Amino acid dipepetide frequency for Dechloromonas sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.467AlaAla: 15.467 ± 0.189	1.381AlaCys: 1.381 ± 0.046	6.319AlaAsp: 6.319 ± 0.097	6.997AlaGlu: 6.997 ± 0.094	3.995AlaPhe: 3.995 ± 0.078	9.855AlaGly: 9.855 ± 0.135	2.364AlaHis: 2.364 ± 0.053	5.995AlaIle: 5.995 ± 0.09	4.195AlaLys: 4.195 ± 0.074	13.176AlaLeu: 13.176 ± 0.154	3.203AlaMet: 3.203 ± 0.069	3.192AlaAsn: 3.192 ± 0.062	4.743AlaPro: 4.743 ± 0.08	4.097AlaGln: 4.097 ± 0.078	7.779AlaArg: 7.779 ± 0.125	5.765AlaSer: 5.765 ± 0.094	5.616AlaThr: 5.616 ± 0.08	8.297AlaVal: 8.297 ± 0.11	1.678AlaTrp: 1.678 ± 0.057	2.681AlaTyr: 2.681 ± 0.049	0.697AlaXaa: 0.697 ± 0.031
Cys	1.158CysAla: 1.158 ± 0.041	0.181CysCys: 0.181 ± 0.014	0.555CysAsp: 0.555 ± 0.027	0.54CysGlu: 0.54 ± 0.025	0.371CysPhe: 0.371 ± 0.019	1.16CysGly: 1.16 ± 0.042	0.386CysHis: 0.386 ± 0.024	0.447CysIle: 0.447 ± 0.023	0.35CysLys: 0.35 ± 0.021	1.048CysLeu: 1.048 ± 0.032	0.196CysMet: 0.196 ± 0.015	0.336CysAsn: 0.336 ± 0.019	0.677CysPro: 0.677 ± 0.031	0.327CysGln: 0.327 ± 0.02	0.851CysArg: 0.851 ± 0.031	0.631CysSer: 0.631 ± 0.026	0.522CysThr: 0.522 ± 0.025	0.692CysVal: 0.692 ± 0.029	0.168CysTrp: 0.168 ± 0.015	0.269CysTyr: 0.269 ± 0.019	0.053CysXaa: 0.053 ± 0.008
Asp	5.9AspAla: 5.9 ± 0.087	0.614AspCys: 0.614 ± 0.029	2.949AspAsp: 2.949 ± 0.055	3.38AspGlu: 3.38 ± 0.074	2.363AspPhe: 2.363 ± 0.051	4.445AspGly: 4.445 ± 0.071	1.116AspHis: 1.116 ± 0.034	2.899AspIle: 2.899 ± 0.06	2.067AspLys: 2.067 ± 0.061	5.476AspLeu: 5.476 ± 0.104	1.17AspMet: 1.17 ± 0.035	1.461AspAsn: 1.461 ± 0.046	2.753AspPro: 2.753 ± 0.057	1.699AspGln: 1.699 ± 0.043	3.38AspArg: 3.38 ± 0.076	2.5AspSer: 2.5 ± 0.05	2.489AspThr: 2.489 ± 0.053	3.488AspVal: 3.488 ± 0.064	0.958AspTrp: 0.958 ± 0.036	1.545AspTyr: 1.545 ± 0.042	0.19AspXaa: 0.19 ± 0.016
Glu	6.809GluAla: 6.809 ± 0.093	0.488GluCys: 0.488 ± 0.025	2.335GluAsp: 2.335 ± 0.059	3.075GluGlu: 3.075 ± 0.067	2.222GluPhe: 2.222 ± 0.054	3.599GluGly: 3.599 ± 0.07	1.357GluHis: 1.357 ± 0.039	3.641GluIle: 3.641 ± 0.073	2.522GluLys: 2.522 ± 0.056	5.971GluLeu: 5.971 ± 0.094	1.596GluMet: 1.596 ± 0.044	1.817GluAsn: 1.817 ± 0.049	2.25GluPro: 2.25 ± 0.052	2.473GluGln: 2.473 ± 0.058	4.743GluArg: 4.743 ± 0.085	2.814GluSer: 2.814 ± 0.056	2.938GluThr: 2.938 ± 0.059	3.989GluVal: 3.989 ± 0.069	0.779GluTrp: 0.779 ± 0.03	1.247GluTyr: 1.247 ± 0.041	0.396GluXaa: 0.396 ± 0.021
Phe	4.595PheAla: 4.595 ± 0.072	0.468PheCys: 0.468 ± 0.024	2.522PheAsp: 2.522 ± 0.051	2.089PheGlu: 2.089 ± 0.046	1.421PhePhe: 1.421 ± 0.053	3.595PheGly: 3.595 ± 0.068	0.813PheHis: 0.813 ± 0.03	1.867PheIle: 1.867 ± 0.049	1.31PheLys: 1.31 ± 0.043	3.362PheLeu: 3.362 ± 0.073	0.902PheMet: 0.902 ± 0.035	1.263PheAsn: 1.263 ± 0.042	1.629PhePro: 1.629 ± 0.041	1.09PheGln: 1.09 ± 0.036	2.352PheArg: 2.352 ± 0.051	2.332PheSer: 2.332 ± 0.055	1.748PheThr: 1.748 ± 0.049	2.835PheVal: 2.835 ± 0.053	0.539PheTrp: 0.539 ± 0.028	1.014PheTyr: 1.014 ± 0.033	0.243PheXaa: 0.243 ± 0.018
Gly	7.632GlyAla: 7.632 ± 0.106	1.058GlyCys: 1.058 ± 0.036	4.203GlyAsp: 4.203 ± 0.066	4.772GlyGlu: 4.772 ± 0.086	3.373GlyPhe: 3.373 ± 0.066	6.305GlyGly: 6.305 ± 0.103	1.845GlyHis: 1.845 ± 0.049	4.776GlyIle: 4.776 ± 0.085	4.109GlyLys: 4.109 ± 0.085	8.227GlyLeu: 8.227 ± 0.111	2.355GlyMet: 2.355 ± 0.078	2.618GlyAsn: 2.618 ± 0.064	2.508GlyPro: 2.508 ± 0.059	3.192GlyGln: 3.192 ± 0.069	5.447GlyArg: 5.447 ± 0.094	4.336GlySer: 4.336 ± 0.07	3.881GlyThr: 3.881 ± 0.08	5.661GlyVal: 5.661 ± 0.082	1.423GlyTrp: 1.423 ± 0.042	2.273GlyTyr: 2.273 ± 0.05	0.465GlyXaa: 0.465 ± 0.025
His	2.409HisAla: 2.409 ± 0.057	0.315HisCys: 0.315 ± 0.018	1.219HisAsp: 1.219 ± 0.037	1.151HisGlu: 1.151 ± 0.034	1.049HisPhe: 1.049 ± 0.034	2.04HisGly: 2.04 ± 0.048	0.642HisHis: 0.642 ± 0.026	1.058HisIle: 1.058 ± 0.035	0.593HisLys: 0.593 ± 0.028	2.399HisLeu: 2.399 ± 0.059	0.411HisMet: 0.411 ± 0.024	0.596HisAsn: 0.596 ± 0.026	1.463HisPro: 1.463 ± 0.039	0.702HisGln: 0.702 ± 0.026	1.529HisArg: 1.529 ± 0.044	1.024HisSer: 1.024 ± 0.033	0.891HisThr: 0.891 ± 0.031	1.47HisVal: 1.47 ± 0.045	0.386HisTrp: 0.386 ± 0.022	0.679HisTyr: 0.679 ± 0.029	0.123HisXaa: 0.123 ± 0.011
