Amino acid dipepetide frequency for Paracoccus zhejiangensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.515AlaAla: 18.515 ± 0.187	0.989AlaCys: 0.989 ± 0.028	7.28AlaAsp: 7.28 ± 0.084	9.27AlaGlu: 9.27 ± 0.119	3.983AlaPhe: 3.983 ± 0.056	12.036AlaGly: 12.036 ± 0.104	2.322AlaHis: 2.322 ± 0.048	6.337AlaIle: 6.337 ± 0.072	3.366AlaLys: 3.366 ± 0.064	14.337AlaLeu: 14.337 ± 0.131	3.985AlaMet: 3.985 ± 0.051	2.625AlaAsn: 2.625 ± 0.043	6.206AlaPro: 6.206 ± 0.093	4.367AlaGln: 4.367 ± 0.067	9.497AlaArg: 9.497 ± 0.096	5.823AlaSer: 5.823 ± 0.065	6.198AlaThr: 6.198 ± 0.076	8.482AlaVal: 8.482 ± 0.077	1.486AlaTrp: 1.486 ± 0.037	2.378AlaTyr: 2.378 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.957CysAla: 0.957 ± 0.028	0.102CysCys: 0.102 ± 0.009	0.547CysAsp: 0.547 ± 0.022	0.372CysGlu: 0.372 ± 0.019	0.291CysPhe: 0.291 ± 0.015	0.848CysGly: 0.848 ± 0.028	0.26CysHis: 0.26 ± 0.017	0.377CysIle: 0.377 ± 0.018	0.155CysLys: 0.155 ± 0.01	0.817CysLeu: 0.817 ± 0.022	0.151CysMet: 0.151 ± 0.011	0.197CysAsn: 0.197 ± 0.011	0.476CysPro: 0.476 ± 0.021	0.217CysGln: 0.217 ± 0.012	0.58CysArg: 0.58 ± 0.023	0.395CysSer: 0.395 ± 0.017	0.407CysThr: 0.407 ± 0.02	0.526CysVal: 0.526 ± 0.022	0.124CysTrp: 0.124 ± 0.01	0.19CysTyr: 0.19 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.055AspAla: 7.055 ± 0.083	0.531AspCys: 0.531 ± 0.021	3.247AspAsp: 3.247 ± 0.069	3.543AspGlu: 3.543 ± 0.058	2.301AspPhe: 2.301 ± 0.041	5.538AspGly: 5.538 ± 0.08	1.489AspHis: 1.489 ± 0.035	2.544AspIle: 2.544 ± 0.054	1.438AspLys: 1.438 ± 0.034	6.874AspLeu: 6.874 ± 0.071	1.417AspMet: 1.417 ± 0.029	1.168AspAsn: 1.168 ± 0.031	4.08AspPro: 4.08 ± 0.062	2.217AspGln: 2.217 ± 0.042	4.883AspArg: 4.883 ± 0.069	2.427AspSer: 2.427 ± 0.046	2.384AspThr: 2.384 ± 0.052	3.535AspVal: 3.535 ± 0.051	1.372AspTrp: 1.372 ± 0.032	1.671AspTyr: 1.671 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	8.646GluAla: 8.646 ± 0.107	0.307GluCys: 0.307 ± 0.015	3.112GluAsp: 3.112 ± 0.05	2.967GluGlu: 2.967 ± 0.05	1.794GluPhe: 1.794 ± 0.041	5.093GluGly: 5.093 ± 0.065	1.028GluHis: 1.028 ± 0.03	3.497GluIle: 3.497 ± 0.063	1.846GluLys: 1.846 ± 0.039	5.063GluLeu: 5.063 ± 0.071	1.73GluMet: 1.73 ± 0.036	1.607GluAsn: 1.607 ± 0.036	2.671GluPro: 2.671 ± 0.057	1.902GluGln: 1.902 ± 0.039	4.192GluArg: 4.192 ± 0.067	2.159GluSer: 2.159 ± 0.034	3.696GluThr: 3.696 ± 0.058	4.162GluVal: 4.162 ± 0.059	0.711GluTrp: 0.711 ± 0.023	0.963GluTyr: 0.963 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.476PheAla: 4.476 ± 0.069	0.379PheCys: 0.379 ± 0.018	2.724PheAsp: 2.724 ± 0.047	1.832PheGlu: 1.832 ± 0.039	1.268PhePhe: 1.268 ± 0.038	3.597PheGly: 3.597 ± 0.048	0.754PheHis: 0.754 ± 0.025	1.683PheIle: 1.683 ± 0.038	0.757PheLys: 0.757 ± 0.025	3.44PheLeu: 3.44 ± 0.067	0.782PheMet: 0.782 ± 0.029	0.922PheAsn: 0.922 ± 0.03	1.633PhePro: 1.633 ± 0.038	1.038PheGln: 1.038 ± 0.024	2.244PheArg: 2.244 ± 0.043	1.965PheSer: 1.965 ± 0.039	1.986PheThr: 1.986 ± 0.035	2.443PheVal: 2.443 ± 0.046	0.599PheTrp: 0.599 ± 0.023	0.869PheTyr: 0.869 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.245GlyAla: 10.245 ± 0.101	0.798GlyCys: 0.798 ± 0.029	5.115GlyAsp: 5.115 ± 0.073	5.03GlyGlu: 5.03 ± 0.071	3.826GlyPhe: 3.826 ± 0.056	8.069GlyGly: 8.069 ± 0.132	1.939GlyHis: 1.939 ± 0.039	4.672GlyIle: 4.672 ± 0.065	3.019GlyLys: 3.019 ± 0.055	9.829GlyLeu: 9.829 ± 0.102	2.778GlyMet: 2.778 ± 0.047	2.25GlyAsn: 2.25 ± 0.064	3.981GlyPro: 3.981 ± 0.064	3.516GlyGln: 3.516 ± 0.054	6.414GlyArg: 6.414 ± 0.076	4.464GlySer: 4.464 ± 0.064	4.545GlyThr: 4.545 ± 0.073	6.111GlyVal: 6.111 ± 0.061	1.721GlyTrp: 1.721 ± 0.039	2.19GlyTyr: 2.19 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.288HisAla: 2.288 ± 0.047	0.201HisCys: 0.201 ± 0.013	1.303HisAsp: 1.303 ± 0.032	1.043HisGlu: 1.043 ± 0.032	0.769HisPhe: 0.769 ± 0.025	1.952HisGly: 1.952 ± 0.041	0.577HisHis: 0.577 ± 0.027	0.889HisIle: 0.889 ± 0.029	0.406HisLys: 0.406 ± 0.018	2.227HisLeu: 2.227 ± 0.043	0.501HisMet: 0.501 ± 0.019	0.396HisAsn: 0.396 ± 0.017	1.466HisPro: 1.466 ± 0.035	0.641HisGln: 0.641 ± 0.021	1.512HisArg: 1.512 ± 0.035	0.921HisSer: 0.921 ± 0.03	0.649HisThr: 0.649 ± 0.024	1.428HisVal: 1.428 ± 0.034	0.339HisTrp: 0.339 ± 0.017	0.535HisTyr: 0.535 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	7.51IleAla: 7.51 ± 0.079	0.553IleCys: 0.553 ± 0.023	3.495IleAsp: 3.495 ± 0.049	3.414IleGlu: 3.414 ± 0.053	1.775IlePhe: 1.775 ± 0.046	5.121IleGly: 5.121 ± 0.075	0.948IleHis: 0.948 ± 0.026	2.34IleIle: 2.34 ± 0.049	1.11IleLys: 1.11 ± 0.033	4.911IleLeu: 4.911 ± 0.075	1.073IleMet: 1.073 ± 0.029	1.251IleAsn: 1.251 ± 0.036	2.411IlePro: 2.411 ± 0.044	1.148IleGln: 1.148 ± 0.029	3.573IleArg: 3.573 ± 0.051	2.869IleSer: 2.869 ± 0.05	2.885IleThr: 2.885 ± 0.059	3.535IleVal: 3.535 ± 0.059	0.821IleTrp: 0.821 ± 0.029	1.124IleTyr: 1.124 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.519LysAla: 3.519 ± 0.064	0.144LysCys: 0.144 ± 0.011	1.497LysAsp: 1.497 ± 0.039	1.134LysGlu: 1.134 ± 0.035	0.784LysPhe: 0.784 ± 0.029	2.546LysGly: 2.546 ± 0.05	0.535LysHis: 0.535 ± 0.022	1.477LysIle: 1.477 ± 0.037	0.908LysLys: 0.908 ± 0.038	2.763LysLeu: 2.763 ± 0.05	0.717LysMet: 0.717 ± 0.029	0.669LysAsn: 0.669 ± 0.025	1.688LysPro: 1.688 ± 0.044	0.805LysGln: 0.805 ± 0.026	1.839LysArg: 1.839 ± 0.04	1.469LysSer: 1.469 ± 0.036	1.594LysThr: 1.594 ± 0.033	1.994LysVal: 1.994 ± 0.045	0.341LysTrp: 0.341 ± 0.017	0.515LysTyr: 0.515 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.538LeuAla: 14.538 ± 0.121	0.861LeuCys: 0.861 ± 0.029	5.987LeuAsp: 5.987 ± 0.078	4.704LeuGlu: 4.704 ± 0.059	3.402LeuPhe: 3.402 ± 0.068	8.604LeuGly: 8.604 ± 0.092	1.821LeuHis: 1.821 ± 0.035	5.701LeuIle: 5.701 ± 0.084	2.847LeuLys: 2.847 ± 0.058	9.299LeuLeu: 9.299 ± 0.112	2.86LeuMet: 2.86 ± 0.047	2.724LeuAsn: 2.724 ± 0.05	6.264LeuPro: 6.264 ± 0.083	2.945LeuGln: 2.945 ± 0.053	7.549LeuArg: 7.549 ± 0.091	6.391LeuSer: 6.391 ± 0.082	6.53LeuThr: 6.53 ± 0.082	6.952LeuVal: 6.952 ± 0.078	1.43LeuTrp: 1.43 ± 0.038	1.924LeuTyr: 1.924 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	3.718MetAla: 3.718 ± 0.057	0.171MetCys: 0.171 ± 0.012	1.384MetAsp: 1.384 ± 0.035	1.19MetGlu: 1.19 ± 0.033	0.786MetPhe: 0.786 ± 0.028	2.244MetGly: 2.244 ± 0.04	0.378MetHis: 0.378 ± 0.017	1.635MetIle: 1.635 ± 0.031	0.879MetLys: 0.879 ± 0.028	2.713MetLeu: 2.713 ± 0.044	0.768MetMet: 0.768 ± 0.024	0.842MetAsn: 0.842 ± 0.027	1.562MetPro: 1.562 ± 0.034	0.967MetGln: 0.967 ± 0.025	1.959MetArg: 1.959 ± 0.043	1.679MetSer: 1.679 ± 0.035	2.085MetThr: 2.085 ± 0.039	1.851MetVal: 1.851 ± 0.041	0.26MetTrp: 0.26 ± 0.013	0.301MetTyr: 0.301 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.972AsnAla: 2.972 ± 0.052	0.236AsnCys: 0.236 ± 0.014	1.432AsnAsp: 1.432 ± 0.05	1.109AsnGlu: 1.109 ± 0.03	0.887AsnPhe: 0.887 ± 0.026	2.288AsnGly: 2.288 ± 0.052	0.513AsnHis: 0.513 ± 0.019	1.263AsnIle: 1.263 ± 0.033	0.529AsnLys: 0.529 ± 0.024	2.487AsnLeu: 2.487 ± 0.047	0.675AsnMet: 0.675 ± 0.023	0.65AsnAsn: 0.65 ± 0.026	1.884AsnPro: 1.884 ± 0.039	0.747AsnGln: 0.747 ± 0.032	1.832AsnArg: 1.832 ± 0.041	1.132AsnSer: 1.132 ± 0.036	1.12AsnThr: 1.12 ± 0.041	1.604AsnVal: 1.604 ± 0.04	0.457AsnTrp: 0.457 ± 0.018	0.586AsnTyr: 0.586 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	7.014ProAla: 7.014 ± 0.091	0.324ProCys: 0.324 ± 0.017	4.042ProAsp: 4.042 ± 0.06	4.448ProGlu: 4.448 ± 0.063	1.926ProPhe: 1.926 ± 0.034	5.238ProGly: 5.238 ± 0.072	1.041ProHis: 1.041 ± 0.029	2.291ProIle: 2.291 ± 0.04	1.4ProLys: 1.4 ± 0.035	4.97ProLeu: 4.97 ± 0.06	1.359ProMet: 1.359 ± 0.033	1.275ProAsn: 1.275 ± 0.037	2.591ProPro: 2.591 ± 0.052	1.701ProGln: 1.701 ± 0.037	3.254ProArg: 3.254 ± 0.058	2.428ProSer: 2.428 ± 0.045	2.337ProThr: 2.337 ± 0.046	4.632ProVal: 4.632 ± 0.059	0.711ProTrp: 0.711 ± 0.023	1.081ProTyr: 1.081 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.194GlnAla: 4.194 ± 0.056	0.184GlnCys: 0.184 ± 0.01	1.649GlnAsp: 1.649 ± 0.035	1.398GlnGlu: 1.398 ± 0.036	1.086GlnPhe: 1.086 ± 0.032	2.927GlnGly: 2.927 ± 0.047	0.638GlnHis: 0.638 ± 0.024	2.137GlnIle: 2.137 ± 0.046	1.049GlnLys: 1.049 ± 0.035	3.049GlnLeu: 3.049 ± 0.045	1.084GlnMet: 1.084 ± 0.031	0.876GlnAsn: 0.876 ± 0.024	2.004GlnPro: 2.004 ± 0.039	1.177GlnGln: 1.177 ± 0.036	2.316GlnArg: 2.316 ± 0.047	1.742GlnSer: 1.742 ± 0.04	1.723GlnThr: 1.723 ± 0.036	2.479GlnVal: 2.479 ± 0.042	0.389GlnTrp: 0.389 ± 0.014	0.568GlnTyr: 0.568 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.76ArgAla: 8.76 ± 0.09	0.48ArgCys: 0.48 ± 0.021	4.578ArgAsp: 4.578 ± 0.055	4.018ArgGlu: 4.018 ± 0.062	2.787ArgPhe: 2.787 ± 0.05	5.055ArgGly: 5.055 ± 0.064	1.675ArgHis: 1.675 ± 0.041	4.085ArgIle: 4.085 ± 0.057	2.07ArgLys: 2.07 ± 0.046	8.224ArgLeu: 8.224 ± 0.104	2.083ArgMet: 2.083 ± 0.041	1.75ArgAsn: 1.75 ± 0.038	3.783ArgPro: 3.783 ± 0.059	2.696ArgGln: 2.696 ± 0.051	5.645ArgArg: 5.645 ± 0.086	3.403ArgSer: 3.403 ± 0.05	2.807ArgThr: 2.807 ± 0.048	4.787ArgVal: 4.787 ± 0.063	1.018ArgTrp: 1.018 ± 0.031	1.552ArgTyr: 1.552 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.027SerAla: 6.027 ± 0.062	0.395SerCys: 0.395 ± 0.018	3.125SerAsp: 3.125 ± 0.048	2.602SerGlu: 2.602 ± 0.046	2.132SerPhe: 2.132 ± 0.041	5.499SerGly: 5.499 ± 0.069	1.072SerHis: 1.072 ± 0.026	2.427SerIle: 2.427 ± 0.041	1.204SerLys: 1.204 ± 0.03	4.987SerLeu: 4.987 ± 0.078	1.256SerMet: 1.256 ± 0.031	1.176SerAsn: 1.176 ± 0.033	2.61SerPro: 2.61 ± 0.045	1.592SerGln: 1.592 ± 0.034	3.38SerArg: 3.38 ± 0.056	2.414SerSer: 2.414 ± 0.058	2.449SerThr: 2.449 ± 0.046	3.548SerVal: 3.548 ± 0.059	0.765SerTrp: 0.765 ± 0.024	1.233SerTyr: 1.233 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.396ThrAla: 6.396 ± 0.072	0.469ThrCys: 0.469 ± 0.018	3.17ThrAsp: 3.17 ± 0.044	3.041ThrGlu: 3.041 ± 0.05	1.653ThrPhe: 1.653 ± 0.043	5.618ThrGly: 5.618 ± 0.086	1.017ThrHis: 1.017 ± 0.029	2.709ThrIle: 2.709 ± 0.051	1.188ThrLys: 1.188 ± 0.034	5.63ThrLeu: 5.63 ± 0.074	1.182ThrMet: 1.182 ± 0.031	1.183ThrAsn: 1.183 ± 0.037	3.39ThrPro: 3.39 ± 0.054	1.398ThrGln: 1.398 ± 0.041	3.636ThrArg: 3.636 ± 0.054	2.419ThrSer: 2.419 ± 0.048	2.679ThrThr: 2.679 ± 0.049	4.132ThrVal: 4.132 ± 0.077	0.61ThrTrp: 0.61 ± 0.024	1.057ThrTyr: 1.057 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.777ValAla: 8.777 ± 0.084	0.529ValCys: 0.529 ± 0.021	3.743ValAsp: 3.743 ± 0.059	4.326ValGlu: 4.326 ± 0.06	2.549ValPhe: 2.549 ± 0.044	5.083ValGly: 5.083 ± 0.073	1.209ValHis: 1.209 ± 0.032	4.269ValIle: 4.269 ± 0.062	1.871ValLys: 1.871 ± 0.042	7.532ValLeu: 7.532 ± 0.076	2.134ValMet: 2.134 ± 0.048	1.865ValAsn: 1.865 ± 0.038	3.548ValPro: 3.548 ± 0.054	2.126ValGln: 2.126 ± 0.038	4.042ValArg: 4.042 ± 0.064	3.896ValSer: 3.896 ± 0.054	4.71ValThr: 4.71 ± 0.082	5.164ValVal: 5.164 ± 0.073	1.023ValTrp: 1.023 ± 0.027	1.303ValTyr: 1.303 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.42TrpAla: 1.42 ± 0.033	0.122TrpCys: 0.122 ± 0.009	0.745TrpAsp: 0.745 ± 0.025	0.575TrpGlu: 0.575 ± 0.021	0.568TrpPhe: 0.568 ± 0.02	1.123TrpGly: 1.123 ± 0.032	0.343TrpHis: 0.343 ± 0.015	0.743TrpIle: 0.743 ± 0.025	0.423TrpLys: 0.423 ± 0.016	1.908TrpLeu: 1.908 ± 0.044	0.424TrpMet: 0.424 ± 0.022	0.433TrpAsn: 0.433 ± 0.017	0.76TrpPro: 0.76 ± 0.026	0.766TrpGln: 0.766 ± 0.024	1.262TrpArg: 1.262 ± 0.034	0.883TrpSer: 0.883 ± 0.026	0.817TrpThr: 0.817 ± 0.026	0.909TrpVal: 0.909 ± 0.028	0.258TrpTrp: 0.258 ± 0.016	0.296TrpTyr: 0.296 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.454TyrAla: 2.454 ± 0.049	0.216TyrCys: 0.216 ± 0.012	1.54TyrAsp: 1.54 ± 0.037	1.128TyrGlu: 1.128 ± 0.031	0.823TyrPhe: 0.823 ± 0.025	2.034TyrGly: 2.034 ± 0.044	0.483TyrHis: 0.483 ± 0.021	0.794TyrIle: 0.794 ± 0.024	0.473TyrLys: 0.473 ± 0.02	2.273TyrLeu: 2.273 ± 0.043	0.413TyrMet: 0.413 ± 0.018	0.544TyrAsn: 0.544 ± 0.022	1.057TyrPro: 1.057 ± 0.027	0.703TyrGln: 0.703 ± 0.021	1.644TyrArg: 1.644 ± 0.041	1.012TyrSer: 1.012 ± 0.032	0.979TyrThr: 0.979 ± 0.028	1.423TyrVal: 1.423 ± 0.032	0.341TyrTrp: 0.341 ± 0.016	0.545TyrTyr: 0.545 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4274 proteins (1366512 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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