 8.167 ± 0.114	0.834GlyCys: 0.834 ± 0.033	5.103GlyAsp: 5.103 ± 0.084	4.716GlyGlu: 4.716 ± 0.08	3.321GlyPhe: 3.321 ± 0.074	6.615GlyGly: 6.615 ± 0.1	1.77GlyHis: 1.77 ± 0.052	4.385GlyIle: 4.385 ± 0.081	3.569GlyLys: 3.569 ± 0.074	7.631GlyLeu: 7.631 ± 0.111	2.351GlyMet: 2.351 ± 0.06	2.661GlyAsn: 2.661 ± 0.07	2.995GlyPro: 2.995 ± 0.056	2.619GlyGln: 2.619 ± 0.062	5.409GlyArg: 5.409 ± 0.095	5.421GlySer: 5.421 ± 0.092	5.26GlyThr: 5.26 ± 0.084	6.815GlyVal: 6.815 ± 0.086	1.417GlyTrp: 1.417 ± 0.056	2.751GlyTyr: 2.751 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	2.324HisAla: 2.324 ± 0.065	0.186HisCys: 0.186 ± 0.015	1.558HisAsp: 1.558 ± 0.035	1.155HisGlu: 1.155 ± 0.043	0.654HisPhe: 0.654 ± 0.029	1.915HisGly: 1.915 ± 0.051	0.545HisHis: 0.545 ± 0.03	1.064HisIle: 1.064 ± 0.045	0.496HisLys: 0.496 ± 0.023	1.622HisLeu: 1.622 ± 0.045	0.513HisMet: 0.513 ± 0.026	0.587HisAsn: 0.587 ± 0.03	1.401HisPro: 1.401 ± 0.044	0.561HisGln: 0.561 ± 0.027	1.383HisArg: 1.383 ± 0.043	0.964HisSer: 0.964 ± 0.035	1.123HisThr: 1.123 ± 0.038	1.774HisVal: 1.774 ± 0.044	0.345HisTrp: 0.345 ± 0.021	0.632HisTyr: 0.632 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.879IleAla: 6.879 ± 0.092	0.518IleCys: 0.518 ± 0.027	3.883IleAsp: 3.883 ± 0.081	2.929IleGlu: 2.929 ± 0.069	1.467IlePhe: 1.467 ± 0.051	4.624IleGly: 4.624 ± 0.087	0.988IleHis: 0.988 ± 0.035	2.627IleIle: 2.627 ± 0.071	1.53IleLys: 1.53 ± 0.056	3.851IleLeu: 3.851 ± 0.075	1.189IleMet: 1.189 ± 0.045	1.685IleAsn: 1.685 ± 0.046	2.671IlePro: 2.671 ± 0.06	1.275IleGln: 1.275 ± 0.04	3.216IleArg: 3.216 ± 0.072	2.834IleSer: 2.834 ± 0.065	3.086IleThr: 3.086 ± 0.069	4.6IleVal: 4.6 ± 0.082	0.614IleTrp: 0.614 ± 0.026	1.122IleTyr: 1.122 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.538LysAla: 4.538 ± 0.094	0.155LysCys: 0.155 ± 0.014	2.362LysAsp: 2.362 ± 0.073	1.846LysGlu: 1.846 ± 0.061	0.896LysPhe: 0.896 ± 0.032	2.585LysGly: 2.585 ± 0.068	0.69LysHis: 0.69 ± 0.029	1.576LysIle: 1.576 ± 0.053	1.257LysLys: 1.257 ± 0.047	3.069LysLeu: 3.069 ± 0.083	0.787LysMet: 0.787 ± 0.033	1.05LysAsn: 1.05 ± 0.047	2.224LysPro: 2.224 ± 0.053	1.175LysGln: 1.175 ± 0.041	2.223LysArg: 2.223 ± 0.055	2.006LysSer: 2.006 ± 0.057	2.311LysThr: 2.311 ± 0.066	2.556LysVal: 2.556 ± 0.07	0.469LysTrp: 0.469 ± 0.024	0.98LysTyr: 0.98 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	10.848LeuAla: 10.848 ± 0.131	0.905LeuCys: 0.905 ± 0.034	6.189LeuAsp: 6.189 ± 0.084	4.281LeuGlu: 4.281 ± 0.081	3.166LeuPhe: 3.166 ± 0.067	7.286LeuGly: 7.286 ± 0.103	1.744LeuHis: 1.744 ± 0.051	4.708LeuIle: 4.708 ± 0.096	3.391LeuLys: 3.391 ± 0.07	8.018LeuLeu: 8.018 ± 0.119	2.25LeuMet: 2.25 ± 0.047	2.964LeuAsn: 2.964 ± 0.06	4.541LeuPro: 4.541 ± 0.078	2.236LeuGln: 2.236 ± 0.054	5.481LeuArg: 5.481 ± 0.099	5.434LeuSer: 5.434 ± 0.092	5.555LeuThr: 5.555 ± 0.084	6.588LeuVal: 6.588 ± 0.107	1.143LeuTrp: 1.143 ± 0.041	2.239LeuTyr: 2.239 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.891MetAla: 2.891 ± 0.062	0.243MetCys: 0.243 ± 0.016	1.346MetAsp: 1.346 ± 0.04	1.047MetGlu: 1.047 ± 0.036	0.868MetPhe: 0.868 ± 0.033	1.949MetGly: 1.949 ± 0.049	0.506MetHis: 0.506 ± 0.027	1.514MetIle: 1.514 ± 0.045	0.863MetLys: 0.863 ± 0.033	2.493MetLeu: 2.493 ± 0.058	0.687MetMet: 0.687 ± 0.036	0.839MetAsn: 0.839 ± 0.032	1.508MetPro: 1.508 ± 0.041	0.733MetGln: 0.733 ± 0.031	1.81MetArg: 1.81 ± 0.046	1.707MetSer: 1.707 ± 0.051	1.86MetThr: 1.86 ± 0.051	1.761MetVal: 1.761 ± 0.049	0.326MetTrp: 0.326 ± 0.02	0.501MetTyr: 0.501 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.791AsnAla: 3.791 ± 0.067	0.222AsnCys: 0.222 ± 0.016	2.013AsnAsp: 2.013 ± 0.054	1.647AsnGlu: 1.647 ± 0.046	0.898AsnPhe: 0.898 ± 0.037	3.256AsnGly: 3.256 ± 0.076	0.588AsnHis: 0.588 ± 0.032	1.505AsnIle: 1.505 ± 0.049	1.018AsnLys: 1.018 ± 0.043	2.507AsnLeu: 2.507 ± 0.053	0.745AsnMet: 0.745 ± 0.029	1.057AsnAsn: 1.057 ± 0.044	2.226AsnPro: 2.226 ± 0.061	0.917AsnGln: 0.917 ± 0.039	1.998AsnArg: 1.998 ± 0.051	1.411AsnSer: 1.411 ± 0.049	1.819AsnThr: 1.819 ± 0.06	2.392AsnVal: 2.392 ± 0.056	0.466AsnTrp: 0.466 ± 0.025	0.861AsnTyr: 0.861 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	5.941ProAla: 5.941 ± 0.116	0.34ProCys: 0.34 ± 0.021	3.889ProAsp: 3.889 ± 0.085	3.309ProGlu: 3.309 ± 0.067	1.837ProPhe: 1.837 ± 0.046	3.966ProGly: 3.966 ± 0.071	0.995ProHis: 0.995 ± 0.037	2.415ProIle: 2.415 ± 0.06	1.789ProLys: 1.789 ± 0.051	3.884ProLeu: 3.884 ± 0.073	1.139ProMet: 1.139 ± 0.04	1.634ProAsn: 1.634 ± 0.047	1.318ProPro: 1.318 ± 0.048	1.769ProGln: 1.769 ± 0.048	2.517ProArg: 2.517 ± 0.06	3.212ProSer: 3.212 ± 0.071	2.783ProThr: 2.783 ± 0.069	4.2ProVal: 4.2 ± 0.084	0.747ProTrp: 0.747 ± 0.031	1.424ProTyr: 1.424 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.513GlnAla: 3.513 ± 0.085	0.291GlnCys: 0.291 ± 0.017	1.54GlnAsp: 1.54 ± 0.047	1.36GlnGlu: 1.36 ± 0.049	0.98GlnPhe: 0.98 ± 0.034	2.318GlnGly: 2.318 ± 0.053	0.632GlnHis: 0.632 ± 0.03	1.824GlnIle: 1.824 ± 0.049	0.92GlnLys: 0.92 ± 0.042	3.03GlnLeu: 3.03 ± 0.067	0.805GlnMet: 0.805 ± 0.035	0.919GlnAsn: 0.919 ± 0.032	1.813GlnPro: 1.813 ± 0.076	1.243GlnGln: 1.243 ± 0.051	2.215GlnArg: 2.215 ± 0.064	2.115GlnSer: 2.115 ± 0.059	1.948GlnThr: 1.948 ± 0.053	2.176GlnVal: 2.176 ± 0.058	0.597GlnTrp: 0.597 ± 0.028	0.997GlnTyr: 0.997 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	6.085ArgAla: 6.085 ± 0.109	0.551ArgCys: 0.551 ± 0.029	4.114ArgAsp: 4.114 ± 0.086	4.079ArgGlu: 4.079 ± 0.079	2.459ArgPhe: 2.459 ± 0.057	4.257ArgGly: 4.257 ± 0.077	1.64ArgHis: 1.64 ± 0.053	3.862ArgIle: 3.862 ± 0.075	2.316ArgLys: 2.316 ± 0.062	5.967ArgLeu: 5.967 ± 0.105	2.011ArgMet: 2.011 ± 0.059	2.182ArgAsn: 2.182 ± 0.055	2.914ArgPro: 2.914 ± 0.077	2.112ArgGln: 2.112 ± 0.058	5.506ArgArg: 5.506 ± 0.13	3.252ArgSer: 3.252 ± 0.074	3.708ArgThr: 3.708 ± 0.07	4.547ArgVal: 4.547 ± 0.084	0.995ArgTrp: 0.995 ± 0.035	1.992ArgTyr: 1.992 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	6.673SerAla: 6.673 ± 0.11	0.509SerCys: 0.509 ± 0.027	3.731SerAsp: 3.731 ± 0.075	2.85SerGlu: 2.85 ± 0.059	2.055SerPhe: 2.055 ± 0.06	5.743SerGly: 5.743 ± 0.106	1.206SerHis: 1.206 ± 0.035	2.981SerIle: 2.981 ± 0.059	2.027SerLys: 2.027 ± 0.05	5.145SerLeu: 5.145 ± 0.095	1.495SerMet: 1.495 ± 0.046	1.791SerAsn: 1.791 ± 0.052	2.721SerPro: 2.721 ± 0.063	1.934SerGln: 1.934 ± 0.052	3.388SerArg: 3.388 ± 0.072	3.679SerSer: 3.679 ± 0.087	3.276SerThr: 3.276 ± 0.063	4.544SerVal: 4.544 ± 0.074	0.871SerTrp: 0.871 ± 0.037	1.557SerTyr: 1.557 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	6.622ThrAla: 6.622 ± 0.108	0.491ThrCys: 0.491 ± 0.025	3.702ThrAsp: 3.702 ± 0.074	2.673ThrGlu: 2.673 ± 0.06	2.077ThrPhe: 2.077 ± 0.058	5.534ThrGly: 5.534 ± 0.091	1.13ThrHis: 1.13 ± 0.035	3.428ThrIle: 3.428 ± 0.072	1.885ThrLys: 1.885 ± 0.056	5.671ThrLeu: 5.671 ± 0.087	1.306ThrMet: 1.306 ± 0.038	1.735ThrAsn: 1.735 ± 0.049	3.407ThrPro: 3.407 ± 0.068	1.702ThrGln: 1.702 ± 0.052	3.231ThrArg: 3.231 ± 0.062	3.159ThrSer: 3.159 ± 0.064	3.546ThrThr: 3.546 ± 0.082	5.524ThrVal: 5.524 ± 0.1	0.877ThrTrp: 0.877 ± 0.034	1.582ThrTyr: 1.582 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	9.007ValAla: 9.007 ± 0.122	0.869ValCys: 0.869 ± 0.033	5.258ValAsp: 5.258 ± 0.081	4.259ValGlu: 4.259 ± 0.069	2.822ValPhe: 2.822 ± 0.063	5.39ValGly: 5.39 ± 0.096	1.414ValHis: 1.414 ± 0.041	4.388ValIle: 4.388 ± 0.087	2.658ValLys: 2.658 ± 0.079	6.987ValLeu: 6.987 ± 0.097	1.889ValMet: 1.889 ± 0.052	2.531ValAsn: 2.531 ± 0.059	4.067ValPro: 4.067 ± 0.081	2.003ValGln: 2.003 ± 0.046	4.876ValArg: 4.876 ± 0.078	4.944ValSer: 4.944 ± 0.075	5.241ValThr: 5.241 ± 0.095	6.188ValVal: 6.188 ± 0.11	1.097ValTrp: 1.097 ± 0.037	1.921ValTyr: 1.921 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	1.363TrpAla: 1.363 ± 0.046	0.153TrpCys: 0.153 ± 0.013	0.856TrpAsp: 0.856 ± 0.031	0.629TrpGlu: 0.629 ± 0.03	0.561TrpPhe: 0.561 ± 0.028	1.01TrpGly: 1.01 ± 0.036	0.35TrpHis: 0.35 ± 0.023	0.823TrpIle: 0.823 ± 0.037	0.545TrpLys: 0.545 ± 0.026	1.52TrpLeu: 1.52 ± 0.049	0.445TrpMet: 0.445 ± 0.025	0.632TrpAsn: 0.632 ± 0.03	0.617TrpPro: 0.617 ± 0.029	0.615TrpGln: 0.615 ± 0.03	1.136TrpArg: 1.136 ± 0.04	0.883TrpSer: 0.883 ± 0.033	0.947TrpThr: 0.947 ± 0.034	0.896TrpVal: 0.896 ± 0.033	0.314TrpTrp: 0.314 ± 0.018	0.467TrpTyr: 0.467 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.258TyrAla: 3.258 ± 0.072	0.313TyrCys: 0.313 ± 0.022	1.948TyrAsp: 1.948 ± 0.057	1.514TyrGlu: 1.514 ± 0.047	0.958TyrPhe: 0.958 ± 0.035	2.585TyrGly: 2.585 ± 0.064	0.484TyrHis: 0.484 ± 0.028	1.147TyrIle: 1.147 ± 0.041	0.793TyrLys: 0.793 ± 0.04	2.354TyrLeu: 2.354 ± 0.058	0.617TyrMet: 0.617 ± 0.029	0.947TyrAsn: 0.947 ± 0.048	1.25TyrPro: 1.25 ± 0.045	0.889TyrGln: 0.889 ± 0.034	1.925TyrArg: 1.925 ± 0.051	1.459TyrSer: 1.459 ± 0.047	1.607TyrThr: 1.607 ± 0.065	2.041TyrVal: 2.041 ± 0.055	0.482TyrTrp: 0.482 ± 0.023	0.868TyrTyr: 0.868 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2281 proteins (834372 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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