Amino acid dipepetide frequency for Paracoccus aestuarii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.787AlaAla: 19.787 ± 0.21	1.101AlaCys: 1.101 ± 0.033	8.103AlaAsp: 8.103 ± 0.105	8.333AlaGlu: 8.333 ± 0.113	4.145AlaPhe: 4.145 ± 0.067	12.112AlaGly: 12.112 ± 0.134	2.551AlaHis: 2.551 ± 0.056	6.325AlaIle: 6.325 ± 0.087	2.586AlaLys: 2.586 ± 0.06	15.638AlaLeu: 15.638 ± 0.153	4.493AlaMet: 4.493 ± 0.068	2.343AlaAsn: 2.343 ± 0.043	6.884AlaPro: 6.884 ± 0.107	5.061AlaGln: 5.061 ± 0.076	11.876AlaArg: 11.876 ± 0.137	5.352AlaSer: 5.352 ± 0.074	6.176AlaThr: 6.176 ± 0.072	9.113AlaVal: 9.113 ± 0.116	1.791AlaTrp: 1.791 ± 0.046	2.218AlaTyr: 2.218 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.079CysAla: 1.079 ± 0.028	0.116CysCys: 0.116 ± 0.01	0.592CysAsp: 0.592 ± 0.024	0.332CysGlu: 0.332 ± 0.017	0.28CysPhe: 0.28 ± 0.019	0.869CysGly: 0.869 ± 0.028	0.29CysHis: 0.29 ± 0.018	0.398CysIle: 0.398 ± 0.02	0.137CysLys: 0.137 ± 0.012	0.822CysLeu: 0.822 ± 0.029	0.161CysMet: 0.161 ± 0.012	0.165CysAsn: 0.165 ± 0.013	0.557CysPro: 0.557 ± 0.023	0.213CysGln: 0.213 ± 0.012	0.651CysArg: 0.651 ± 0.028	0.377CysSer: 0.377 ± 0.021	0.397CysThr: 0.397 ± 0.021	0.479CysVal: 0.479 ± 0.024	0.126CysTrp: 0.126 ± 0.012	0.172CysTyr: 0.172 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.366AspAla: 8.366 ± 0.094	0.514AspCys: 0.514 ± 0.023	3.762AspAsp: 3.762 ± 0.067	3.123AspGlu: 3.123 ± 0.058	2.231AspPhe: 2.231 ± 0.05	5.801AspGly: 5.801 ± 0.073	1.743AspHis: 1.743 ± 0.047	2.651AspIle: 2.651 ± 0.046	1.205AspLys: 1.205 ± 0.035	7.399AspLeu: 7.399 ± 0.088	1.621AspMet: 1.621 ± 0.04	1.039AspAsn: 1.039 ± 0.036	4.49AspPro: 4.49 ± 0.07	2.406AspGln: 2.406 ± 0.054	6.259AspArg: 6.259 ± 0.083	2.114AspSer: 2.114 ± 0.045	2.307AspThr: 2.307 ± 0.046	3.569AspVal: 3.569 ± 0.06	1.424AspTrp: 1.424 ± 0.039	1.528AspTyr: 1.528 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	8.239GluAla: 8.239 ± 0.11	0.324GluCys: 0.324 ± 0.017	3.05GluAsp: 3.05 ± 0.048	2.721GluGlu: 2.721 ± 0.056	1.518GluPhe: 1.518 ± 0.034	4.893GluGly: 4.893 ± 0.077	0.91GluHis: 0.91 ± 0.029	2.922GluIle: 2.922 ± 0.063	1.284GluLys: 1.284 ± 0.036	4.353GluLeu: 4.353 ± 0.069	1.526GluMet: 1.526 ± 0.036	1.228GluAsn: 1.228 ± 0.033	2.419GluPro: 2.419 ± 0.054	1.638GluGln: 1.638 ± 0.042	4.193GluArg: 4.193 ± 0.064	1.897GluSer: 1.897 ± 0.047	2.955GluThr: 2.955 ± 0.051	3.732GluVal: 3.732 ± 0.061	0.75GluTrp: 0.75 ± 0.028	0.882GluTyr: 0.882 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.37PheAla: 4.37 ± 0.064	0.373PheCys: 0.373 ± 0.021	2.692PheAsp: 2.692 ± 0.048	1.673PheGlu: 1.673 ± 0.042	1.247PhePhe: 1.247 ± 0.042	3.425PheGly: 3.425 ± 0.061	0.696PheHis: 0.696 ± 0.026	1.528PheIle: 1.528 ± 0.039	0.615PheLys: 0.615 ± 0.026	3.277PheLeu: 3.277 ± 0.065	0.778PheMet: 0.778 ± 0.027	0.829PheAsn: 0.829 ± 0.029	1.504PhePro: 1.504 ± 0.032	1.032PheGln: 1.032 ± 0.03	2.335PheArg: 2.335 ± 0.049	1.721PheSer: 1.721 ± 0.039	1.866PheThr: 1.866 ± 0.04	2.387PheVal: 2.387 ± 0.049	0.623PheTrp: 0.623 ± 0.027	0.762PheTyr: 0.762 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.897GlyAla: 10.897 ± 0.1	0.884GlyCys: 0.884 ± 0.027	5.152GlyAsp: 5.152 ± 0.071	3.881GlyGlu: 3.881 ± 0.061	3.711GlyPhe: 3.711 ± 0.065	7.659GlyGly: 7.659 ± 0.109	2.203GlyHis: 2.203 ± 0.046	4.528GlyIle: 4.528 ± 0.06	2.209GlyLys: 2.209 ± 0.056	10.245GlyLeu: 10.245 ± 0.105	2.761GlyMet: 2.761 ± 0.054	1.831GlyAsn: 1.831 ± 0.044	4.535GlyPro: 4.535 ± 0.074	3.591GlyGln: 3.591 ± 0.065	7.636GlyArg: 7.636 ± 0.081	3.96GlySer: 3.96 ± 0.059	4.523GlyThr: 4.523 ± 0.067	6.122GlyVal: 6.122 ± 0.082	1.624GlyTrp: 1.624 ± 0.042	2.006GlyTyr: 2.006 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.677HisAla: 2.677 ± 0.051	0.228HisCys: 0.228 ± 0.014	1.543HisAsp: 1.543 ± 0.043	0.956HisGlu: 0.956 ± 0.029	0.733HisPhe: 0.733 ± 0.024	2.177HisGly: 2.177 ± 0.05	0.586HisHis: 0.586 ± 0.026	0.795HisIle: 0.795 ± 0.027	0.388HisLys: 0.388 ± 0.021	2.316HisLeu: 2.316 ± 0.05	0.537HisMet: 0.537 ± 0.024	0.398HisAsn: 0.398 ± 0.019	1.568HisPro: 1.568 ± 0.042	0.655HisGln: 0.655 ± 0.027	1.665HisArg: 1.665 ± 0.045	0.835HisSer: 0.835 ± 0.028	0.623HisThr: 0.623 ± 0.027	1.626HisVal: 1.626 ± 0.042	0.343HisTrp: 0.343 ± 0.019	0.483HisTyr: 0.483 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.48IleAla: 7.48 ± 0.085	0.582IleCys: 0.582 ± 0.023	3.45IleAsp: 3.45 ± 0.051	3.055IleGlu: 3.055 ± 0.056	1.66IlePhe: 1.66 ± 0.044	4.826IleGly: 4.826 ± 0.076	0.979IleHis: 0.979 ± 0.032	2.035IleIle: 2.035 ± 0.053	0.927IleLys: 0.927 ± 0.034	4.973IleLeu: 4.973 ± 0.075	1.124IleMet: 1.124 ± 0.038	1.064IleAsn: 1.064 ± 0.032	2.459IlePro: 2.459 ± 0.045	1.212IleGln: 1.212 ± 0.036	3.917IleArg: 3.917 ± 0.06	2.31IleSer: 2.31 ± 0.045	2.764IleThr: 2.764 ± 0.047	3.472IleVal: 3.472 ± 0.059	0.778IleTrp: 0.778 ± 0.029	1.002IleTyr: 1.002 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	2.799LysAla: 2.799 ± 0.06	0.135LysCys: 0.135 ± 0.011	1.222LysAsp: 1.222 ± 0.037	0.912LysGlu: 0.912 ± 0.034	0.551LysPhe: 0.551 ± 0.026	2.002LysGly: 2.002 ± 0.05	0.38LysHis: 0.38 ± 0.02	1.1LysIle: 1.1 ± 0.039	0.724LysLys: 0.724 ± 0.032	1.943LysLeu: 1.943 ± 0.041	0.523LysMet: 0.523 ± 0.023	0.478LysAsn: 0.478 ± 0.021	1.358LysPro: 1.358 ± 0.039	0.599LysGln: 0.599 ± 0.023	1.668LysArg: 1.668 ± 0.041	1.194LysSer: 1.194 ± 0.037	1.326LysThr: 1.326 ± 0.039	1.588LysVal: 1.588 ± 0.044	0.268LysTrp: 0.268 ± 0.014	0.431LysTyr: 0.431 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	15.263LeuAla: 15.263 ± 0.166	0.823LeuCys: 0.823 ± 0.029	6.779LeuAsp: 6.779 ± 0.092	4.859LeuGlu: 4.859 ± 0.075	3.207LeuPhe: 3.207 ± 0.062	8.679LeuGly: 8.679 ± 0.096	1.952LeuHis: 1.952 ± 0.045	5.495LeuIle: 5.495 ± 0.074	2.202LeuLys: 2.202 ± 0.054	8.854LeuLeu: 8.854 ± 0.11	2.958LeuMet: 2.958 ± 0.057	2.36LeuAsn: 2.36 ± 0.048	6.397LeuPro: 6.397 ± 0.092	2.799LeuGln: 2.799 ± 0.056	8.575LeuArg: 8.575 ± 0.102	6.357LeuSer: 6.357 ± 0.081	6.52LeuThr: 6.52 ± 0.078	6.941LeuVal: 6.941 ± 0.085	1.378LeuTrp: 1.378 ± 0.039	1.81LeuTyr: 1.81 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	4.076MetAla: 4.076 ± 0.064	0.162MetCys: 0.162 ± 0.013	1.47MetAsp: 1.47 ± 0.037	1.182MetGlu: 1.182 ± 0.034	0.735MetPhe: 0.735 ± 0.028	2.543MetGly: 2.543 ± 0.06	0.417MetHis: 0.417 ± 0.019	1.621MetIle: 1.621 ± 0.039	0.703MetLys: 0.703 ± 0.026	2.853MetLeu: 2.853 ± 0.054	0.812MetMet: 0.812 ± 0.028	0.766MetAsn: 0.766 ± 0.026	1.746MetPro: 1.746 ± 0.049	0.927MetGln: 0.927 ± 0.028	2.296MetArg: 2.296 ± 0.052	1.513MetSer: 1.513 ± 0.042	2.322MetThr: 2.322 ± 0.049	1.966MetVal: 1.966 ± 0.038	0.242MetTrp: 0.242 ± 0.014	0.279MetTyr: 0.279 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.656AsnAla: 2.656 ± 0.054	0.211AsnCys: 0.211 ± 0.013	1.17AsnAsp: 1.17 ± 0.037	0.93AsnGlu: 0.93 ± 0.033	0.783AsnPhe: 0.783 ± 0.03	1.825AsnGly: 1.825 ± 0.043	0.432AsnHis: 0.432 ± 0.02	1.096AsnIle: 1.096 ± 0.033	0.416AsnLys: 0.416 ± 0.019	2.293AsnLeu: 2.293 ± 0.049	0.585AsnMet: 0.585 ± 0.023	0.471AsnAsn: 0.471 ± 0.022	1.642AsnPro: 1.642 ± 0.042	0.685AsnGln: 0.685 ± 0.025	1.808AsnArg: 1.808 ± 0.043	0.96AsnSer: 0.96 ± 0.029	0.941AsnThr: 0.941 ± 0.03	1.434AsnVal: 1.434 ± 0.04	0.363AsnTrp: 0.363 ± 0.018	0.503AsnTyr: 0.503 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	7.568ProAla: 7.568 ± 0.095	0.37ProCys: 0.37 ± 0.018	4.83ProAsp: 4.83 ± 0.072	4.17ProGlu: 4.17 ± 0.064	1.875ProPhe: 1.875 ± 0.039	5.539ProGly: 5.539 ± 0.076	1.171ProHis: 1.171 ± 0.034	2.231ProIle: 2.231 ± 0.048	1.165ProLys: 1.165 ± 0.034	5.051ProLeu: 5.051 ± 0.081	1.524ProMet: 1.524 ± 0.036	1.069ProAsn: 1.069 ± 0.029	2.776ProPro: 2.776 ± 0.063	1.975ProGln: 1.975 ± 0.047	3.873ProArg: 3.873 ± 0.071	2.343ProSer: 2.343 ± 0.048	2.259ProThr: 2.259 ± 0.044	4.686ProVal: 4.686 ± 0.068	0.81ProTrp: 0.81 ± 0.028	1.0ProTyr: 1.0 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.948GlnAla: 4.948 ± 0.073	0.167GlnCys: 0.167 ± 0.013	1.99GlnAsp: 1.99 ± 0.048	1.24GlnGlu: 1.24 ± 0.035	0.944GlnPhe: 0.944 ± 0.032	3.443GlnGly: 3.443 ± 0.055	0.583GlnHis: 0.583 ± 0.025	2.111GlnIle: 2.111 ± 0.046	0.712GlnLys: 0.712 ± 0.026	2.897GlnLeu: 2.897 ± 0.058	1.178GlnMet: 1.178 ± 0.034	0.773GlnAsn: 0.773 ± 0.028	1.983GlnPro: 1.983 ± 0.044	1.115GlnGln: 1.115 ± 0.035	2.351GlnArg: 2.351 ± 0.05	1.518GlnSer: 1.518 ± 0.042	1.814GlnThr: 1.814 ± 0.04	2.648GlnVal: 2.648 ± 0.053	0.361GlnTrp: 0.361 ± 0.018	0.481GlnTyr: 0.481 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	10.717ArgAla: 10.717 ± 0.134	0.555ArgCys: 0.555 ± 0.023	5.678ArgAsp: 5.678 ± 0.086	3.848ArgGlu: 3.848 ± 0.067	2.829ArgPhe: 2.829 ± 0.049	5.782ArgGly: 5.782 ± 0.067	2.08ArgHis: 2.08 ± 0.052	4.967ArgIle: 4.967 ± 0.07	1.77ArgLys: 1.77 ± 0.047	9.184ArgLeu: 9.184 ± 0.103	2.605ArgMet: 2.605 ± 0.052	1.705ArgAsn: 1.705 ± 0.045	4.637ArgPro: 4.637 ± 0.071	2.901ArgGln: 2.901 ± 0.046	6.817ArgArg: 6.817 ± 0.102	3.415ArgSer: 3.415 ± 0.064	3.218ArgThr: 3.218 ± 0.051	5.343ArgVal: 5.343 ± 0.067	1.162ArgTrp: 1.162 ± 0.032	1.514ArgTyr: 1.514 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.382SerAla: 5.382 ± 0.065	0.385SerCys: 0.385 ± 0.019	2.932SerAsp: 2.932 ± 0.059	2.123SerGlu: 2.123 ± 0.048	1.869SerPhe: 1.869 ± 0.048	4.924SerGly: 4.924 ± 0.06	1.01SerHis: 1.01 ± 0.034	2.061SerIle: 2.061 ± 0.043	0.906SerLys: 0.906 ± 0.025	4.765SerLeu: 4.765 ± 0.077	1.204SerMet: 1.204 ± 0.036	1.001SerAsn: 1.001 ± 0.032	2.511SerPro: 2.511 ± 0.045	1.436SerGln: 1.436 ± 0.041	3.497SerArg: 3.497 ± 0.058	2.091SerSer: 2.091 ± 0.046	2.15SerThr: 2.15 ± 0.052	3.286SerVal: 3.286 ± 0.063	0.727SerTrp: 0.727 ± 0.025	1.019SerTyr: 1.019 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.46ThrAla: 6.46 ± 0.084	0.41ThrCys: 0.41 ± 0.02	3.095ThrAsp: 3.095 ± 0.052	2.783ThrGlu: 2.783 ± 0.052	1.529ThrPhe: 1.529 ± 0.041	5.416ThrGly: 5.416 ± 0.074	1.068ThrHis: 1.068 ± 0.03	2.576ThrIle: 2.576 ± 0.051	0.993ThrLys: 0.993 ± 0.031	5.645ThrLeu: 5.645 ± 0.076	1.17ThrMet: 1.17 ± 0.032	1.091ThrAsn: 1.091 ± 0.034	3.419ThrPro: 3.419 ± 0.061	1.462ThrGln: 1.462 ± 0.037	4.006ThrArg: 4.006 ± 0.063	2.188ThrSer: 2.188 ± 0.044	2.646ThrThr: 2.646 ± 0.06	3.933ThrVal: 3.933 ± 0.059	0.601ThrTrp: 0.601 ± 0.027	0.985ThrTyr: 0.985 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.399ValAla: 9.399 ± 0.105	0.525ValCys: 0.525 ± 0.022	3.75ValAsp: 3.75 ± 0.058	3.847ValGlu: 3.847 ± 0.069	2.567ValPhe: 2.567 ± 0.046	5.099ValGly: 5.099 ± 0.081	1.245ValHis: 1.245 ± 0.036	4.253ValIle: 4.253 ± 0.073	1.54ValLys: 1.54 ± 0.046	7.706ValLeu: 7.706 ± 0.088	2.262ValMet: 2.262 ± 0.053	1.711ValAsn: 1.711 ± 0.04	3.535ValPro: 3.535 ± 0.056	2.155ValGln: 2.155 ± 0.044	4.313ValArg: 4.313 ± 0.068	3.409ValSer: 3.409 ± 0.054	4.986ValThr: 4.986 ± 0.067	5.287ValVal: 5.287 ± 0.081	0.941ValTrp: 0.941 ± 0.028	1.218ValTyr: 1.218 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.538TrpAla: 1.538 ± 0.042	0.141TrpCys: 0.141 ± 0.012	0.82TrpAsp: 0.82 ± 0.027	0.515TrpGlu: 0.515 ± 0.023	0.618TrpPhe: 0.618 ± 0.023	1.068TrpGly: 1.068 ± 0.033	0.383TrpHis: 0.383 ± 0.018	0.684TrpIle: 0.684 ± 0.027	0.356TrpLys: 0.356 ± 0.018	1.924TrpLeu: 1.924 ± 0.046	0.428TrpMet: 0.428 ± 0.02	0.384TrpAsn: 0.384 ± 0.02	0.869TrpPro: 0.869 ± 0.027	0.769TrpGln: 0.769 ± 0.024	1.401TrpArg: 1.401 ± 0.038	0.842TrpSer: 0.842 ± 0.029	0.832TrpThr: 0.832 ± 0.027	0.829TrpVal: 0.829 ± 0.027	0.265TrpTrp: 0.265 ± 0.016	0.24TrpTyr: 0.24 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.29TyrAla: 2.29 ± 0.049	0.205TyrCys: 0.205 ± 0.015	1.473TyrAsp: 1.473 ± 0.043	0.951TyrGlu: 0.951 ± 0.035	0.701TyrPhe: 0.701 ± 0.03	1.877TyrGly: 1.877 ± 0.04	0.454TyrHis: 0.454 ± 0.026	0.694TyrIle: 0.694 ± 0.023	0.367TyrLys: 0.367 ± 0.018	2.07TyrLeu: 2.07 ± 0.041	0.38TyrMet: 0.38 ± 0.018	0.496TyrAsn: 0.496 ± 0.022	0.997TyrPro: 0.997 ± 0.033	0.626TyrGln: 0.626 ± 0.026	1.588TyrArg: 1.588 ± 0.043	0.882TyrSer: 0.882 ± 0.031	0.851TyrThr: 0.851 ± 0.028	1.307TyrVal: 1.307 ± 0.038	0.324TyrTrp: 0.324 ± 0.017	0.466TyrTyr: 0.466 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3662 proteins (1101469 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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