Ile	6.771IleAla: 6.771 ± 0.099	0.519IleCys: 0.519 ± 0.024	3.42IleAsp: 3.42 ± 0.063	3.42IleGlu: 3.42 ± 0.061	1.704IlePhe: 1.704 ± 0.052	4.796IleGly: 4.796 ± 0.079	1.047IleHis: 1.047 ± 0.038	2.126IleIle: 2.126 ± 0.053	1.972IleLys: 1.972 ± 0.054	4.474IleLeu: 4.474 ± 0.087	0.89IleMet: 0.89 ± 0.038	1.566IleAsn: 1.566 ± 0.041	2.5IlePro: 2.5 ± 0.052	1.421IleGln: 1.421 ± 0.04	3.263IleArg: 3.263 ± 0.065	2.894IleSer: 2.894 ± 0.06	2.498IleThr: 2.498 ± 0.059	4.156IleVal: 4.156 ± 0.077	0.532IleTrp: 0.532 ± 0.023	1.199IleTyr: 1.199 ± 0.041	0.223IleXaa: 0.223 ± 0.015
Lys	4.609LysAla: 4.609 ± 0.08	0.258LysCys: 0.258 ± 0.02	1.84LysAsp: 1.84 ± 0.052	2.073LysGlu: 2.073 ± 0.059	1.2LysPhe: 1.2 ± 0.037	2.511LysGly: 2.511 ± 0.059	0.823LysHis: 0.823 ± 0.032	1.991LysIle: 1.991 ± 0.048	1.571LysLys: 1.571 ± 0.055	4.147LysLeu: 4.147 ± 0.083	1.059LysMet: 1.059 ± 0.036	1.146LysAsn: 1.146 ± 0.038	2.318LysPro: 2.318 ± 0.055	1.517LysGln: 1.517 ± 0.041	2.626LysArg: 2.626 ± 0.06	1.967LysSer: 1.967 ± 0.052	2.198LysThr: 2.198 ± 0.049	2.754LysVal: 2.754 ± 0.062	0.421LysTrp: 0.421 ± 0.021	0.906LysTyr: 0.906 ± 0.037	0.313LysXaa: 0.313 ± 0.021
Leu	14.573LeuAla: 14.573 ± 0.178	1.12LeuCys: 1.12 ± 0.042	5.863LeuAsp: 5.863 ± 0.077	5.725LeuGlu: 5.725 ± 0.102	3.741LeuPhe: 3.741 ± 0.07	8.404LeuGly: 8.404 ± 0.115	2.213LeuHis: 2.213 ± 0.054	5.186LeuIle: 5.186 ± 0.09	4.287LeuLys: 4.287 ± 0.079	11.545LeuLeu: 11.545 ± 0.169	2.414LeuMet: 2.414 ± 0.046	3.016LeuAsn: 3.016 ± 0.063	6.305LeuPro: 6.305 ± 0.09	3.368LeuGln: 3.368 ± 0.067	7.024LeuArg: 7.024 ± 0.109	5.705LeuSer: 5.705 ± 0.084	5.403LeuThr: 5.403 ± 0.09	7.407LeuVal: 7.407 ± 0.105	1.303LeuTrp: 1.303 ± 0.042	2.188LeuTyr: 2.188 ± 0.052	0.446LeuXaa: 0.446 ± 0.022
Met	2.914MetAla: 2.914 ± 0.059	0.159MetCys: 0.159 ± 0.013	1.054MetAsp: 1.054 ± 0.035	1.164MetGlu: 1.164 ± 0.04	0.798MetPhe: 0.798 ± 0.03	1.641MetGly: 1.641 ± 0.047	0.527MetHis: 0.527 ± 0.024	1.17MetIle: 1.17 ± 0.044	1.149MetLys: 1.149 ± 0.033	2.743MetLeu: 2.743 ± 0.059	0.61MetMet: 0.61 ± 0.027	0.922MetAsn: 0.922 ± 0.034	1.494MetPro: 1.494 ± 0.041	0.956MetGln: 0.956 ± 0.04	1.693MetArg: 1.693 ± 0.043	1.518MetSer: 1.518 ± 0.05	1.48MetThr: 1.48 ± 0.041	1.619MetVal: 1.619 ± 0.041	0.217MetTrp: 0.217 ± 0.018	0.41MetTyr: 0.41 ± 0.023	0.059MetXaa: 0.059 ± 0.008
Asn	3.189AsnAla: 3.189 ± 0.066	0.352AsnCys: 0.352 ± 0.023	1.519AsnAsp: 1.519 ± 0.043	1.503AsnGlu: 1.503 ± 0.047	1.186AsnPhe: 1.186 ± 0.036	2.462AsnGly: 2.462 ± 0.061	0.594AsnHis: 0.594 ± 0.028	1.56AsnIle: 1.56 ± 0.042	1.062AsnLys: 1.062 ± 0.037	3.2AsnLeu: 3.2 ± 0.067	0.655AsnMet: 0.655 ± 0.028	0.845AsnAsn: 0.845 ± 0.029	2.105AsnPro: 2.105 ± 0.052	0.984AsnGln: 0.984 ± 0.036	2.032AsnArg: 2.032 ± 0.05	1.43AsnSer: 1.43 ± 0.045	1.473AsnThr: 1.473 ± 0.04	1.99AsnVal: 1.99 ± 0.053	0.485AsnTrp: 0.485 ± 0.026	0.831AsnTyr: 0.831 ± 0.033	0.111AsnXaa: 0.111 ± 0.013
Pro	6.153ProAla: 6.153 ± 0.097	0.47ProCys: 0.47 ± 0.024	3.073ProAsp: 3.073 ± 0.059	3.816ProGlu: 3.816 ± 0.078	1.749ProPhe: 1.749 ± 0.044	4.319ProGly: 4.319 ± 0.074	1.029ProHis: 1.029 ± 0.039	2.179ProIle: 2.179 ± 0.052	1.773ProLys: 1.773 ± 0.049	5.074ProLeu: 5.074 ± 0.085	1.166ProMet: 1.166 ± 0.035	1.423ProAsn: 1.423 ± 0.035	2.454ProPro: 2.454 ± 0.059	1.799ProGln: 1.799 ± 0.045	2.711ProArg: 2.711 ± 0.065	2.345ProSer: 2.345 ± 0.046	2.349ProThr: 2.349 ± 0.051	4.089ProVal: 4.089 ± 0.071	0.683ProTrp: 0.683 ± 0.027	1.176ProTyr: 1.176 ± 0.039	0.328ProXaa: 0.328 ± 0.02
Gln	4.45GlnAla: 4.45 ± 0.076	0.299GlnCys: 0.299 ± 0.016	1.378GlnAsp: 1.378 ± 0.041	1.781GlnGlu: 1.781 ± 0.048	1.269GlnPhe: 1.269 ± 0.039	2.438GlnGly: 2.438 ± 0.054	0.854GlnHis: 0.854 ± 0.033	1.927GlnIle: 1.927 ± 0.053	1.239GlnLys: 1.239 ± 0.04	3.995GlnLeu: 3.995 ± 0.071	0.942GlnMet: 0.942 ± 0.038	1.003GlnAsn: 1.003 ± 0.034	2.098GlnPro: 2.098 ± 0.043	1.659GlnGln: 1.659 ± 0.047	2.861GlnArg: 2.861 ± 0.064	1.804GlnSer: 1.804 ± 0.048	1.723GlnThr: 1.723 ± 0.052	2.522GlnVal: 2.522 ± 0.046	0.493GlnTrp: 0.493 ± 0.022	0.77GlnTyr: 0.77 ± 0.032	0.224GlnXaa: 0.224 ± 0.015
Arg	6.51ArgAla: 6.51 ± 0.088	0.78ArgCys: 0.78 ± 0.032	3.393ArgAsp: 3.393 ± 0.063	4.137ArgGlu: 4.137 ± 0.081	3.043ArgPhe: 3.043 ± 0.066	4.171ArgGly: 4.171 ± 0.081	1.915ArgHis: 1.915 ± 0.044	3.921ArgIle: 3.921 ± 0.069	2.452ArgLys: 2.452 ± 0.055	8.25ArgLeu: 8.25 ± 0.131	1.792ArgMet: 1.792 ± 0.049	2.172ArgAsn: 2.172 ± 0.055	3.284ArgPro: 3.284 ± 0.065	3.137ArgGln: 3.137 ± 0.068	5.242ArgArg: 5.242 ± 0.094	3.352ArgSer: 3.352 ± 0.055	2.835ArgThr: 2.835 ± 0.057	4.351ArgVal: 4.351 ± 0.075	1.063ArgTrp: 1.063 ± 0.037	1.983ArgTyr: 1.983 ± 0.049	0.477ArgXaa: 0.477 ± 0.023
Ser	5.672SerAla: 5.672 ± 0.082	0.617SerCys: 0.617 ± 0.027	2.569SerAsp: 2.569 ± 0.058	2.734SerGlu: 2.734 ± 0.051	1.993SerPhe: 1.993 ± 0.046	5.214SerGly: 5.214 ± 0.082	1.139SerHis: 1.139 ± 0.039	2.591SerIle: 2.591 ± 0.059	1.75SerLys: 1.75 ± 0.042	5.744SerLeu: 5.744 ± 0.092	1.216SerMet: 1.216 ± 0.044	1.469SerAsn: 1.469 ± 0.044	2.619SerPro: 2.619 ± 0.051	1.71SerGln: 1.71 ± 0.04	3.528SerArg: 3.528 ± 0.071	2.77SerSer: 2.77 ± 0.076	2.546SerThr: 2.546 ± 0.057	3.58SerVal: 3.58 ± 0.075	0.662SerTrp: 0.662 ± 0.029	1.258SerTyr: 1.258 ± 0.04	0.358SerXaa: 0.358 ± 0.022
Thr	5.485ThrAla: 5.485 ± 0.067	0.523ThrCys: 0.523 ± 0.028	2.246ThrAsp: 2.246 ± 0.059	2.377ThrGlu: 2.377 ± 0.053	1.802ThrPhe: 1.802 ± 0.055	4.472ThrGly: 4.472 ± 0.073	1.076ThrHis: 1.076 ± 0.035	2.399ThrIle: 2.399 ± 0.063	1.395ThrLys: 1.395 ± 0.045	5.873ThrLeu: 5.873 ± 0.084	1.04ThrMet: 1.04 ± 0.031	1.298ThrAsn: 1.298 ± 0.044	3.029ThrPro: 3.029 ± 0.054	1.694ThrGln: 1.694 ± 0.048	3.174ThrArg: 3.174 ± 0.064	2.329ThrSer: 2.329 ± 0.059	2.595ThrThr: 2.595 ± 0.06	3.929ThrVal: 3.929 ± 0.067	0.687ThrTrp: 0.687 ± 0.029	1.231ThrTyr: 1.231 ± 0.042	0.279ThrXaa: 0.279 ± 0.019
Val	9.02ValAla: 9.02 ± 0.127	0.791ValCys: 0.791 ± 0.029	4.296ValAsp: 4.296 ± 0.074	4.19ValGlu: 4.19 ± 0.073	2.785ValPhe: 2.785 ± 0.069	5.485ValGly: 5.485 ± 0.093	1.402ValHis: 1.402 ± 0.039	3.871ValIle: 3.871 ± 0.064	2.604ValLys: 2.604 ± 0.058	7.289ValLeu: 7.289 ± 0.101	1.769ValMet: 1.769 ± 0.048	2.084ValAsn: 2.084 ± 0.045	3.481ValPro: 3.481 ± 0.07	2.064ValGln: 2.064 ± 0.052	4.496ValArg: 4.496 ± 0.074	3.91ValSer: 3.91 ± 0.077	3.8ValThr: 3.8 ± 0.064	5.903ValVal: 5.903 ± 0.11	0.894ValTrp: 0.894 ± 0.031	1.148ValTyr: 1.148 ± 0.036	0.423ValXaa: 0.423 ± 0.022
Trp	1.233TrpAla: 1.233 ± 0.04	0.158TrpCys: 0.158 ± 0.015	0.528TrpAsp: 0.528 ± 0.025	0.643TrpGlu: 0.643 ± 0.031	0.577TrpPhe: 0.577 ± 0.029	0.768TrpGly: 0.768 ± 0.032	0.345TrpHis: 0.345 ± 0.022	0.7TrpIle: 0.7 ± 0.029	0.563TrpLys: 0.563 ± 0.027	2.181TrpLeu: 2.181 ± 0.051	0.331TrpMet: 0.331 ± 0.019	0.48TrpAsn: 0.48 ± 0.026	0.712TrpPro: 0.712 ± 0.026	0.771TrpGln: 0.771 ± 0.032	1.214TrpArg: 1.214 ± 0.04	0.746TrpSer: 0.746 ± 0.032	0.572TrpThr: 0.572 ± 0.031	0.919TrpVal: 0.919 ± 0.033	0.264TrpTrp: 0.264 ± 0.019	0.316TrpTyr: 0.316 ± 0.021	0.119TrpXaa: 0.119 ± 0.012
Tyr	2.479TyrAla: 2.479 ± 0.056	0.311TyrCys: 0.311 ± 0.018	1.349TyrAsp: 1.349 ± 0.04	1.228TyrGlu: 1.228 ± 0.041	1.064TyrPhe: 1.064 ± 0.032	2.07TyrGly: 2.07 ± 0.056	0.559TyrHis: 0.559 ± 0.027	0.931TyrIle: 0.931 ± 0.035	0.806TyrLys: 0.806 ± 0.033	2.535TyrLeu: 2.535 ± 0.06	0.492TyrMet: 0.492 ± 0.022	0.695TyrAsn: 0.695 ± 0.031	1.223TyrPro: 1.223 ± 0.035	0.907TyrGln: 0.907 ± 0.031	1.909TyrArg: 1.909 ± 0.044	1.267TyrSer: 1.267 ± 0.044	1.181TyrThr: 1.181 ± 0.037	1.71TyrVal: 1.71 ± 0.042	0.43TyrTrp: 0.43 ± 0.024	0.708TyrTyr: 0.708 ± 0.029	0.106TyrXaa: 0.106 ± 0.011
Xaa	0.464XaaAla: 0.464 ± 0.026	0.057XaaCys: 0.057 ± 0.008	0.215XaaAsp: 0.215 ± 0.015	0.267XaaGlu: 0.267 ± 0.018	0.286XaaPhe: 0.286 ± 0.018	0.711XaaGly: 0.711 ± 0.032	0.104XaaHis: 0.104 ± 0.011	0.157XaaIle: 0.157 ± 0.012	0.48XaaLys: 0.48 ± 0.025	0.526XaaLeu: 0.526 ± 0.026	0.084XaaMet: 0.084 ± 0.01	0.165XaaAsn: 0.165 ± 0.013	0.512XaaPro: 0.512 ± 0.023	0.164XaaGln: 0.164 ± 0.017	0.402XaaArg: 0.402 ± 0.025	0.3XaaSer: 0.3 ± 0.02	0.195XaaThr: 0.195 ± 0.017	0.345XaaVal: 0.345 ± 0.018	0.076XaaTrp: 0.076 ± 0.009	0.126XaaTyr: 0.126 ± 0.011	0.09XaaXaa: 0.09 ± 0.011

Statistics based on 2873 proteins (878941 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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