Amino acid dipepetide frequency for Scytonema millei VB511283

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.95AlaAla: 6.95 ± 0.091	0.843AlaCys: 0.843 ± 0.024	3.762AlaAsp: 3.762 ± 0.053	4.841AlaGlu: 4.841 ± 0.07	3.148AlaPhe: 3.148 ± 0.059	5.047AlaGly: 5.047 ± 0.068	1.289AlaHis: 1.289 ± 0.028	6.311AlaIle: 6.311 ± 0.082	4.209AlaLys: 4.209 ± 0.062	8.539AlaLeu: 8.539 ± 0.1	1.637AlaMet: 1.637 ± 0.034	3.329AlaAsn: 3.329 ± 0.07	2.668AlaPro: 2.668 ± 0.047	4.272AlaGln: 4.272 ± 0.06	3.535AlaArg: 3.535 ± 0.053	4.905AlaSer: 4.905 ± 0.069	4.518AlaThr: 4.518 ± 0.058	5.646AlaVal: 5.646 ± 0.07	1.004AlaTrp: 1.004 ± 0.028	2.463AlaTyr: 2.463 ± 0.041	0.004AlaXaa: 0.004 ± 0.002
Cys	0.677CysAla: 0.677 ± 0.023	0.197CysCys: 0.197 ± 0.01	0.539CysAsp: 0.539 ± 0.019	0.587CysGlu: 0.587 ± 0.022	0.475CysPhe: 0.475 ± 0.018	0.798CysGly: 0.798 ± 0.021	0.263CysHis: 0.263 ± 0.013	0.602CysIle: 0.602 ± 0.02	0.43CysLys: 0.43 ± 0.018	1.174CysLeu: 1.174 ± 0.034	0.176CysMet: 0.176 ± 0.012	0.401CysAsn: 0.401 ± 0.017	0.543CysPro: 0.543 ± 0.021	0.587CysGln: 0.587 ± 0.021	0.552CysArg: 0.552 ± 0.022	0.682CysSer: 0.682 ± 0.022	0.508CysThr: 0.508 ± 0.019	0.649CysVal: 0.649 ± 0.023	0.15CysTrp: 0.15 ± 0.011	0.361CysTyr: 0.361 ± 0.018	0.001CysXaa: 0.001 ± 0.001
Asp	3.644AspAla: 3.644 ± 0.052	0.526AspCys: 0.526 ± 0.02	2.154AspAsp: 2.154 ± 0.046	3.146AspGlu: 3.146 ± 0.05	2.375AspPhe: 2.375 ± 0.041	3.257AspGly: 3.257 ± 0.062	0.619AspHis: 0.619 ± 0.021	3.431AspIle: 3.431 ± 0.058	2.531AspLys: 2.531 ± 0.043	5.164AspLeu: 5.164 ± 0.069	0.764AspMet: 0.764 ± 0.023	2.089AspAsn: 2.089 ± 0.041	2.122AspPro: 2.122 ± 0.042	1.519AspGln: 1.519 ± 0.035	2.629AspArg: 2.629 ± 0.054	2.976AspSer: 2.976 ± 0.048	2.503AspThr: 2.503 ± 0.042	3.14AspVal: 3.14 ± 0.05	0.851AspTrp: 0.851 ± 0.025	1.861AspTyr: 1.861 ± 0.04	0.001AspXaa: 0.001 ± 0.001
Glu	5.386GluAla: 5.386 ± 0.076	0.537GluCys: 0.537 ± 0.021	2.661GluAsp: 2.661 ± 0.05	4.376GluGlu: 4.376 ± 0.063	2.566GluPhe: 2.566 ± 0.039	3.168GluGly: 3.168 ± 0.047	1.087GluHis: 1.087 ± 0.03	4.7GluIle: 4.7 ± 0.056	3.753GluLys: 3.753 ± 0.056	7.096GluLeu: 7.096 ± 0.075	1.362GluMet: 1.362 ± 0.033	2.85GluAsn: 2.85 ± 0.047	2.39GluPro: 2.39 ± 0.042	3.895GluGln: 3.895 ± 0.062	3.621GluArg: 3.621 ± 0.057	3.314GluSer: 3.314 ± 0.048	3.286GluThr: 3.286 ± 0.046	4.448GluVal: 4.448 ± 0.051	0.86GluTrp: 0.86 ± 0.024	2.113GluTyr: 2.113 ± 0.046	0.003GluXaa: 0.003 ± 0.001
