Amino acid dipepetide frequency for Olsenella umbonata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.794AlaAla: 14.794 ± 0.257
1.877AlaCys: 1.877 ± 0.068
7.215AlaAsp: 7.215 ± 0.134
6.734AlaGlu: 6.734 ± 0.124
3.674AlaPhe: 3.674 ± 0.085
9.762AlaGly: 9.762 ± 0.144
2.265AlaHis: 2.265 ± 0.07
5.409AlaIle: 5.409 ± 0.118
4.564AlaLys: 4.564 ± 0.135
11.075AlaLeu: 11.075 ± 0.16
3.051AlaMet: 3.051 ± 0.075
2.908AlaAsn: 2.908 ± 0.077
4.621AlaPro: 4.621 ± 0.121
3.913AlaGln: 3.913 ± 0.089
8.156AlaArg: 8.156 ± 0.142
6.667AlaSer: 6.667 ± 0.149
6.021AlaThr: 6.021 ± 0.092
8.125AlaVal: 8.125 ± 0.137
1.259AlaTrp: 1.259 ± 0.049
2.998AlaTyr: 2.998 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
1.666CysAla: 1.666 ± 0.057
0.27CysCys: 0.27 ± 0.024
1.129CysAsp: 1.129 ± 0.044
0.986CysGlu: 0.986 ± 0.048
0.408CysPhe: 0.408 ± 0.023
1.806CysGly: 1.806 ± 0.068
0.383CysHis: 0.383 ± 0.025
0.665CysIle: 0.665 ± 0.035
0.468CysLys: 0.468 ± 0.026
1.197CysLeu: 1.197 ± 0.042
0.36CysMet: 0.36 ± 0.023
0.349CysAsn: 0.349 ± 0.025
0.834CysPro: 0.834 ± 0.043
0.353CysGln: 0.353 ± 0.025
0.913CysArg: 0.913 ± 0.038
0.769CysSer: 0.769 ± 0.035
0.859CysThr: 0.859 ± 0.038
1.325CysVal: 1.325 ± 0.045
0.136CysTrp: 0.136 ± 0.014
0.445CysTyr: 0.445 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
8.703AspAla: 8.703 ± 0.147
0.803AspCys: 0.803 ± 0.043
4.234AspAsp: 4.234 ± 0.113
5.153AspGlu: 5.153 ± 0.098
2.31AspPhe: 2.31 ± 0.056
5.937AspGly: 5.937 ± 0.106
1.231AspHis: 1.231 ± 0.05
2.851AspIle: 2.851 ± 0.065
2.029AspLys: 2.029 ± 0.068
5.795AspLeu: 5.795 ± 0.114
1.671AspMet: 1.671 ± 0.057
1.457AspAsn: 1.457 ± 0.049
3.17AspPro: 3.17 ± 0.071
1.62AspGln: 1.62 ± 0.044
3.522AspArg: 3.522 ± 0.097
3.052AspSer: 3.052 ± 0.078
2.854AspThr: 2.854 ± 0.071
6.401AspVal: 6.401 ± 0.111
0.885AspTrp: 0.885 ± 0.039
2.004AspTyr: 2.004 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
7.018GluAla: 7.018 ± 0.1
0.877GluCys: 0.877 ± 0.034
3.955GluAsp: 3.955 ± 0.094
4.221GluGlu: 4.221 ± 0.117
2.011GluPhe: 2.011 ± 0.054
5.127GluGly: 5.127 ± 0.084
1.505GluHis: 1.505 ± 0.049
2.211GluIle: 2.211 ± 0.076
3.35GluLys: 3.35 ± 0.084
6.708GluLeu: 6.708 ± 0.119
1.546GluMet: 1.546 ± 0.058
1.471GluAsn: 1.471 ± 0.049
2.572GluPro: 2.572 ± 0.089
2.091GluGln: 2.091 ± 0.06
5.15GluArg: 5.15 ± 0.115
2.949GluSer: 2.949 ± 0.07
2.466GluThr: 2.466 ± 0.066
4.933GluVal: 4.933 ± 0.092
0.667GluTrp: 0.667 ± 0.034
1.558GluTyr: 1.558 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
3.659PheAla: 3.659 ± 0.081
0.631PheCys: 0.631 ± 0.032
2.749PheAsp: 2.749 ± 0.071
2.068PheGlu: 2.068 ± 0.056
1.274PhePhe: 1.274 ± 0.049
3.367PheGly: 3.367 ± 0.075
0.608PheHis: 0.608 ± 0.03
1.206PheIle: 1.206 ± 0.042
1.118PheLys: 1.118 ± 0.043
2.93PheLeu: 2.93 ± 0.086
0.842PheMet: 0.842 ± 0.037
0.879PheAsn: 0.879 ± 0.033
1.293PhePro: 1.293 ± 0.042
0.859PheGln: 0.859 ± 0.035
1.688PheArg: 1.688 ± 0.047
2.477PheSer: 2.477 ± 0.059
1.665PheThr: 1.665 ± 0.05
3.004PheVal: 3.004 ± 0.072
0.398PheTrp: 0.398 ± 0.025
0.947PheTyr: 0.947 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
8.828GlyAla: 8.828 ± 0.149
1.449GlyCys: 1.449 ± 0.053
4.81GlyAsp: 4.81 ± 0.096
5.39GlyGlu: 5.39 ± 0.1
3.252GlyPhe: 3.252 ± 0.073
6.791GlyGly: 6.791 ± 0.143
1.896GlyHis: 1.896 ± 0.064
4.672GlyIle: 4.672 ± 0.095
3.919GlyLys: 3.919 ± 0.091
7.176GlyLeu: 7.176 ± 0.102
2.739GlyMet: 2.739 ± 0.073
2.259GlyAsn: 2.259 ± 0.065
2.53GlyPro: 2.53 ± 0.068
2.394GlyGln: 2.394 ± 0.06
5.827GlyArg: 5.827 ± 0.118
5.105GlySer: 5.105 ± 0.099
5.328GlyThr: 5.328 ± 0.101
7.1GlyVal: 7.1 ± 0.119
0.972GlyTrp: 0.972 ± 0.043
2.704GlyTyr: 2.704 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
2.282HisAla: 2.282 ± 0.065
0.305HisCys: 0.305 ± 0.023
1.521HisAsp: 1.521 ± 0.056
1.333HisGlu: 1.333 ± 0.047
0.677HisPhe: 0.677 ± 0.034
1.977HisGly: 1.977 ± 0.059
0.46HisHis: 0.46 ± 0.029
0.843HisIle: 0.843 ± 0.036
0.684HisLys: 0.684 ± 0.04
1.604HisLeu: 1.604 ± 0.053
0.566HisMet: 0.566 ± 0.027
0.526HisAsn: 0.526 ± 0.03
1.183HisPro: 1.183 ± 0.042
0.491HisGln: 0.491 ± 0.028
1.175HisArg: 1.175 ± 0.041
0.874HisSer: 0.874 ± 0.037
0.96HisThr: 0.96 ± 0.041
1.941HisVal: 1.941 ± 0.06
0.189HisTrp: 0.189 ± 0.017
0.581HisTyr: 0.581 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.421IleAla: 5.421 ± 0.105
0.877IleCys: 0.877 ± 0.037
3.417IleAsp: 3.417 ± 0.068
2.986IleGlu: 2.986 ± 0.08
1.27IlePhe: 1.27 ± 0.048
3.697IleGly: 3.697 ± 0.074
0.826IleHis: 0.826 ± 0.034
1.959IleIle: 1.959 ± 0.058
1.598IleLys: 1.598 ± 0.047
3.659IleLeu: 3.659 ± 0.075
1.135IleMet: 1.135 ± 0.043
1.333IleAsn: 1.333 ± 0.041
2.161IlePro: 2.161 ± 0.056
1.107IleGln: 1.107 ± 0.044
2.508IleArg: 2.508 ± 0.068
2.673IleSer: 2.673 ± 0.07
2.325IleThr: 2.325 ± 0.069
4.286IleVal: 4.286 ± 0.092
0.346IleTrp: 0.346 ± 0.025
1.091IleTyr: 1.091 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
4.494LysAla: 4.494 ± 0.115
0.431LysCys: 0.431 ± 0.026
2.625LysAsp: 2.625 ± 0.073
2.037LysGlu: 2.037 ± 0.072
1.056LysPhe: 1.056 ± 0.04
3.11LysGly: 3.11 ± 0.077
0.677LysHis: 0.677 ± 0.031
1.973LysIle: 1.973 ± 0.069
2.037LysLys: 2.037 ± 0.077
3.065LysLeu: 3.065 ± 0.071
0.992LysMet: 0.992 ± 0.042
1.322LysAsn: 1.322 ± 0.051
1.888LysPro: 1.888 ± 0.072
1.139LysGln: 1.139 ± 0.05
2.566LysArg: 2.566 ± 0.072
2.559LysSer: 2.559 ± 0.063
2.288LysThr: 2.288 ± 0.067
3.314LysVal: 3.314 ± 0.073
0.355LysTrp: 0.355 ± 0.024
1.065LysTyr: 1.065 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
11.658LeuAla: 11.658 ± 0.164
1.398LeuCys: 1.398 ± 0.048
6.64LeuAsp: 6.64 ± 0.11
5.426LeuGlu: 5.426 ± 0.112
2.972LeuPhe: 2.972 ± 0.074
8.162LeuGly: 8.162 ± 0.119
1.524LeuHis: 1.524 ± 0.05
3.234LeuIle: 3.234 ± 0.074
3.066LeuLys: 3.066 ± 0.071
8.046LeuLeu: 8.046 ± 0.154
2.547LeuMet: 2.547 ± 0.065
2.226LeuAsn: 2.226 ± 0.065
4.244LeuPro: 4.244 ± 0.1
2.282LeuGln: 2.282 ± 0.065
5.959LeuArg: 5.959 ± 0.114
5.832LeuSer: 5.832 ± 0.116
4.843LeuThr: 4.843 ± 0.084
7.878LeuVal: 7.878 ± 0.122
0.814LeuTrp: 0.814 ± 0.037
2.077LeuTyr: 2.077 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
3.136MetAla: 3.136 ± 0.076
0.357MetCys: 0.357 ± 0.025
1.639MetAsp: 1.639 ± 0.053
1.479MetGlu: 1.479 ± 0.054
0.758MetPhe: 0.758 ± 0.036
2.586MetGly: 2.586 ± 0.066
0.535MetHis: 0.535 ± 0.026
1.005MetIle: 1.005 ± 0.048
0.805MetLys: 0.805 ± 0.036
2.442MetLeu: 2.442 ± 0.07
0.64MetMet: 0.64 ± 0.033
0.842MetAsn: 0.842 ± 0.043
1.454MetPro: 1.454 ± 0.038
0.865MetGln: 0.865 ± 0.038
2.099MetArg: 2.099 ± 0.051
1.89MetSer: 1.89 ± 0.054
1.437MetThr: 1.437 ± 0.045
2.11MetVal: 2.11 ± 0.054
0.191MetTrp: 0.191 ± 0.016
0.578MetTyr: 0.578 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.006AsnAla: 3.006 ± 0.064
0.375AsnCys: 0.375 ± 0.025
1.663AsnAsp: 1.663 ± 0.06
1.454AsnGlu: 1.454 ± 0.054
0.893AsnPhe: 0.893 ± 0.034
2.328AsnGly: 2.328 ± 0.06
0.586AsnHis: 0.586 ± 0.029
1.296AsnIle: 1.296 ± 0.049
1.028AsnLys: 1.028 ± 0.044
2.474AsnLeu: 2.474 ± 0.062
0.757AsnMet: 0.757 ± 0.037
0.718AsnAsn: 0.718 ± 0.037
1.648AsnPro: 1.648 ± 0.051
0.791AsnGln: 0.791 ± 0.038
1.423AsnArg: 1.423 ± 0.049
1.37AsnSer: 1.37 ± 0.047
1.322AsnThr: 1.322 ± 0.044
2.555AsnVal: 2.555 ± 0.071
0.296AsnTrp: 0.296 ± 0.026
0.814AsnTyr: 0.814 ± 0.041
0.0AsnXaa: 0.0 ± 0.0
Pro
5.049ProAla: 5.049 ± 0.127
0.56ProCys: 0.56 ± 0.03
3.102ProAsp: 3.102 ± 0.072
3.486ProGlu: 3.486 ± 0.087
1.635ProPhe: 1.635 ± 0.056
3.513ProGly: 3.513 ± 0.071
0.925ProHis: 0.925 ± 0.045
1.825ProIle: 1.825 ± 0.056
1.964ProLys: 1.964 ± 0.072
3.496ProLeu: 3.496 ± 0.08
0.978ProMet: 0.978 ± 0.033
1.256ProAsn: 1.256 ± 0.048
1.105ProPro: 1.105 ± 0.048
1.702ProGln: 1.702 ± 0.052
2.527ProArg: 2.527 ± 0.063
2.558ProSer: 2.558 ± 0.068
2.544ProThr: 2.544 ± 0.062
3.699ProVal: 3.699 ± 0.076
0.53ProTrp: 0.53 ± 0.027
1.352ProTyr: 1.352 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
3.369GlnAla: 3.369 ± 0.075
0.307GlnCys: 0.307 ± 0.024
1.778GlnAsp: 1.778 ± 0.053
1.955GlnGlu: 1.955 ± 0.057
0.792GlnPhe: 0.792 ± 0.036
2.403GlnGly: 2.403 ± 0.061
0.526GlnHis: 0.526 ± 0.028
1.581GlnIle: 1.581 ± 0.056
1.384GlnLys: 1.384 ± 0.055
2.733GlnLeu: 2.733 ± 0.069
1.059GlnMet: 1.059 ± 0.04
0.966GlnAsn: 0.966 ± 0.04
1.129GlnPro: 1.129 ± 0.041
1.048GlnGln: 1.048 ± 0.047
2.059GlnArg: 2.059 ± 0.065
1.663GlnSer: 1.663 ± 0.055
1.815GlnThr: 1.815 ± 0.054
2.414GlnVal: 2.414 ± 0.062
0.298GlnTrp: 0.298 ± 0.019
0.753GlnTyr: 0.753 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
6.853ArgAla: 6.853 ± 0.113
0.924ArgCys: 0.924 ± 0.042
4.204ArgAsp: 4.204 ± 0.095
4.886ArgGlu: 4.886 ± 0.1
2.107ArgPhe: 2.107 ± 0.061
4.905ArgGly: 4.905 ± 0.095
1.515ArgHis: 1.515 ± 0.052
3.034ArgIle: 3.034 ± 0.073
2.628ArgLys: 2.628 ± 0.073
6.21ArgLeu: 6.21 ± 0.135
2.034ArgMet: 2.034 ± 0.057
1.786ArgAsn: 1.786 ± 0.058
2.939ArgPro: 2.939 ± 0.076
2.338ArgGln: 2.338 ± 0.064
5.638ArgArg: 5.638 ± 0.115
3.376ArgSer: 3.376 ± 0.076
3.201ArgThr: 3.201 ± 0.075
5.247ArgVal: 5.247 ± 0.107
0.688ArgTrp: 0.688 ± 0.033
1.977ArgTyr: 1.977 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
6.252SerAla: 6.252 ± 0.114
0.865SerCys: 0.865 ± 0.038
3.42SerAsp: 3.42 ± 0.088
3.069SerGlu: 3.069 ± 0.076
2.294SerPhe: 2.294 ± 0.063
5.311SerGly: 5.311 ± 0.124
1.192SerHis: 1.192 ± 0.037
2.691SerIle: 2.691 ± 0.065
2.296SerLys: 2.296 ± 0.068
5.567SerLeu: 5.567 ± 0.1
1.48SerMet: 1.48 ± 0.054
1.577SerAsn: 1.577 ± 0.05
2.322SerPro: 2.322 ± 0.064
1.899SerGln: 1.899 ± 0.053
3.699SerArg: 3.699 ± 0.084
3.713SerSer: 3.713 ± 0.112
3.097SerThr: 3.097 ± 0.067
5.003SerVal: 5.003 ± 0.092
0.715SerTrp: 0.715 ± 0.036
1.755SerTyr: 1.755 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
5.04ThrAla: 5.04 ± 0.107
0.916ThrCys: 0.916 ± 0.043
3.232ThrAsp: 3.232 ± 0.068
2.549ThrGlu: 2.549 ± 0.068
2.079ThrPhe: 2.079 ± 0.061
4.675ThrGly: 4.675 ± 0.082
1.166ThrHis: 1.166 ± 0.042
2.852ThrIle: 2.852 ± 0.074
1.86ThrLys: 1.86 ± 0.054
4.99ThrLeu: 4.99 ± 0.088
1.364ThrMet: 1.364 ± 0.046
1.581ThrAsn: 1.581 ± 0.054
2.927ThrPro: 2.927 ± 0.064
1.577ThrGln: 1.577 ± 0.052
3.104ThrArg: 3.104 ± 0.072
3.31ThrSer: 3.31 ± 0.091
2.989ThrThr: 2.989 ± 0.082
4.462ThrVal: 4.462 ± 0.09
0.558ThrTrp: 0.558 ± 0.029
1.803ThrTyr: 1.803 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
9.946ValAla: 9.946 ± 0.16
1.549ValCys: 1.549 ± 0.06
5.599ValAsp: 5.599 ± 0.101
4.908ValGlu: 4.908 ± 0.101
2.784ValPhe: 2.784 ± 0.077
6.401ValGly: 6.401 ± 0.116
1.453ValHis: 1.453 ± 0.041
3.965ValIle: 3.965 ± 0.08
2.759ValLys: 2.759 ± 0.069
7.818ValLeu: 7.818 ± 0.123
2.161ValMet: 2.161 ± 0.059
2.248ValAsn: 2.248 ± 0.065
4.139ValPro: 4.139 ± 0.073
2.101ValGln: 2.101 ± 0.06
5.948ValArg: 5.948 ± 0.115
5.415ValSer: 5.415 ± 0.083
5.119ValThr: 5.119 ± 0.088
7.694ValVal: 7.694 ± 0.146
0.786ValTrp: 0.786 ± 0.037
1.95ValTyr: 1.95 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
1.036TrpAla: 1.036 ± 0.04
0.206TrpCys: 0.206 ± 0.018
0.702TrpAsp: 0.702 ± 0.033
0.62TrpGlu: 0.62 ± 0.034
0.358TrpPhe: 0.358 ± 0.024
0.874TrpGly: 0.874 ± 0.038
0.268TrpHis: 0.268 ± 0.022
0.42TrpIle: 0.42 ± 0.025
0.454TrpLys: 0.454 ± 0.031
1.07TrpLeu: 1.07 ± 0.043
0.315TrpMet: 0.315 ± 0.02
0.304TrpAsn: 0.304 ± 0.023
0.446TrpPro: 0.446 ± 0.023
0.436TrpGln: 0.436 ± 0.029
0.735TrpArg: 0.735 ± 0.037
0.598TrpSer: 0.598 ± 0.031
0.454TrpThr: 0.454 ± 0.025
0.764TrpVal: 0.764 ± 0.039
0.161TrpTrp: 0.161 ± 0.014
0.299TrpTyr: 0.299 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.879TyrAla: 2.879 ± 0.074
0.343TyrCys: 0.343 ± 0.023
2.051TyrAsp: 2.051 ± 0.064
1.643TyrGlu: 1.643 ± 0.045
1.057TyrPhe: 1.057 ± 0.041
2.411TyrGly: 2.411 ± 0.069
0.632TyrHis: 0.632 ± 0.033
0.983TyrIle: 0.983 ± 0.046
0.983TyrLys: 0.983 ± 0.04
2.775TyrLeu: 2.775 ± 0.065
0.608TyrMet: 0.608 ± 0.031
0.791TyrAsn: 0.791 ± 0.035
1.2TyrPro: 1.2 ± 0.04
1.026TyrGln: 1.026 ± 0.04
1.795TyrArg: 1.795 ± 0.053
1.366TyrSer: 1.366 ± 0.045
1.445TyrThr: 1.445 ± 0.053
2.488TyrVal: 2.488 ± 0.054
0.277TyrTrp: 0.277 ± 0.024
0.819TyrTyr: 0.819 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1943 proteins (645073 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski