Amino acid dipepetide frequency for Bifidobacterium aemilianum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.993AlaAla: 11.993 ± 0.224
1.084AlaCys: 1.084 ± 0.055
7.034AlaAsp: 7.034 ± 0.134
4.992AlaGlu: 4.992 ± 0.096
3.336AlaPhe: 3.336 ± 0.083
9.605AlaGly: 9.605 ± 0.162
1.933AlaHis: 1.933 ± 0.064
5.27AlaIle: 5.27 ± 0.111
4.656AlaLys: 4.656 ± 0.106
10.348AlaLeu: 10.348 ± 0.164
3.042AlaMet: 3.042 ± 0.077
2.819AlaAsn: 2.819 ± 0.077
4.185AlaPro: 4.185 ± 0.129
5.577AlaGln: 5.577 ± 0.132
5.769AlaArg: 5.769 ± 0.126
7.163AlaSer: 7.163 ± 0.128
4.828AlaThr: 4.828 ± 0.109
7.339AlaVal: 7.339 ± 0.147
1.337AlaTrp: 1.337 ± 0.047
2.521AlaTyr: 2.521 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.899CysAla: 0.899 ± 0.043
0.125CysCys: 0.125 ± 0.015
0.447CysAsp: 0.447 ± 0.032
0.405CysGlu: 0.405 ± 0.026
0.339CysPhe: 0.339 ± 0.024
0.928CysGly: 0.928 ± 0.046
0.182CysHis: 0.182 ± 0.018
0.418CysIle: 0.418 ± 0.026
0.277CysLys: 0.277 ± 0.025
1.071CysLeu: 1.071 ± 0.052
0.24CysMet: 0.24 ± 0.023
0.183CysAsn: 0.183 ± 0.02
0.502CysPro: 0.502 ± 0.035
0.385CysGln: 0.385 ± 0.03
0.548CysArg: 0.548 ± 0.037
0.594CysSer: 0.594 ± 0.037
0.491CysThr: 0.491 ± 0.026
0.559CysVal: 0.559 ± 0.031
0.127CysTrp: 0.127 ± 0.015
0.209CysTyr: 0.209 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
5.597AspAla: 5.597 ± 0.111
0.526AspCys: 0.526 ± 0.03
3.856AspAsp: 3.856 ± 0.112
3.767AspGlu: 3.767 ± 0.092
2.338AspPhe: 2.338 ± 0.066
5.369AspGly: 5.369 ± 0.109
1.436AspHis: 1.436 ± 0.049
2.934AspIle: 2.934 ± 0.076
2.479AspLys: 2.479 ± 0.07
6.638AspLeu: 6.638 ± 0.112
1.687AspMet: 1.687 ± 0.062
1.451AspAsn: 1.451 ± 0.05
3.979AspPro: 3.979 ± 0.096
3.756AspGln: 3.756 ± 0.099
3.908AspArg: 3.908 ± 0.109
3.878AspSer: 3.878 ± 0.096
2.918AspThr: 2.918 ± 0.092
3.781AspVal: 3.781 ± 0.098
0.992AspTrp: 0.992 ± 0.046
1.823AspTyr: 1.823 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
6.244GluAla: 6.244 ± 0.109
0.369GluCys: 0.369 ± 0.028
3.378GluAsp: 3.378 ± 0.093
3.702GluGlu: 3.702 ± 0.109
1.57GluPhe: 1.57 ± 0.05
4.416GluGly: 4.416 ± 0.096
1.449GluHis: 1.449 ± 0.052
2.457GluIle: 2.457 ± 0.08
1.647GluLys: 1.647 ± 0.068
5.184GluLeu: 5.184 ± 0.119
1.234GluMet: 1.234 ± 0.051
1.496GluAsn: 1.496 ± 0.057
2.454GluPro: 2.454 ± 0.082
2.609GluGln: 2.609 ± 0.069
3.613GluArg: 3.613 ± 0.108
3.493GluSer: 3.493 ± 0.083
2.811GluThr: 2.811 ± 0.076
3.425GluVal: 3.425 ± 0.083
