Amino acid dipepetide frequency for Vibrio hepatarius

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.735AlaAla: 7.735 ± 0.1	0.915AlaCys: 0.915 ± 0.028	4.533AlaAsp: 4.533 ± 0.064	5.857AlaGlu: 5.857 ± 0.085	3.477AlaPhe: 3.477 ± 0.061	5.832AlaGly: 5.832 ± 0.076	1.587AlaHis: 1.587 ± 0.034	5.98AlaIle: 5.98 ± 0.07	5.216AlaLys: 5.216 ± 0.066	9.781AlaLeu: 9.781 ± 0.089	2.786AlaMet: 2.786 ± 0.047	3.502AlaAsn: 3.502 ± 0.059	2.869AlaPro: 2.869 ± 0.049	3.981AlaGln: 3.981 ± 0.062	3.59AlaArg: 3.59 ± 0.059	5.47AlaSer: 5.47 ± 0.066	4.469AlaThr: 4.469 ± 0.06	5.892AlaVal: 5.892 ± 0.066	0.975AlaTrp: 0.975 ± 0.032	2.35AlaTyr: 2.35 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.801CysAla: 0.801 ± 0.025	0.162CysCys: 0.162 ± 0.011	0.634CysAsp: 0.634 ± 0.021	0.642CysGlu: 0.642 ± 0.022	0.472CysPhe: 0.472 ± 0.02	0.948CysGly: 0.948 ± 0.025	0.342CysHis: 0.342 ± 0.017	0.568CysIle: 0.568 ± 0.021	0.436CysLys: 0.436 ± 0.019	0.95CysLeu: 0.95 ± 0.028	0.231CysMet: 0.231 ± 0.013	0.369CysAsn: 0.369 ± 0.017	0.457CysPro: 0.457 ± 0.02	0.451CysGln: 0.451 ± 0.019	0.458CysArg: 0.458 ± 0.019	0.715CysSer: 0.715 ± 0.022	0.473CysThr: 0.473 ± 0.019	0.713CysVal: 0.713 ± 0.024	0.134CysTrp: 0.134 ± 0.01	0.328CysTyr: 0.328 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.585AspAla: 4.585 ± 0.063	0.553AspCys: 0.553 ± 0.02	3.117AspAsp: 3.117 ± 0.055	4.004AspGlu: 4.004 ± 0.059	2.452AspPhe: 2.452 ± 0.041	3.837AspGly: 3.837 ± 0.08	1.075AspHis: 1.075 ± 0.027	3.865AspIle: 3.865 ± 0.055	3.329AspLys: 3.329 ± 0.045	5.169AspLeu: 5.169 ± 0.063	1.429AspMet: 1.429 ± 0.033	2.389AspAsn: 2.389 ± 0.047	2.095AspPro: 2.095 ± 0.042	2.03AspGln: 2.03 ± 0.036	2.261AspArg: 2.261 ± 0.04	3.408AspSer: 3.408 ± 0.055	2.65AspThr: 2.65 ± 0.047	4.1AspVal: 4.1 ± 0.059	0.906AspTrp: 0.906 ± 0.027	2.041AspTyr: 2.041 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	5.352GluAla: 5.352 ± 0.072	0.575GluCys: 0.575 ± 0.021	3.011GluAsp: 3.011 ± 0.052	4.236GluGlu: 4.236 ± 0.081	2.67GluPhe: 2.67 ± 0.044	3.648GluGly: 3.648 ± 0.058	1.694GluHis: 1.694 ± 0.033	3.847GluIle: 3.847 ± 0.062	3.873GluLys: 3.873 ± 0.056	7.647GluLeu: 7.647 ± 0.074	1.866GluMet: 1.866 ± 0.042	2.648GluAsn: 2.648 ± 0.044	2.183GluPro: 2.183 ± 0.049	4.373GluGln: 4.373 ± 0.071	3.573GluArg: 3.573 ± 0.06	4.057GluSer: 4.057 ± 0.057	3.185GluThr: 3.185 ± 0.051	4.564GluVal: 4.564 ± 0.059	0.819GluTrp: 0.819 ± 0.024	1.904GluTyr: 1.904 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.754PheAla: 3.754 ± 0.056	0.512PheCys: 0.512 ± 0.018	2.717PheAsp: 2.717 ± 0.046	2.675PheGlu: 2.675 ± 0.045	1.694PhePhe: 1.694 ± 0.04	3.276PheGly: 3.276 ± 0.054	0.791PheHis: 0.791 ± 0.027	2.717PheIle: 2.717 ± 0.054	2.02PheLys: 2.02 ± 0.039	3.389PheLeu: 3.389 ± 0.06	0.985PheMet: 0.985 ± 0.027	1.933PheAsn: 1.933 ± 0.044	1.464PhePro: 1.464 ± 0.038	1.244PheGln: 1.244 ± 0.029	1.518PheArg: 1.518 ± 0.034	3.25PheSer: 3.25 ± 0.054	2.348PheThr: 2.348 ± 0.039	2.936PheVal: 2.936 ± 0.05	0.529PheTrp: 0.529 ± 0.02	1.326PheTyr: 1.326 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	5.294GlyAla: 5.294 ± 0.071	0.892GlyCys: 0.892 ± 0.026	3.635GlyAsp: 3.635 ± 0.061	4.642GlyGlu: 4.642 ± 0.066	3.263GlyPhe: 3.263 ± 0.054	4.752GlyGly: 4.752 ± 0.082	1.543GlyHis: 1.543 ± 0.035	4.678GlyIle: 4.678 ± 0.057	3.975GlyLys: 3.975 ± 0.062	6.863GlyLeu: 6.863 ± 0.075	2.033GlyMet: 2.033 ± 0.042	2.578GlyAsn: 2.578 ± 0.049	1.58GlyPro: 1.58 ± 0.036	2.809GlyGln: 2.809 ± 0.04	3.066GlyArg: 3.066 ± 0.055	4.132GlySer: 4.132 ± 0.063	3.464GlyThr: 3.464 ± 0.065	5.338GlyVal: 5.338 ± 0.066	0.964GlyTrp: 0.964 ± 0.025	2.6GlyTyr: 2.6 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.634HisAla: 1.634 ± 0.037	0.312HisCys: 0.312 ± 0.016	1.129HisAsp: 1.129 ± 0.031	1.104HisGlu: 1.104 ± 0.032	1.042HisPhe: 1.042 ± 0.027	1.497HisGly: 1.497 ± 0.035	0.664HisHis: 0.664 ± 0.028	1.349HisIle: 1.349 ± 0.031	1.068HisLys: 1.068 ± 0.026	2.221HisLeu: 2.221 ± 0.041	0.493HisMet: 0.493 ± 0.018	0.907HisAsn: 0.907 ± 0.028	1.132HisPro: 1.132 ± 0.033	1.152HisGln: 1.152 ± 0.034	1.029HisArg: 1.029 ± 0.027	1.479HisSer: 1.479 ± 0.033	1.068HisThr: 1.068 ± 0.028	1.303HisVal: 1.303 ± 0.027	0.352HisTrp: 0.352 ± 0.018	0.853HisTyr: 0.853 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.419IleAla: 6.419 ± 0.078	0.671IleCys: 0.671 ± 0.023	4.08IleAsp: 4.08 ± 0.051	4.872IleGlu: 4.872 ± 0.068	2.112IlePhe: 2.112 ± 0.045	4.634IleGly: 4.634 ± 0.065	1.236IleHis: 1.236 ± 0.031	3.407IleIle: 3.407 ± 0.062	3.138IleLys: 3.138 ± 0.045	5.122IleLeu: 5.122 ± 0.068	1.254IleMet: 1.254 ± 0.031	2.786IleAsn: 2.786 ± 0.049	2.605IlePro: 2.605 ± 0.045	2.294IleGln: 2.294 ± 0.039	2.739IleArg: 2.739 ± 0.047	4.382IleSer: 4.382 ± 0.064	3.493IleThr: 3.493 ± 0.053	4.252IleVal: 4.252 ± 0.061	0.616IleTrp: 0.616 ± 0.023	1.727IleTyr: 1.727 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.872LysAla: 4.872 ± 0.06	0.342LysCys: 0.342 ± 0.016	2.776LysAsp: 2.776 ± 0.044	3.531LysGlu: 3.531 ± 0.068	1.672LysPhe: 1.672 ± 0.04	3.448LysGly: 3.448 ± 0.057	1.329LysHis: 1.329 ± 0.028	2.681LysIle: 2.681 ± 0.046	2.87LysLys: 2.87 ± 0.056	5.628LysLeu: 5.628 ± 0.065	1.495LysMet: 1.495 ± 0.031	2.051LysAsn: 2.051 ± 0.044	2.491LysPro: 2.491 ± 0.042	3.21LysGln: 3.21 ± 0.048	2.812LysArg: 2.812 ± 0.044	3.162LysSer: 3.162 ± 0.051	2.694LysThr: 2.694 ± 0.041	4.127LysVal: 4.127 ± 0.057	0.608LysTrp: 0.608 ± 0.022	1.5LysTyr: 1.5 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	9.89LeuAla: 9.89 ± 0.1	1.087LeuCys: 1.087 ± 0.027	5.924LeuAsp: 5.924 ± 0.067	6.527LeuGlu: 6.527 ± 0.078	4.149LeuPhe: 4.149 ± 0.068	7.004LeuGly: 7.004 ± 0.081	1.94LeuHis: 1.94 ± 0.039	6.043LeuIle: 6.043 ± 0.083	5.479LeuLys: 5.479 ± 0.066	10.332LeuLeu: 10.332 ± 0.135	2.744LeuMet: 2.744 ± 0.046	4.489LeuAsn: 4.489 ± 0.065	4.653LeuPro: 4.653 ± 0.068	3.56LeuGln: 3.56 ± 0.05	4.283LeuArg: 4.283 ± 0.067	8.042LeuSer: 8.042 ± 0.077	5.999LeuThr: 5.999 ± 0.069	7.371LeuVal: 7.371 ± 0.077	1.02LeuTrp: 1.02 ± 0.031	2.666LeuTyr: 2.666 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.579MetAla: 2.579 ± 0.049	0.226MetCys: 0.226 ± 0.013	1.311MetAsp: 1.311 ± 0.028	1.39MetGlu: 1.39 ± 0.03	0.98MetPhe: 0.98 ± 0.032	1.831MetGly: 1.831 ± 0.043	0.484MetHis: 0.484 ± 0.018	1.545MetIle: 1.545 ± 0.034	1.575MetLys: 1.575 ± 0.032	2.82MetLeu: 2.82 ± 0.054	0.825MetMet: 0.825 ± 0.028	1.131MetAsn: 1.131 ± 0.029	1.229MetPro: 1.229 ± 0.031	1.09MetGln: 1.09 ± 0.031	1.201MetArg: 1.201 ± 0.029	2.046MetSer: 2.046 ± 0.037	1.673MetThr: 1.673 ± 0.034	1.916MetVal: 1.916 ± 0.037	0.239MetTrp: 0.239 ± 0.011	0.593MetTyr: 0.593 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.415AsnAla: 3.415 ± 0.052	0.38AsnCys: 0.38 ± 0.016	2.299AsnAsp: 2.299 ± 0.042	2.413AsnGlu: 2.413 ± 0.041	1.528AsnPhe: 1.528 ± 0.035	2.925AsnGly: 2.925 ± 0.06	0.954AsnHis: 0.954 ± 0.028	2.571AsnIle: 2.571 ± 0.051	2.247AsnLys: 2.247 ± 0.039	3.886AsnLeu: 3.886 ± 0.059	1.009AsnMet: 1.009 ± 0.026	1.807AsnAsn: 1.807 ± 0.039	2.162AsnPro: 2.162 ± 0.044	2.217AsnGln: 2.217 ± 0.043	1.958AsnArg: 1.958 ± 0.038	2.505AsnSer: 2.505 ± 0.042	2.111AsnThr: 2.111 ± 0.039	2.859AsnVal: 2.859 ± 0.049	0.552AsnTrp: 0.552 ± 0.022	1.342AsnTyr: 1.342 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	3.101ProAla: 3.101 ± 0.053	0.324ProCys: 0.324 ± 0.015	2.297ProAsp: 2.297 ± 0.036	3.287ProGlu: 3.287 ± 0.055	1.716ProPhe: 1.716 ± 0.039	2.199ProGly: 2.199 ± 0.046	0.837ProHis: 0.837 ± 0.026	2.486ProIle: 2.486 ± 0.04	2.0ProLys: 2.0 ± 0.041	4.018ProLeu: 4.018 ± 0.06	1.083ProMet: 1.083 ± 0.025	1.725ProAsn: 1.725 ± 0.034	1.121ProPro: 1.121 ± 0.029	1.734ProGln: 1.734 ± 0.04	1.347ProArg: 1.347 ± 0.035	2.503ProSer: 2.503 ± 0.047	2.199ProThr: 2.199 ± 0.039	3.166ProVal: 3.166 ± 0.05	0.51ProTrp: 0.51 ± 0.021	1.275ProTyr: 1.275 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.245GlnAla: 4.245 ± 0.059	0.387GlnCys: 0.387 ± 0.02	2.19GlnAsp: 2.19 ± 0.046	2.716GlnGlu: 2.716 ± 0.051	1.777GlnPhe: 1.777 ± 0.035	3.04GlnGly: 3.04 ± 0.054	1.196GlnHis: 1.196 ± 0.032	2.526GlnIle: 2.526 ± 0.047	2.065GlnLys: 2.065 ± 0.04	5.222GlnLeu: 5.222 ± 0.076	1.174GlnMet: 1.174 ± 0.03	1.642GlnAsn: 1.642 ± 0.038	1.795GlnPro: 1.795 ± 0.033	2.922GlnGln: 2.922 ± 0.056	2.373GlnArg: 2.373 ± 0.047	2.874GlnSer: 2.874 ± 0.055	2.267GlnThr: 2.267 ± 0.042	3.284GlnVal: 3.284 ± 0.048	0.654GlnTrp: 0.654 ± 0.027	1.425GlnTyr: 1.425 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.464ArgAla: 3.464 ± 0.053	0.458ArgCys: 0.458 ± 0.02	2.511ArgAsp: 2.511 ± 0.044	3.101ArgGlu: 3.101 ± 0.054	2.206ArgPhe: 2.206 ± 0.039	2.522ArgGly: 2.522 ± 0.048	1.097ArgHis: 1.097 ± 0.03	3.029ArgIle: 3.029 ± 0.048	2.485ArgLys: 2.485 ± 0.046	4.781ArgLeu: 4.781 ± 0.062	1.211ArgMet: 1.211 ± 0.028	1.849ArgAsn: 1.849 ± 0.036	1.5ArgPro: 1.5 ± 0.036	2.061ArgGln: 2.061 ± 0.039	2.293ArgArg: 2.293 ± 0.05	2.714ArgSer: 2.714 ± 0.04	2.198ArgThr: 2.198 ± 0.04	3.244ArgVal: 3.244 ± 0.05	0.622ArgTrp: 0.622 ± 0.022	1.731ArgTyr: 1.731 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.506SerAla: 5.506 ± 0.076	0.639SerCys: 0.639 ± 0.026	3.778SerAsp: 3.778 ± 0.054	4.275SerGlu: 4.275 ± 0.061	2.877SerPhe: 2.877 ± 0.053	5.005SerGly: 5.005 ± 0.066	1.444SerHis: 1.444 ± 0.03	4.138SerIle: 4.138 ± 0.062	3.326SerLys: 3.326 ± 0.052	7.04SerLeu: 7.04 ± 0.083	1.83SerMet: 1.83 ± 0.038	2.723SerAsn: 2.723 ± 0.049	2.401SerPro: 2.401 ± 0.046	3.135SerGln: 3.135 ± 0.05	2.909SerArg: 2.909 ± 0.047	4.505SerSer: 4.505 ± 0.079	3.287SerThr: 3.287 ± 0.048	4.841SerVal: 4.841 ± 0.063	0.849SerTrp: 0.849 ± 0.028	2.086SerTyr: 2.086 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.296ThrAla: 4.296 ± 0.06	0.471ThrCys: 0.471 ± 0.021	2.832ThrAsp: 2.832 ± 0.05	3.101ThrGlu: 3.101 ± 0.044	2.108ThrPhe: 2.108 ± 0.038	4.01ThrGly: 4.01 ± 0.057	1.191ThrHis: 1.191 ± 0.03	3.31ThrIle: 3.31 ± 0.063	2.418ThrLys: 2.418 ± 0.039	6.197ThrLeu: 6.197 ± 0.076	1.163ThrMet: 1.163 ± 0.027	2.005ThrAsn: 2.005 ± 0.041	2.645ThrPro: 2.645 ± 0.045	2.419ThrGln: 2.419 ± 0.048	2.262ThrArg: 2.262 ± 0.05	3.398ThrSer: 3.398 ± 0.056	2.949ThrThr: 2.949 ± 0.055	3.845ThrVal: 3.845 ± 0.063	0.628ThrTrp: 0.628 ± 0.023	1.529ThrTyr: 1.529 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	6.669ValAla: 6.669 ± 0.081	0.85ValCys: 0.85 ± 0.023	4.191ValAsp: 4.191 ± 0.06	5.185ValGlu: 5.185 ± 0.07	2.91ValPhe: 2.91 ± 0.053	4.846ValGly: 4.846 ± 0.065	1.289ValHis: 1.289 ± 0.033	4.766ValIle: 4.766 ± 0.07	3.798ValLys: 3.798 ± 0.061	7.02ValLeu: 7.02 ± 0.082	2.053ValMet: 2.053 ± 0.039	2.964ValAsn: 2.964 ± 0.05	2.745ValPro: 2.745 ± 0.046	2.253ValGln: 2.253 ± 0.042	3.04ValArg: 3.04 ± 0.048	5.154ValSer: 5.154 ± 0.07	4.192ValThr: 4.192 ± 0.057	5.9ValVal: 5.9 ± 0.084	0.791ValTrp: 0.791 ± 0.023	1.916ValTyr: 1.916 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.829TrpAla: 0.829 ± 0.025	0.159TrpCys: 0.159 ± 0.011	0.645TrpAsp: 0.645 ± 0.021	0.564TrpGlu: 0.564 ± 0.021	0.612TrpPhe: 0.612 ± 0.021	0.791TrpGly: 0.791 ± 0.023	0.338TrpHis: 0.338 ± 0.016	0.694TrpIle: 0.694 ± 0.022	0.566TrpLys: 0.566 ± 0.019	1.742TrpLeu: 1.742 ± 0.038	0.344TrpMet: 0.344 ± 0.014	0.513TrpAsn: 0.513 ± 0.019	0.431TrpPro: 0.431 ± 0.017	0.879TrpGln: 0.879 ± 0.031	0.628TrpArg: 0.628 ± 0.02	0.747TrpSer: 0.747 ± 0.024	0.519TrpThr: 0.519 ± 0.023	0.899TrpVal: 0.899 ± 0.027	0.195TrpTrp: 0.195 ± 0.013	0.387TrpTyr: 0.387 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.357TyrAla: 2.357 ± 0.042	0.369TyrCys: 0.369 ± 0.018	1.684TyrAsp: 1.684 ± 0.036	1.603TyrGlu: 1.603 ± 0.031	1.36TyrPhe: 1.36 ± 0.026	2.054TyrGly: 2.054 ± 0.038	0.758TyrHis: 0.758 ± 0.023	1.642TyrIle: 1.642 ± 0.036	1.417TyrLys: 1.417 ± 0.029	3.373TyrLeu: 3.373 ± 0.053	0.677TyrMet: 0.677 ± 0.02	1.129TyrAsn: 1.129 ± 0.031	1.365TyrPro: 1.365 ± 0.026	1.963TyrGln: 1.963 ± 0.043	1.738TyrArg: 1.738 ± 0.041	2.053TyrSer: 2.053 ± 0.035	1.539TyrThr: 1.539 ± 0.039	1.981TyrVal: 1.981 ± 0.04	0.519TyrTrp: 0.519 ± 0.02	1.029TyrTyr: 1.029 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4313 proteins (1386379 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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