Amino acid dipepetide frequency for Adhaeribacter aerolatus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.941AlaAla: 7.941 ± 0.087	0.664AlaCys: 0.664 ± 0.021	4.31AlaAsp: 4.31 ± 0.053	5.009AlaGlu: 5.009 ± 0.057	3.629AlaPhe: 3.629 ± 0.049	6.668AlaGly: 6.668 ± 0.084	1.385AlaHis: 1.385 ± 0.03	5.232AlaIle: 5.232 ± 0.06	4.46AlaLys: 4.46 ± 0.058	7.993AlaLeu: 7.993 ± 0.085	1.712AlaMet: 1.712 ± 0.038	3.961AlaAsn: 3.961 ± 0.056	3.209AlaPro: 3.209 ± 0.057	3.601AlaGln: 3.601 ± 0.048	3.419AlaArg: 3.419 ± 0.04	4.419AlaSer: 4.419 ± 0.056	4.895AlaThr: 4.895 ± 0.067	5.231AlaVal: 5.231 ± 0.063	0.926AlaTrp: 0.926 ± 0.022	2.988AlaTyr: 2.988 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.492CysAla: 0.492 ± 0.021	0.113CysCys: 0.113 ± 0.009	0.338CysAsp: 0.338 ± 0.016	0.389CysGlu: 0.389 ± 0.016	0.341CysPhe: 0.341 ± 0.014	0.585CysGly: 0.585 ± 0.026	0.203CysHis: 0.203 ± 0.012	0.429CysIle: 0.429 ± 0.016	0.322CysLys: 0.322 ± 0.014	0.742CysLeu: 0.742 ± 0.02	0.14CysMet: 0.14 ± 0.008	0.317CysAsn: 0.317 ± 0.015	0.33CysPro: 0.33 ± 0.014	0.302CysGln: 0.302 ± 0.013	0.328CysArg: 0.328 ± 0.013	0.46CysSer: 0.46 ± 0.019	0.423CysThr: 0.423 ± 0.017	0.38CysVal: 0.38 ± 0.016	0.079CysTrp: 0.079 ± 0.006	0.27CysTyr: 0.27 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.78AspAla: 3.78 ± 0.049	0.345AspCys: 0.345 ± 0.015	2.004AspAsp: 2.004 ± 0.035	2.984AspGlu: 2.984 ± 0.048	2.861AspPhe: 2.861 ± 0.044	3.377AspGly: 3.377 ± 0.055	0.785AspHis: 0.785 ± 0.021	3.461AspIle: 3.461 ± 0.046	3.564AspLys: 3.564 ± 0.049	5.062AspLeu: 5.062 ± 0.061	1.037AspMet: 1.037 ± 0.025	2.593AspAsn: 2.593 ± 0.041	2.098AspPro: 2.098 ± 0.036	1.815AspGln: 1.815 ± 0.032	2.091AspArg: 2.091 ± 0.04	2.374AspSer: 2.374 ± 0.045	2.366AspThr: 2.366 ± 0.043	2.936AspVal: 2.936 ± 0.044	0.813AspTrp: 0.813 ± 0.019	2.395AspTyr: 2.395 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.136GluAla: 5.136 ± 0.062	0.265GluCys: 0.265 ± 0.011	2.65GluAsp: 2.65 ± 0.049	4.053GluGlu: 4.053 ± 0.059	2.303GluPhe: 2.303 ± 0.037	3.446GluGly: 3.446 ± 0.046	1.11GluHis: 1.11 ± 0.025	4.242GluIle: 4.242 ± 0.046	4.56GluLys: 4.56 ± 0.059	5.654GluLeu: 5.654 ± 0.056	1.373GluMet: 1.373 ± 0.031	3.485GluAsn: 3.485 ± 0.044	2.149GluPro: 2.149 ± 0.038	2.587GluGln: 2.587 ± 0.044	2.659GluArg: 2.659 ± 0.044	2.703GluSer: 2.703 ± 0.041	3.062GluThr: 3.062 ± 0.043	4.352GluVal: 4.352 ± 0.054	0.671GluTrp: 0.671 ± 0.021	2.079GluTyr: 2.079 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.352PheAla: 3.352 ± 0.043	0.401PheCys: 0.401 ± 0.017	2.466PheAsp: 2.466 ± 0.038	2.41PheGlu: 2.41 ± 0.035	2.253PhePhe: 2.253 ± 0.039	3.388PheGly: 3.388 ± 0.053	0.751PheHis: 0.751 ± 0.019	3.16PheIle: 3.16 ± 0.041	2.665PheLys: 2.665 ± 0.041	4.684PheLeu: 4.684 ± 0.064	1.042PheMet: 1.042 ± 0.025	2.701PheAsn: 2.701 ± 0.04	1.786PhePro: 1.786 ± 0.035	1.569PheGln: 1.569 ± 0.03	2.305PheArg: 2.305 ± 0.043	3.377PheSer: 3.377 ± 0.049	3.191PheThr: 3.191 ± 0.048	2.675PheVal: 2.675 ± 0.042	0.619PheTrp: 0.619 ± 0.02	1.982PheTyr: 1.982 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	5.035GlyAla: 5.035 ± 0.069	0.609GlyCys: 0.609 ± 0.021	3.069GlyAsp: 3.069 ± 0.043	3.637GlyGlu: 3.637 ± 0.048	3.459GlyPhe: 3.459 ± 0.05	5.232GlyGly: 5.232 ± 0.078	1.344GlyHis: 1.344 ± 0.031	4.878GlyIle: 4.878 ± 0.063	4.955GlyLys: 4.955 ± 0.058	6.889GlyLeu: 6.889 ± 0.073	1.596GlyMet: 1.596 ± 0.029	3.854GlyAsn: 3.854 ± 0.067	2.09GlyPro: 2.09 ± 0.039	2.931GlyGln: 2.931 ± 0.046	3.02GlyArg: 3.02 ± 0.044	4.312GlySer: 4.312 ± 0.061	4.686GlyThr: 4.686 ± 0.083	4.552GlyVal: 4.552 ± 0.061	1.021GlyTrp: 1.021 ± 0.025	3.095GlyTyr: 3.095 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.227HisAla: 1.227 ± 0.028	0.165HisCys: 0.165 ± 0.01	0.857HisAsp: 0.857 ± 0.02	1.006HisGlu: 1.006 ± 0.024	1.02HisPhe: 1.02 ± 0.026	1.214HisGly: 1.214 ± 0.03	0.542HisHis: 0.542 ± 0.02	1.115HisIle: 1.115 ± 0.024	0.96HisLys: 0.96 ± 0.019	2.159HisLeu: 2.159 ± 0.034	0.338HisMet: 0.338 ± 0.014	0.963HisAsn: 0.963 ± 0.02	1.129HisPro: 1.129 ± 0.027	0.999HisGln: 0.999 ± 0.025	0.868HisArg: 0.868 ± 0.025	0.918HisSer: 0.918 ± 0.025	1.032HisThr: 1.032 ± 0.027	1.033HisVal: 1.033 ± 0.026	0.273HisTrp: 0.273 ± 0.012	0.837HisTyr: 0.837 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.056IleAla: 5.056 ± 0.073	0.578IleCys: 0.578 ± 0.018	3.28IleAsp: 3.28 ± 0.045	3.253IleGlu: 3.253 ± 0.042	3.036IlePhe: 3.036 ± 0.047	4.543IleGly: 4.543 ± 0.053	1.118IleHis: 1.118 ± 0.028	4.578IleIle: 4.578 ± 0.064	4.14IleLys: 4.14 ± 0.05	6.036IleLeu: 6.036 ± 0.064	1.258IleMet: 1.258 ± 0.026	3.741IleAsn: 3.741 ± 0.049	3.069IlePro: 3.069 ± 0.041	2.582IleGln: 2.582 ± 0.039	3.151IleArg: 3.151 ± 0.044	4.525IleSer: 4.525 ± 0.059	4.381IleThr: 4.381 ± 0.062	3.335IleVal: 3.335 ± 0.045	0.696IleTrp: 0.696 ± 0.019	2.435IleTyr: 2.435 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	5.173LysAla: 5.173 ± 0.063	0.262LysCys: 0.262 ± 0.013	3.223LysAsp: 3.223 ± 0.052	4.351LysGlu: 4.351 ± 0.063	2.23LysPhe: 2.23 ± 0.037	4.04LysGly: 4.04 ± 0.051	1.063LysHis: 1.063 ± 0.025	4.334LysIle: 4.334 ± 0.047	4.465LysLys: 4.465 ± 0.064	5.766LysLeu: 5.766 ± 0.056	1.502LysMet: 1.502 ± 0.027	3.72LysAsn: 3.72 ± 0.048	2.927LysPro: 2.927 ± 0.04	2.491LysGln: 2.491 ± 0.046	2.503LysArg: 2.503 ± 0.041	3.279LysSer: 3.279 ± 0.038	3.706LysThr: 3.706 ± 0.045	4.182LysVal: 4.182 ± 0.051	0.742LysTrp: 0.742 ± 0.023	2.563LysTyr: 2.563 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	8.631LeuAla: 8.631 ± 0.093	0.672LeuCys: 0.672 ± 0.018	4.807LeuAsp: 4.807 ± 0.058	5.604LeuGlu: 5.604 ± 0.062	4.576LeuPhe: 4.576 ± 0.06	6.384LeuGly: 6.384 ± 0.07	1.839LeuHis: 1.839 ± 0.034	5.8LeuIle: 5.8 ± 0.057	6.464LeuLys: 6.464 ± 0.056	10.252LeuLeu: 10.252 ± 0.114	2.015LeuMet: 2.015 ± 0.036	5.618LeuAsn: 5.618 ± 0.065	4.921LeuPro: 4.921 ± 0.053	4.592LeuGln: 4.592 ± 0.059	4.342LeuArg: 4.342 ± 0.055	6.16LeuSer: 6.16 ± 0.056	6.235LeuThr: 6.235 ± 0.064	6.401LeuVal: 6.401 ± 0.056	0.948LeuTrp: 0.948 ± 0.023	3.384LeuTyr: 3.384 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.013MetAla: 2.013 ± 0.037	0.104MetCys: 0.104 ± 0.007	1.011MetAsp: 1.011 ± 0.024	1.196MetGlu: 1.196 ± 0.024	0.722MetPhe: 0.722 ± 0.02	1.479MetGly: 1.479 ± 0.033	0.475MetHis: 0.475 ± 0.014	1.102MetIle: 1.102 ± 0.027	1.474MetLys: 1.474 ± 0.027	2.115MetLeu: 2.115 ± 0.04	0.476MetMet: 0.476 ± 0.019	1.054MetAsn: 1.054 ± 0.022	1.14MetPro: 1.14 ± 0.025	1.082MetGln: 1.082 ± 0.027	0.999MetArg: 0.999 ± 0.025	1.061MetSer: 1.061 ± 0.027	0.947MetThr: 0.947 ± 0.024	1.505MetVal: 1.505 ± 0.031	0.206MetTrp: 0.206 ± 0.01	0.606MetTyr: 0.606 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.963AsnAla: 3.963 ± 0.047	0.383AsnCys: 0.383 ± 0.017	2.218AsnAsp: 2.218 ± 0.04	2.579AsnGlu: 2.579 ± 0.042	2.736AsnPhe: 2.736 ± 0.042	3.891AsnGly: 3.891 ± 0.066	0.94AsnHis: 0.94 ± 0.024	4.238AsnIle: 4.238 ± 0.051	3.31AsnLys: 3.31 ± 0.05	5.767AsnLeu: 5.767 ± 0.068	1.028AsnMet: 1.028 ± 0.022	3.384AsnAsn: 3.384 ± 0.056	3.153AsnPro: 3.153 ± 0.048	2.645AsnGln: 2.645 ± 0.047	2.641AsnArg: 2.641 ± 0.046	2.97AsnSer: 2.97 ± 0.041	3.256AsnThr: 3.256 ± 0.052	2.766AsnVal: 2.766 ± 0.044	0.86AsnTrp: 0.86 ± 0.023	2.538AsnTyr: 2.538 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	4.513ProAla: 4.513 ± 0.064	0.208ProCys: 0.208 ± 0.014	2.97ProAsp: 2.97 ± 0.041	3.697ProGlu: 3.697 ± 0.047	1.996ProPhe: 1.996 ± 0.034	3.364ProGly: 3.364 ± 0.053	0.854ProHis: 0.854 ± 0.021	2.406ProIle: 2.406 ± 0.038	2.232ProLys: 2.232 ± 0.038	3.799ProLeu: 3.799 ± 0.047	0.774ProMet: 0.774 ± 0.02	2.345ProAsn: 2.345 ± 0.034	1.395ProPro: 1.395 ± 0.031	1.756ProGln: 1.756 ± 0.033	1.437ProArg: 1.437 ± 0.031	2.081ProSer: 2.081 ± 0.031	2.48ProThr: 2.48 ± 0.043	3.678ProVal: 3.678 ± 0.048	0.502ProTrp: 0.502 ± 0.016	1.696ProTyr: 1.696 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.724GlnAla: 3.724 ± 0.053	0.192GlnCys: 0.192 ± 0.01	1.967GlnAsp: 1.967 ± 0.038	2.989GlnGlu: 2.989 ± 0.046	1.71GlnPhe: 1.71 ± 0.031	2.503GlnGly: 2.503 ± 0.038	1.0GlnHis: 1.0 ± 0.023	2.524GlnIle: 2.524 ± 0.038	3.004GlnLys: 3.004 ± 0.046	4.268GlnLeu: 4.268 ± 0.059	0.905GlnMet: 0.905 ± 0.025	2.65GlnAsn: 2.65 ± 0.039	2.039GlnPro: 2.039 ± 0.038	2.449GlnGln: 2.449 ± 0.049	1.85GlnArg: 1.85 ± 0.032	2.043GlnSer: 2.043 ± 0.039	2.52GlnThr: 2.52 ± 0.038	3.223GlnVal: 3.223 ± 0.045	0.482GlnTrp: 0.482 ± 0.016	1.569GlnTyr: 1.569 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	3.027ArgAla: 3.027 ± 0.041	0.241ArgCys: 0.241 ± 0.012	2.034ArgAsp: 2.034 ± 0.041	2.751ArgGlu: 2.751 ± 0.042	2.21ArgPhe: 2.21 ± 0.037	2.502ArgGly: 2.502 ± 0.041	0.897ArgHis: 0.897 ± 0.021	3.067ArgIle: 3.067 ± 0.041	2.847ArgLys: 2.847 ± 0.045	4.627ArgLeu: 4.627 ± 0.061	1.07ArgMet: 1.07 ± 0.023	2.632ArgAsn: 2.632 ± 0.041	1.772ArgPro: 1.772 ± 0.034	2.256ArgGln: 2.256 ± 0.038	2.054ArgArg: 2.054 ± 0.035	2.249ArgSer: 2.249 ± 0.037	2.466ArgThr: 2.466 ± 0.039	2.84ArgVal: 2.84 ± 0.039	0.631ArgTrp: 0.631 ± 0.019	1.967ArgTyr: 1.967 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	4.387SerAla: 4.387 ± 0.054	0.521SerCys: 0.521 ± 0.02	2.688SerAsp: 2.688 ± 0.037	3.008SerGlu: 3.008 ± 0.039	3.268SerPhe: 3.268 ± 0.047	4.699SerGly: 4.699 ± 0.065	1.046SerHis: 1.046 ± 0.023	3.481SerIle: 3.481 ± 0.048	3.011SerLys: 3.011 ± 0.037	5.944SerLeu: 5.944 ± 0.063	1.118SerMet: 1.118 ± 0.027	2.74SerAsn: 2.74 ± 0.046	2.601SerPro: 2.601 ± 0.048	2.225SerGln: 2.225 ± 0.04	2.609SerArg: 2.609 ± 0.045	3.473SerSer: 3.473 ± 0.058	3.167SerThr: 3.167 ± 0.048	3.803SerVal: 3.803 ± 0.048	0.728SerTrp: 0.728 ± 0.024	2.403SerTyr: 2.403 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.023ThrAla: 5.023 ± 0.077	0.365ThrCys: 0.365 ± 0.019	3.298ThrAsp: 3.298 ± 0.043	3.385ThrGlu: 3.385 ± 0.044	2.795ThrPhe: 2.795 ± 0.048	5.098ThrGly: 5.098 ± 0.074	1.052ThrHis: 1.052 ± 0.026	3.834ThrIle: 3.834 ± 0.054	2.989ThrLys: 2.989 ± 0.044	5.808ThrLeu: 5.808 ± 0.061	0.954ThrMet: 0.954 ± 0.022	3.022ThrAsn: 3.022 ± 0.048	3.076ThrPro: 3.076 ± 0.042	2.321ThrGln: 2.321 ± 0.042	2.348ThrArg: 2.348 ± 0.039	3.487ThrSer: 3.487 ± 0.05	3.792ThrThr: 3.792 ± 0.069	3.962ThrVal: 3.962 ± 0.065	0.779ThrTrp: 0.779 ± 0.024	2.431ThrTyr: 2.431 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	5.379ValAla: 5.379 ± 0.063	0.514ValCys: 0.514 ± 0.019	2.927ValAsp: 2.927 ± 0.047	3.376ValGlu: 3.376 ± 0.052	2.866ValPhe: 2.866 ± 0.038	4.2ValGly: 4.2 ± 0.05	1.098ValHis: 1.098 ± 0.026	4.178ValIle: 4.178 ± 0.053	4.224ValLys: 4.224 ± 0.047	6.324ValLeu: 6.324 ± 0.061	1.458ValMet: 1.458 ± 0.029	3.552ValAsn: 3.552 ± 0.051	3.066ValPro: 3.066 ± 0.042	2.597ValGln: 2.597 ± 0.044	2.751ValArg: 2.751 ± 0.042	4.034ValSer: 4.034 ± 0.048	4.041ValThr: 4.041 ± 0.07	4.599ValVal: 4.599 ± 0.057	0.719ValTrp: 0.719 ± 0.022	2.41ValTyr: 2.41 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.911TrpAla: 0.911 ± 0.027	0.094TrpCys: 0.094 ± 0.007	0.633TrpAsp: 0.633 ± 0.021	0.756TrpGlu: 0.756 ± 0.02	0.567TrpPhe: 0.567 ± 0.017	0.852TrpGly: 0.852 ± 0.022	0.327TrpHis: 0.327 ± 0.015	0.617TrpIle: 0.617 ± 0.019	0.641TrpLys: 0.641 ± 0.019	1.432TrpLeu: 1.432 ± 0.031	0.288TrpMet: 0.288 ± 0.012	0.602TrpAsn: 0.602 ± 0.019	0.469TrpPro: 0.469 ± 0.017	0.821TrpGln: 0.821 ± 0.023	0.638TrpArg: 0.638 ± 0.02	0.649TrpSer: 0.649 ± 0.021	0.641TrpThr: 0.641 ± 0.02	0.797TrpVal: 0.797 ± 0.022	0.184TrpTrp: 0.184 ± 0.01	0.49TrpTyr: 0.49 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.89TyrAla: 2.89 ± 0.044	0.289TyrCys: 0.289 ± 0.011	1.994TyrAsp: 1.994 ± 0.033	2.103TyrGlu: 2.103 ± 0.039	2.2TyrPhe: 2.2 ± 0.039	2.8TyrGly: 2.8 ± 0.043	0.828TyrHis: 0.828 ± 0.022	2.114TyrIle: 2.114 ± 0.036	2.236TyrLys: 2.236 ± 0.034	4.323TyrLeu: 4.323 ± 0.06	0.681TyrMet: 0.681 ± 0.019	2.328TyrAsn: 2.328 ± 0.038	1.766TyrPro: 1.766 ± 0.032	1.99TyrGln: 1.99 ± 0.042	2.124TyrArg: 2.124 ± 0.036	2.345TyrSer: 2.345 ± 0.039	2.533TyrThr: 2.533 ± 0.042	2.062TyrVal: 2.062 ± 0.035	0.532TyrTrp: 0.532 ± 0.017	1.868TyrTyr: 1.868 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5168 proteins (1833445 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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