Amino acid dipepetide frequency for Sphingomonas sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.916AlaAla: 16.916 ± 0.205	1.062AlaCys: 1.062 ± 0.038	7.163AlaAsp: 7.163 ± 0.108	6.475AlaGlu: 6.475 ± 0.104	4.422AlaPhe: 4.422 ± 0.077	10.529AlaGly: 10.529 ± 0.12	2.237AlaHis: 2.237 ± 0.063	6.6AlaIle: 6.6 ± 0.106	4.335AlaLys: 4.335 ± 0.083	12.566AlaLeu: 12.566 ± 0.174	3.862AlaMet: 3.862 ± 0.081	3.298AlaAsn: 3.298 ± 0.072	5.601AlaPro: 5.601 ± 0.097	4.378AlaGln: 4.378 ± 0.079	8.618AlaArg: 8.618 ± 0.136	7.051AlaSer: 7.051 ± 0.106	7.172AlaThr: 7.172 ± 0.105	8.482AlaVal: 8.482 ± 0.113	1.644AlaTrp: 1.644 ± 0.054	2.694AlaTyr: 2.694 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.954CysAla: 0.954 ± 0.031	0.068CysCys: 0.068 ± 0.01	0.537CysAsp: 0.537 ± 0.025	0.366CysGlu: 0.366 ± 0.025	0.296CysPhe: 0.296 ± 0.019	0.823CysGly: 0.823 ± 0.033	0.212CysHis: 0.212 ± 0.017	0.369CysIle: 0.369 ± 0.024	0.183CysLys: 0.183 ± 0.016	0.7CysLeu: 0.7 ± 0.031	0.198CysMet: 0.198 ± 0.017	0.219CysAsn: 0.219 ± 0.021	0.422CysPro: 0.422 ± 0.022	0.209CysGln: 0.209 ± 0.017	0.57CysArg: 0.57 ± 0.028	0.481CysSer: 0.481 ± 0.028	0.449CysThr: 0.449 ± 0.024	0.581CysVal: 0.581 ± 0.029	0.14CysTrp: 0.14 ± 0.015	0.173CysTyr: 0.173 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.901AspAla: 7.901 ± 0.119	0.442AspCys: 0.442 ± 0.026	3.78AspAsp: 3.78 ± 0.078	3.355AspGlu: 3.355 ± 0.066	2.163AspPhe: 2.163 ± 0.06	5.537AspGly: 5.537 ± 0.095	1.478AspHis: 1.478 ± 0.042	2.85AspIle: 2.85 ± 0.061	1.778AspLys: 1.778 ± 0.05	5.792AspLeu: 5.792 ± 0.093	1.338AspMet: 1.338 ± 0.045	1.344AspAsn: 1.344 ± 0.049	3.794AspPro: 3.794 ± 0.064	2.003AspGln: 2.003 ± 0.054	5.203AspArg: 5.203 ± 0.083	2.34AspSer: 2.34 ± 0.057	3.177AspThr: 3.177 ± 0.067	4.497AspVal: 4.497 ± 0.084	1.075AspTrp: 1.075 ± 0.037	1.586AspTyr: 1.586 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	6.612GluAla: 6.612 ± 0.105	0.287GluCys: 0.287 ± 0.019	2.646GluAsp: 2.646 ± 0.057	2.422GluGlu: 2.422 ± 0.061	1.492GluPhe: 1.492 ± 0.045	4.054GluGly: 4.054 ± 0.075	1.123GluHis: 1.123 ± 0.036	2.776GluIle: 2.776 ± 0.063	1.822GluLys: 1.822 ± 0.05	4.579GluLeu: 4.579 ± 0.091	1.294GluMet: 1.294 ± 0.047	1.224GluAsn: 1.224 ± 0.046	2.468GluPro: 2.468 ± 0.054	2.044GluGln: 2.044 ± 0.053	4.725GluArg: 4.725 ± 0.081	1.953GluSer: 1.953 ± 0.055	3.323GluThr: 3.323 ± 0.062	3.482GluVal: 3.482 ± 0.072	0.711GluTrp: 0.711 ± 0.033	1.038GluTyr: 1.038 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	4.565PheAla: 4.565 ± 0.081	0.339PheCys: 0.339 ± 0.021	2.773PheAsp: 2.773 ± 0.066	1.994PheGlu: 1.994 ± 0.051	1.251PhePhe: 1.251 ± 0.037	3.547PheGly: 3.547 ± 0.072	0.699PheHis: 0.699 ± 0.03	1.41PheIle: 1.41 ± 0.04	0.95PheLys: 0.95 ± 0.039	3.055PheLeu: 3.055 ± 0.078	0.714PheMet: 0.714 ± 0.033	1.092PheAsn: 1.092 ± 0.044	1.573PhePro: 1.573 ± 0.049	0.967PheGln: 0.967 ± 0.032	2.236PheArg: 2.236 ± 0.053	2.028PheSer: 2.028 ± 0.051	2.131PheThr: 2.131 ± 0.053	2.694PheVal: 2.694 ± 0.064	0.577PheTrp: 0.577 ± 0.028	1.003PheTyr: 1.003 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	9.04GlyAla: 9.04 ± 0.132	0.796GlyCys: 0.796 ± 0.032	4.752GlyAsp: 4.752 ± 0.075	4.295GlyGlu: 4.295 ± 0.085	3.61GlyPhe: 3.61 ± 0.08	7.328GlyGly: 7.328 ± 0.139	1.854GlyHis: 1.854 ± 0.053	4.436GlyIle: 4.436 ± 0.083	3.289GlyLys: 3.289 ± 0.086	8.244GlyLeu: 8.244 ± 0.129	2.288GlyMet: 2.288 ± 0.056	2.302GlyAsn: 2.302 ± 0.067	3.265GlyPro: 3.265 ± 0.074	2.915GlyGln: 2.915 ± 0.068	6.281GlyArg: 6.281 ± 0.097	4.875GlySer: 4.875 ± 0.09	5.143GlyThr: 5.143 ± 0.085	6.657GlyVal: 6.657 ± 0.078	1.545GlyTrp: 1.545 ± 0.047	2.692GlyTyr: 2.692 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	2.555HisAla: 2.555 ± 0.068	0.184HisCys: 0.184 ± 0.014	1.406HisAsp: 1.406 ± 0.044	1.108HisGlu: 1.108 ± 0.039	0.748HisPhe: 0.748 ± 0.029	2.04HisGly: 2.04 ± 0.051	0.609HisHis: 0.609 ± 0.031	0.937HisIle: 0.937 ± 0.036	0.393HisLys: 0.393 ± 0.019	1.935HisLeu: 1.935 ± 0.054	0.422HisMet: 0.422 ± 0.023	0.518HisAsn: 0.518 ± 0.026	1.296HisPro: 1.296 ± 0.046	0.545HisGln: 0.545 ± 0.028	1.618HisArg: 1.618 ± 0.053	0.98HisSer: 0.98 ± 0.036	0.79HisThr: 0.79 ± 0.032	1.603HisVal: 1.603 ± 0.045	0.403HisTrp: 0.403 ± 0.025	0.617HisTyr: 0.617 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.469IleAla: 7.469 ± 0.103	0.407IleCys: 0.407 ± 0.024	4.015IleAsp: 4.015 ± 0.061	3.43IleGlu: 3.43 ± 0.065	1.359IlePhe: 1.359 ± 0.04	5.072IleGly: 5.072 ± 0.088	0.895IleHis: 0.895 ± 0.03	1.986IleIle: 1.986 ± 0.059	1.314IleLys: 1.314 ± 0.039	3.914IleLeu: 3.914 ± 0.075	0.868IleMet: 0.868 ± 0.033	1.395IleAsn: 1.395 ± 0.048	2.222IlePro: 2.222 ± 0.055	1.259IleGln: 1.259 ± 0.04	3.101IleArg: 3.101 ± 0.063	2.523IleSer: 2.523 ± 0.051	2.77IleThr: 2.77 ± 0.061	4.57IleVal: 4.57 ± 0.083	0.623IleTrp: 0.623 ± 0.027	1.069IleTyr: 1.069 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.053LysAla: 4.053 ± 0.09	0.148LysCys: 0.148 ± 0.013	1.716LysAsp: 1.716 ± 0.055	1.142LysGlu: 1.142 ± 0.04	0.865LysPhe: 0.865 ± 0.039	2.62LysGly: 2.62 ± 0.06	0.667LysHis: 0.667 ± 0.035	1.486LysIle: 1.486 ± 0.045	1.227LysLys: 1.227 ± 0.042	3.382LysLeu: 3.382 ± 0.067	0.749LysMet: 0.749 ± 0.034	0.797LysAsn: 0.797 ± 0.034	2.262LysPro: 2.262 ± 0.056	1.05LysGln: 1.05 ± 0.034	2.409LysArg: 2.409 ± 0.062	1.68LysSer: 1.68 ± 0.053	2.074LysThr: 2.074 ± 0.053	2.325LysVal: 2.325 ± 0.055	0.4LysTrp: 0.4 ± 0.025	0.693LysTyr: 0.693 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	12.858LeuAla: 12.858 ± 0.165	0.77LeuCys: 0.77 ± 0.034	6.134LeuAsp: 6.134 ± 0.091	4.449LeuGlu: 4.449 ± 0.079	3.315LeuPhe: 3.315 ± 0.065	7.98LeuGly: 7.98 ± 0.117	1.989LeuHis: 1.989 ± 0.056	4.656LeuIle: 4.656 ± 0.083	3.182LeuLys: 3.182 ± 0.069	8.858LeuLeu: 8.858 ± 0.145	2.14LeuMet: 2.14 ± 0.056	2.581LeuAsn: 2.581 ± 0.055	5.211LeuPro: 5.211 ± 0.076	2.649LeuGln: 2.649 ± 0.057	6.952LeuArg: 6.952 ± 0.108	5.866LeuSer: 5.866 ± 0.095	5.794LeuThr: 5.794 ± 0.086	7.119LeuVal: 7.119 ± 0.092	1.164LeuTrp: 1.164 ± 0.043	2.152LeuTyr: 2.152 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	3.176MetAla: 3.176 ± 0.072	0.147MetCys: 0.147 ± 0.013	1.111MetAsp: 1.111 ± 0.041	0.978MetGlu: 0.978 ± 0.036	0.714MetPhe: 0.714 ± 0.032	1.635MetGly: 1.635 ± 0.052	0.49MetHis: 0.49 ± 0.027	1.464MetIle: 1.464 ± 0.043	0.989MetLys: 0.989 ± 0.038	2.648MetLeu: 2.648 ± 0.061	0.644MetMet: 0.644 ± 0.032	0.726MetAsn: 0.726 ± 0.031	1.349MetPro: 1.349 ± 0.041	0.783MetGln: 0.783 ± 0.033	1.867MetArg: 1.867 ± 0.054	1.498MetSer: 1.498 ± 0.05	2.026MetThr: 2.026 ± 0.048	1.656MetVal: 1.656 ± 0.042	0.238MetTrp: 0.238 ± 0.018	0.377MetTyr: 0.377 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.315AsnAla: 3.315 ± 0.072	0.266AsnCys: 0.266 ± 0.02	1.643AsnAsp: 1.643 ± 0.052	1.21AsnGlu: 1.21 ± 0.044	0.984AsnPhe: 0.984 ± 0.041	2.697AsnGly: 2.697 ± 0.069	0.509AsnHis: 0.509 ± 0.026	1.271AsnIle: 1.271 ± 0.046	0.671AsnLys: 0.671 ± 0.027	2.568AsnLeu: 2.568 ± 0.062	0.574AsnMet: 0.574 ± 0.029	0.713AsnAsn: 0.713 ± 0.033	1.73AsnPro: 1.73 ± 0.053	0.866AsnGln: 0.866 ± 0.037	1.865AsnArg: 1.865 ± 0.051	1.35AsnSer: 1.35 ± 0.043	1.509AsnThr: 1.509 ± 0.05	1.979AsnVal: 1.979 ± 0.055	0.515AsnTrp: 0.515 ± 0.025	0.829AsnTyr: 0.829 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	6.433ProAla: 6.433 ± 0.093	0.344ProCys: 0.344 ± 0.023	3.772ProAsp: 3.772 ± 0.079	2.927ProGlu: 2.927 ± 0.059	1.872ProPhe: 1.872 ± 0.05	4.515ProGly: 4.515 ± 0.081	1.054ProHis: 1.054 ± 0.04	2.588ProIle: 2.588 ± 0.061	1.69ProLys: 1.69 ± 0.05	4.586ProLeu: 4.586 ± 0.085	1.3ProMet: 1.3 ± 0.041	1.51ProAsn: 1.51 ± 0.04	2.385ProPro: 2.385 ± 0.066	1.533ProGln: 1.533 ± 0.04	2.973ProArg: 2.973 ± 0.057	3.106ProSer: 3.106 ± 0.075	2.975ProThr: 2.975 ± 0.064	4.069ProVal: 4.069 ± 0.081	0.711ProTrp: 0.711 ± 0.028	1.179ProTyr: 1.179 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.118GlnAla: 4.118 ± 0.073	0.239GlnCys: 0.239 ± 0.018	1.621GlnAsp: 1.621 ± 0.047	1.192GlnGlu: 1.192 ± 0.045	1.151GlnPhe: 1.151 ± 0.039	2.436GlnGly: 2.436 ± 0.066	0.628GlnHis: 0.628 ± 0.03	1.759GlnIle: 1.759 ± 0.049	0.977GlnLys: 0.977 ± 0.032	3.087GlnLeu: 3.087 ± 0.064	0.814GlnMet: 0.814 ± 0.032	0.847GlnAsn: 0.847 ± 0.038	1.856GlnPro: 1.856 ± 0.046	1.249GlnGln: 1.249 ± 0.045	2.702GlnArg: 2.702 ± 0.063	1.885GlnSer: 1.885 ± 0.051	1.926GlnThr: 1.926 ± 0.053	2.312GlnVal: 2.312 ± 0.054	0.389GlnTrp: 0.389 ± 0.024	0.766GlnTyr: 0.766 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	7.891ArgAla: 7.891 ± 0.12	0.541ArgCys: 0.541 ± 0.029	4.544ArgAsp: 4.544 ± 0.08	3.572ArgGlu: 3.572 ± 0.075	3.162ArgPhe: 3.162 ± 0.056	5.037ArgGly: 5.037 ± 0.076	1.827ArgHis: 1.827 ± 0.054	3.95ArgIle: 3.95 ± 0.066	2.113ArgLys: 2.113 ± 0.056	7.438ArgLeu: 7.438 ± 0.113	2.04ArgMet: 2.04 ± 0.05	2.033ArgAsn: 2.033 ± 0.056	3.53ArgPro: 3.53 ± 0.062	2.518ArgGln: 2.518 ± 0.064	5.892ArgArg: 5.892 ± 0.12	4.304ArgSer: 4.304 ± 0.073	4.103ArgThr: 4.103 ± 0.073	4.956ArgVal: 4.956 ± 0.089	1.267ArgTrp: 1.267 ± 0.045	2.195ArgTyr: 2.195 ± 0.058	0.0ArgXaa: 0.0 ± 0.0
Ser	6.482SerAla: 6.482 ± 0.099	0.49SerCys: 0.49 ± 0.026	3.22SerAsp: 3.22 ± 0.06	2.503SerGlu: 2.503 ± 0.061	2.21SerPhe: 2.21 ± 0.056	5.236SerGly: 5.236 ± 0.093	1.032SerHis: 1.032 ± 0.032	2.89SerIle: 2.89 ± 0.061	1.679SerLys: 1.679 ± 0.048	5.197SerLeu: 5.197 ± 0.095	1.305SerMet: 1.305 ± 0.046	1.594SerAsn: 1.594 ± 0.061	2.96SerPro: 2.96 ± 0.073	1.663SerGln: 1.663 ± 0.045	3.691SerArg: 3.691 ± 0.066	3.315SerSer: 3.315 ± 0.1	3.158SerThr: 3.158 ± 0.066	4.215SerVal: 4.215 ± 0.072	0.769SerTrp: 0.769 ± 0.036	1.517SerTyr: 1.517 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	6.903ThrAla: 6.903 ± 0.106	0.42ThrCys: 0.42 ± 0.024	3.481ThrAsp: 3.481 ± 0.067	2.419ThrGlu: 2.419 ± 0.058	2.097ThrPhe: 2.097 ± 0.058	5.606ThrGly: 5.606 ± 0.089	1.133ThrHis: 1.133 ± 0.037	3.431ThrIle: 3.431 ± 0.072	1.729ThrLys: 1.729 ± 0.053	6.459ThrLeu: 6.459 ± 0.097	1.42ThrMet: 1.42 ± 0.042	1.616ThrAsn: 1.616 ± 0.054	3.677ThrPro: 3.677 ± 0.074	1.699ThrGln: 1.699 ± 0.047	3.723ThrArg: 3.723 ± 0.066	3.066ThrSer: 3.066 ± 0.074	3.409ThrThr: 3.409 ± 0.081	4.759ThrVal: 4.759 ± 0.077	0.707ThrTrp: 0.707 ± 0.031	1.423ThrTyr: 1.423 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	9.593ValAla: 9.593 ± 0.122	0.566ValCys: 0.566 ± 0.027	4.516ValAsp: 4.516 ± 0.078	4.422ValGlu: 4.422 ± 0.086	2.349ValPhe: 2.349 ± 0.053	5.657ValGly: 5.657 ± 0.075	1.366ValHis: 1.366 ± 0.047	3.808ValIle: 3.808 ± 0.075	2.183ValLys: 2.183 ± 0.06	6.909ValLeu: 6.909 ± 0.096	1.739ValMet: 1.739 ± 0.047	2.074ValAsn: 2.074 ± 0.054	4.035ValPro: 4.035 ± 0.066	2.205ValGln: 2.205 ± 0.053	5.215ValArg: 5.215 ± 0.086	4.508ValSer: 4.508 ± 0.087	4.918ValThr: 4.918 ± 0.085	5.924ValVal: 5.924 ± 0.102	0.947ValTrp: 0.947 ± 0.038	1.491ValTyr: 1.491 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.317TrpAla: 1.317 ± 0.04	0.147TrpCys: 0.147 ± 0.013	0.806TrpAsp: 0.806 ± 0.039	0.572TrpGlu: 0.572 ± 0.027	0.56TrpPhe: 0.56 ± 0.028	0.918TrpGly: 0.918 ± 0.033	0.4TrpHis: 0.4 ± 0.021	0.649TrpIle: 0.649 ± 0.028	0.538TrpLys: 0.538 ± 0.03	1.645TrpLeu: 1.645 ± 0.05	0.386TrpMet: 0.386 ± 0.023	0.472TrpAsn: 0.472 ± 0.022	0.723TrpPro: 0.723 ± 0.032	0.619TrpGln: 0.619 ± 0.032	1.251TrpArg: 1.251 ± 0.036	0.955TrpSer: 0.955 ± 0.035	1.056TrpThr: 1.056 ± 0.04	0.828TrpVal: 0.828 ± 0.033	0.263TrpTrp: 0.263 ± 0.019	0.355TrpTyr: 0.355 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.956TyrAla: 2.956 ± 0.066	0.288TyrCys: 0.288 ± 0.02	1.797TyrAsp: 1.797 ± 0.05	1.241TyrGlu: 1.241 ± 0.041	0.976TyrPhe: 0.976 ± 0.036	2.338TyrGly: 2.338 ± 0.055	0.505TyrHis: 0.505 ± 0.022	0.949TyrIle: 0.949 ± 0.032	0.703TyrLys: 0.703 ± 0.031	2.259TyrLeu: 2.259 ± 0.057	0.42TyrMet: 0.42 ± 0.023	0.709TyrAsn: 0.709 ± 0.037	1.162TyrPro: 1.162 ± 0.039	0.798TyrGln: 0.798 ± 0.033	2.021TyrArg: 2.021 ± 0.057	1.358TyrSer: 1.358 ± 0.047	1.273TyrThr: 1.273 ± 0.044	1.719TyrVal: 1.719 ± 0.042	0.375TyrTrp: 0.375 ± 0.021	0.699TyrTyr: 0.699 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3455 proteins (776787 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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