Amino acid dipepetide frequency for Altererythrobacter confluentis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.844AlaAla: 17.844 ± 0.208	1.047AlaCys: 1.047 ± 0.036	7.82AlaAsp: 7.82 ± 0.109	7.656AlaGlu: 7.656 ± 0.104	4.151AlaPhe: 4.151 ± 0.08	11.151AlaGly: 11.151 ± 0.153	2.287AlaHis: 2.287 ± 0.054	6.944AlaIle: 6.944 ± 0.09	4.228AlaLys: 4.228 ± 0.077	12.868AlaLeu: 12.868 ± 0.147	4.038AlaMet: 4.038 ± 0.081	3.528AlaAsn: 3.528 ± 0.07	5.766AlaPro: 5.766 ± 0.103	5.078AlaGln: 5.078 ± 0.089	8.753AlaArg: 8.753 ± 0.124	7.007AlaSer: 7.007 ± 0.1	5.792AlaThr: 5.792 ± 0.087	7.803AlaVal: 7.803 ± 0.103	1.486AlaTrp: 1.486 ± 0.047	2.491AlaTyr: 2.491 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	1.058CysAla: 1.058 ± 0.04	0.086CysCys: 0.086 ± 0.011	0.625CysAsp: 0.625 ± 0.028	0.504CysGlu: 0.504 ± 0.028	0.294CysPhe: 0.294 ± 0.019	0.92CysGly: 0.92 ± 0.035	0.206CysHis: 0.206 ± 0.017	0.391CysIle: 0.391 ± 0.021	0.205CysLys: 0.205 ± 0.016	0.731CysLeu: 0.731 ± 0.028	0.141CysMet: 0.141 ± 0.013	0.236CysAsn: 0.236 ± 0.015	0.442CysPro: 0.442 ± 0.023	0.237CysGln: 0.237 ± 0.017	0.493CysArg: 0.493 ± 0.025	0.493CysSer: 0.493 ± 0.025	0.41CysThr: 0.41 ± 0.023	0.618CysVal: 0.618 ± 0.029	0.122CysTrp: 0.122 ± 0.01	0.177CysTyr: 0.177 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.835AspAla: 7.835 ± 0.11	0.529AspCys: 0.529 ± 0.025	3.808AspAsp: 3.808 ± 0.082	3.793AspGlu: 3.793 ± 0.077	2.328AspPhe: 2.328 ± 0.049	5.679AspGly: 5.679 ± 0.093	1.339AspHis: 1.339 ± 0.039	3.246AspIle: 3.246 ± 0.068	1.915AspLys: 1.915 ± 0.048	5.732AspLeu: 5.732 ± 0.086	1.579AspMet: 1.579 ± 0.045	1.637AspAsn: 1.637 ± 0.045	3.351AspPro: 3.351 ± 0.065	1.988AspGln: 1.988 ± 0.054	4.604AspArg: 4.604 ± 0.071	2.643AspSer: 2.643 ± 0.069	2.905AspThr: 2.905 ± 0.062	3.968AspVal: 3.968 ± 0.071	1.039AspTrp: 1.039 ± 0.034	1.633AspTyr: 1.633 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.21GluAla: 7.21 ± 0.104	0.387GluCys: 0.387 ± 0.024	3.158GluAsp: 3.158 ± 0.064	3.283GluGlu: 3.283 ± 0.087	2.006GluPhe: 2.006 ± 0.05	4.355GluGly: 4.355 ± 0.073	1.084GluHis: 1.084 ± 0.039	3.289GluIle: 3.289 ± 0.064	2.468GluLys: 2.468 ± 0.063	5.502GluLeu: 5.502 ± 0.084	1.778GluMet: 1.778 ± 0.05	1.923GluAsn: 1.923 ± 0.049	2.391GluPro: 2.391 ± 0.054	2.313GluGln: 2.313 ± 0.05	4.384GluArg: 4.384 ± 0.075	2.28GluSer: 2.28 ± 0.052	3.456GluThr: 3.456 ± 0.07	3.433GluVal: 3.433 ± 0.073	0.849GluTrp: 0.849 ± 0.029	1.214GluTyr: 1.214 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.947PheAla: 4.947 ± 0.08	0.372PheCys: 0.372 ± 0.02	2.772PheAsp: 2.772 ± 0.064	2.138PheGlu: 2.138 ± 0.051	1.304PhePhe: 1.304 ± 0.046	3.641PheGly: 3.641 ± 0.072	0.708PheHis: 0.708 ± 0.031	1.679PheIle: 1.679 ± 0.048	0.938PheLys: 0.938 ± 0.034	3.169PheLeu: 3.169 ± 0.071	0.788PheMet: 0.788 ± 0.028	1.034PheAsn: 1.034 ± 0.038	1.52PhePro: 1.52 ± 0.042	0.928PheGln: 0.928 ± 0.032	2.154PheArg: 2.154 ± 0.049	2.296PheSer: 2.296 ± 0.055	2.085PheThr: 2.085 ± 0.053	2.598PheVal: 2.598 ± 0.057	0.512PheTrp: 0.512 ± 0.026	0.932PheTyr: 0.932 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	9.58GlyAla: 9.58 ± 0.131	0.827GlyCys: 0.827 ± 0.036	4.919GlyAsp: 4.919 ± 0.091	4.721GlyGlu: 4.721 ± 0.078	3.606GlyPhe: 3.606 ± 0.063	7.697GlyGly: 7.697 ± 0.164	1.825GlyHis: 1.825 ± 0.044	4.752GlyIle: 4.752 ± 0.13	3.675GlyLys: 3.675 ± 0.063	8.332GlyLeu: 8.332 ± 0.102	2.578GlyMet: 2.578 ± 0.06	2.635GlyAsn: 2.635 ± 0.072	3.557GlyPro: 3.557 ± 0.07	3.267GlyGln: 3.267 ± 0.065	5.727GlyArg: 5.727 ± 0.093	5.02GlySer: 5.02 ± 0.109	4.931GlyThr: 4.931 ± 0.119	5.642GlyVal: 5.642 ± 0.086	1.572GlyTrp: 1.572 ± 0.045	2.113GlyTyr: 2.113 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.258HisAla: 2.258 ± 0.055	0.27HisCys: 0.27 ± 0.018	1.301HisAsp: 1.301 ± 0.04	1.05HisGlu: 1.05 ± 0.034	0.829HisPhe: 0.829 ± 0.031	1.944HisGly: 1.944 ± 0.052	0.543HisHis: 0.543 ± 0.028	1.038HisIle: 1.038 ± 0.037	0.528HisLys: 0.528 ± 0.027	1.871HisLeu: 1.871 ± 0.046	0.449HisMet: 0.449 ± 0.023	0.505HisAsn: 0.505 ± 0.024	1.181HisPro: 1.181 ± 0.039	0.623HisGln: 0.623 ± 0.028	1.292HisArg: 1.292 ± 0.045	1.119HisSer: 1.119 ± 0.031	0.791HisThr: 0.791 ± 0.033	1.258HisVal: 1.258 ± 0.04	0.333HisTrp: 0.333 ± 0.02	0.558HisTyr: 0.558 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.737IleAla: 7.737 ± 0.108	0.524IleCys: 0.524 ± 0.027	3.996IleAsp: 3.996 ± 0.07	3.499IleGlu: 3.499 ± 0.072	1.806IlePhe: 1.806 ± 0.048	5.059IleGly: 5.059 ± 0.085	0.884IleHis: 0.884 ± 0.036	2.731IleIle: 2.731 ± 0.063	1.425IleLys: 1.425 ± 0.044	4.15IleLeu: 4.15 ± 0.075	1.136IleMet: 1.136 ± 0.035	1.518IleAsn: 1.518 ± 0.047	2.352IlePro: 2.352 ± 0.057	1.187IleGln: 1.187 ± 0.038	3.26IleArg: 3.26 ± 0.063	3.212IleSer: 3.212 ± 0.059	2.895IleThr: 2.895 ± 0.085	3.978IleVal: 3.978 ± 0.077	0.667IleTrp: 0.667 ± 0.028	1.126IleTyr: 1.126 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.103LysAla: 4.103 ± 0.083	0.188LysCys: 0.188 ± 0.014	1.667LysAsp: 1.667 ± 0.051	1.441LysGlu: 1.441 ± 0.05	1.077LysPhe: 1.077 ± 0.037	2.675LysGly: 2.675 ± 0.059	0.648LysHis: 0.648 ± 0.031	1.792LysIle: 1.792 ± 0.052	1.383LysLys: 1.383 ± 0.059	3.495LysLeu: 3.495 ± 0.068	0.961LysMet: 0.961 ± 0.039	0.939LysAsn: 0.939 ± 0.034	1.963LysPro: 1.963 ± 0.055	1.092LysGln: 1.092 ± 0.04	2.421LysArg: 2.421 ± 0.058	1.915LysSer: 1.915 ± 0.048	1.858LysThr: 1.858 ± 0.044	2.251LysVal: 2.251 ± 0.058	0.477LysTrp: 0.477 ± 0.023	0.633LysTyr: 0.633 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	13.982LeuAla: 13.982 ± 0.167	0.79LeuCys: 0.79 ± 0.031	6.084LeuAsp: 6.084 ± 0.084	5.359LeuGlu: 5.359 ± 0.088	3.451LeuPhe: 3.451 ± 0.065	8.186LeuGly: 8.186 ± 0.094	1.816LeuHis: 1.816 ± 0.045	4.561LeuIle: 4.561 ± 0.076	3.126LeuLys: 3.126 ± 0.063	9.021LeuLeu: 9.021 ± 0.142	2.283LeuMet: 2.283 ± 0.06	2.369LeuAsn: 2.369 ± 0.054	5.378LeuPro: 5.378 ± 0.086	2.788LeuGln: 2.788 ± 0.055	6.346LeuArg: 6.346 ± 0.11	5.944LeuSer: 5.944 ± 0.095	5.369LeuThr: 5.369 ± 0.083	7.305LeuVal: 7.305 ± 0.104	1.123LeuTrp: 1.123 ± 0.037	1.816LeuTyr: 1.816 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.731MetAla: 3.731 ± 0.073	0.173MetCys: 0.173 ± 0.014	1.343MetAsp: 1.343 ± 0.042	1.335MetGlu: 1.335 ± 0.037	0.693MetPhe: 0.693 ± 0.03	2.131MetGly: 2.131 ± 0.053	0.482MetHis: 0.482 ± 0.022	1.392MetIle: 1.392 ± 0.048	0.99MetLys: 0.99 ± 0.033	2.829MetLeu: 2.829 ± 0.063	0.727MetMet: 0.727 ± 0.03	0.828MetAsn: 0.828 ± 0.031	1.568MetPro: 1.568 ± 0.041	0.971MetGln: 0.971 ± 0.033	1.879MetArg: 1.879 ± 0.043	1.489MetSer: 1.489 ± 0.043	1.64MetThr: 1.64 ± 0.047	1.904MetVal: 1.904 ± 0.056	0.268MetTrp: 0.268 ± 0.017	0.286MetTyr: 0.286 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.49AsnAla: 3.49 ± 0.065	0.288AsnCys: 0.288 ± 0.02	1.588AsnAsp: 1.588 ± 0.045	1.264AsnGlu: 1.264 ± 0.037	1.116AsnPhe: 1.116 ± 0.039	2.612AsnGly: 2.612 ± 0.078	0.506AsnHis: 0.506 ± 0.024	1.559AsnIle: 1.559 ± 0.042	0.716AsnLys: 0.716 ± 0.029	2.735AsnLeu: 2.735 ± 0.059	0.644AsnMet: 0.644 ± 0.031	0.759AsnAsn: 0.759 ± 0.035	1.856AsnPro: 1.856 ± 0.052	0.875AsnGln: 0.875 ± 0.029	1.969AsnArg: 1.969 ± 0.056	1.565AsnSer: 1.565 ± 0.05	1.296AsnThr: 1.296 ± 0.041	2.034AsnVal: 2.034 ± 0.052	0.447AsnTrp: 0.447 ± 0.02	0.708AsnTyr: 0.708 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	6.572ProAla: 6.572 ± 0.116	0.319ProCys: 0.319 ± 0.02	3.612ProAsp: 3.612 ± 0.061	3.607ProGlu: 3.607 ± 0.066	1.9ProPhe: 1.9 ± 0.044	4.13ProGly: 4.13 ± 0.076	1.012ProHis: 1.012 ± 0.038	2.32ProIle: 2.32 ± 0.045	1.481ProLys: 1.481 ± 0.044	4.663ProLeu: 4.663 ± 0.076	1.22ProMet: 1.22 ± 0.042	1.173ProAsn: 1.173 ± 0.037	2.409ProPro: 2.409 ± 0.075	1.931ProGln: 1.931 ± 0.048	2.812ProArg: 2.812 ± 0.065	2.629ProSer: 2.629 ± 0.056	2.276ProThr: 2.276 ± 0.051	4.203ProVal: 4.203 ± 0.081	0.623ProTrp: 0.623 ± 0.029	1.042ProTyr: 1.042 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.257GlnAla: 4.257 ± 0.085	0.295GlnCys: 0.295 ± 0.017	1.731GlnAsp: 1.731 ± 0.055	1.578GlnGlu: 1.578 ± 0.041	1.304GlnPhe: 1.304 ± 0.036	2.649GlnGly: 2.649 ± 0.064	0.717GlnHis: 0.717 ± 0.03	2.073GlnIle: 2.073 ± 0.045	1.114GlnLys: 1.114 ± 0.035	3.459GlnLeu: 3.459 ± 0.062	1.052GlnMet: 1.052 ± 0.036	0.946GlnAsn: 0.946 ± 0.031	1.972GlnPro: 1.972 ± 0.048	1.593GlnGln: 1.593 ± 0.053	2.545GlnArg: 2.545 ± 0.056	2.043GlnSer: 2.043 ± 0.06	1.819GlnThr: 1.819 ± 0.047	2.433GlnVal: 2.433 ± 0.057	0.528GlnTrp: 0.528 ± 0.024	0.68GlnTyr: 0.68 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	7.517ArgAla: 7.517 ± 0.115	0.456ArgCys: 0.456 ± 0.024	4.183ArgAsp: 4.183 ± 0.067	4.083ArgGlu: 4.083 ± 0.081	2.885ArgPhe: 2.885 ± 0.064	4.736ArgGly: 4.736 ± 0.081	1.549ArgHis: 1.549 ± 0.046	4.07ArgIle: 4.07 ± 0.079	2.56ArgLys: 2.56 ± 0.059	7.355ArgLeu: 7.355 ± 0.108	1.992ArgMet: 1.992 ± 0.053	2.048ArgAsn: 2.048 ± 0.049	3.094ArgPro: 3.094 ± 0.069	2.69ArgGln: 2.69 ± 0.063	4.826ArgArg: 4.826 ± 0.088	3.847ArgSer: 3.847 ± 0.072	3.231ArgThr: 3.231 ± 0.057	4.129ArgVal: 4.129 ± 0.072	1.032ArgTrp: 1.032 ± 0.034	1.657ArgTyr: 1.657 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	7.075SerAla: 7.075 ± 0.103	0.453SerCys: 0.453 ± 0.021	3.466SerAsp: 3.466 ± 0.064	2.953SerGlu: 2.953 ± 0.06	2.236SerPhe: 2.236 ± 0.052	5.876SerGly: 5.876 ± 0.107	1.051SerHis: 1.051 ± 0.038	2.893SerIle: 2.893 ± 0.063	1.606SerLys: 1.606 ± 0.043	5.355SerLeu: 5.355 ± 0.076	1.373SerMet: 1.373 ± 0.039	1.526SerAsn: 1.526 ± 0.045	2.791SerPro: 2.791 ± 0.059	1.979SerGln: 1.979 ± 0.05	3.792SerArg: 3.792 ± 0.068	3.159SerSer: 3.159 ± 0.07	2.747SerThr: 2.747 ± 0.069	3.692SerVal: 3.692 ± 0.071	0.798SerTrp: 0.798 ± 0.032	1.304SerTyr: 1.304 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.179ThrAla: 6.179 ± 0.108	0.438ThrCys: 0.438 ± 0.024	3.043ThrAsp: 3.043 ± 0.061	2.45ThrGlu: 2.45 ± 0.06	1.832ThrPhe: 1.832 ± 0.048	5.384ThrGly: 5.384 ± 0.121	0.981ThrHis: 0.981 ± 0.039	3.013ThrIle: 3.013 ± 0.068	1.362ThrLys: 1.362 ± 0.039	5.338ThrLeu: 5.338 ± 0.099	1.305ThrMet: 1.305 ± 0.038	1.361ThrAsn: 1.361 ± 0.052	3.056ThrPro: 3.056 ± 0.055	1.775ThrGln: 1.775 ± 0.045	3.279ThrArg: 3.279 ± 0.064	3.042ThrSer: 3.042 ± 0.074	2.577ThrThr: 2.577 ± 0.075	3.936ThrVal: 3.936 ± 0.084	0.511ThrTrp: 0.511 ± 0.027	1.179ThrTyr: 1.179 ± 0.046	0.001ThrXaa: 0.001 ± 0.001
Val	8.508ValAla: 8.508 ± 0.112	0.568ValCys: 0.568 ± 0.029	4.194ValAsp: 4.194 ± 0.078	4.306ValGlu: 4.306 ± 0.076	2.214ValPhe: 2.214 ± 0.054	5.154ValGly: 5.154 ± 0.087	1.262ValHis: 1.262 ± 0.041	3.783ValIle: 3.783 ± 0.076	2.171ValLys: 2.171 ± 0.055	6.591ValLeu: 6.591 ± 0.1	1.813ValMet: 1.813 ± 0.046	2.031ValAsn: 2.031 ± 0.056	3.619ValPro: 3.619 ± 0.065	2.04ValGln: 2.04 ± 0.053	4.469ValArg: 4.469 ± 0.072	4.277ValSer: 4.277 ± 0.077	4.257ValThr: 4.257 ± 0.094	4.736ValVal: 4.736 ± 0.084	0.841ValTrp: 0.841 ± 0.033	1.26ValTyr: 1.26 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.383TrpAla: 1.383 ± 0.049	0.125TrpCys: 0.125 ± 0.013	0.715TrpAsp: 0.715 ± 0.026	0.587TrpGlu: 0.587 ± 0.026	0.588TrpPhe: 0.588 ± 0.021	0.914TrpGly: 0.914 ± 0.033	0.371TrpHis: 0.371 ± 0.02	0.674TrpIle: 0.674 ± 0.031	0.486TrpLys: 0.486 ± 0.023	1.806TrpLeu: 1.806 ± 0.049	0.405TrpMet: 0.405 ± 0.021	0.453TrpAsn: 0.453 ± 0.022	0.617TrpPro: 0.617 ± 0.027	0.73TrpGln: 0.73 ± 0.029	1.141TrpArg: 1.141 ± 0.035	0.833TrpSer: 0.833 ± 0.036	0.718TrpThr: 0.718 ± 0.029	0.748TrpVal: 0.748 ± 0.03	0.243TrpTrp: 0.243 ± 0.016	0.27TrpTyr: 0.27 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.474TyrAla: 2.474 ± 0.053	0.254TyrCys: 0.254 ± 0.017	1.527TyrAsp: 1.527 ± 0.048	1.156TyrGlu: 1.156 ± 0.043	0.893TyrPhe: 0.893 ± 0.03	2.082TyrGly: 2.082 ± 0.051	0.466TyrHis: 0.466 ± 0.023	0.942TyrIle: 0.942 ± 0.035	0.602TyrLys: 0.602 ± 0.028	2.094TyrLeu: 2.094 ± 0.048	0.396TyrMet: 0.396 ± 0.022	0.58TyrAsn: 0.58 ± 0.026	1.05TyrPro: 1.05 ± 0.038	0.703TyrGln: 0.703 ± 0.027	1.795TyrArg: 1.795 ± 0.053	1.311TyrSer: 1.311 ± 0.043	0.989TyrThr: 0.989 ± 0.048	1.426TyrVal: 1.426 ± 0.038	0.337TyrTrp: 0.337 ± 0.019	0.6TyrTyr: 0.6 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 2678 proteins (877066 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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