Phe	3.27PheAla: 3.27 ± 0.048	0.561PheCys: 0.561 ± 0.02	2.18PheAsp: 2.18 ± 0.04	2.384PheGlu: 2.384 ± 0.047	1.92PhePhe: 1.92 ± 0.04	2.951PheGly: 2.951 ± 0.044	0.86PheHis: 0.86 ± 0.026	2.459PheIle: 2.459 ± 0.051	1.77PheLys: 1.77 ± 0.037	4.3PheLeu: 4.3 ± 0.061	0.671PheMet: 0.671 ± 0.022	1.819PheAsn: 1.819 ± 0.037	1.859PhePro: 1.859 ± 0.035	1.805PheGln: 1.805 ± 0.036	1.925PheArg: 1.925 ± 0.042	3.007PheSer: 3.007 ± 0.051	2.309PheThr: 2.309 ± 0.04	2.666PheVal: 2.666 ± 0.045	0.706PheTrp: 0.706 ± 0.023	1.426PheTyr: 1.426 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	4.481GlyAla: 4.481 ± 0.072	0.801GlyCys: 0.801 ± 0.025	3.124GlyAsp: 3.124 ± 0.048	4.061GlyGlu: 4.061 ± 0.054	2.966GlyPhe: 2.966 ± 0.046	4.498GlyGly: 4.498 ± 0.079	1.283GlyHis: 1.283 ± 0.038	4.84GlyIle: 4.84 ± 0.051	4.109GlyLys: 4.109 ± 0.056	6.66GlyLeu: 6.66 ± 0.077	1.406GlyMet: 1.406 ± 0.035	3.01GlyAsn: 3.01 ± 0.073	1.302GlyPro: 1.302 ± 0.035	2.743GlyGln: 2.743 ± 0.05	3.271GlyArg: 3.271 ± 0.049	4.123GlySer: 4.123 ± 0.067	3.74GlyThr: 3.74 ± 0.057	4.736GlyVal: 4.736 ± 0.062	1.087GlyTrp: 1.087 ± 0.028	2.351GlyTyr: 2.351 ± 0.042	0.005GlyXaa: 0.005 ± 0.002
His	1.105HisAla: 1.105 ± 0.029	0.266HisCys: 0.266 ± 0.014	0.78HisAsp: 0.78 ± 0.026	0.998HisGlu: 0.998 ± 0.029	0.846HisPhe: 0.846 ± 0.022	1.169HisGly: 1.169 ± 0.032	0.587HisHis: 0.587 ± 0.022	1.134HisIle: 1.134 ± 0.028	0.96HisLys: 0.96 ± 0.026	2.218HisLeu: 2.218 ± 0.046	0.268HisMet: 0.268 ± 0.014	0.789HisAsn: 0.789 ± 0.023	1.284HisPro: 1.284 ± 0.031	1.148HisGln: 1.148 ± 0.028	1.081HisArg: 1.081 ± 0.028	1.306HisSer: 1.306 ± 0.035	1.013HisThr: 1.013 ± 0.029	0.903HisVal: 0.903 ± 0.026	0.354HisTrp: 0.354 ± 0.016	0.686HisTyr: 0.686 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.586IleAla: 6.586 ± 0.069	0.801IleCys: 0.801 ± 0.021	3.475IleAsp: 3.475 ± 0.051	4.238IleGlu: 4.238 ± 0.056	2.498IlePhe: 2.498 ± 0.046	4.439IleGly: 4.439 ± 0.071	1.326IleHis: 1.326 ± 0.033	3.617IleIle: 3.617 ± 0.053	3.132IleLys: 3.132 ± 0.06	6.655IleLeu: 6.655 ± 0.073	0.817IleMet: 0.817 ± 0.024	2.903IleAsn: 2.903 ± 0.053	3.436IlePro: 3.436 ± 0.052	2.976IleGln: 2.976 ± 0.05	3.221IleArg: 3.221 ± 0.049	4.509IleSer: 4.509 ± 0.061	3.583IleThr: 3.583 ± 0.057	4.308IleVal: 4.308 ± 0.062	0.855IleTrp: 0.855 ± 0.024	1.94IleTyr: 1.94 ± 0.035	0.001IleXaa: 0.001 ± 0.001
Lys	4.293LysAla: 4.293 ± 0.058	0.359LysCys: 0.359 ± 0.016	2.45LysAsp: 2.45 ± 0.049	3.296LysGlu: 3.296 ± 0.059	1.953LysPhe: 1.953 ± 0.039	2.931LysGly: 2.931 ± 0.048	0.96LysHis: 0.96 ± 0.026	3.461LysIle: 3.461 ± 0.052	2.711LysLys: 2.711 ± 0.054	5.688LysLeu: 5.688 ± 0.074	0.981LysMet: 0.981 ± 0.024	2.365LysAsn: 2.365 ± 0.048	2.629LysPro: 2.629 ± 0.047	3.093LysGln: 3.093 ± 0.051	2.738LysArg: 2.738 ± 0.045	3.191LysSer: 3.191 ± 0.039	3.158LysThr: 3.158 ± 0.053	3.521LysVal: 3.521 ± 0.053	0.56LysTrp: 0.56 ± 0.022	1.577LysTyr: 1.577 ± 0.035	0.001LysXaa: 0.001 ± 0.001
Leu	9.216LeuAla: 9.216 ± 0.096	1.094LeuCys: 1.094 ± 0.03	5.089LeuAsp: 5.089 ± 0.059	7.196LeuGlu: 7.196 ± 0.076	4.011LeuPhe: 4.011 ± 0.062	7.237LeuGly: 7.237 ± 0.081	2.015LeuHis: 2.015 ± 0.036	6.348LeuIle: 6.348 ± 0.067	5.798LeuLys: 5.798 ± 0.068	11.646LeuLeu: 11.646 ± 0.121	2.052LeuMet: 2.052 ± 0.041	4.689LeuAsn: 4.689 ± 0.074	5.623LeuPro: 5.623 ± 0.073	5.897LeuGln: 5.897 ± 0.067	5.799LeuArg: 5.799 ± 0.076	7.641LeuSer: 7.641 ± 0.085	6.239LeuThr: 6.239 ± 0.069	7.471LeuVal: 7.471 ± 0.084	1.49LeuTrp: 1.49 ± 0.041	2.846LeuTyr: 2.846 ± 0.049	0.002LeuXaa: 0.002 ± 0.001
Met	1.583MetAla: 1.583 ± 0.034	0.132MetCys: 0.132 ± 0.01	0.67MetAsp: 0.67 ± 0.023	0.961MetGlu: 0.961 ± 0.024	0.597MetPhe: 0.597 ± 0.02	1.15MetGly: 1.15 ± 0.03	0.323MetHis: 0.323 ± 0.015	1.068MetIle: 1.068 ± 0.027	1.042MetLys: 1.042 ± 0.027	1.994MetLeu: 1.994 ± 0.034	0.394MetMet: 0.394 ± 0.016	0.865MetAsn: 0.865 ± 0.021	0.891MetPro: 0.891 ± 0.026	0.995MetGln: 0.995 ± 0.029	0.998MetArg: 0.998 ± 0.027	1.349MetSer: 1.349 ± 0.032	1.335MetThr: 1.335 ± 0.029	1.284MetVal: 1.284 ± 0.029	0.169MetTrp: 0.169 ± 0.01	0.366MetTyr: 0.366 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.081AsnAla: 3.081 ± 0.056	0.493AsnCys: 0.493 ± 0.019	1.723AsnAsp: 1.723 ± 0.034	2.032AsnGlu: 2.032 ± 0.041	1.992AsnPhe: 1.992 ± 0.043	2.784AsnGly: 2.784 ± 0.065	0.894AsnHis: 0.894 ± 0.025	2.921AsnIle: 2.921 ± 0.056	1.949AsnLys: 1.949 ± 0.042	5.378AsnLeu: 5.378 ± 0.088	0.642AsnMet: 0.642 ± 0.021	2.119AsnAsn: 2.119 ± 0.054	2.872AsnPro: 2.872 ± 0.044	2.603AsnGln: 2.603 ± 0.052	2.463AsnArg: 2.463 ± 0.043	3.143AsnSer: 3.143 ± 0.058	2.354AsnThr: 2.354 ± 0.048	2.411AsnVal: 2.411 ± 0.046	0.745AsnTrp: 0.745 ± 0.021	1.521AsnTyr: 1.521 ± 0.035	0.003AsnXaa: 0.003 ± 0.001
Pro	2.937ProAla: 2.937 ± 0.046	0.334ProCys: 0.334 ± 0.018	2.905ProAsp: 2.905 ± 0.051	3.727ProGlu: 3.727 ± 0.055	1.775ProPhe: 1.775 ± 0.033	2.902ProGly: 2.902 ± 0.047	0.874ProHis: 0.874 ± 0.023	2.931ProIle: 2.931 ± 0.051	2.425ProLys: 2.425 ± 0.043	4.531ProLeu: 4.531 ± 0.058	0.754ProMet: 0.754 ± 0.023	2.334ProAsn: 2.334 ± 0.043	2.183ProPro: 2.183 ± 0.046	2.548ProGln: 2.548 ± 0.043	1.789ProArg: 1.789 ± 0.038	2.922ProSer: 2.922 ± 0.047	2.795ProThr: 2.795 ± 0.047	3.291ProVal: 3.291 ± 0.055	0.6ProTrp: 0.6 ± 0.02	1.317ProTyr: 1.317 ± 0.034	0.001ProXaa: 0.001 ± 0.001
Gln	4.647GlnAla: 4.647 ± 0.06	0.362GlnCys: 0.362 ± 0.016	2.095GlnAsp: 2.095 ± 0.042	3.829GlnGlu: 3.829 ± 0.053	1.752GlnPhe: 1.752 ± 0.036	3.018GlnGly: 3.018 ± 0.049	0.931GlnHis: 0.931 ± 0.027	3.557GlnIle: 3.557 ± 0.056	3.147GlnLys: 3.147 ± 0.052	6.117GlnLeu: 6.117 ± 0.076	1.076GlnMet: 1.076 ± 0.026	2.169GlnAsn: 2.169 ± 0.042	2.59GlnPro: 2.59 ± 0.042	4.042GlnGln: 4.042 ± 0.07	3.05GlnArg: 3.05 ± 0.05	2.8GlnSer: 2.8 ± 0.052	3.069GlnThr: 3.069 ± 0.051	3.878GlnVal: 3.878 ± 0.052	0.652GlnTrp: 0.652 ± 0.022	1.346GlnTyr: 1.346 ± 0.03	0.001GlnXaa: 0.001 ± 0.001
Arg	3.249ArgAla: 3.249 ± 0.049	0.528ArgCys: 0.528 ± 0.02	2.498ArgAsp: 2.498 ± 0.05	3.359ArgGlu: 3.359 ± 0.058	2.308ArgPhe: 2.308 ± 0.043	2.837ArgGly: 2.837 ± 0.05	1.051ArgHis: 1.051 ± 0.028	3.423ArgIle: 3.423 ± 0.049	2.579ArgLys: 2.579 ± 0.046	6.055ArgLeu: 6.055 ± 0.067	1.045ArgMet: 1.045 ± 0.026	2.238ArgAsn: 2.238 ± 0.038	1.993ArgPro: 1.993 ± 0.033	3.221ArgGln: 3.221 ± 0.044	3.2ArgArg: 3.2 ± 0.058	3.212ArgSer: 3.212 ± 0.053	2.658ArgThr: 2.658 ± 0.042	3.55ArgVal: 3.55 ± 0.057	0.843ArgTrp: 0.843 ± 0.027	2.002ArgTyr: 2.002 ± 0.045	0.001ArgXaa: 0.001 ± 0.001
Ser	4.468SerAla: 4.468 ± 0.058	0.682SerCys: 0.682 ± 0.023	3.091SerAsp: 3.091 ± 0.049	3.786SerGlu: 3.786 ± 0.054	2.811SerPhe: 2.811 ± 0.05	4.635SerGly: 4.635 ± 0.065	1.338SerHis: 1.338 ± 0.029	3.847SerIle: 3.847 ± 0.056	3.057SerLys: 3.057 ± 0.043	7.142SerLeu: 7.142 ± 0.083	1.164SerMet: 1.164 ± 0.03	2.787SerAsn: 2.787 ± 0.049	3.325SerPro: 3.325 ± 0.06	3.675SerGln: 3.675 ± 0.047	3.247SerArg: 3.247 ± 0.046	4.695SerSer: 4.695 ± 0.071	3.696SerThr: 3.696 ± 0.052	4.351SerVal: 4.351 ± 0.058	0.923SerTrp: 0.923 ± 0.027	1.86SerTyr: 1.86 ± 0.035	0.002SerXaa: 0.002 ± 0.001
Thr	4.595ThrAla: 4.595 ± 0.064	0.497ThrCys: 0.497 ± 0.021	2.591ThrAsp: 2.591 ± 0.045	3.206ThrGlu: 3.206 ± 0.056	2.167ThrPhe: 2.167 ± 0.037	4.16ThrGly: 4.16 ± 0.063	1.064ThrHis: 1.064 ± 0.025	3.632ThrIle: 3.632 ± 0.059	2.492ThrLys: 2.492 ± 0.045	6.353ThrLeu: 6.353 ± 0.08	0.793ThrMet: 0.793 ± 0.024	2.371ThrAsn: 2.371 ± 0.042	3.347ThrPro: 3.347 ± 0.053	2.981ThrGln: 2.981 ± 0.046	2.485ThrArg: 2.485 ± 0.038	3.602ThrSer: 3.602 ± 0.055	3.392ThrThr: 3.392 ± 0.059	4.146ThrVal: 4.146 ± 0.056	0.682ThrTrp: 0.682 ± 0.023	1.691ThrTyr: 1.691 ± 0.035	0.002ThrXaa: 0.002 ± 0.001
Val	5.805ValAla: 5.805 ± 0.071	0.768ValCys: 0.768 ± 0.024	3.371ValAsp: 3.371 ± 0.053	4.699ValGlu: 4.699 ± 0.067	2.716ValPhe: 2.716 ± 0.047	4.612ValGly: 4.612 ± 0.06	1.083ValHis: 1.083 ± 0.032	4.376ValIle: 4.376 ± 0.058	3.648ValLys: 3.648 ± 0.06	7.138ValLeu: 7.138 ± 0.076	1.399ValMet: 1.399 ± 0.034	2.976ValAsn: 2.976 ± 0.049	2.981ValPro: 2.981 ± 0.047	3.105ValGln: 3.105 ± 0.051	3.392ValArg: 3.392 ± 0.051	4.371ValSer: 4.371 ± 0.054	3.838ValThr: 3.838 ± 0.052	5.199ValVal: 5.199 ± 0.072	0.898ValTrp: 0.898 ± 0.029	2.005ValTyr: 2.005 ± 0.04	0.003ValXaa: 0.003 ± 0.001
Trp	0.832TrpAla: 0.832 ± 0.026	0.168TrpCys: 0.168 ± 0.011	0.672TrpAsp: 0.672 ± 0.021	0.887TrpGlu: 0.887 ± 0.024	0.586TrpPhe: 0.586 ± 0.02	0.947TrpGly: 0.947 ± 0.026	0.345TrpHis: 0.345 ± 0.017	0.864TrpIle: 0.864 ± 0.025	0.688TrpLys: 0.688 ± 0.022	1.903TrpLeu: 1.903 ± 0.042	0.316TrpMet: 0.316 ± 0.015	0.678TrpAsn: 0.678 ± 0.027	0.172TrpPro: 0.172 ± 0.011	1.071TrpGln: 1.071 ± 0.031	0.898TrpArg: 0.898 ± 0.027	0.885TrpSer: 0.885 ± 0.024	0.646TrpThr: 0.646 ± 0.021	0.997TrpVal: 0.997 ± 0.027	0.259TrpTrp: 0.259 ± 0.015	0.461TrpTyr: 0.461 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.117TyrAla: 2.117 ± 0.036	0.403TyrCys: 0.403 ± 0.016	1.468TyrAsp: 1.468 ± 0.032	1.864TyrGlu: 1.864 ± 0.036	1.384TyrPhe: 1.384 ± 0.036	2.052TyrGly: 2.052 ± 0.041	0.702TyrHis: 0.702 ± 0.024	1.795TyrIle: 1.795 ± 0.039	1.484TyrLys: 1.484 ± 0.034	3.641TyrLeu: 3.641 ± 0.057	0.449TyrMet: 0.449 ± 0.017	1.339TyrAsn: 1.339 ± 0.03	1.67TyrPro: 1.67 ± 0.039	1.951TyrGln: 1.951 ± 0.039	1.954TyrArg: 1.954 ± 0.04	1.946TyrSer: 1.946 ± 0.036	1.603TyrThr: 1.603 ± 0.034	1.783TyrVal: 1.783 ± 0.035	0.587TyrTrp: 0.587 ± 0.02	1.126TyrTyr: 1.126 ± 0.03	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.002XaaAsp: 0.002 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.003XaaLys: 0.003 ± 0.002	0.005XaaLeu: 0.005 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.002XaaArg: 0.002 ± 0.001	0.003XaaSer: 0.003 ± 0.002	0.005XaaThr: 0.005 ± 0.002	0.003XaaVal: 0.003 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 4950 proteins (1457382 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---