0.559GluTrp: 0.559 ± 0.033
1.396GluTyr: 1.396 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.387PheAla: 3.387 ± 0.078
0.35PheCys: 0.35 ± 0.023
2.384PheAsp: 2.384 ± 0.067
1.581PheGlu: 1.581 ± 0.057
1.216PhePhe: 1.216 ± 0.058
3.015PheGly: 3.015 ± 0.08
0.656PheHis: 0.656 ± 0.036
1.693PheIle: 1.693 ± 0.071
1.192PheLys: 1.192 ± 0.046
2.976PheLeu: 2.976 ± 0.091
0.811PheMet: 0.811 ± 0.042
1.214PheAsn: 1.214 ± 0.047
1.298PhePro: 1.298 ± 0.047
1.027PheGln: 1.027 ± 0.041
1.484PheArg: 1.484 ± 0.054
2.369PheSer: 2.369 ± 0.07
2.024PheThr: 2.024 ± 0.065
2.285PheVal: 2.285 ± 0.075
0.411PheTrp: 0.411 ± 0.031
0.836PheTyr: 0.836 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
7.275GlyAla: 7.275 ± 0.139
0.785GlyCys: 0.785 ± 0.041
4.502GlyAsp: 4.502 ± 0.092
4.053GlyGlu: 4.053 ± 0.096
3.007GlyPhe: 3.007 ± 0.071
6.534GlyGly: 6.534 ± 0.141
2.136GlyHis: 2.136 ± 0.069
4.652GlyIle: 4.652 ± 0.121
4.524GlyLys: 4.524 ± 0.103
8.703GlyLeu: 8.703 ± 0.142
2.208GlyMet: 2.208 ± 0.067
2.597GlyAsn: 2.597 ± 0.081
3.629GlyPro: 3.629 ± 0.085
4.852GlyGln: 4.852 ± 0.102
5.487GlyArg: 5.487 ± 0.132
6.688GlySer: 6.688 ± 0.13
4.612GlyThr: 4.612 ± 0.134
5.41GlyVal: 5.41 ± 0.101
1.318GlyTrp: 1.318 ± 0.066
2.549GlyTyr: 2.549 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
1.759HisAla: 1.759 ± 0.054
0.207HisCys: 0.207 ± 0.019
1.307HisAsp: 1.307 ± 0.054
1.21HisGlu: 1.21 ± 0.055
0.66HisPhe: 0.66 ± 0.033
1.927HisGly: 1.927 ± 0.065
0.521HisHis: 0.521 ± 0.034
1.111HisIle: 1.111 ± 0.049
0.713HisLys: 0.713 ± 0.035
1.878HisLeu: 1.878 ± 0.06
0.616HisMet: 0.616 ± 0.032
0.642HisAsn: 0.642 ± 0.033
1.293HisPro: 1.293 ± 0.055
0.933HisGln: 0.933 ± 0.044
1.366HisArg: 1.366 ± 0.047
1.263HisSer: 1.263 ± 0.053
1.126HisThr: 1.126 ± 0.045
1.513HisVal: 1.513 ± 0.046
0.334HisTrp: 0.334 ± 0.027
0.651HisTyr: 0.651 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.298IleAla: 5.298 ± 0.113
0.64IleCys: 0.64 ± 0.035
3.66IleAsp: 3.66 ± 0.079
2.996IleGlu: 2.996 ± 0.077
1.755IlePhe: 1.755 ± 0.06
4.493IleGly: 4.493 ± 0.106
1.076IleHis: 1.076 ± 0.048
2.76IleIle: 2.76 ± 0.074
2.001IleLys: 2.001 ± 0.067
4.33IleLeu: 4.33 ± 0.095
1.199IleMet: 1.199 ± 0.052
1.729IleAsn: 1.729 ± 0.057
2.666IlePro: 2.666 ± 0.071
1.584IleGln: 1.584 ± 0.052
2.82IleArg: 2.82 ± 0.076
3.922IleSer: 3.922 ± 0.092
2.705IleThr: 2.705 ± 0.084
3.921IleVal: 3.921 ± 0.094
0.66IleTrp: 0.66 ± 0.039
1.207IleTyr: 1.207 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
5.21LysAla: 5.21 ± 0.093
0.15LysCys: 0.15 ± 0.02
2.866LysAsp: 2.866 ± 0.095
2.391LysGlu: 2.391 ± 0.07
0.853LysPhe: 0.853 ± 0.04
3.209LysGly: 3.209 ± 0.069
0.759LysHis: 0.759 ± 0.04
1.768LysIle: 1.768 ± 0.065
1.493LysLys: 1.493 ± 0.063
3.418LysLeu: 3.418 ± 0.09
0.831LysMet: 0.831 ± 0.038
1.172LysAsn: 1.172 ± 0.06
2.373LysPro: 2.373 ± 0.081
1.542LysGln: 1.542 ± 0.056
2.228LysArg: 2.228 ± 0.062
2.483LysSer: 2.483 ± 0.072
2.604LysThr: 2.604 ± 0.08
3.05LysVal: 3.05 ± 0.085
0.458LysTrp: 0.458 ± 0.032
0.86LysTyr: 0.86 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
11.426LeuAla: 11.426 ± 0.191
0.996LeuCys: 0.996 ± 0.037
6.312LeuAsp: 6.312 ± 0.131
4.891LeuGlu: 4.891 ± 0.119
2.901LeuPhe: 2.901 ± 0.089
8.213LeuGly: 8.213 ± 0.139
1.742LeuHis: 1.742 ± 0.054
4.885LeuIle: 4.885 ± 0.109
3.558LeuLys: 3.558 ± 0.087
9.728LeuLeu: 9.728 ± 0.19
2.309LeuMet: 2.309 ± 0.081
2.817LeuAsn: 2.817 ± 0.079
5.116LeuPro: 5.116 ± 0.107
2.962LeuGln: 2.962 ± 0.082
5.037LeuArg: 5.037 ± 0.121
6.246LeuSer: 6.246 ± 0.119
6.424LeuThr: 6.424 ± 0.122
7.959LeuVal: 7.959 ± 0.156
1.058LeuTrp: 1.058 ± 0.045
2.133LeuTyr: 2.133 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
3.15MetAla: 3.15 ± 0.076
0.185MetCys: 0.185 ± 0.019
1.672MetAsp: 1.672 ± 0.051
1.298MetGlu: 1.298 ± 0.052
0.618MetPhe: 0.618 ± 0.033
2.065MetGly: 2.065 ± 0.065
0.477MetHis: 0.477 ± 0.028
1.186MetIle: 1.186 ± 0.051
0.9MetLys: 0.9 ± 0.042
2.305MetLeu: 2.305 ± 0.066
0.581MetMet: 0.581 ± 0.031
0.866MetAsn: 0.866 ± 0.04
1.469MetPro: 1.469 ± 0.052
0.801MetGln: 0.801 ± 0.043
1.502MetArg: 1.502 ± 0.058
1.771MetSer: 1.771 ± 0.056
1.854MetThr: 1.854 ± 0.059
2.169MetVal: 2.169 ± 0.068
0.242MetTrp: 0.242 ± 0.021
0.444MetTyr: 0.444 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
2.716AsnAla: 2.716 ± 0.06
0.249AsnCys: 0.249 ± 0.022
1.619AsnAsp: 1.619 ± 0.059
1.366AsnGlu: 1.366 ± 0.056
0.847AsnPhe: 0.847 ± 0.043
2.54AsnGly: 2.54 ± 0.075
0.693AsnHis: 0.693 ± 0.041
1.557AsnIle: 1.557 ± 0.056
1.196AsnLys: 1.196 ± 0.046
2.822AsnLeu: 2.822 ± 0.081
0.823AsnMet: 0.823 ± 0.039
0.9AsnAsn: 0.9 ± 0.059
2.342AsnPro: 2.342 ± 0.071
1.353AsnGln: 1.353 ± 0.063
1.806AsnArg: 1.806 ± 0.061
1.722AsnSer: 1.722 ± 0.069
1.696AsnThr: 1.696 ± 0.077
1.795AsnVal: 1.795 ± 0.063
0.444AsnTrp: 0.444 ± 0.031
0.818AsnTyr: 0.818 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
5.532ProAla: 5.532 ± 0.112
0.328ProCys: 0.328 ± 0.025
3.629ProAsp: 3.629 ± 0.088
3.097ProGlu: 3.097 ± 0.079
1.5ProPhe: 1.5 ± 0.054
4.236ProGly: 4.236 ± 0.11
0.961ProHis: 0.961 ± 0.043
2.433ProIle: 2.433 ± 0.069
1.984ProLys: 1.984 ± 0.061
4.251ProLeu: 4.251 ± 0.102
1.13ProMet: 1.13 ± 0.046
1.474ProAsn: 1.474 ± 0.05
1.465ProPro: 1.465 ± 0.065
2.483ProGln: 2.483 ± 0.073
2.254ProArg: 2.254 ± 0.069
3.611ProSer: 3.611 ± 0.089
2.923ProThr: 2.923 ± 0.087
4.032ProVal: 4.032 ± 0.08
0.708ProTrp: 0.708 ± 0.036
1.377ProTyr: 1.377 ± 0.059
0.0ProXaa: 0.0 ± 0.0
Gln
6.499GlnAla: 6.499 ± 0.134
0.249GlnCys: 0.249 ± 0.023
2.336GlnAsp: 2.336 ± 0.056
3.002GlnGlu: 3.002 ± 0.085
1.021GlnPhe: 1.021 ± 0.043
4.203GlnGly: 4.203 ± 0.093
0.812GlnHis: 0.812 ± 0.044
2.155GlnIle: 2.155 ± 0.064
1.232GlnLys: 1.232 ± 0.052
3.983GlnLeu: 3.983 ± 0.088
1.078GlnMet: 1.078 ± 0.045
0.946GlnAsn: 0.946 ± 0.048
2.221GlnPro: 2.221 ± 0.072
2.127GlnGln: 2.127 ± 0.08
2.415GlnArg: 2.415 ± 0.08
2.808GlnSer: 2.808 ± 0.069
2.551GlnThr: 2.551 ± 0.079
3.734GlnVal: 3.734 ± 0.089
0.609GlnTrp: 0.609 ± 0.025
1.051GlnTyr: 1.051 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
4.79ArgAla: 4.79 ± 0.107
0.44ArgCys: 0.44 ± 0.032
3.182ArgAsp: 3.182 ± 0.083
3.235ArgGlu: 3.235 ± 0.101
2.081ArgPhe: 2.081 ± 0.06
3.873ArgGly: 3.873 ± 0.093
1.441ArgHis: 1.441 ± 0.057
3.462ArgIle: 3.462 ± 0.085
2.576ArgLys: 2.576 ± 0.085
5.837ArgLeu: 5.837 ± 0.127
1.583ArgMet: 1.583 ± 0.051
1.627ArgAsn: 1.627 ± 0.051
2.837ArgPro: 2.837 ± 0.081
3.339ArgGln: 3.339 ± 0.099
4.179ArgArg: 4.179 ± 0.138
3.712ArgSer: 3.712 ± 0.102
3.167ArgThr: 3.167 ± 0.084
4.031ArgVal: 4.031 ± 0.104
0.822ArgTrp: 0.822 ± 0.038
1.671ArgTyr: 1.671 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
6.448SerAla: 6.448 ± 0.117
0.557SerCys: 0.557 ± 0.035
4.054SerAsp: 4.054 ± 0.094
2.877SerGlu: 2.877 ± 0.075
2.516SerPhe: 2.516 ± 0.073
6.341SerGly: 6.341 ± 0.126
1.456SerHis: 1.456 ± 0.054
3.569SerIle: 3.569 ± 0.099
2.976SerLys: 2.976 ± 0.077
6.99SerLeu: 6.99 ± 0.138
1.883SerMet: 1.883 ± 0.056
2.054SerAsn: 2.054 ± 0.078
3.178SerPro: 3.178 ± 0.078
3.383SerGln: 3.383 ± 0.088
3.95SerArg: 3.95 ± 0.092
5.014SerSer: 5.014 ± 0.123
3.677SerThr: 3.677 ± 0.073
4.374SerVal: 4.374 ± 0.102
1.124SerTrp: 1.124 ± 0.042
1.92SerTyr: 1.92 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
5.641ThrAla: 5.641 ± 0.118
0.458ThrCys: 0.458 ± 0.024
3.554ThrAsp: 3.554 ± 0.084
2.463ThrGlu: 2.463 ± 0.067
1.674ThrPhe: 1.674 ± 0.056
5.399ThrGly: 5.399 ± 0.117
1.153ThrHis: 1.153 ± 0.045
3.293ThrIle: 3.293 ± 0.09
2.023ThrLys: 2.023 ± 0.077
5.426ThrLeu: 5.426 ± 0.119
1.506ThrMet: 1.506 ± 0.056
1.748ThrAsn: 1.748 ± 0.062
3.211ThrPro: 3.211 ± 0.093
2.057ThrGln: 2.057 ± 0.07
2.822ThrArg: 2.822 ± 0.075
3.702ThrSer: 3.702 ± 0.095
3.136ThrThr: 3.136 ± 0.104
4.533ThrVal: 4.533 ± 0.102
0.796ThrTrp: 0.796 ± 0.043
1.473ThrTyr: 1.473 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
7.311ValAla: 7.311 ± 0.115
0.825ValCys: 0.825 ± 0.046
4.96ValAsp: 4.96 ± 0.11
4.009ValGlu: 4.009 ± 0.099
2.622ValPhe: 2.622 ± 0.079
5.564ValGly: 5.564 ± 0.118
1.372ValHis: 1.372 ± 0.046
4.036ValIle: 4.036 ± 0.096
2.841ValLys: 2.841 ± 0.086
6.891ValLeu: 6.891 ± 0.141
1.786ValMet: 1.786 ± 0.055
2.298ValAsn: 2.298 ± 0.071
3.422ValPro: 3.422 ± 0.088
2.263ValGln: 2.263 ± 0.063
3.959ValArg: 3.959 ± 0.086
5.437ValSer: 5.437 ± 0.101
4.242ValThr: 4.242 ± 0.09
5.663ValVal: 5.663 ± 0.12
0.93ValTrp: 0.93 ± 0.043
1.656ValTyr: 1.656 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
1.164TrpAla: 1.164 ± 0.048
0.123TrpCys: 0.123 ± 0.015
0.723TrpAsp: 0.723 ± 0.042
0.638TrpGlu: 0.638 ± 0.03
0.501TrpPhe: 0.501 ± 0.037
0.961TrpGly: 0.961 ± 0.044
0.297TrpHis: 0.297 ± 0.022
0.669TrpIle: 0.669 ± 0.032
0.535TrpLys: 0.535 ± 0.035
1.524TrpLeu: 1.524 ± 0.061
0.378TrpMet: 0.378 ± 0.025
0.51TrpAsn: 0.51 ± 0.032
0.618TrpPro: 0.618 ± 0.033
0.721TrpGln: 0.721 ± 0.037
0.919TrpArg: 0.919 ± 0.04
0.895TrpSer: 0.895 ± 0.047
0.884TrpThr: 0.884 ± 0.052
0.893TrpVal: 0.893 ± 0.04
0.264TrpTrp: 0.264 ± 0.024
0.407TrpTyr: 0.407 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.492TyrAla: 2.492 ± 0.072
0.282TyrCys: 0.282 ± 0.021
1.636TyrAsp: 1.636 ± 0.051
1.533TyrGlu: 1.533 ± 0.056
0.853TyrPhe: 0.853 ± 0.042
2.63TyrGly: 2.63 ± 0.081
0.479TyrHis: 0.479 ± 0.03
1.113TyrIle: 1.113 ± 0.049
0.915TyrLys: 0.915 ± 0.044
2.408TyrLeu: 2.408 ± 0.07
0.631TyrMet: 0.631 ± 0.038
0.765TyrAsn: 0.765 ± 0.039
1.152TyrPro: 1.152 ± 0.047
1.278TyrGln: 1.278 ± 0.059
1.817TyrArg: 1.817 ± 0.067
1.57TyrSer: 1.57 ± 0.059
1.396TyrThr: 1.396 ± 0.065
1.621TyrVal: 1.621 ± 0.059
0.431TyrTrp: 0.431 ± 0.028
0.706TyrTyr: 0.706 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1589 proteins (545325 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski