Amino acid dipepetide frequency for Acinetobacter sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.399AlaAla: 7.399 ± 0.094	0.84AlaCys: 0.84 ± 0.029	4.41AlaAsp: 4.41 ± 0.061	5.595AlaGlu: 5.595 ± 0.083	3.361AlaPhe: 3.361 ± 0.052	5.94AlaGly: 5.94 ± 0.098	1.674AlaHis: 1.674 ± 0.038	5.935AlaIle: 5.935 ± 0.088	5.323AlaLys: 5.323 ± 0.074	9.172AlaLeu: 9.172 ± 0.101	2.369AlaMet: 2.369 ± 0.054	3.608AlaAsn: 3.608 ± 0.065	2.797AlaPro: 2.797 ± 0.05	4.29AlaGln: 4.29 ± 0.073	3.279AlaArg: 3.279 ± 0.045	4.874AlaSer: 4.874 ± 0.067	4.519AlaThr: 4.519 ± 0.076	5.593AlaVal: 5.593 ± 0.081	1.031AlaTrp: 1.031 ± 0.034	2.729AlaTyr: 2.729 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.683CysAla: 0.683 ± 0.027	0.15CysCys: 0.15 ± 0.013	0.484CysAsp: 0.484 ± 0.021	0.47CysGlu: 0.47 ± 0.021	0.461CysPhe: 0.461 ± 0.02	0.735CysGly: 0.735 ± 0.028	0.243CysHis: 0.243 ± 0.013	0.606CysIle: 0.606 ± 0.024	0.427CysLys: 0.427 ± 0.018	0.983CysLeu: 0.983 ± 0.033	0.219CysMet: 0.219 ± 0.014	0.382CysAsn: 0.382 ± 0.018	0.412CysPro: 0.412 ± 0.023	0.398CysGln: 0.398 ± 0.018	0.375CysArg: 0.375 ± 0.016	0.591CysSer: 0.591 ± 0.025	0.444CysThr: 0.444 ± 0.019	0.617CysVal: 0.617 ± 0.023	0.084CysTrp: 0.084 ± 0.01	0.312CysTyr: 0.312 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.43AspAla: 4.43 ± 0.064	0.439AspCys: 0.439 ± 0.023	2.545AspAsp: 2.545 ± 0.052	3.434AspGlu: 3.434 ± 0.058	2.611AspPhe: 2.611 ± 0.049	3.189AspGly: 3.189 ± 0.057	1.197AspHis: 1.197 ± 0.033	3.707AspIle: 3.707 ± 0.06	2.888AspLys: 2.888 ± 0.05	5.508AspLeu: 5.508 ± 0.071	1.235AspMet: 1.235 ± 0.035	2.011AspAsn: 2.011 ± 0.043	2.044AspPro: 2.044 ± 0.039	2.645AspGln: 2.645 ± 0.051	2.266AspArg: 2.266 ± 0.054	2.612AspSer: 2.612 ± 0.047	2.285AspThr: 2.285 ± 0.052	3.593AspVal: 3.593 ± 0.057	0.791AspTrp: 0.791 ± 0.025	2.094AspTyr: 2.094 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	4.775GluAla: 4.775 ± 0.076	0.37GluCys: 0.37 ± 0.017	2.751GluAsp: 2.751 ± 0.046	3.252GluGlu: 3.252 ± 0.069	2.33GluPhe: 2.33 ± 0.051	3.272GluGly: 3.272 ± 0.055	1.442GluHis: 1.442 ± 0.037	4.372GluIle: 4.372 ± 0.075	4.258GluLys: 4.258 ± 0.067	6.027GluLeu: 6.027 ± 0.096	1.542GluMet: 1.542 ± 0.039	3.095GluAsn: 3.095 ± 0.058	1.691GluPro: 1.691 ± 0.041	3.871GluGln: 3.871 ± 0.071	2.752GluArg: 2.752 ± 0.058	2.994GluSer: 2.994 ± 0.045	3.059GluThr: 3.059 ± 0.049	3.836GluVal: 3.836 ± 0.057	0.733GluTrp: 0.733 ± 0.025	1.86GluTyr: 1.86 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.778PheAla: 3.778 ± 0.064	0.492PheCys: 0.492 ± 0.022	2.685PheAsp: 2.685 ± 0.047	2.667PheGlu: 2.667 ± 0.049	2.048PhePhe: 2.048 ± 0.05	3.256PheGly: 3.256 ± 0.06	0.815PheHis: 0.815 ± 0.025	3.276PheIle: 3.276 ± 0.061	2.836PheLys: 2.836 ± 0.055	3.972PheLeu: 3.972 ± 0.067	1.047PheMet: 1.047 ± 0.033	2.428PheAsn: 2.428 ± 0.049	1.519PhePro: 1.519 ± 0.041	1.609PheGln: 1.609 ± 0.034	1.454PheArg: 1.454 ± 0.034	3.264PheSer: 3.264 ± 0.057	2.421PheThr: 2.421 ± 0.048	2.731PheVal: 2.731 ± 0.048	0.617PheTrp: 0.617 ± 0.026	1.732PheTyr: 1.732 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	5.115GlyAla: 5.115 ± 0.08	0.766GlyCys: 0.766 ± 0.028	3.114GlyAsp: 3.114 ± 0.063	3.559GlyGlu: 3.559 ± 0.055	3.43GlyPhe: 3.43 ± 0.059	4.606GlyGly: 4.606 ± 0.095	1.458GlyHis: 1.458 ± 0.036	5.039GlyIle: 5.039 ± 0.074	4.257GlyLys: 4.257 ± 0.068	7.029GlyLeu: 7.029 ± 0.096	1.879GlyMet: 1.879 ± 0.047	2.881GlyAsn: 2.881 ± 0.062	1.525GlyPro: 1.525 ± 0.04	2.93GlyGln: 2.93 ± 0.048	2.745GlyArg: 2.745 ± 0.051	4.006GlySer: 4.006 ± 0.069	3.676GlyThr: 3.676 ± 0.063	4.704GlyVal: 4.704 ± 0.072	0.932GlyTrp: 0.932 ± 0.03	2.549GlyTyr: 2.549 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.823HisAla: 1.823 ± 0.047	0.254HisCys: 0.254 ± 0.014	1.024HisAsp: 1.024 ± 0.029	1.099HisGlu: 1.099 ± 0.034	1.185HisPhe: 1.185 ± 0.035	1.422HisGly: 1.422 ± 0.038	0.702HisHis: 0.702 ± 0.025	1.516HisIle: 1.516 ± 0.036	0.958HisLys: 0.958 ± 0.029	2.318HisLeu: 2.318 ± 0.045	0.469HisMet: 0.469 ± 0.022	0.8HisAsn: 0.8 ± 0.029	1.34HisPro: 1.34 ± 0.037	1.23HisGln: 1.23 ± 0.034	0.926HisArg: 0.926 ± 0.032	1.276HisSer: 1.276 ± 0.033	1.016HisThr: 1.016 ± 0.033	1.288HisVal: 1.288 ± 0.033	0.346HisTrp: 0.346 ± 0.016	0.918HisTyr: 0.918 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.456IleAla: 6.456 ± 0.082	0.757IleCys: 0.757 ± 0.026	4.092IleAsp: 4.092 ± 0.063	4.57IleGlu: 4.57 ± 0.061	2.868IlePhe: 2.868 ± 0.066	4.97IleGly: 4.97 ± 0.089	1.455IleHis: 1.455 ± 0.037	4.409IleIle: 4.409 ± 0.078	3.952IleLys: 3.952 ± 0.072	6.461IleLeu: 6.461 ± 0.087	1.415IleMet: 1.415 ± 0.04	3.4IleAsn: 3.4 ± 0.055	3.045IlePro: 3.045 ± 0.047	3.269IleGln: 3.269 ± 0.068	2.965IleArg: 2.965 ± 0.059	4.719IleSer: 4.719 ± 0.066	3.716IleThr: 3.716 ± 0.065	4.329IleVal: 4.329 ± 0.067	0.737IleTrp: 0.737 ± 0.029	2.297IleTyr: 2.297 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	5.185LysAla: 5.185 ± 0.085	0.323LysCys: 0.323 ± 0.016	3.305LysAsp: 3.305 ± 0.05	3.457LysGlu: 3.457 ± 0.066	2.345LysPhe: 2.345 ± 0.051	3.642LysGly: 3.642 ± 0.066	1.258LysHis: 1.258 ± 0.032	4.406LysIle: 4.406 ± 0.074	4.116LysLys: 4.116 ± 0.068	5.655LysLeu: 5.655 ± 0.07	1.68LysMet: 1.68 ± 0.04	3.342LysAsn: 3.342 ± 0.058	2.52LysPro: 2.52 ± 0.053	3.299LysGln: 3.299 ± 0.057	2.536LysArg: 2.536 ± 0.044	3.531LysSer: 3.531 ± 0.052	3.604LysThr: 3.604 ± 0.064	4.075LysVal: 4.075 ± 0.069	0.678LysTrp: 0.678 ± 0.024	2.018LysTyr: 2.018 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	9.046LeuAla: 9.046 ± 0.09	0.987LeuCys: 0.987 ± 0.032	5.466LeuAsp: 5.466 ± 0.076	5.75LeuGlu: 5.75 ± 0.093	4.397LeuPhe: 4.397 ± 0.074	6.901LeuGly: 6.901 ± 0.083	1.944LeuHis: 1.944 ± 0.043	7.032LeuIle: 7.032 ± 0.095	6.969LeuLys: 6.969 ± 0.086	9.788LeuLeu: 9.788 ± 0.131	2.618LeuMet: 2.618 ± 0.06	5.471LeuAsn: 5.471 ± 0.076	4.457LeuPro: 4.457 ± 0.064	4.342LeuGln: 4.342 ± 0.08	4.001LeuArg: 4.001 ± 0.061	7.075LeuSer: 7.075 ± 0.084	5.682LeuThr: 5.682 ± 0.075	6.064LeuVal: 6.064 ± 0.075	1.124LeuTrp: 1.124 ± 0.031	2.855LeuTyr: 2.855 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.202MetAla: 2.202 ± 0.047	0.196MetCys: 0.196 ± 0.013	1.174MetAsp: 1.174 ± 0.034	1.104MetGlu: 1.104 ± 0.031	0.915MetPhe: 0.915 ± 0.032	1.74MetGly: 1.74 ± 0.044	0.539MetHis: 0.539 ± 0.025	1.676MetIle: 1.676 ± 0.039	1.661MetLys: 1.661 ± 0.038	2.539MetLeu: 2.539 ± 0.053	0.761MetMet: 0.761 ± 0.029	1.338MetAsn: 1.338 ± 0.034	1.124MetPro: 1.124 ± 0.035	1.37MetGln: 1.37 ± 0.039	1.054MetArg: 1.054 ± 0.031	1.819MetSer: 1.819 ± 0.042	1.401MetThr: 1.401 ± 0.039	1.576MetVal: 1.576 ± 0.04	0.23MetTrp: 0.23 ± 0.015	0.605MetTyr: 0.605 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.849AsnAla: 3.849 ± 0.059	0.401AsnCys: 0.401 ± 0.019	2.291AsnAsp: 2.291 ± 0.043	2.518AsnGlu: 2.518 ± 0.05	2.262AsnPhe: 2.262 ± 0.05	3.151AsnGly: 3.151 ± 0.065	1.048AsnHis: 1.048 ± 0.032	3.573AsnIle: 3.573 ± 0.065	2.79AsnLys: 2.79 ± 0.062	4.758AsnLeu: 4.758 ± 0.071	1.097AsnMet: 1.097 ± 0.03	2.378AsnAsn: 2.378 ± 0.064	2.473AsnPro: 2.473 ± 0.048	2.36AsnGln: 2.36 ± 0.054	2.001AsnArg: 2.001 ± 0.044	2.956AsnSer: 2.956 ± 0.064	2.782AsnThr: 2.782 ± 0.054	2.956AsnVal: 2.956 ± 0.053	0.633AsnTrp: 0.633 ± 0.026	1.85AsnTyr: 1.85 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	3.22ProAla: 3.22 ± 0.057	0.277ProCys: 0.277 ± 0.017	2.164ProAsp: 2.164 ± 0.05	3.241ProGlu: 3.241 ± 0.054	1.818ProPhe: 1.818 ± 0.041	2.01ProGly: 2.01 ± 0.049	0.84ProHis: 0.84 ± 0.027	2.549ProIle: 2.549 ± 0.05	2.406ProLys: 2.406 ± 0.049	3.836ProLeu: 3.836 ± 0.052	0.914ProMet: 0.914 ± 0.031	2.085ProAsn: 2.085 ± 0.04	1.042ProPro: 1.042 ± 0.036	1.774ProGln: 1.774 ± 0.045	1.369ProArg: 1.369 ± 0.038	2.343ProSer: 2.343 ± 0.042	2.14ProThr: 2.14 ± 0.047	3.095ProVal: 3.095 ± 0.051	0.478ProTrp: 0.478 ± 0.021	1.428ProTyr: 1.428 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.447GlnAla: 4.447 ± 0.077	0.33GlnCys: 0.33 ± 0.017	2.23GlnAsp: 2.23 ± 0.046	2.456GlnGlu: 2.456 ± 0.05	2.072GlnPhe: 2.072 ± 0.042	2.922GlnGly: 2.922 ± 0.052	1.495GlnHis: 1.495 ± 0.041	3.22GlnIle: 3.22 ± 0.055	3.012GlnLys: 3.012 ± 0.053	5.296GlnLeu: 5.296 ± 0.088	1.231GlnMet: 1.231 ± 0.031	2.494GlnAsn: 2.494 ± 0.056	1.96GlnPro: 1.96 ± 0.044	3.724GlnGln: 3.724 ± 0.1	2.262GlnArg: 2.262 ± 0.05	2.794GlnSer: 2.794 ± 0.051	2.505GlnThr: 2.505 ± 0.055	3.201GlnVal: 3.201 ± 0.056	0.605GlnTrp: 0.605 ± 0.025	1.716GlnTyr: 1.716 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	3.072ArgAla: 3.072 ± 0.054	0.344ArgCys: 0.344 ± 0.019	2.141ArgAsp: 2.141 ± 0.042	2.636ArgGlu: 2.636 ± 0.052	2.058ArgPhe: 2.058 ± 0.044	2.312ArgGly: 2.312 ± 0.049	0.937ArgHis: 0.937 ± 0.031	3.068ArgIle: 3.068 ± 0.054	2.445ArgLys: 2.445 ± 0.05	4.46ArgLeu: 4.46 ± 0.074	1.113ArgMet: 1.113 ± 0.029	1.909ArgAsn: 1.909 ± 0.038	1.606ArgPro: 1.606 ± 0.049	2.099ArgGln: 2.099 ± 0.049	1.889ArgArg: 1.889 ± 0.047	2.251ArgSer: 2.251 ± 0.045	2.014ArgThr: 2.014 ± 0.04	2.577ArgVal: 2.577 ± 0.051	0.515ArgTrp: 0.515 ± 0.023	1.753ArgTyr: 1.753 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.998SerAla: 4.998 ± 0.073	0.576SerCys: 0.576 ± 0.022	2.971SerAsp: 2.971 ± 0.055	3.221SerGlu: 3.221 ± 0.059	3.039SerPhe: 3.039 ± 0.053	4.344SerGly: 4.344 ± 0.06	1.355SerHis: 1.355 ± 0.032	4.389SerIle: 4.389 ± 0.072	3.498SerLys: 3.498 ± 0.057	6.408SerLeu: 6.408 ± 0.074	1.56SerMet: 1.56 ± 0.038	2.896SerAsn: 2.896 ± 0.064	2.351SerPro: 2.351 ± 0.043	2.717SerGln: 2.717 ± 0.05	2.504SerArg: 2.504 ± 0.043	4.178SerSer: 4.178 ± 0.074	3.533SerThr: 3.533 ± 0.06	3.891SerVal: 3.891 ± 0.061	0.714SerTrp: 0.714 ± 0.026	2.221SerTyr: 2.221 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.934ThrAla: 4.934 ± 0.075	0.423ThrCys: 0.423 ± 0.02	2.776ThrAsp: 2.776 ± 0.047	3.112ThrGlu: 3.112 ± 0.054	2.27ThrPhe: 2.27 ± 0.054	4.201ThrGly: 4.201 ± 0.069	1.169ThrHis: 1.169 ± 0.032	3.565ThrIle: 3.565 ± 0.068	2.627ThrLys: 2.627 ± 0.049	5.749ThrLeu: 5.749 ± 0.072	1.044ThrMet: 1.044 ± 0.03	2.155ThrAsn: 2.155 ± 0.052	2.653ThrPro: 2.653 ± 0.044	2.56ThrGln: 2.56 ± 0.048	2.116ThrArg: 2.116 ± 0.041	3.183ThrSer: 3.183 ± 0.057	3.173ThrThr: 3.173 ± 0.071	3.816ThrVal: 3.816 ± 0.058	0.65ThrTrp: 0.65 ± 0.025	1.733ThrTyr: 1.733 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	5.567ValAla: 5.567 ± 0.079	0.655ValCys: 0.655 ± 0.027	3.58ValAsp: 3.58 ± 0.066	3.999ValGlu: 3.999 ± 0.067	2.854ValPhe: 2.854 ± 0.051	4.471ValGly: 4.471 ± 0.065	1.246ValHis: 1.246 ± 0.036	4.651ValIle: 4.651 ± 0.074	3.945ValLys: 3.945 ± 0.068	6.728ValLeu: 6.728 ± 0.085	1.752ValMet: 1.752 ± 0.04	3.248ValAsn: 3.248 ± 0.064	2.578ValPro: 2.578 ± 0.053	2.761ValGln: 2.761 ± 0.051	2.543ValArg: 2.543 ± 0.047	4.008ValSer: 4.008 ± 0.059	3.538ValThr: 3.538 ± 0.061	4.7ValVal: 4.7 ± 0.069	0.78ValTrp: 0.78 ± 0.027	1.956ValTyr: 1.956 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.871TrpAla: 0.871 ± 0.027	0.145TrpCys: 0.145 ± 0.01	0.568TrpAsp: 0.568 ± 0.023	0.51TrpGlu: 0.51 ± 0.022	0.601TrpPhe: 0.601 ± 0.023	0.757TrpGly: 0.757 ± 0.027	0.294TrpHis: 0.294 ± 0.017	0.845TrpIle: 0.845 ± 0.031	0.684TrpLys: 0.684 ± 0.021	1.541TrpLeu: 1.541 ± 0.037	0.425TrpMet: 0.425 ± 0.02	0.654TrpAsn: 0.654 ± 0.023	0.379TrpPro: 0.379 ± 0.018	0.783TrpGln: 0.783 ± 0.031	0.54TrpArg: 0.54 ± 0.021	0.752TrpSer: 0.752 ± 0.022	0.584TrpThr: 0.584 ± 0.025	0.848TrpVal: 0.848 ± 0.03	0.177TrpTrp: 0.177 ± 0.013	0.393TrpTyr: 0.393 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.889TyrAla: 2.889 ± 0.061	0.349TyrCys: 0.349 ± 0.018	1.754TyrAsp: 1.754 ± 0.04	1.63TyrGlu: 1.63 ± 0.041	1.721TyrPhe: 1.721 ± 0.043	2.357TyrGly: 2.357 ± 0.054	0.802TyrHis: 0.802 ± 0.026	2.047TyrIle: 2.047 ± 0.041	1.924TyrLys: 1.924 ± 0.044	3.745TyrLeu: 3.745 ± 0.064	0.653TyrMet: 0.653 ± 0.026	1.548TyrAsn: 1.548 ± 0.043	1.514TyrPro: 1.514 ± 0.035	1.94TyrGln: 1.94 ± 0.041	1.622TyrArg: 1.622 ± 0.038	2.138TyrSer: 2.138 ± 0.048	1.818TyrThr: 1.818 ± 0.045	2.069TyrVal: 2.069 ± 0.043	0.5TyrTrp: 0.5 ± 0.023	1.223TyrTyr: 1.223 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3709 proteins (1144572 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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