Amino acid dipepetide frequency for Dyadobacter koreensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.0AlaAla: 6.0 ± 0.07	0.577AlaCys: 0.577 ± 0.019	4.091AlaAsp: 4.091 ± 0.041	4.336AlaGlu: 4.336 ± 0.052	3.443AlaPhe: 3.443 ± 0.044	5.704AlaGly: 5.704 ± 0.053	1.164AlaHis: 1.164 ± 0.023	4.874AlaIle: 4.874 ± 0.053	4.306AlaLys: 4.306 ± 0.048	6.82AlaLeu: 6.82 ± 0.066	1.654AlaMet: 1.654 ± 0.03	3.405AlaAsn: 3.405 ± 0.049	2.39AlaPro: 2.39 ± 0.035	2.783AlaGln: 2.783 ± 0.04	2.793AlaArg: 2.793 ± 0.041	4.776AlaSer: 4.776 ± 0.055	3.93AlaThr: 3.93 ± 0.05	4.779AlaVal: 4.779 ± 0.05	0.837AlaTrp: 0.837 ± 0.022	2.734AlaTyr: 2.734 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.471CysAla: 0.471 ± 0.015	0.122CysCys: 0.122 ± 0.009	0.361CysAsp: 0.361 ± 0.014	0.389CysGlu: 0.389 ± 0.015	0.412CysPhe: 0.412 ± 0.013	0.554CysGly: 0.554 ± 0.019	0.19CysHis: 0.19 ± 0.009	0.51CysIle: 0.51 ± 0.016	0.408CysLys: 0.408 ± 0.016	0.698CysLeu: 0.698 ± 0.018	0.168CysMet: 0.168 ± 0.009	0.317CysAsn: 0.317 ± 0.011	0.284CysPro: 0.284 ± 0.013	0.266CysGln: 0.266 ± 0.011	0.304CysArg: 0.304 ± 0.013	0.511CysSer: 0.511 ± 0.016	0.383CysThr: 0.383 ± 0.014	0.449CysVal: 0.449 ± 0.014	0.087CysTrp: 0.087 ± 0.007	0.292CysTyr: 0.292 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.658AspAla: 3.658 ± 0.037	0.351AspCys: 0.351 ± 0.014	2.488AspAsp: 2.488 ± 0.038	3.31AspGlu: 3.31 ± 0.046	3.256AspPhe: 3.256 ± 0.041	3.95AspGly: 3.95 ± 0.06	1.002AspHis: 1.002 ± 0.022	3.861AspIle: 3.861 ± 0.049	3.637AspLys: 3.637 ± 0.044	5.299AspLeu: 5.299 ± 0.052	1.187AspMet: 1.187 ± 0.023	2.543AspAsn: 2.543 ± 0.04	2.201AspPro: 2.201 ± 0.031	1.966AspGln: 1.966 ± 0.029	2.316AspArg: 2.316 ± 0.032	3.198AspSer: 3.198 ± 0.042	2.551AspThr: 2.551 ± 0.034	3.346AspVal: 3.346 ± 0.042	0.853AspTrp: 0.853 ± 0.021	2.383AspTyr: 2.383 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	4.231GluAla: 4.231 ± 0.05	0.292GluCys: 0.292 ± 0.013	2.862GluAsp: 2.862 ± 0.043	3.852GluGlu: 3.852 ± 0.061	2.607GluPhe: 2.607 ± 0.039	3.521GluGly: 3.521 ± 0.048	1.051GluHis: 1.051 ± 0.024	4.908GluIle: 4.908 ± 0.054	5.426GluLys: 5.426 ± 0.061	5.681GluLeu: 5.681 ± 0.059	1.518GluMet: 1.518 ± 0.028	3.823GluAsn: 3.823 ± 0.046	1.724GluPro: 1.724 ± 0.028	2.173GluGln: 2.173 ± 0.034	2.673GluArg: 2.673 ± 0.04	3.422GluSer: 3.422 ± 0.043	3.274GluThr: 3.274 ± 0.044	3.848GluVal: 3.848 ± 0.045	0.734GluTrp: 0.734 ± 0.021	2.14GluTyr: 2.14 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.348PheAla: 3.348 ± 0.046	0.479PheCys: 0.479 ± 0.018	3.022PheAsp: 3.022 ± 0.042	3.004PheGlu: 3.004 ± 0.043	2.694PhePhe: 2.694 ± 0.047	3.616PheGly: 3.616 ± 0.043	0.888PheHis: 0.888 ± 0.02	3.367PheIle: 3.367 ± 0.044	3.032PheLys: 3.032 ± 0.04	4.887PheLeu: 4.887 ± 0.057	1.104PheMet: 1.104 ± 0.022	2.632PheAsn: 2.632 ± 0.038	1.94PhePro: 1.94 ± 0.032	1.754PheGln: 1.754 ± 0.03	2.215PheArg: 2.215 ± 0.032	4.151PheSer: 4.151 ± 0.052	2.974PheThr: 2.974 ± 0.039	3.164PheVal: 3.164 ± 0.042	0.641PheTrp: 0.641 ± 0.02	2.057PheTyr: 2.057 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	4.651GlyAla: 4.651 ± 0.062	0.591GlyCys: 0.591 ± 0.018	3.374GlyAsp: 3.374 ± 0.036	3.559GlyGlu: 3.559 ± 0.043	3.737GlyPhe: 3.737 ± 0.041	4.941GlyGly: 4.941 ± 0.068	1.187GlyHis: 1.187 ± 0.028	5.416GlyIle: 5.416 ± 0.05	5.461GlyLys: 5.461 ± 0.05	6.439GlyLeu: 6.439 ± 0.055	1.672GlyMet: 1.672 ± 0.028	3.719GlyAsn: 3.719 ± 0.054	1.71GlyPro: 1.71 ± 0.033	2.413GlyGln: 2.413 ± 0.036	2.805GlyArg: 2.805 ± 0.041	4.738GlySer: 4.738 ± 0.061	4.227GlyThr: 4.227 ± 0.053	4.5GlyVal: 4.5 ± 0.054	0.997GlyTrp: 0.997 ± 0.022	3.07GlyTyr: 3.07 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.159HisAla: 1.159 ± 0.024	0.165HisCys: 0.165 ± 0.009	0.861HisAsp: 0.861 ± 0.021	1.003HisGlu: 1.003 ± 0.023	1.166HisPhe: 1.166 ± 0.023	1.177HisGly: 1.177 ± 0.028	0.499HisHis: 0.499 ± 0.018	1.283HisIle: 1.283 ± 0.025	0.941HisLys: 0.941 ± 0.022	1.762HisLeu: 1.762 ± 0.034	0.378HisMet: 0.378 ± 0.015	0.842HisAsn: 0.842 ± 0.023	0.965HisPro: 0.965 ± 0.022	0.732HisGln: 0.732 ± 0.017	0.757HisArg: 0.757 ± 0.02	1.107HisSer: 1.107 ± 0.023	0.974HisThr: 0.974 ± 0.024	0.993HisVal: 0.993 ± 0.023	0.275HisTrp: 0.275 ± 0.011	0.843HisTyr: 0.843 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.318IleAla: 5.318 ± 0.055	0.651IleCys: 0.651 ± 0.019	3.946IleAsp: 3.946 ± 0.047	4.369IleGlu: 4.369 ± 0.052	3.386IlePhe: 3.386 ± 0.048	4.881IleGly: 4.881 ± 0.052	1.338IleHis: 1.338 ± 0.024	4.828IleIle: 4.828 ± 0.065	4.424IleLys: 4.424 ± 0.05	6.641IleLeu: 6.641 ± 0.068	1.364IleMet: 1.364 ± 0.027	3.726IleAsn: 3.726 ± 0.046	3.33IlePro: 3.33 ± 0.038	2.502IleGln: 2.502 ± 0.036	3.272IleArg: 3.272 ± 0.04	5.598IleSer: 5.598 ± 0.05	4.205IleThr: 4.205 ± 0.048	4.314IleVal: 4.314 ± 0.048	0.778IleTrp: 0.778 ± 0.024	2.528IleTyr: 2.528 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.792LysAla: 4.792 ± 0.048	0.289LysCys: 0.289 ± 0.012	3.796LysAsp: 3.796 ± 0.049	4.659LysGlu: 4.659 ± 0.053	2.638LysPhe: 2.638 ± 0.037	4.474LysGly: 4.474 ± 0.048	1.136LysHis: 1.136 ± 0.025	5.185LysIle: 5.185 ± 0.055	5.196LysLys: 5.196 ± 0.054	6.0LysLeu: 6.0 ± 0.057	1.86LysMet: 1.86 ± 0.03	4.33LysAsn: 4.33 ± 0.042	2.682LysPro: 2.682 ± 0.039	2.403LysGln: 2.403 ± 0.033	2.769LysArg: 2.769 ± 0.036	4.519LysSer: 4.519 ± 0.051	4.159LysThr: 4.159 ± 0.042	4.27LysVal: 4.27 ± 0.041	0.851LysTrp: 0.851 ± 0.019	2.623LysTyr: 2.623 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	6.978LeuAla: 6.978 ± 0.057	0.741LeuCys: 0.741 ± 0.02	4.891LeuAsp: 4.891 ± 0.049	5.211LeuGlu: 5.211 ± 0.059	4.808LeuPhe: 4.808 ± 0.057	6.04LeuGly: 6.04 ± 0.057	1.709LeuHis: 1.709 ± 0.033	6.751LeuIle: 6.751 ± 0.071	6.864LeuLys: 6.864 ± 0.061	9.371LeuLeu: 9.371 ± 0.092	2.144LeuMet: 2.144 ± 0.035	5.109LeuAsn: 5.109 ± 0.055	4.194LeuPro: 4.194 ± 0.052	3.271LeuGln: 3.271 ± 0.046	4.1LeuArg: 4.1 ± 0.046	7.305LeuSer: 7.305 ± 0.063	5.782LeuThr: 5.782 ± 0.054	5.634LeuVal: 5.634 ± 0.052	1.009LeuTrp: 1.009 ± 0.025	3.215LeuTyr: 3.215 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	1.785MetAla: 1.785 ± 0.03	0.126MetCys: 0.126 ± 0.008	1.185MetAsp: 1.185 ± 0.026	1.336MetGlu: 1.336 ± 0.023	0.826MetPhe: 0.826 ± 0.021	1.492MetGly: 1.492 ± 0.026	0.432MetHis: 0.432 ± 0.015	1.575MetIle: 1.575 ± 0.033	1.982MetLys: 1.982 ± 0.034	2.112MetLeu: 2.112 ± 0.035	0.598MetMet: 0.598 ± 0.019	1.303MetAsn: 1.303 ± 0.024	1.058MetPro: 1.058 ± 0.022	0.881MetGln: 0.881 ± 0.021	0.981MetArg: 0.981 ± 0.024	1.389MetSer: 1.389 ± 0.024	1.217MetThr: 1.217 ± 0.025	1.395MetVal: 1.395 ± 0.027	0.21MetTrp: 0.21 ± 0.011	0.641MetTyr: 0.641 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.668AsnAla: 3.668 ± 0.046	0.343AsnCys: 0.343 ± 0.013	2.618AsnAsp: 2.618 ± 0.037	2.884AsnGlu: 2.884 ± 0.038	2.798AsnPhe: 2.798 ± 0.04	3.896AsnGly: 3.896 ± 0.05	0.97AsnHis: 0.97 ± 0.021	3.822AsnIle: 3.822 ± 0.049	3.233AsnLys: 3.233 ± 0.044	5.083AsnLeu: 5.083 ± 0.048	1.105AsnMet: 1.105 ± 0.024	2.971AsnAsn: 2.971 ± 0.056	2.859AsnPro: 2.859 ± 0.036	2.066AsnGln: 2.066 ± 0.035	2.385AsnArg: 2.385 ± 0.032	3.508AsnSer: 3.508 ± 0.04	3.023AsnThr: 3.023 ± 0.047	3.246AsnVal: 3.246 ± 0.045	0.794AsnTrp: 0.794 ± 0.022	2.345AsnTyr: 2.345 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	3.045ProAla: 3.045 ± 0.041	0.192ProCys: 0.192 ± 0.01	2.765ProAsp: 2.765 ± 0.034	3.125ProGlu: 3.125 ± 0.041	2.078ProPhe: 2.078 ± 0.032	2.907ProGly: 2.907 ± 0.037	0.652ProHis: 0.652 ± 0.019	2.355ProIle: 2.355 ± 0.025	2.294ProLys: 2.294 ± 0.036	3.319ProLeu: 3.319 ± 0.042	0.826ProMet: 0.826 ± 0.019	1.944ProAsn: 1.944 ± 0.034	1.012ProPro: 1.012 ± 0.025	1.279ProGln: 1.279 ± 0.023	1.22ProArg: 1.22 ± 0.024	2.519ProSer: 2.519 ± 0.035	2.036ProThr: 2.036 ± 0.033	3.403ProVal: 3.403 ± 0.045	0.445ProTrp: 0.445 ± 0.015	1.522ProTyr: 1.522 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	2.461GlnAla: 2.461 ± 0.039	0.18GlnCys: 0.18 ± 0.008	1.667GlnAsp: 1.667 ± 0.03	2.234GlnGlu: 2.234 ± 0.034	1.72GlnPhe: 1.72 ± 0.032	2.064GlnGly: 2.064 ± 0.035	0.696GlnHis: 0.696 ± 0.018	2.801GlnIle: 2.801 ± 0.036	2.842GlnLys: 2.842 ± 0.044	3.585GlnLeu: 3.585 ± 0.042	0.886GlnMet: 0.886 ± 0.019	2.164GlnAsn: 2.164 ± 0.032	1.402GlnPro: 1.402 ± 0.027	1.722GlnGln: 1.722 ± 0.034	1.579GlnArg: 1.579 ± 0.034	2.311GlnSer: 2.311 ± 0.033	2.182GlnThr: 2.182 ± 0.034	2.254GlnVal: 2.254 ± 0.035	0.458GlnTrp: 0.458 ± 0.014	1.447GlnTyr: 1.447 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	2.643ArgAla: 2.643 ± 0.034	0.226ArgCys: 0.226 ± 0.011	2.125ArgAsp: 2.125 ± 0.034	2.623ArgGlu: 2.623 ± 0.042	2.315ArgPhe: 2.315 ± 0.034	2.344ArgGly: 2.344 ± 0.035	0.73ArgHis: 0.73 ± 0.019	3.34ArgIle: 3.34 ± 0.04	3.131ArgLys: 3.131 ± 0.043	4.083ArgLeu: 4.083 ± 0.047	1.083ArgMet: 1.083 ± 0.021	2.485ArgAsn: 2.485 ± 0.039	1.519ArgPro: 1.519 ± 0.03	1.763ArgGln: 1.763 ± 0.031	1.876ArgArg: 1.876 ± 0.028	2.6ArgSer: 2.6 ± 0.036	2.242ArgThr: 2.242 ± 0.031	2.51ArgVal: 2.51 ± 0.034	0.566ArgTrp: 0.566 ± 0.016	1.945ArgTyr: 1.945 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	4.818SerAla: 4.818 ± 0.055	0.572SerCys: 0.572 ± 0.016	3.686SerAsp: 3.686 ± 0.041	4.114SerGlu: 4.114 ± 0.05	3.95SerPhe: 3.95 ± 0.037	5.395SerGly: 5.395 ± 0.057	1.161SerHis: 1.161 ± 0.023	4.733SerIle: 4.733 ± 0.053	4.29SerLys: 4.29 ± 0.047	6.714SerLeu: 6.714 ± 0.055	1.415SerMet: 1.415 ± 0.026	3.14SerAsn: 3.14 ± 0.042	2.538SerPro: 2.538 ± 0.034	2.455SerGln: 2.455 ± 0.038	2.771SerArg: 2.771 ± 0.037	4.613SerSer: 4.613 ± 0.047	3.666SerThr: 3.666 ± 0.051	4.762SerVal: 4.762 ± 0.055	0.871SerTrp: 0.871 ± 0.02	2.815SerTyr: 2.815 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.387ThrAla: 4.387 ± 0.056	0.331ThrCys: 0.331 ± 0.013	3.335ThrAsp: 3.335 ± 0.044	3.264ThrGlu: 3.264 ± 0.039	2.957ThrPhe: 2.957 ± 0.04	4.699ThrGly: 4.699 ± 0.055	0.918ThrHis: 0.918 ± 0.023	3.986ThrIle: 3.986 ± 0.048	3.232ThrLys: 3.232 ± 0.043	5.419ThrLeu: 5.419 ± 0.052	1.028ThrMet: 1.028 ± 0.023	2.826ThrAsn: 2.826 ± 0.038	2.567ThrPro: 2.567 ± 0.036	1.845ThrGln: 1.845 ± 0.031	2.107ThrArg: 2.107 ± 0.032	3.823ThrSer: 3.823 ± 0.048	3.258ThrThr: 3.258 ± 0.045	3.859ThrVal: 3.859 ± 0.039	0.671ThrTrp: 0.671 ± 0.018	2.29ThrTyr: 2.29 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	4.58ValAla: 4.58 ± 0.047	0.524ValCys: 0.524 ± 0.015	3.388ValAsp: 3.388 ± 0.043	3.652ValGlu: 3.652 ± 0.049	3.24ValPhe: 3.24 ± 0.039	3.939ValGly: 3.939 ± 0.051	1.111ValHis: 1.111 ± 0.024	4.58ValIle: 4.58 ± 0.051	4.446ValLys: 4.446 ± 0.046	6.138ValLeu: 6.138 ± 0.055	1.427ValMet: 1.427 ± 0.028	3.414ValAsn: 3.414 ± 0.044	2.512ValPro: 2.512 ± 0.034	2.093ValGln: 2.093 ± 0.034	2.763ValArg: 2.763 ± 0.035	4.963ValSer: 4.963 ± 0.051	3.831ValThr: 3.831 ± 0.04	4.267ValVal: 4.267 ± 0.055	0.735ValTrp: 0.735 ± 0.016	2.354ValTyr: 2.354 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.793TrpAla: 0.793 ± 0.019	0.1TrpCys: 0.1 ± 0.007	0.678TrpAsp: 0.678 ± 0.019	0.729TrpGlu: 0.729 ± 0.022	0.629TrpPhe: 0.629 ± 0.018	0.854TrpGly: 0.854 ± 0.019	0.249TrpHis: 0.249 ± 0.011	0.88TrpIle: 0.88 ± 0.021	0.939TrpLys: 0.939 ± 0.021	1.256TrpLeu: 1.256 ± 0.029	0.367TrpMet: 0.367 ± 0.012	0.707TrpAsn: 0.707 ± 0.018	0.391TrpPro: 0.391 ± 0.013	0.571TrpGln: 0.571 ± 0.017	0.537TrpArg: 0.537 ± 0.017	0.709TrpSer: 0.709 ± 0.019	0.717TrpThr: 0.717 ± 0.021	0.737TrpVal: 0.737 ± 0.019	0.204TrpTrp: 0.204 ± 0.01	0.49TrpTyr: 0.49 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.612TyrAla: 2.612 ± 0.037	0.326TyrCys: 0.326 ± 0.014	2.219TyrAsp: 2.219 ± 0.034	2.107TyrGlu: 2.107 ± 0.032	2.308TyrPhe: 2.308 ± 0.033	2.756TyrGly: 2.756 ± 0.037	0.798TyrHis: 0.798 ± 0.02	2.343TyrIle: 2.343 ± 0.035	2.544TyrLys: 2.544 ± 0.034	3.824TyrLeu: 3.824 ± 0.044	0.74TyrMet: 0.74 ± 0.019	2.217TyrAsn: 2.217 ± 0.041	1.66TyrPro: 1.66 ± 0.028	1.718TyrGln: 1.718 ± 0.032	1.926TyrArg: 1.926 ± 0.034	2.72TyrSer: 2.72 ± 0.038	2.173TyrThr: 2.173 ± 0.037	2.224TyrVal: 2.224 ± 0.033	0.52TyrTrp: 0.52 ± 0.019	1.71TyrTyr: 1.71 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5986 proteins (2116298 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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