Amino acid dipepetide frequency for Clostridium tepidiprofundi DSM 19306

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.602AlaAla: 3.602 ± 0.087	0.703AlaCys: 0.703 ± 0.03	2.513AlaAsp: 2.513 ± 0.06	3.38AlaGlu: 3.38 ± 0.077	2.353AlaPhe: 2.353 ± 0.058	3.289AlaGly: 3.289 ± 0.071	0.832AlaHis: 0.832 ± 0.033	5.531AlaIle: 5.531 ± 0.089	4.483AlaLys: 4.483 ± 0.093	5.284AlaLeu: 5.284 ± 0.085	1.403AlaMet: 1.403 ± 0.044	2.557AlaAsn: 2.557 ± 0.058	1.211AlaPro: 1.211 ± 0.048	1.299AlaGln: 1.299 ± 0.047	1.954AlaArg: 1.954 ± 0.05	3.074AlaSer: 3.074 ± 0.061	2.288AlaThr: 2.288 ± 0.06	4.005AlaVal: 4.005 ± 0.082	0.331AlaTrp: 0.331 ± 0.02	2.187AlaTyr: 2.187 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.639CysAla: 0.639 ± 0.028	0.208CysCys: 0.208 ± 0.016	0.764CysAsp: 0.764 ± 0.031	0.875CysGlu: 0.875 ± 0.047	0.512CysPhe: 0.512 ± 0.023	1.061CysGly: 1.061 ± 0.044	0.22CysHis: 0.22 ± 0.018	1.325CysIle: 1.325 ± 0.044	1.092CysLys: 1.092 ± 0.039	0.909CysLeu: 0.909 ± 0.029	0.309CysMet: 0.309 ± 0.022	0.809CysAsn: 0.809 ± 0.036	0.446CysPro: 0.446 ± 0.027	0.251CysGln: 0.251 ± 0.061	0.439CysArg: 0.439 ± 0.023	0.869CysSer: 0.869 ± 0.038	0.588CysThr: 0.588 ± 0.027	0.727CysVal: 0.727 ± 0.03	0.076CysTrp: 0.076 ± 0.01	0.499CysTyr: 0.499 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	2.518AspAla: 2.518 ± 0.058	0.617AspCys: 0.617 ± 0.031	3.106AspAsp: 3.106 ± 0.078	4.65AspGlu: 4.65 ± 0.088	2.766AspPhe: 2.766 ± 0.064	3.216AspGly: 3.216 ± 0.083	0.441AspHis: 0.441 ± 0.02	7.1AspIle: 7.1 ± 0.103	5.868AspLys: 5.868 ± 0.097	4.376AspLeu: 4.376 ± 0.07	1.635AspMet: 1.635 ± 0.048	3.749AspAsn: 3.749 ± 0.074	1.159AspPro: 1.159 ± 0.04	0.601AspGln: 0.601 ± 0.028	1.97AspArg: 1.97 ± 0.05	3.129AspSer: 3.129 ± 0.07	2.489AspThr: 2.489 ± 0.063	3.822AspVal: 3.822 ± 0.072	0.379AspTrp: 0.379 ± 0.021	2.605AspTyr: 2.605 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	3.739GluAla: 3.739 ± 0.088	0.791GluCys: 0.791 ± 0.03	3.721GluAsp: 3.721 ± 0.071	6.078GluGlu: 6.078 ± 0.122	3.094GluPhe: 3.094 ± 0.07	3.996GluGly: 3.996 ± 0.076	1.038GluHis: 1.038 ± 0.039	7.626GluIle: 7.626 ± 0.111	7.764GluLys: 7.764 ± 0.12	6.831GluLeu: 6.831 ± 0.113	1.873GluMet: 1.873 ± 0.048	5.508GluAsn: 5.508 ± 0.094	1.429GluPro: 1.429 ± 0.045	1.886GluGln: 1.886 ± 0.048	2.651GluArg: 2.651 ± 0.064	3.179GluSer: 3.179 ± 0.06	2.634GluThr: 2.634 ± 0.071	4.213GluVal: 4.213 ± 0.073	0.522GluTrp: 0.522 ± 0.027	3.541GluTyr: 3.541 ± 0.066	0.0GluXaa: 0.0 ± 0.0
Phe	2.238PheAla: 2.238 ± 0.056	0.589PheCys: 0.589 ± 0.025	2.767PheAsp: 2.767 ± 0.055	2.871PheGlu: 2.871 ± 0.068	1.873PhePhe: 1.873 ± 0.057	2.695PheGly: 2.695 ± 0.059	0.55PheHis: 0.55 ± 0.029	4.788PheIle: 4.788 ± 0.096	3.954PheLys: 3.954 ± 0.071	3.781PheLeu: 3.781 ± 0.09	1.17PheMet: 1.17 ± 0.037	2.955PheAsn: 2.955 ± 0.058	1.16PhePro: 1.16 ± 0.042	0.808PheGln: 0.808 ± 0.031	1.338PheArg: 1.338 ± 0.044	3.152PheSer: 3.152 ± 0.068	2.265PheThr: 2.265 ± 0.052	2.766PheVal: 2.766 ± 0.06	0.287PheTrp: 0.287 ± 0.023	1.887PheTyr: 1.887 ± 0.057	0.0PheXaa: 0.0 ± 0.0
Gly	3.523GlyAla: 3.523 ± 0.073	0.886GlyCys: 0.886 ± 0.039	3.068GlyAsp: 3.068 ± 0.065	3.952GlyGlu: 3.952 ± 0.083	2.833GlyPhe: 2.833 ± 0.064	3.71GlyGly: 3.71 ± 0.083	0.983GlyHis: 0.983 ± 0.035	6.979GlyIle: 6.979 ± 0.113	5.902GlyLys: 5.902 ± 0.09	4.86GlyLeu: 4.86 ± 0.079	1.67GlyMet: 1.67 ± 0.053	3.396GlyAsn: 3.396 ± 0.072	1.11GlyPro: 1.11 ± 0.055	1.357GlyGln: 1.357 ± 0.044	2.226GlyArg: 2.226 ± 0.058	3.201GlySer: 3.201 ± 0.06	3.168GlyThr: 3.168 ± 0.081	4.183GlyVal: 4.183 ± 0.075	0.446GlyTrp: 0.446 ± 0.024	2.882GlyTyr: 2.882 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	0.618HisAla: 0.618 ± 0.028	0.216HisCys: 0.216 ± 0.017	0.754HisAsp: 0.754 ± 0.029	0.881HisGlu: 0.881 ± 0.039	0.658HisPhe: 0.658 ± 0.029	0.942HisGly: 0.942 ± 0.038	0.249HisHis: 0.249 ± 0.019	1.477HisIle: 1.477 ± 0.047	1.247HisLys: 1.247 ± 0.042	1.087HisLeu: 1.087 ± 0.037	0.385HisMet: 0.385 ± 0.021	0.913HisAsn: 0.913 ± 0.031	0.549HisPro: 0.549 ± 0.026	0.285HisGln: 0.285 ± 0.02	0.507HisArg: 0.507 ± 0.023	0.848HisSer: 0.848 ± 0.037	0.73HisThr: 0.73 ± 0.034	0.814HisVal: 0.814 ± 0.029	0.112HisTrp: 0.112 ± 0.012	0.639HisTyr: 0.639 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.773IleAla: 5.773 ± 0.095	1.402IleCys: 1.402 ± 0.045	6.735IleAsp: 6.735 ± 0.107	7.746IleGlu: 7.746 ± 0.112	4.471IlePhe: 4.471 ± 0.086	6.176IleGly: 6.176 ± 0.105	1.402IleHis: 1.402 ± 0.048	10.523IleIle: 10.523 ± 0.163	9.945IleLys: 9.945 ± 0.13	9.336IleLeu: 9.336 ± 0.129	2.608IleMet: 2.608 ± 0.071	7.182IleAsn: 7.182 ± 0.112	3.449IlePro: 3.449 ± 0.068	2.182IleGln: 2.182 ± 0.051	3.485IleArg: 3.485 ± 0.074	7.07IleSer: 7.07 ± 0.108	4.876IleThr: 4.876 ± 0.104	6.743IleVal: 6.743 ± 0.111	0.563IleTrp: 0.563 ± 0.029	3.822IleTyr: 3.822 ± 0.072	0.0IleXaa: 0.0 ± 0.0
Lys	4.741LysAla: 4.741 ± 0.097	1.105LysCys: 1.105 ± 0.045	5.614LysAsp: 5.614 ± 0.094	8.33LysGlu: 8.33 ± 0.129	3.585LysPhe: 3.585 ± 0.062	5.201LysGly: 5.201 ± 0.078	1.384LysHis: 1.384 ± 0.042	9.42LysIle: 9.42 ± 0.111	9.452LysLys: 9.452 ± 0.133	8.348LysLeu: 8.348 ± 0.112	2.544LysMet: 2.544 ± 0.056	7.472LysAsn: 7.472 ± 0.113	2.167LysPro: 2.167 ± 0.055	2.403LysGln: 2.403 ± 0.061	3.563LysArg: 3.563 ± 0.07	5.31LysSer: 5.31 ± 0.084	4.212LysThr: 4.212 ± 0.07	5.832LysVal: 5.832 ± 0.1	0.68LysTrp: 0.68 ± 0.032	5.107LysTyr: 5.107 ± 0.072	0.0LysXaa: 0.0 ± 0.0
Leu	4.636LeuAla: 4.636 ± 0.092	1.034LeuCys: 1.034 ± 0.038	4.783LeuAsp: 4.783 ± 0.09	5.788LeuGlu: 5.788 ± 0.097	3.788LeuPhe: 3.788 ± 0.088	5.505LeuGly: 5.505 ± 0.091	1.178LeuHis: 1.178 ± 0.036	8.414LeuIle: 8.414 ± 0.132	8.868LeuLys: 8.868 ± 0.104	7.463LeuLeu: 7.463 ± 0.116	2.292LeuMet: 2.292 ± 0.054	6.153LeuAsn: 6.153 ± 0.098	2.679LeuPro: 2.679 ± 0.063	1.962LeuGln: 1.962 ± 0.052	3.147LeuArg: 3.147 ± 0.064	6.065LeuSer: 6.065 ± 0.097	4.058LeuThr: 4.058 ± 0.075	4.953LeuVal: 4.953 ± 0.08	0.556LeuTrp: 0.556 ± 0.03	3.512LeuTyr: 3.512 ± 0.074	0.0LeuXaa: 0.0 ± 0.0
Met	1.49MetAla: 1.49 ± 0.051	0.315MetCys: 0.315 ± 0.021	1.464MetAsp: 1.464 ± 0.04	1.609MetGlu: 1.609 ± 0.044	1.11MetPhe: 1.11 ± 0.04	1.692MetGly: 1.692 ± 0.047	0.367MetHis: 0.367 ± 0.021	2.425MetIle: 2.425 ± 0.058	2.639MetLys: 2.639 ± 0.063	2.429MetLeu: 2.429 ± 0.061	0.656MetMet: 0.656 ± 0.029	1.8MetAsn: 1.8 ± 0.057	0.907MetPro: 0.907 ± 0.037	0.732MetGln: 0.732 ± 0.03	0.925MetArg: 0.925 ± 0.039	1.771MetSer: 1.771 ± 0.039	1.116MetThr: 1.116 ± 0.038	1.598MetVal: 1.598 ± 0.039	0.138MetTrp: 0.138 ± 0.014	0.999MetTyr: 0.999 ± 0.036	0.0MetXaa: 0.0 ± 0.0
Asn	3.058AsnAla: 3.058 ± 0.053	0.829AsnCys: 0.829 ± 0.036	3.751AsnAsp: 3.751 ± 0.069	4.685AsnGlu: 4.685 ± 0.098	2.652AsnPhe: 2.652 ± 0.067	3.684AsnGly: 3.684 ± 0.075	0.744AsnHis: 0.744 ± 0.029	8.277AsnIle: 8.277 ± 0.112	6.99AsnLys: 6.99 ± 0.112	5.266AsnLeu: 5.266 ± 0.095	1.892AsnMet: 1.892 ± 0.054	5.173AsnAsn: 5.173 ± 0.115	1.901AsnPro: 1.901 ± 0.05	1.299AsnGln: 1.299 ± 0.04	2.253AsnArg: 2.253 ± 0.058	4.289AsnSer: 4.289 ± 0.097	3.173AsnThr: 3.173 ± 0.075	4.109AsnVal: 4.109 ± 0.082	0.472AsnTrp: 0.472 ± 0.026	3.002AsnTyr: 3.002 ± 0.059	0.001AsnXaa: 0.001 ± 0.001
Pro	1.242ProAla: 1.242 ± 0.04	0.329ProCys: 0.329 ± 0.022	1.392ProAsp: 1.392 ± 0.048	2.002ProGlu: 2.002 ± 0.054	1.34ProPhe: 1.34 ± 0.043	1.627ProGly: 1.627 ± 0.046	0.488ProHis: 0.488 ± 0.026	2.65ProIle: 2.65 ± 0.063	2.39ProLys: 2.39 ± 0.056	2.284ProLeu: 2.284 ± 0.052	0.653ProMet: 0.653 ± 0.03	1.627ProAsn: 1.627 ± 0.05	0.633ProPro: 0.633 ± 0.033	0.749ProGln: 0.749 ± 0.034	0.834ProArg: 0.834 ± 0.037	1.695ProSer: 1.695 ± 0.051	1.346ProThr: 1.346 ± 0.046	2.027ProVal: 2.027 ± 0.06	0.203ProTrp: 0.203 ± 0.017	1.316ProTyr: 1.316 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	1.193GlnAla: 1.193 ± 0.041	0.292GlnCys: 0.292 ± 0.025	1.013GlnAsp: 1.013 ± 0.034	1.577GlnGlu: 1.577 ± 0.054	1.005GlnPhe: 1.005 ± 0.037	1.205GlnGly: 1.205 ± 0.044	0.336GlnHis: 0.336 ± 0.022	2.217GlnIle: 2.217 ± 0.054	2.196GlnLys: 2.196 ± 0.058	1.952GlnLeu: 1.952 ± 0.05	0.638GlnMet: 0.638 ± 0.026	1.624GlnAsn: 1.624 ± 0.047	0.541GlnPro: 0.541 ± 0.028	0.611GlnGln: 0.611 ± 0.03	0.909GlnArg: 0.909 ± 0.037	1.236GlnSer: 1.236 ± 0.039	1.007GlnThr: 1.007 ± 0.038	1.294GlnVal: 1.294 ± 0.041	0.172GlnTrp: 0.172 ± 0.014	1.071GlnTyr: 1.071 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	1.891ArgAla: 1.891 ± 0.046	0.453ArgCys: 0.453 ± 0.023	1.808ArgAsp: 1.808 ± 0.05	3.007ArgGlu: 3.007 ± 0.07	1.533ArgPhe: 1.533 ± 0.047	2.134ArgGly: 2.134 ± 0.055	0.488ArgHis: 0.488 ± 0.026	3.576ArgIle: 3.576 ± 0.072	3.609ArgLys: 3.609 ± 0.071	2.966ArgLeu: 2.966 ± 0.068	1.008ArgMet: 1.008 ± 0.038	2.404ArgAsn: 2.404 ± 0.051	0.88ArgPro: 0.88 ± 0.03	0.907ArgGln: 0.907 ± 0.03	1.589ArgArg: 1.589 ± 0.049	1.439ArgSer: 1.439 ± 0.042	1.676ArgThr: 1.676 ± 0.053	2.258ArgVal: 2.258 ± 0.058	0.29ArgTrp: 0.29 ± 0.021	1.568ArgTyr: 1.568 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	2.876SerAla: 2.876 ± 0.064	0.732SerCys: 0.732 ± 0.039	3.237SerAsp: 3.237 ± 0.075	4.08SerGlu: 4.08 ± 0.082	2.787SerPhe: 2.787 ± 0.062	3.837SerGly: 3.837 ± 0.068	0.852SerHis: 0.852 ± 0.036	6.764SerIle: 6.764 ± 0.11	6.001SerLys: 6.001 ± 0.096	5.366SerLeu: 5.366 ± 0.083	1.611SerMet: 1.611 ± 0.05	3.996SerAsn: 3.996 ± 0.082	1.584SerPro: 1.584 ± 0.042	1.407SerGln: 1.407 ± 0.037	2.074SerArg: 2.074 ± 0.052	4.07SerSer: 4.07 ± 0.087	2.997SerThr: 2.997 ± 0.074	3.697SerVal: 3.697 ± 0.061	0.362SerTrp: 0.362 ± 0.025	2.498SerTyr: 2.498 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	2.773ThrAla: 2.773 ± 0.073	0.491ThrCys: 0.491 ± 0.031	2.369ThrAsp: 2.369 ± 0.059	2.861ThrGlu: 2.861 ± 0.068	2.058ThrPhe: 2.058 ± 0.049	3.43ThrGly: 3.43 ± 0.075	0.725ThrHis: 0.725 ± 0.031	4.801ThrIle: 4.801 ± 0.084	3.744ThrLys: 3.744 ± 0.072	4.246ThrLeu: 4.246 ± 0.076	1.044ThrMet: 1.044 ± 0.032	2.77ThrAsn: 2.77 ± 0.073	1.601ThrPro: 1.601 ± 0.048	1.104ThrGln: 1.104 ± 0.04	1.573ThrArg: 1.573 ± 0.039	2.933ThrSer: 2.933 ± 0.082	2.371ThrThr: 2.371 ± 0.071	3.355ThrVal: 3.355 ± 0.079	0.323ThrTrp: 0.323 ± 0.02	1.874ThrTyr: 1.874 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	3.442ValAla: 3.442 ± 0.073	0.907ValCys: 0.907 ± 0.039	3.985ValAsp: 3.985 ± 0.075	4.327ValGlu: 4.327 ± 0.087	2.944ValPhe: 2.944 ± 0.064	3.864ValGly: 3.864 ± 0.082	0.864ValHis: 0.864 ± 0.033	6.49ValIle: 6.49 ± 0.101	5.687ValLys: 5.687 ± 0.08	5.847ValLeu: 5.847 ± 0.085	1.618ValMet: 1.618 ± 0.05	3.743ValAsn: 3.743 ± 0.064	1.994ValPro: 1.994 ± 0.05	1.348ValGln: 1.348 ± 0.038	2.123ValArg: 2.123 ± 0.045	4.14ValSer: 4.14 ± 0.068	3.16ValThr: 3.16 ± 0.079	4.316ValVal: 4.316 ± 0.085	0.389ValTrp: 0.389 ± 0.023	2.557ValTyr: 2.557 ± 0.065	0.0ValXaa: 0.0 ± 0.0
Trp	0.359TrpAla: 0.359 ± 0.024	0.088TrpCys: 0.088 ± 0.01	0.35TrpAsp: 0.35 ± 0.021	0.406TrpGlu: 0.406 ± 0.022	0.323TrpPhe: 0.323 ± 0.023	0.489TrpGly: 0.489 ± 0.028	0.134TrpHis: 0.134 ± 0.012	0.691TrpIle: 0.691 ± 0.031	0.565TrpLys: 0.565 ± 0.031	0.583TrpLeu: 0.583 ± 0.028	0.183TrpMet: 0.183 ± 0.014	0.524TrpAsn: 0.524 ± 0.027	0.152TrpPro: 0.152 ± 0.016	0.171TrpGln: 0.171 ± 0.013	0.243TrpArg: 0.243 ± 0.017	0.378TrpSer: 0.378 ± 0.021	0.266TrpThr: 0.266 ± 0.019	0.403TrpVal: 0.403 ± 0.024	0.073TrpTrp: 0.073 ± 0.009	0.313TrpTyr: 0.313 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.929TyrAla: 1.929 ± 0.049	0.629TyrCys: 0.629 ± 0.032	3.003TyrAsp: 3.003 ± 0.064	3.009TyrGlu: 3.009 ± 0.066	2.211TyrPhe: 2.211 ± 0.051	2.581TyrGly: 2.581 ± 0.054	0.638TyrHis: 0.638 ± 0.029	4.414TyrIle: 4.414 ± 0.076	4.071TyrLys: 4.071 ± 0.08	3.619TyrLeu: 3.619 ± 0.068	0.988TyrMet: 0.988 ± 0.039	3.145TyrAsn: 3.145 ± 0.064	1.274TyrPro: 1.274 ± 0.04	0.73TyrGln: 0.73 ± 0.03	1.679TyrArg: 1.679 ± 0.043	2.98TyrSer: 2.98 ± 0.06	2.028TyrThr: 2.028 ± 0.052	2.629TyrVal: 2.629 ± 0.063	0.32TyrTrp: 0.32 ± 0.023	2.188TyrTyr: 2.188 ± 0.068	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2724 proteins (818141 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---