Amino acid dipepetide frequency for Streptomyces cinnamoneus (Streptoverticillium cinnamoneum)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.548AlaAla: 22.548 ± 0.192	1.209AlaCys: 1.209 ± 0.03	8.298AlaAsp: 8.298 ± 0.075	9.028AlaGlu: 9.028 ± 0.109	3.628AlaPhe: 3.628 ± 0.049	14.391AlaGly: 14.391 ± 0.121	3.087AlaHis: 3.087 ± 0.048	2.958AlaIle: 2.958 ± 0.045	2.933AlaLys: 2.933 ± 0.056	15.04AlaLeu: 15.04 ± 0.142	2.563AlaMet: 2.563 ± 0.038	1.774AlaAsn: 1.774 ± 0.038	7.679AlaPro: 7.679 ± 0.096	3.662AlaGln: 3.662 ± 0.049	10.883AlaArg: 10.883 ± 0.094	5.81AlaSer: 5.81 ± 0.054	6.944AlaThr: 6.944 ± 0.077	13.009AlaVal: 13.009 ± 0.115	1.887AlaTrp: 1.887 ± 0.034	2.721AlaTyr: 2.721 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.284CysAla: 1.284 ± 0.03	0.108CysCys: 0.108 ± 0.007	0.51CysAsp: 0.51 ± 0.018	0.435CysGlu: 0.435 ± 0.014	0.25CysPhe: 0.25 ± 0.011	1.051CysGly: 1.051 ± 0.029	0.193CysHis: 0.193 ± 0.01	0.147CysIle: 0.147 ± 0.009	0.119CysLys: 0.119 ± 0.008	0.775CysLeu: 0.775 ± 0.022	0.129CysMet: 0.129 ± 0.009	0.118CysAsn: 0.118 ± 0.008	0.538CysPro: 0.538 ± 0.02	0.187CysGln: 0.187 ± 0.01	0.683CysArg: 0.683 ± 0.022	0.457CysSer: 0.457 ± 0.017	0.502CysThr: 0.502 ± 0.016	0.721CysVal: 0.721 ± 0.02	0.135CysTrp: 0.135 ± 0.008	0.155CysTyr: 0.155 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.804AspAla: 7.804 ± 0.087	0.442AspCys: 0.442 ± 0.016	3.598AspAsp: 3.598 ± 0.056	3.878AspGlu: 3.878 ± 0.052	1.571AspPhe: 1.571 ± 0.03	6.322AspGly: 6.322 ± 0.068	1.463AspHis: 1.463 ± 0.029	1.584AspIle: 1.584 ± 0.035	1.287AspLys: 1.287 ± 0.034	5.924AspLeu: 5.924 ± 0.073	0.793AspMet: 0.793 ± 0.022	0.839AspAsn: 0.839 ± 0.022	4.327AspPro: 4.327 ± 0.049	1.436AspGln: 1.436 ± 0.028	4.973AspArg: 4.973 ± 0.058	2.293AspSer: 2.293 ± 0.037	2.848AspThr: 2.848 ± 0.045	4.964AspVal: 4.964 ± 0.053	1.018AspTrp: 1.018 ± 0.029	1.135AspTyr: 1.135 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	7.753GluAla: 7.753 ± 0.107	0.41GluCys: 0.41 ± 0.015	2.891GluAsp: 2.891 ± 0.044	3.638GluGlu: 3.638 ± 0.067	1.397GluPhe: 1.397 ± 0.029	4.686GluGly: 4.686 ± 0.052	1.564GluHis: 1.564 ± 0.03	2.05GluIle: 2.05 ± 0.039	1.453GluLys: 1.453 ± 0.038	6.836GluLeu: 6.836 ± 0.076	0.867GluMet: 0.867 ± 0.021	0.994GluAsn: 0.994 ± 0.028	3.396GluPro: 3.396 ± 0.045	2.117GluGln: 2.117 ± 0.041	5.896GluArg: 5.896 ± 0.071	2.353GluSer: 2.353 ± 0.037	2.861GluThr: 2.861 ± 0.044	4.478GluVal: 4.478 ± 0.057	0.742GluTrp: 0.742 ± 0.02	0.974GluTyr: 0.974 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.767PheAla: 3.767 ± 0.052	0.279PheCys: 0.279 ± 0.012	1.879PheAsp: 1.879 ± 0.033	1.395PheGlu: 1.395 ± 0.028	0.919PhePhe: 0.919 ± 0.027	3.007PheGly: 3.007 ± 0.041	0.663PheHis: 0.663 ± 0.02	0.656PheIle: 0.656 ± 0.019	0.498PheLys: 0.498 ± 0.018	2.546PheLeu: 2.546 ± 0.038	0.391PheMet: 0.391 ± 0.015	0.509PheAsn: 0.509 ± 0.017	1.391PhePro: 1.391 ± 0.028	0.626PheGln: 0.626 ± 0.019	1.882PheArg: 1.882 ± 0.036	1.467PheSer: 1.467 ± 0.031	1.986PheThr: 1.986 ± 0.036	2.243PheVal: 2.243 ± 0.034	0.391PheTrp: 0.391 ± 0.016	0.547PheTyr: 0.547 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	11.692GlyAla: 11.692 ± 0.111	0.883GlyCys: 0.883 ± 0.024	5.368GlyAsp: 5.368 ± 0.059	5.422GlyGlu: 5.422 ± 0.059	2.842GlyPhe: 2.842 ± 0.045	9.557GlyGly: 9.557 ± 0.105	2.52GlyHis: 2.52 ± 0.039	2.995GlyIle: 2.995 ± 0.039	2.595GlyLys: 2.595 ± 0.052	9.755GlyLeu: 9.755 ± 0.092	2.079GlyMet: 2.079 ± 0.032	1.584GlyAsn: 1.584 ± 0.035	5.644GlyPro: 5.644 ± 0.059	2.631GlyGln: 2.631 ± 0.039	8.547GlyArg: 8.547 ± 0.081	5.132GlySer: 5.132 ± 0.048	6.379GlyThr: 6.379 ± 0.08	8.031GlyVal: 8.031 ± 0.085	1.706GlyTrp: 1.706 ± 0.034	2.2GlyTyr: 2.2 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.796HisAla: 2.796 ± 0.041	0.233HisCys: 0.233 ± 0.011	1.387HisAsp: 1.387 ± 0.031	1.284HisGlu: 1.284 ± 0.026	0.617HisPhe: 0.617 ± 0.019	2.598HisGly: 2.598 ± 0.046	0.736HisHis: 0.736 ± 0.02	0.608HisIle: 0.608 ± 0.021	0.369HisLys: 0.369 ± 0.013	2.442HisLeu: 2.442 ± 0.037	0.346HisMet: 0.346 ± 0.015	0.326HisAsn: 0.326 ± 0.014	1.894HisPro: 1.894 ± 0.036	0.639HisGln: 0.639 ± 0.019	2.202HisArg: 2.202 ± 0.038	0.985HisSer: 0.985 ± 0.021	1.333HisThr: 1.333 ± 0.029	1.866HisVal: 1.866 ± 0.037	0.366HisTrp: 0.366 ± 0.015	0.481HisTyr: 0.481 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	4.309IleAla: 4.309 ± 0.058	0.257IleCys: 0.257 ± 0.012	1.887IleAsp: 1.887 ± 0.036	1.768IleGlu: 1.768 ± 0.038	0.581IlePhe: 0.581 ± 0.021	3.107IleGly: 3.107 ± 0.048	0.547IleHis: 0.547 ± 0.017	0.733IleIle: 0.733 ± 0.022	0.729IleLys: 0.729 ± 0.024	2.017IleLeu: 2.017 ± 0.04	0.398IleMet: 0.398 ± 0.016	0.601IleAsn: 0.601 ± 0.019	1.572IlePro: 1.572 ± 0.026	0.633IleGln: 0.633 ± 0.021	2.045IleArg: 2.045 ± 0.034	1.484IleSer: 1.484 ± 0.026	1.921IleThr: 1.921 ± 0.036	2.443IleVal: 2.443 ± 0.041	0.307IleTrp: 0.307 ± 0.013	0.434IleTyr: 0.434 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.014LysAla: 3.014 ± 0.054	0.134LysCys: 0.134 ± 0.009	1.366LysAsp: 1.366 ± 0.038	1.196LysGlu: 1.196 ± 0.031	0.456LysPhe: 0.456 ± 0.018	1.919LysGly: 1.919 ± 0.041	0.419LysHis: 0.419 ± 0.015	0.82LysIle: 0.82 ± 0.028	0.91LysLys: 0.91 ± 0.036	1.988LysLeu: 1.988 ± 0.04	0.403LysMet: 0.403 ± 0.015	0.536LysAsn: 0.536 ± 0.019	1.397LysPro: 1.397 ± 0.039	0.666LysGln: 0.666 ± 0.024	1.474LysArg: 1.474 ± 0.03	1.135LysSer: 1.135 ± 0.031	1.272LysThr: 1.272 ± 0.035	1.948LysVal: 1.948 ± 0.044	0.249LysTrp: 0.249 ± 0.011	0.393LysTyr: 0.393 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	15.806LeuAla: 15.806 ± 0.134	0.91LeuCys: 0.91 ± 0.022	6.647LeuAsp: 6.647 ± 0.067	4.826LeuGlu: 4.826 ± 0.061	2.713LeuPhe: 2.713 ± 0.044	9.325LeuGly: 9.325 ± 0.082	2.278LeuHis: 2.278 ± 0.035	2.906LeuIle: 2.906 ± 0.046	1.931LeuLys: 1.931 ± 0.042	11.339LeuLeu: 11.339 ± 0.122	1.59LeuMet: 1.59 ± 0.031	1.531LeuAsn: 1.531 ± 0.032	6.653LeuPro: 6.653 ± 0.071	2.054LeuGln: 2.054 ± 0.037	8.972LeuArg: 8.972 ± 0.085	5.207LeuSer: 5.207 ± 0.06	6.761LeuThr: 6.761 ± 0.059	8.862LeuVal: 8.862 ± 0.068	1.35LeuTrp: 1.35 ± 0.033	1.778LeuTyr: 1.778 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.339MetAla: 2.339 ± 0.036	0.152MetCys: 0.152 ± 0.009	0.896MetAsp: 0.896 ± 0.023	0.771MetGlu: 0.771 ± 0.024	0.449MetPhe: 0.449 ± 0.017	1.381MetGly: 1.381 ± 0.027	0.327MetHis: 0.327 ± 0.013	0.602MetIle: 0.602 ± 0.02	0.398MetLys: 0.398 ± 0.015	1.687MetLeu: 1.687 ± 0.031	0.317MetMet: 0.317 ± 0.014	0.408MetAsn: 0.408 ± 0.014	1.148MetPro: 1.148 ± 0.025	0.407MetGln: 0.407 ± 0.016	1.453MetArg: 1.453 ± 0.03	1.234MetSer: 1.234 ± 0.022	1.465MetThr: 1.465 ± 0.032	1.286MetVal: 1.286 ± 0.026	0.201MetTrp: 0.201 ± 0.009	0.335MetTyr: 0.335 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.106AsnAla: 2.106 ± 0.041	0.156AsnCys: 0.156 ± 0.009	0.862AsnAsp: 0.862 ± 0.022	0.751AsnGlu: 0.751 ± 0.021	0.424AsnPhe: 0.424 ± 0.015	1.73AsnGly: 1.73 ± 0.036	0.359AsnHis: 0.359 ± 0.014	0.572AsnIle: 0.572 ± 0.017	0.418AsnLys: 0.418 ± 0.019	1.545AsnLeu: 1.545 ± 0.034	0.276AsnMet: 0.276 ± 0.014	0.368AsnAsn: 0.368 ± 0.015	1.25AsnPro: 1.25 ± 0.03	0.434AsnGln: 0.434 ± 0.017	1.157AsnArg: 1.157 ± 0.026	0.778AsnSer: 0.778 ± 0.021	0.999AsnThr: 0.999 ± 0.025	1.323AsnVal: 1.323 ± 0.03	0.255AsnTrp: 0.255 ± 0.012	0.382AsnTyr: 0.382 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	9.452ProAla: 9.452 ± 0.118	0.426ProCys: 0.426 ± 0.016	4.3ProAsp: 4.3 ± 0.057	4.327ProGlu: 4.327 ± 0.049	1.576ProPhe: 1.576 ± 0.027	7.305ProGly: 7.305 ± 0.072	1.518ProHis: 1.518 ± 0.031	1.05ProIle: 1.05 ± 0.024	1.196ProLys: 1.196 ± 0.027	5.597ProLeu: 5.597 ± 0.06	0.965ProMet: 0.965 ± 0.027	0.829ProAsn: 0.829 ± 0.025	3.859ProPro: 3.859 ± 0.073	1.773ProGln: 1.773 ± 0.034	4.39ProArg: 4.39 ± 0.056	3.108ProSer: 3.108 ± 0.047	2.92ProThr: 2.92 ± 0.038	5.772ProVal: 5.772 ± 0.061	0.9ProTrp: 0.9 ± 0.022	1.358ProTyr: 1.358 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.631GlnAla: 3.631 ± 0.051	0.178GlnCys: 0.178 ± 0.009	1.346GlnAsp: 1.346 ± 0.027	1.413GlnGlu: 1.413 ± 0.03	0.588GlnPhe: 0.588 ± 0.019	2.288GlnGly: 2.288 ± 0.034	0.631GlnHis: 0.631 ± 0.021	0.951GlnIle: 0.951 ± 0.026	0.598GlnLys: 0.598 ± 0.02	2.841GlnLeu: 2.841 ± 0.039	0.463GlnMet: 0.463 ± 0.017	0.448GlnAsn: 0.448 ± 0.017	1.729GlnPro: 1.729 ± 0.033	1.16GlnGln: 1.16 ± 0.033	2.477GlnArg: 2.477 ± 0.037	1.15GlnSer: 1.15 ± 0.024	1.198GlnThr: 1.198 ± 0.03	2.226GlnVal: 2.226 ± 0.039	0.454GlnTrp: 0.454 ± 0.016	0.524GlnTyr: 0.524 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	10.498ArgAla: 10.498 ± 0.103	0.682ArgCys: 0.682 ± 0.02	4.339ArgAsp: 4.339 ± 0.06	5.06ArgGlu: 5.06 ± 0.063	2.393ArgPhe: 2.393 ± 0.036	6.245ArgGly: 6.245 ± 0.065	2.306ArgHis: 2.306 ± 0.04	2.886ArgIle: 2.886 ± 0.044	1.682ArgLys: 1.682 ± 0.036	9.292ArgLeu: 9.292 ± 0.089	1.798ArgMet: 1.798 ± 0.034	1.311ArgAsn: 1.311 ± 0.029	5.472ArgPro: 5.472 ± 0.068	2.34ArgGln: 2.34 ± 0.036	8.307ArgArg: 8.307 ± 0.079	4.003ArgSer: 4.003 ± 0.05	5.406ArgThr: 5.406 ± 0.064	6.274ArgVal: 6.274 ± 0.062	1.434ArgTrp: 1.434 ± 0.03	1.792ArgTyr: 1.792 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.574SerAla: 6.574 ± 0.067	0.419SerCys: 0.419 ± 0.014	2.396SerAsp: 2.396 ± 0.035	2.22SerGlu: 2.22 ± 0.039	1.486SerPhe: 1.486 ± 0.029	5.789SerGly: 5.789 ± 0.061	1.003SerHis: 1.003 ± 0.023	1.182SerIle: 1.182 ± 0.028	0.954SerLys: 0.954 ± 0.025	4.7SerLeu: 4.7 ± 0.058	0.996SerMet: 0.996 ± 0.023	0.73SerAsn: 0.73 ± 0.02	3.275SerPro: 3.275 ± 0.05	1.162SerGln: 1.162 ± 0.027	3.676SerArg: 3.676 ± 0.043	2.651SerSer: 2.651 ± 0.053	2.723SerThr: 2.723 ± 0.037	4.262SerVal: 4.262 ± 0.048	0.86SerTrp: 0.86 ± 0.024	1.135SerTyr: 1.135 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.928ThrAla: 8.928 ± 0.08	0.435ThrCys: 0.435 ± 0.018	3.359ThrAsp: 3.359 ± 0.051	3.036ThrGlu: 3.036 ± 0.039	1.532ThrPhe: 1.532 ± 0.03	6.929ThrGly: 6.929 ± 0.076	1.122ThrHis: 1.122 ± 0.023	1.513ThrIle: 1.513 ± 0.03	1.064ThrLys: 1.064 ± 0.027	5.561ThrLeu: 5.561 ± 0.058	0.888ThrMet: 0.888 ± 0.022	0.894ThrAsn: 0.894 ± 0.024	3.965ThrPro: 3.965 ± 0.046	1.211ThrGln: 1.211 ± 0.026	3.832ThrArg: 3.832 ± 0.055	2.874ThrSer: 2.874 ± 0.041	3.653ThrThr: 3.653 ± 0.065	5.973ThrVal: 5.973 ± 0.054	0.867ThrTrp: 0.867 ± 0.022	1.264ThrTyr: 1.264 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	11.314ValAla: 11.314 ± 0.104	0.842ValCys: 0.842 ± 0.021	4.949ValAsp: 4.949 ± 0.058	4.919ValGlu: 4.919 ± 0.057	2.499ValPhe: 2.499 ± 0.045	6.618ValGly: 6.618 ± 0.08	2.022ValHis: 2.022 ± 0.036	2.691ValIle: 2.691 ± 0.044	1.819ValLys: 1.819 ± 0.037	9.778ValLeu: 9.778 ± 0.094	1.467ValMet: 1.467 ± 0.027	1.585ValAsn: 1.585 ± 0.03	5.572ValPro: 5.572 ± 0.075	2.027ValGln: 2.027 ± 0.036	7.526ValArg: 7.526 ± 0.068	4.376ValSer: 4.376 ± 0.053	5.645ValThr: 5.645 ± 0.058	8.45ValVal: 8.45 ± 0.1	1.147ValTrp: 1.147 ± 0.028	1.548ValTyr: 1.548 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.672TrpAla: 1.672 ± 0.032	0.17TrpCys: 0.17 ± 0.01	0.834TrpAsp: 0.834 ± 0.025	0.729TrpGlu: 0.729 ± 0.021	0.506TrpPhe: 0.506 ± 0.018	1.082TrpGly: 1.082 ± 0.028	0.374TrpHis: 0.374 ± 0.014	0.474TrpIle: 0.474 ± 0.018	0.352TrpLys: 0.352 ± 0.014	1.764TrpLeu: 1.764 ± 0.034	0.288TrpMet: 0.288 ± 0.011	0.386TrpAsn: 0.386 ± 0.017	0.795TrpPro: 0.795 ± 0.023	0.613TrpGln: 0.613 ± 0.021	1.363TrpArg: 1.363 ± 0.029	0.855TrpSer: 0.855 ± 0.021	1.015TrpThr: 1.015 ± 0.025	0.997TrpVal: 0.997 ± 0.022	0.324TrpTrp: 0.324 ± 0.014	0.344TrpTyr: 0.344 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.765TyrAla: 2.765 ± 0.036	0.174TyrCys: 0.174 ± 0.009	1.388TyrAsp: 1.388 ± 0.039	1.259TyrGlu: 1.259 ± 0.031	0.614TyrPhe: 0.614 ± 0.019	2.232TyrGly: 2.232 ± 0.037	0.374TyrHis: 0.374 ± 0.015	0.397TyrIle: 0.397 ± 0.015	0.392TyrLys: 0.392 ± 0.018	2.013TyrLeu: 2.013 ± 0.036	0.24TyrMet: 0.24 ± 0.012	0.372TyrAsn: 0.372 ± 0.013	1.062TyrPro: 1.062 ± 0.025	0.517TyrGln: 0.517 ± 0.017	1.781TyrArg: 1.781 ± 0.033	0.839TyrSer: 0.839 ± 0.021	1.068TyrThr: 1.068 ± 0.026	1.67TyrVal: 1.67 ± 0.031	0.345TyrTrp: 0.345 ± 0.014	0.407TyrTyr: 0.407 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5593 proteins (1876415 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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