Amino acid dipepetide frequency for Rotavirus F chicken/03V0568/DEU/2003

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.011AlaAla: 4.011 ± 0.956
1.046AlaCys: 1.046 ± 0.345
2.093AlaAsp: 2.093 ± 0.332
3.662AlaGlu: 3.662 ± 0.692
1.57AlaPhe: 1.57 ± 0.549
2.616AlaGly: 2.616 ± 0.366
0.523AlaHis: 0.523 ± 0.358
7.15AlaIle: 7.15 ± 0.829
4.534AlaLys: 4.534 ± 1.386
4.186AlaLeu: 4.186 ± 0.794
1.744AlaMet: 1.744 ± 0.412
4.534AlaAsn: 4.534 ± 0.931
1.395AlaPro: 1.395 ± 0.672
2.442AlaGln: 2.442 ± 0.734
2.965AlaArg: 2.965 ± 0.628
5.581AlaSer: 5.581 ± 0.933
4.011AlaThr: 4.011 ± 0.778
4.36AlaVal: 4.36 ± 1.106
0.523AlaTrp: 0.523 ± 0.231
3.488AlaTyr: 3.488 ± 0.713
0.0AlaXaa: 0.0 ± 0.0
Cys
0.698CysAla: 0.698 ± 0.349
0.523CysCys: 0.523 ± 0.277
0.0CysAsp: 0.0 ± 0.0
1.57CysGlu: 1.57 ± 0.728
0.174CysPhe: 0.174 ± 0.174
0.174CysGly: 0.174 ± 0.152
0.349CysHis: 0.349 ± 0.303
1.046CysIle: 1.046 ± 0.5
0.872CysLys: 0.872 ± 0.492
1.046CysLeu: 1.046 ± 0.439
0.523CysMet: 0.523 ± 0.281
1.046CysAsn: 1.046 ± 0.49
0.523CysPro: 0.523 ± 0.265
0.174CysGln: 0.174 ± 0.198
0.523CysArg: 0.523 ± 0.32
0.523CysSer: 0.523 ± 0.322
0.872CysThr: 0.872 ± 0.462
1.57CysVal: 1.57 ± 0.784
0.0CysTrp: 0.0 ± 0.0
0.349CysTyr: 0.349 ± 0.255
0.0CysXaa: 0.0 ± 0.0
Asp
4.011AspAla: 4.011 ± 0.694
0.872AspCys: 0.872 ± 0.358
4.534AspAsp: 4.534 ± 0.943
3.314AspGlu: 3.314 ± 0.571
2.79AspPhe: 2.79 ± 0.756
2.79AspGly: 2.79 ± 0.671
0.872AspHis: 0.872 ± 0.388
3.662AspIle: 3.662 ± 1.008
1.918AspLys: 1.918 ± 0.444
5.93AspLeu: 5.93 ± 1.12
0.698AspMet: 0.698 ± 0.402
2.79AspAsn: 2.79 ± 0.859
1.744AspPro: 1.744 ± 0.362
2.965AspGln: 2.965 ± 0.274
1.57AspArg: 1.57 ± 0.567
2.965AspSer: 2.965 ± 0.719
4.534AspThr: 4.534 ± 0.578
5.581AspVal: 5.581 ± 0.785
0.349AspTrp: 0.349 ± 0.178
3.662AspTyr: 3.662 ± 0.441
0.0AspXaa: 0.0 ± 0.0
Glu
3.314GluAla: 3.314 ± 1.319
0.698GluCys: 0.698 ± 0.305
2.442GluAsp: 2.442 ± 0.74
3.488GluGlu: 3.488 ± 1.236
2.79GluPhe: 2.79 ± 0.495
1.046GluGly: 1.046 ± 0.447
0.349GluHis: 0.349 ± 0.197
3.488GluIle: 3.488 ± 0.734
5.058GluLys: 5.058 ± 1.679
6.802GluLeu: 6.802 ± 0.988
2.093GluMet: 2.093 ± 0.555
2.965GluAsn: 2.965 ± 0.553
0.872GluPro: 0.872 ± 0.422
1.744GluGln: 1.744 ± 0.368
3.314GluArg: 3.314 ± 0.7
4.534GluSer: 4.534 ± 0.76
5.058GluThr: 5.058 ± 0.81
3.488GluVal: 3.488 ± 0.644
0.523GluTrp: 0.523 ± 0.403
4.36GluTyr: 4.36 ± 0.891
0.0GluXaa: 0.0 ± 0.0
Phe
1.744PheAla: 1.744 ± 0.519
0.0PheCys: 0.0 ± 0.0
3.488PheAsp: 3.488 ± 0.89
2.093PheGlu: 2.093 ± 0.464
1.046PhePhe: 1.046 ± 0.31
1.046PheGly: 1.046 ± 0.446
0.698PheHis: 0.698 ± 0.304
2.442PheIle: 2.442 ± 0.53
4.011PheLys: 4.011 ± 1.168
3.139PheLeu: 3.139 ± 0.836
0.872PheMet: 0.872 ± 0.42
2.442PheAsn: 2.442 ± 0.576
1.046PhePro: 1.046 ± 0.376
1.57PheGln: 1.57 ± 0.326
2.267PheArg: 2.267 ± 0.38
3.139PheSer: 3.139 ± 0.865
3.314PheThr: 3.314 ± 0.44
2.267PheVal: 2.267 ± 0.66
0.523PheTrp: 0.523 ± 0.353
1.395PheTyr: 1.395 ± 0.324
0.0PheXaa: 0.0 ± 0.0
Gly
2.442GlyAla: 2.442 ± 0.273
0.698GlyCys: 0.698 ± 0.446
1.918GlyAsp: 1.918 ± 0.458
0.872GlyGlu: 0.872 ± 0.433
1.046GlyPhe: 1.046 ± 0.441
1.744GlyGly: 1.744 ± 0.476
0.698GlyHis: 0.698 ± 0.356
2.442GlyIle: 2.442 ± 0.466
2.267GlyLys: 2.267 ± 0.58
2.616GlyLeu: 2.616 ± 0.527
1.046GlyMet: 1.046 ± 0.418
2.79GlyAsn: 2.79 ± 0.717
1.395GlyPro: 1.395 ± 0.602
0.872GlyGln: 0.872 ± 0.473
1.395GlyArg: 1.395 ± 0.44
2.093GlySer: 2.093 ± 0.588
3.314GlyThr: 3.314 ± 0.897
2.442GlyVal: 2.442 ± 0.578
0.0GlyTrp: 0.0 ± 0.0
1.918GlyTyr: 1.918 ± 0.569
0.0GlyXaa: 0.0 ± 0.0
His
2.442HisAla: 2.442 ± 0.753
0.174HisCys: 0.174 ± 0.185
1.57HisAsp: 1.57 ± 0.481
0.872HisGlu: 0.872 ± 0.316
0.872HisPhe: 0.872 ± 0.271
0.523HisGly: 0.523 ± 0.329
0.523HisHis: 0.523 ± 0.156
1.046HisIle: 1.046 ± 0.499
0.174HisLys: 0.174 ± 0.192
1.221HisLeu: 1.221 ± 0.72
0.0HisMet: 0.0 ± 0.0
1.046HisAsn: 1.046 ± 0.344
0.174HisPro: 0.174 ± 0.156
0.698HisGln: 0.698 ± 0.262
1.395HisArg: 1.395 ± 0.565
0.523HisSer: 0.523 ± 0.258
0.872HisThr: 0.872 ± 0.255
1.57HisVal: 1.57 ± 0.304
0.349HisTrp: 0.349 ± 0.349
1.744HisTyr: 1.744 ± 0.557
0.0HisXaa: 0.0 ± 0.0
Ile
5.581IleAla: 5.581 ± 0.799
0.872IleCys: 0.872 ± 0.337
5.581IleAsp: 5.581 ± 1.17
4.186IleGlu: 4.186 ± 0.866
2.093IlePhe: 2.093 ± 0.486
2.79IleGly: 2.79 ± 0.846
1.046IleHis: 1.046 ± 0.494
4.534IleIle: 4.534 ± 0.848
6.104IleLys: 6.104 ± 1.078
5.581IleLeu: 5.581 ± 0.98
1.918IleMet: 1.918 ± 0.456
4.883IleAsn: 4.883 ± 0.803
3.662IlePro: 3.662 ± 0.61
2.442IleGln: 2.442 ± 0.903
2.093IleArg: 2.093 ± 0.379
5.755IleSer: 5.755 ± 0.851
6.802IleThr: 6.802 ± 0.866
5.406IleVal: 5.406 ± 0.933
0.174IleTrp: 0.174 ± 0.156
3.139IleTyr: 3.139 ± 0.97
0.0IleXaa: 0.0 ± 0.0
Lys
4.011LysAla: 4.011 ± 0.945
0.698LysCys: 0.698 ± 0.367
2.093LysAsp: 2.093 ± 0.55
3.837LysGlu: 3.837 ± 1.211
3.662LysPhe: 3.662 ± 0.905
1.918LysGly: 1.918 ± 0.829
1.918LysHis: 1.918 ± 0.526
4.883LysIle: 4.883 ± 1.014
4.709LysLys: 4.709 ± 0.83
7.848LysLeu: 7.848 ± 1.007
1.918LysMet: 1.918 ± 0.901
2.616LysAsn: 2.616 ± 0.699
1.744LysPro: 1.744 ± 0.547
3.837LysGln: 3.837 ± 0.737
4.36LysArg: 4.36 ± 0.836
4.011LysSer: 4.011 ± 0.736
4.36LysThr: 4.36 ± 0.799
3.314LysVal: 3.314 ± 0.802
0.523LysTrp: 0.523 ± 0.302
3.314LysTyr: 3.314 ± 1.368
0.0LysXaa: 0.0 ± 0.0
Leu
4.709LeuAla: 4.709 ± 0.516
0.872LeuCys: 0.872 ± 0.349
3.488LeuAsp: 3.488 ± 0.76
5.581LeuGlu: 5.581 ± 1.204
4.186LeuPhe: 4.186 ± 0.581
2.093LeuGly: 2.093 ± 0.778
1.221LeuHis: 1.221 ± 0.538
6.453LeuIle: 6.453 ± 1.251
5.058LeuLys: 5.058 ± 0.523
6.802LeuLeu: 6.802 ± 1.276
3.139LeuMet: 3.139 ± 0.552
6.278LeuAsn: 6.278 ± 1.084
2.442LeuPro: 2.442 ± 0.557
4.709LeuGln: 4.709 ± 1.398
4.709LeuArg: 4.709 ± 0.912
9.418LeuSer: 9.418 ± 0.813
5.755LeuThr: 5.755 ± 0.613
4.883LeuVal: 4.883 ± 0.98
0.872LeuTrp: 0.872 ± 0.526
3.314LeuTyr: 3.314 ± 0.899
0.0LeuXaa: 0.0 ± 0.0
Met
2.442MetAla: 2.442 ± 0.943
0.174MetCys: 0.174 ± 0.185
1.395MetAsp: 1.395 ± 0.49
2.093MetGlu: 2.093 ± 0.517
1.57MetPhe: 1.57 ± 0.365
0.698MetGly: 0.698 ± 0.285
0.523MetHis: 0.523 ± 0.204
1.744MetIle: 1.744 ± 0.411
1.395MetLys: 1.395 ± 0.519
3.837MetLeu: 3.837 ± 0.796
0.523MetMet: 0.523 ± 0.287
2.79MetAsn: 2.79 ± 0.617
0.698MetPro: 0.698 ± 0.266
2.093MetGln: 2.093 ± 0.896
2.616MetArg: 2.616 ± 0.698
3.488MetSer: 3.488 ± 0.603
1.918MetThr: 1.918 ± 0.425
0.698MetVal: 0.698 ± 0.299
0.349MetTrp: 0.349 ± 0.196
0.698MetTyr: 0.698 ± 0.19
0.0MetXaa: 0.0 ± 0.0
Asn
3.314AsnAla: 3.314 ± 1.129
1.395AsnCys: 1.395 ± 0.714
3.488AsnAsp: 3.488 ± 0.685
4.186AsnGlu: 4.186 ± 0.757
2.616AsnPhe: 2.616 ± 0.91
2.093AsnGly: 2.093 ± 0.602
1.395AsnHis: 1.395 ± 0.435
4.186AsnIle: 4.186 ± 0.88
4.36AsnLys: 4.36 ± 0.791
4.186AsnLeu: 4.186 ± 0.741
3.139AsnMet: 3.139 ± 0.906
3.488AsnAsn: 3.488 ± 0.817
1.918AsnPro: 1.918 ± 0.571
2.965AsnGln: 2.965 ± 0.663
1.57AsnArg: 1.57 ± 0.43
5.232AsnSer: 5.232 ± 0.75
3.139AsnThr: 3.139 ± 0.859
4.186AsnVal: 4.186 ± 0.759
0.523AsnTrp: 0.523 ± 0.361
4.534AsnTyr: 4.534 ± 0.707
0.0AsnXaa: 0.0 ± 0.0
Pro
1.918ProAla: 1.918 ± 0.402
0.174ProCys: 0.174 ± 0.152
1.918ProAsp: 1.918 ± 0.608
0.698ProGlu: 0.698 ± 0.267
1.918ProPhe: 1.918 ± 0.509
1.221ProGly: 1.221 ± 0.516
0.174ProHis: 0.174 ± 0.152
3.139ProIle: 3.139 ± 0.551
1.046ProLys: 1.046 ± 0.295
2.442ProLeu: 2.442 ± 0.653
0.698ProMet: 0.698 ± 0.423
1.744ProAsn: 1.744 ± 0.455
1.57ProPro: 1.57 ± 0.444
1.046ProGln: 1.046 ± 0.352
1.221ProArg: 1.221 ± 0.311
1.221ProSer: 1.221 ± 0.444
2.616ProThr: 2.616 ± 0.605
2.616ProVal: 2.616 ± 0.713
0.523ProTrp: 0.523 ± 0.253
1.744ProTyr: 1.744 ± 0.42
0.0ProXaa: 0.0 ± 0.0
Gln
2.79GlnAla: 2.79 ± 0.552
0.698GlnCys: 0.698 ± 0.274
2.965GlnAsp: 2.965 ± 0.504
1.744GlnGlu: 1.744 ± 0.468
2.093GlnPhe: 2.093 ± 0.592
1.046GlnGly: 1.046 ± 0.268
1.395GlnHis: 1.395 ± 0.395
2.79GlnIle: 2.79 ± 0.845
2.267GlnLys: 2.267 ± 0.431
5.058GlnLeu: 5.058 ± 0.728
2.442GlnMet: 2.442 ± 0.541
2.79GlnAsn: 2.79 ± 0.607
1.046GlnPro: 1.046 ± 0.595
3.488GlnGln: 3.488 ± 0.749
2.442GlnArg: 2.442 ± 0.723
3.139GlnSer: 3.139 ± 0.739
2.965GlnThr: 2.965 ± 0.56
2.442GlnVal: 2.442 ± 0.558
0.872GlnTrp: 0.872 ± 0.477
2.79GlnTyr: 2.79 ± 0.448
0.0GlnXaa: 0.0 ± 0.0
Arg
2.093ArgAla: 2.093 ± 0.909
0.349ArgCys: 0.349 ± 0.272
1.744ArgAsp: 1.744 ± 0.311
3.139ArgGlu: 3.139 ± 0.49
2.093ArgPhe: 2.093 ± 0.596
1.744ArgGly: 1.744 ± 0.511
1.918ArgHis: 1.918 ± 0.452
2.965ArgIle: 2.965 ± 0.342
4.011ArgLys: 4.011 ± 0.813
5.058ArgLeu: 5.058 ± 1.031
2.442ArgMet: 2.442 ± 0.714
3.314ArgAsn: 3.314 ± 0.626
0.698ArgPro: 0.698 ± 0.268
2.79ArgGln: 2.79 ± 0.629
3.139ArgArg: 3.139 ± 0.456
3.314ArgSer: 3.314 ± 0.568
2.965ArgThr: 2.965 ± 0.844
2.79ArgVal: 2.79 ± 0.412
0.174ArgTrp: 0.174 ± 0.157
2.442ArgTyr: 2.442 ± 0.39
0.0ArgXaa: 0.0 ± 0.0
Ser
3.488SerAla: 3.488 ± 1.112
1.57SerCys: 1.57 ± 0.673
4.534SerAsp: 4.534 ± 1.04
4.36SerGlu: 4.36 ± 0.838
1.57SerPhe: 1.57 ± 0.477
2.267SerGly: 2.267 ± 0.404
1.395SerHis: 1.395 ± 0.458
5.755SerIle: 5.755 ± 0.956
4.883SerLys: 4.883 ± 1.378
6.104SerLeu: 6.104 ± 1.152
2.267SerMet: 2.267 ± 0.753
6.104SerAsn: 6.104 ± 1.195
1.744SerPro: 1.744 ± 0.594
4.883SerGln: 4.883 ± 0.845
3.662SerArg: 3.662 ± 0.64
4.883SerSer: 4.883 ± 1.198
5.058SerThr: 5.058 ± 1.255
5.406SerVal: 5.406 ± 1.132
0.523SerTrp: 0.523 ± 0.266
3.488SerTyr: 3.488 ± 0.958
0.0SerXaa: 0.0 ± 0.0
Thr
4.186ThrAla: 4.186 ± 0.709
0.523ThrCys: 0.523 ± 0.299
5.755ThrAsp: 5.755 ± 0.967
5.058ThrGlu: 5.058 ± 0.8
2.267ThrPhe: 2.267 ± 0.524
2.965ThrGly: 2.965 ± 0.586
1.395ThrHis: 1.395 ± 0.487
6.453ThrIle: 6.453 ± 1.286
3.488ThrLys: 3.488 ± 0.623
6.104ThrLeu: 6.104 ± 0.95
1.744ThrMet: 1.744 ± 0.438
3.837ThrAsn: 3.837 ± 0.662
1.57ThrPro: 1.57 ± 0.644
3.488ThrGln: 3.488 ± 0.938
3.488ThrArg: 3.488 ± 0.733
4.883ThrSer: 4.883 ± 1.311
3.662ThrThr: 3.662 ± 0.547
4.709ThrVal: 4.709 ± 0.496
0.698ThrTrp: 0.698 ± 0.354
4.011ThrTyr: 4.011 ± 0.908
0.0ThrXaa: 0.0 ± 0.0
Val
4.709ValAla: 4.709 ± 0.534
1.046ValCys: 1.046 ± 0.441
5.581ValAsp: 5.581 ± 1.034
3.837ValGlu: 3.837 ± 0.529
1.918ValPhe: 1.918 ± 0.528
3.139ValGly: 3.139 ± 0.668
1.046ValHis: 1.046 ± 0.479
5.406ValIle: 5.406 ± 0.743
4.186ValLys: 4.186 ± 0.676
5.232ValLeu: 5.232 ± 1.016
1.918ValMet: 1.918 ± 0.591
2.442ValAsn: 2.442 ± 0.743
4.186ValPro: 4.186 ± 1.087
2.442ValGln: 2.442 ± 0.638
3.837ValArg: 3.837 ± 0.964
3.837ValSer: 3.837 ± 0.865
3.662ValThr: 3.662 ± 0.491
4.186ValVal: 4.186 ± 0.751
0.349ValTrp: 0.349 ± 0.236
3.488ValTyr: 3.488 ± 0.5
0.0ValXaa: 0.0 ± 0.0
Trp
0.523TrpAla: 0.523 ± 0.246
0.0TrpCys: 0.0 ± 0.0
0.872TrpAsp: 0.872 ± 0.306
1.046TrpGlu: 1.046 ± 0.261
0.349TrpPhe: 0.349 ± 0.203
0.174TrpGly: 0.174 ± 0.192
0.0TrpHis: 0.0 ± 0.0
0.174TrpIle: 0.174 ± 0.14
0.698TrpLys: 0.698 ± 0.256
0.523TrpLeu: 0.523 ± 0.365
0.174TrpMet: 0.174 ± 0.174
0.0TrpAsn: 0.0 ± 0.0
0.349TrpPro: 0.349 ± 0.178
0.698TrpGln: 0.698 ± 0.501
0.349TrpArg: 0.349 ± 0.231
0.523TrpSer: 0.523 ± 0.225
0.523TrpThr: 0.523 ± 0.256
0.698TrpVal: 0.698 ± 0.256
0.174TrpTrp: 0.174 ± 0.211
0.523TrpTyr: 0.523 ± 0.193
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.011TyrAla: 4.011 ± 0.65
0.174TyrCys: 0.174 ± 0.152
2.093TyrAsp: 2.093 ± 0.618
2.79TyrGlu: 2.79 ± 0.595
1.918TyrPhe: 1.918 ± 0.339
1.918TyrGly: 1.918 ± 0.628
0.349TyrHis: 0.349 ± 0.212
4.883TyrIle: 4.883 ± 0.685
4.534TyrLys: 4.534 ± 0.971
2.267TyrLeu: 2.267 ± 0.438
2.267TyrMet: 2.267 ± 0.434
4.186TyrAsn: 4.186 ± 0.744
0.872TyrPro: 0.872 ± 0.264
1.918TyrGln: 1.918 ± 0.553
2.267TyrArg: 2.267 ± 0.649
4.883TyrSer: 4.883 ± 1.269
4.883TyrThr: 4.883 ± 0.695
3.837TyrVal: 3.837 ± 0.858
0.349TyrTrp: 0.349 ± 0.22
3.314TyrTyr: 3.314 ± 0.929
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (5735 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski