Amino acid dipepetide frequency for Salmonella phage PVPSE1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.756AlaAla: 5.756 ± 0.541
0.767AlaCys: 0.767 ± 0.146
4.604AlaAsp: 4.604 ± 0.318
4.582AlaGlu: 4.582 ± 0.348
3.047AlaPhe: 3.047 ± 0.263
5.778AlaGly: 5.778 ± 0.427
1.174AlaHis: 1.174 ± 0.17
3.86AlaIle: 3.86 ± 0.296
5.259AlaLys: 5.259 ± 0.428
5.688AlaLeu: 5.688 ± 0.392
2.46AlaMet: 2.46 ± 0.243
3.16AlaAsn: 3.16 ± 0.33
2.28AlaPro: 2.28 ± 0.216
2.596AlaGln: 2.596 ± 0.235
3.589AlaArg: 3.589 ± 0.324
3.882AlaSer: 3.882 ± 0.282
3.814AlaThr: 3.814 ± 0.328
5.033AlaVal: 5.033 ± 0.339
1.287AlaTrp: 1.287 ± 0.182
2.912AlaTyr: 2.912 ± 0.251
0.0AlaXaa: 0.0 ± 0.0
Cys
0.88CysAla: 0.88 ± 0.14
0.181CysCys: 0.181 ± 0.072
0.993CysAsp: 0.993 ± 0.151
0.655CysGlu: 0.655 ± 0.129
0.767CysPhe: 0.767 ± 0.144
0.88CysGly: 0.88 ± 0.137
0.361CysHis: 0.361 ± 0.091
0.587CysIle: 0.587 ± 0.109
0.745CysLys: 0.745 ± 0.174
1.129CysLeu: 1.129 ± 0.144
0.226CysMet: 0.226 ± 0.086
0.79CysAsn: 0.79 ± 0.154
0.542CysPro: 0.542 ± 0.123
0.384CysGln: 0.384 ± 0.091
0.564CysArg: 0.564 ± 0.121
0.767CysSer: 0.767 ± 0.137
0.451CysThr: 0.451 ± 0.113
0.813CysVal: 0.813 ± 0.134
0.226CysTrp: 0.226 ± 0.066
0.451CysTyr: 0.451 ± 0.112
0.0CysXaa: 0.0 ± 0.0
Asp
4.537AspAla: 4.537 ± 0.329
0.429AspCys: 0.429 ± 0.089
4.04AspAsp: 4.04 ± 0.361
4.288AspGlu: 4.288 ± 0.278
3.002AspPhe: 3.002 ± 0.234
6.094AspGly: 6.094 ± 0.391
1.219AspHis: 1.219 ± 0.161
3.905AspIle: 3.905 ± 0.314
3.544AspLys: 3.544 ± 0.306
5.688AspLeu: 5.688 ± 0.317
1.828AspMet: 1.828 ± 0.176
3.318AspAsn: 3.318 ± 0.294
3.273AspPro: 3.273 ± 0.26
2.144AspGln: 2.144 ± 0.26
2.708AspArg: 2.708 ± 0.245
3.566AspSer: 3.566 ± 0.303
3.566AspThr: 3.566 ± 0.343
4.582AspVal: 4.582 ± 0.374
1.467AspTrp: 1.467 ± 0.184
2.573AspTyr: 2.573 ± 0.227
0.0AspXaa: 0.0 ± 0.0
Glu
4.943GluAla: 4.943 ± 0.323
0.903GluCys: 0.903 ± 0.158
3.611GluAsp: 3.611 ± 0.331
5.462GluGlu: 5.462 ± 0.385
2.799GluPhe: 2.799 ± 0.264
4.288GluGly: 4.288 ± 0.308
1.287GluHis: 1.287 ± 0.166
3.927GluIle: 3.927 ± 0.334
5.327GluLys: 5.327 ± 0.409
5.53GluLeu: 5.53 ± 0.347
2.438GluMet: 2.438 ± 0.23
2.912GluAsn: 2.912 ± 0.266
1.806GluPro: 1.806 ± 0.203
2.415GluGln: 2.415 ± 0.234
3.476GluArg: 3.476 ± 0.232
3.431GluSer: 3.431 ± 0.288
3.295GluThr: 3.295 ± 0.313
4.243GluVal: 4.243 ± 0.313
1.332GluTrp: 1.332 ± 0.196
2.663GluTyr: 2.663 ± 0.238
0.0GluXaa: 0.0 ± 0.0
Phe
2.776PheAla: 2.776 ± 0.268
0.722PheCys: 0.722 ± 0.121
3.273PheAsp: 3.273 ± 0.259
2.122PheGlu: 2.122 ± 0.231
1.806PhePhe: 1.806 ± 0.193
3.431PheGly: 3.431 ± 0.26
0.677PheHis: 0.677 ± 0.12
2.438PheIle: 2.438 ± 0.24
2.28PheLys: 2.28 ± 0.263
2.979PheLeu: 2.979 ± 0.258
1.422PheMet: 1.422 ± 0.168
2.144PheAsn: 2.144 ± 0.2
1.49PhePro: 1.49 ± 0.17
1.377PheGln: 1.377 ± 0.158
2.099PheArg: 2.099 ± 0.213
3.047PheSer: 3.047 ± 0.293
2.731PheThr: 2.731 ± 0.266
3.273PheVal: 3.273 ± 0.269
0.745PheTrp: 0.745 ± 0.13
1.557PheTyr: 1.557 ± 0.197
0.0PheXaa: 0.0 ± 0.0
Gly
4.492GlyAla: 4.492 ± 0.396
0.903GlyCys: 0.903 ± 0.174
5.056GlyAsp: 5.056 ± 0.73
4.853GlyGlu: 4.853 ± 0.292
3.589GlyPhe: 3.589 ± 0.291
5.914GlyGly: 5.914 ± 0.598
1.106GlyHis: 1.106 ± 0.184
4.063GlyIle: 4.063 ± 0.304
5.462GlyLys: 5.462 ± 0.397
5.372GlyLeu: 5.372 ± 0.333
1.783GlyMet: 1.783 ± 0.177
3.995GlyAsn: 3.995 ± 0.349
2.393GlyPro: 2.393 ± 0.819
2.708GlyGln: 2.708 ± 0.21
3.521GlyArg: 3.521 ± 0.24
3.927GlySer: 3.927 ± 0.339
4.311GlyThr: 4.311 ± 0.418
5.575GlyVal: 5.575 ± 0.348
1.693GlyTrp: 1.693 ± 0.211
3.318GlyTyr: 3.318 ± 0.293
0.0GlyXaa: 0.0 ± 0.0
His
1.016HisAla: 1.016 ± 0.144
0.316HisCys: 0.316 ± 0.085
0.925HisAsp: 0.925 ± 0.184
1.151HisGlu: 1.151 ± 0.167
0.79HisPhe: 0.79 ± 0.135
1.377HisGly: 1.377 ± 0.184
0.474HisHis: 0.474 ± 0.102
1.241HisIle: 1.241 ± 0.203
1.241HisLys: 1.241 ± 0.165
1.151HisLeu: 1.151 ± 0.158
0.7HisMet: 0.7 ± 0.142
0.88HisAsn: 0.88 ± 0.157
0.948HisPro: 0.948 ± 0.16
0.497HisGln: 0.497 ± 0.092
0.903HisArg: 0.903 ± 0.149
0.971HisSer: 0.971 ± 0.12
1.264HisThr: 1.264 ± 0.174
0.767HisVal: 0.767 ± 0.145
0.339HisTrp: 0.339 ± 0.101
0.948HisTyr: 0.948 ± 0.142
0.0HisXaa: 0.0 ± 0.0
Ile
4.221IleAla: 4.221 ± 0.304
0.564IleCys: 0.564 ± 0.102
4.13IleAsp: 4.13 ± 0.325
4.018IleGlu: 4.018 ± 0.33
2.144IlePhe: 2.144 ± 0.225
3.476IleGly: 3.476 ± 0.314
1.264IleHis: 1.264 ± 0.169
3.927IleIle: 3.927 ± 0.346
3.634IleLys: 3.634 ± 0.283
4.469IleLeu: 4.469 ± 0.329
1.241IleMet: 1.241 ± 0.17
2.663IleAsn: 2.663 ± 0.258
2.844IlePro: 2.844 ± 0.249
1.986IleGln: 1.986 ± 0.23
2.889IleArg: 2.889 ± 0.281
3.656IleSer: 3.656 ± 0.264
3.205IleThr: 3.205 ± 0.26
3.656IleVal: 3.656 ± 0.282
0.745IleTrp: 0.745 ± 0.126
2.144IleTyr: 2.144 ± 0.209
0.0IleXaa: 0.0 ± 0.0
Lys
5.959LysAla: 5.959 ± 0.423
0.609LysCys: 0.609 ± 0.145
4.943LysAsp: 4.943 ± 0.32
4.898LysGlu: 4.898 ± 0.394
2.46LysPhe: 2.46 ± 0.216
4.74LysGly: 4.74 ± 0.453
1.512LysHis: 1.512 ± 0.239
3.566LysIle: 3.566 ± 0.3
5.033LysLys: 5.033 ± 0.385
4.785LysLeu: 4.785 ± 0.296
2.438LysMet: 2.438 ± 0.202
3.25LysAsn: 3.25 ± 0.233
2.37LysPro: 2.37 ± 0.28
2.077LysGln: 2.077 ± 0.193
3.702LysArg: 3.702 ± 0.313
3.408LysSer: 3.408 ± 0.261
3.927LysThr: 3.927 ± 0.286
5.53LysVal: 5.53 ± 0.38
1.061LysTrp: 1.061 ± 0.141
2.483LysTyr: 2.483 ± 0.191
0.0LysXaa: 0.0 ± 0.0
Leu
6.23LeuAla: 6.23 ± 0.354
1.196LeuCys: 1.196 ± 0.203
5.214LeuAsp: 5.214 ± 0.297
5.936LeuGlu: 5.936 ± 0.424
2.821LeuPhe: 2.821 ± 0.297
4.582LeuGly: 4.582 ± 0.355
1.196LeuHis: 1.196 ± 0.162
3.972LeuIle: 3.972 ± 0.293
5.914LeuLys: 5.914 ± 0.335
6.184LeuLeu: 6.184 ± 0.436
2.325LeuMet: 2.325 ± 0.229
3.702LeuAsn: 3.702 ± 0.304
3.205LeuPro: 3.205 ± 0.29
2.754LeuGln: 2.754 ± 0.299
3.837LeuArg: 3.837 ± 0.316
5.462LeuSer: 5.462 ± 0.342
5.236LeuThr: 5.236 ± 0.348
4.604LeuVal: 4.604 ± 0.328
1.264LeuTrp: 1.264 ± 0.168
3.228LeuTyr: 3.228 ± 0.244
0.0LeuXaa: 0.0 ± 0.0
Met
2.438MetAla: 2.438 ± 0.242
0.181MetCys: 0.181 ± 0.062
1.603MetAsp: 1.603 ± 0.199
1.873MetGlu: 1.873 ± 0.244
1.241MetPhe: 1.241 ± 0.185
1.828MetGly: 1.828 ± 0.202
0.248MetHis: 0.248 ± 0.069
1.964MetIle: 1.964 ± 0.244
2.821MetLys: 2.821 ± 0.245
2.415MetLeu: 2.415 ± 0.243
0.993MetMet: 0.993 ± 0.195
1.241MetAsn: 1.241 ± 0.169
0.925MetPro: 0.925 ± 0.119
0.971MetGln: 0.971 ± 0.155
1.151MetArg: 1.151 ± 0.145
2.054MetSer: 2.054 ± 0.204
1.964MetThr: 1.964 ± 0.225
1.964MetVal: 1.964 ± 0.199
0.406MetTrp: 0.406 ± 0.092
1.264MetTyr: 1.264 ± 0.161
0.0MetXaa: 0.0 ± 0.0
Asn
3.476AsnAla: 3.476 ± 0.283
0.542AsnCys: 0.542 ± 0.121
2.754AsnAsp: 2.754 ± 0.308
2.212AsnGlu: 2.212 ± 0.21
2.009AsnPhe: 2.009 ± 0.186
4.266AsnGly: 4.266 ± 0.363
0.971AsnHis: 0.971 ± 0.156
3.115AsnIle: 3.115 ± 0.265
2.979AsnLys: 2.979 ± 0.221
3.769AsnLeu: 3.769 ± 0.339
1.377AsnMet: 1.377 ± 0.176
1.986AsnAsn: 1.986 ± 0.232
2.528AsnPro: 2.528 ± 0.212
1.806AsnGln: 1.806 ± 0.202
2.077AsnArg: 2.077 ± 0.217
2.641AsnSer: 2.641 ± 0.248
2.641AsnThr: 2.641 ± 0.264
3.34AsnVal: 3.34 ± 0.291
0.858AsnTrp: 0.858 ± 0.166
1.896AsnTyr: 1.896 ± 0.218
0.0AsnXaa: 0.0 ± 0.0
Pro
2.393ProAla: 2.393 ± 0.246
0.316ProCys: 0.316 ± 0.078
2.596ProAsp: 2.596 ± 0.238
3.634ProGlu: 3.634 ± 0.287
1.964ProPhe: 1.964 ± 0.197
2.167ProGly: 2.167 ± 0.221
0.609ProHis: 0.609 ± 0.138
1.445ProIle: 1.445 ± 0.157
2.641ProLys: 2.641 ± 0.249
2.708ProLeu: 2.708 ± 0.258
0.993ProMet: 0.993 ± 0.154
1.806ProAsn: 1.806 ± 0.205
0.971ProPro: 0.971 ± 0.188
1.896ProGln: 1.896 ± 0.449
1.58ProArg: 1.58 ± 0.222
2.009ProSer: 2.009 ± 0.213
2.551ProThr: 2.551 ± 0.264
3.115ProVal: 3.115 ± 0.243
0.384ProTrp: 0.384 ± 0.083
1.625ProTyr: 1.625 ± 0.176
0.0ProXaa: 0.0 ± 0.0
Gln
2.754GlnAla: 2.754 ± 0.287
0.361GlnCys: 0.361 ± 0.079
2.054GlnAsp: 2.054 ± 0.201
2.054GlnGlu: 2.054 ± 0.179
1.693GlnPhe: 1.693 ± 0.174
2.912GlnGly: 2.912 ± 0.724
0.542GlnHis: 0.542 ± 0.097
2.077GlnIle: 2.077 ± 0.236
2.257GlnLys: 2.257 ± 0.195
2.528GlnLeu: 2.528 ± 0.213
1.174GlnMet: 1.174 ± 0.186
1.648GlnAsn: 1.648 ± 0.165
1.106GlnPro: 1.106 ± 0.161
1.557GlnGln: 1.557 ± 0.188
1.941GlnArg: 1.941 ± 0.188
2.077GlnSer: 2.077 ± 0.205
1.941GlnThr: 1.941 ± 0.19
2.393GlnVal: 2.393 ± 0.218
0.519GlnTrp: 0.519 ± 0.104
1.715GlnTyr: 1.715 ± 0.204
0.0GlnXaa: 0.0 ± 0.0
Arg
2.776ArgAla: 2.776 ± 0.261
0.88ArgCys: 0.88 ± 0.15
3.476ArgAsp: 3.476 ± 0.315
3.002ArgGlu: 3.002 ± 0.282
2.099ArgPhe: 2.099 ± 0.244
3.634ArgGly: 3.634 ± 0.25
0.925ArgHis: 0.925 ± 0.142
2.844ArgIle: 2.844 ± 0.252
3.566ArgLys: 3.566 ± 0.265
4.379ArgLeu: 4.379 ± 0.327
1.422ArgMet: 1.422 ± 0.171
2.505ArgAsn: 2.505 ± 0.24
1.625ArgPro: 1.625 ± 0.194
1.896ArgGln: 1.896 ± 0.203
2.731ArgArg: 2.731 ± 0.281
2.663ArgSer: 2.663 ± 0.211
2.438ArgThr: 2.438 ± 0.225
3.318ArgVal: 3.318 ± 0.31
0.79ArgTrp: 0.79 ± 0.133
1.783ArgTyr: 1.783 ± 0.201
0.0ArgXaa: 0.0 ± 0.0
Ser
4.198SerAla: 4.198 ± 0.288
0.767SerCys: 0.767 ± 0.144
4.018SerAsp: 4.018 ± 0.286
3.386SerGlu: 3.386 ± 0.327
2.686SerPhe: 2.686 ± 0.292
4.898SerGly: 4.898 ± 0.406
0.948SerHis: 0.948 ± 0.149
3.611SerIle: 3.611 ± 0.305
3.882SerLys: 3.882 ± 0.311
4.537SerLeu: 4.537 ± 0.324
1.625SerMet: 1.625 ± 0.173
2.189SerAsn: 2.189 ± 0.203
2.031SerPro: 2.031 ± 0.213
1.986SerGln: 1.986 ± 0.183
3.024SerArg: 3.024 ± 0.243
3.792SerSer: 3.792 ± 0.378
3.273SerThr: 3.273 ± 0.296
4.672SerVal: 4.672 ± 0.315
0.948SerTrp: 0.948 ± 0.168
2.009SerTyr: 2.009 ± 0.228
0.0SerXaa: 0.0 ± 0.0
Thr
4.243ThrAla: 4.243 ± 0.364
0.655ThrCys: 0.655 ± 0.114
3.589ThrAsp: 3.589 ± 0.262
3.521ThrGlu: 3.521 ± 0.297
2.618ThrPhe: 2.618 ± 0.208
5.462ThrGly: 5.462 ± 0.5
0.993ThrHis: 0.993 ± 0.128
3.25ThrIle: 3.25 ± 0.25
3.747ThrLys: 3.747 ± 0.327
4.943ThrLeu: 4.943 ± 0.317
1.422ThrMet: 1.422 ± 0.194
2.889ThrAsn: 2.889 ± 0.246
2.505ThrPro: 2.505 ± 0.224
2.235ThrGln: 2.235 ± 0.227
2.28ThrArg: 2.28 ± 0.194
2.957ThrSer: 2.957 ± 0.266
3.882ThrThr: 3.882 ± 0.364
4.627ThrVal: 4.627 ± 0.4
1.174ThrTrp: 1.174 ± 0.179
2.099ThrTyr: 2.099 ± 0.205
0.0ThrXaa: 0.0 ± 0.0
Val
4.785ValAla: 4.785 ± 0.391
1.129ValCys: 1.129 ± 0.159
4.898ValAsp: 4.898 ± 0.355
5.101ValGlu: 5.101 ± 0.385
2.754ValPhe: 2.754 ± 0.227
4.198ValGly: 4.198 ± 0.306
1.219ValHis: 1.219 ± 0.179
3.905ValIle: 3.905 ± 0.257
4.966ValLys: 4.966 ± 0.422
5.169ValLeu: 5.169 ± 0.354
2.054ValMet: 2.054 ± 0.215
3.634ValAsn: 3.634 ± 0.294
2.28ValPro: 2.28 ± 0.202
1.941ValGln: 1.941 ± 0.237
3.589ValArg: 3.589 ± 0.307
4.672ValSer: 4.672 ± 0.322
5.078ValThr: 5.078 ± 0.421
6.816ValVal: 6.816 ± 0.517
1.174ValTrp: 1.174 ± 0.166
2.912ValTyr: 2.912 ± 0.266
0.0ValXaa: 0.0 ± 0.0
Trp
1.016TrpAla: 1.016 ± 0.152
0.316TrpCys: 0.316 ± 0.09
1.129TrpAsp: 1.129 ± 0.216
1.174TrpGlu: 1.174 ± 0.183
0.632TrpPhe: 0.632 ± 0.156
1.106TrpGly: 1.106 ± 0.176
0.384TrpHis: 0.384 ± 0.102
1.106TrpIle: 1.106 ± 0.16
1.038TrpLys: 1.038 ± 0.172
1.648TrpLeu: 1.648 ± 0.182
0.722TrpMet: 0.722 ± 0.13
0.767TrpAsn: 0.767 ± 0.14
0.519TrpPro: 0.519 ± 0.116
0.632TrpGln: 0.632 ± 0.124
0.7TrpArg: 0.7 ± 0.136
1.106TrpSer: 1.106 ± 0.153
1.106TrpThr: 1.106 ± 0.157
1.219TrpVal: 1.219 ± 0.192
0.429TrpTrp: 0.429 ± 0.099
0.813TrpTyr: 0.813 ± 0.134
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.641TyrAla: 2.641 ± 0.234
0.655TyrCys: 0.655 ± 0.124
2.866TyrAsp: 2.866 ± 0.284
2.167TyrGlu: 2.167 ± 0.202
1.467TyrPhe: 1.467 ± 0.153
3.002TyrGly: 3.002 ± 0.268
0.79TyrHis: 0.79 ± 0.161
2.077TyrIle: 2.077 ± 0.244
2.415TyrLys: 2.415 ± 0.258
3.792TyrLeu: 3.792 ± 0.321
0.88TyrMet: 0.88 ± 0.14
1.761TyrAsn: 1.761 ± 0.18
1.761TyrPro: 1.761 ± 0.197
1.445TyrGln: 1.445 ± 0.192
2.393TyrArg: 2.393 ± 0.219
2.393TyrSer: 2.393 ± 0.242
2.415TyrThr: 2.415 ± 0.237
2.754TyrVal: 2.754 ± 0.248
0.722TyrTrp: 0.722 ± 0.122
1.377TyrTyr: 1.377 ± 0.187
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 244 proteins (44306 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski