Amino acid dipepetide frequency for Beggiatoa sp. SS

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.668AlaAla: 5.668 ± 0.229
0.918AlaCys: 0.918 ± 0.072
3.672AlaAsp: 3.672 ± 0.143
4.26AlaGlu: 4.26 ± 0.148
3.168AlaPhe: 3.168 ± 0.133
4.877AlaGly: 4.877 ± 0.181
1.746AlaHis: 1.746 ± 0.103
4.952AlaIle: 4.952 ± 0.151
4.237AlaLys: 4.237 ± 0.152
8.634AlaLeu: 8.634 ± 0.247
1.859AlaMet: 1.859 ± 0.1
3.163AlaAsn: 3.163 ± 0.127
2.843AlaPro: 2.843 ± 0.113
3.761AlaGln: 3.761 ± 0.129
3.309AlaArg: 3.309 ± 0.125
4.538AlaSer: 4.538 ± 0.178
3.968AlaThr: 3.968 ± 0.157
4.684AlaVal: 4.684 ± 0.158
0.97AlaTrp: 0.97 ± 0.062
2.198AlaTyr: 2.198 ± 0.104
0.038AlaXaa: 0.038 ± 0.014
Cys
0.777CysAla: 0.777 ± 0.065
0.273CysCys: 0.273 ± 0.047
0.56CysAsp: 0.56 ± 0.057
0.678CysGlu: 0.678 ± 0.058
0.64CysPhe: 0.64 ± 0.05
0.913CysGly: 0.913 ± 0.084
0.48CysHis: 0.48 ± 0.051
0.584CysIle: 0.584 ± 0.056
0.485CysLys: 0.485 ± 0.053
1.393CysLeu: 1.393 ± 0.081
0.226CysMet: 0.226 ± 0.033
0.381CysAsn: 0.381 ± 0.044
0.734CysPro: 0.734 ± 0.073
0.617CysGln: 0.617 ± 0.055
0.701CysArg: 0.701 ± 0.065
0.777CysSer: 0.777 ± 0.061
0.659CysThr: 0.659 ± 0.069
0.805CysVal: 0.805 ± 0.076
0.141CysTrp: 0.141 ± 0.025
0.485CysTyr: 0.485 ± 0.048
0.014CysXaa: 0.014 ± 0.009
Asp
3.305AspAla: 3.305 ± 0.129
0.683AspCys: 0.683 ± 0.067
3.272AspAsp: 3.272 ± 0.419
3.192AspGlu: 3.192 ± 0.136
2.556AspPhe: 2.556 ± 0.113
3.752AspGly: 3.752 ± 0.163
0.861AspHis: 0.861 ± 0.067
3.705AspIle: 3.705 ± 0.136
3.234AspLys: 3.234 ± 0.131
4.886AspLeu: 4.886 ± 0.291
1.252AspMet: 1.252 ± 0.091
2.655AspAsn: 2.655 ± 0.134
1.789AspPro: 1.789 ± 0.101
1.586AspGln: 1.586 ± 0.092
1.808AspArg: 1.808 ± 0.09
3.154AspSer: 3.154 ± 0.126
2.476AspThr: 2.476 ± 0.115
2.608AspVal: 2.608 ± 0.118
0.678AspTrp: 0.678 ± 0.052
2.147AspTyr: 2.147 ± 0.103
0.005AspXaa: 0.005 ± 0.005
Glu
4.999GluAla: 4.999 ± 0.196
0.603GluCys: 0.603 ± 0.065
2.514GluAsp: 2.514 ± 0.118
3.771GluGlu: 3.771 ± 0.153
1.662GluPhe: 1.662 ± 0.082
3.719GluGly: 3.719 ± 0.127
1.295GluHis: 1.295 ± 0.069
4.331GluIle: 4.331 ± 0.157
3.818GluLys: 3.818 ± 0.139
5.428GluLeu: 5.428 ± 0.178
1.751GluMet: 1.751 ± 0.1
3.018GluAsn: 3.018 ± 0.123
2.302GluPro: 2.302 ± 0.103
3.488GluGln: 3.488 ± 0.137
3.319GluArg: 3.319 ± 0.146
3.102GluSer: 3.102 ± 0.136
3.742GluThr: 3.742 ± 0.141
3.446GluVal: 3.446 ± 0.141
0.753GluTrp: 0.753 ± 0.062
1.511GluTyr: 1.511 ± 0.098
0.005GluXaa: 0.005 ± 0.005
Phe
2.773PheAla: 2.773 ± 0.106
0.833PheCys: 0.833 ± 0.1
2.401PheAsp: 2.401 ± 0.111
2.716PheGlu: 2.716 ± 0.112
2.825PhePhe: 2.825 ± 0.187
2.947PheGly: 2.947 ± 0.136
1.054PheHis: 1.054 ± 0.073
2.975PheIle: 2.975 ± 0.13
2.448PheLys: 2.448 ± 0.121
4.138PheLeu: 4.138 ± 0.164
1.182PheMet: 1.182 ± 0.069
1.991PheAsn: 1.991 ± 0.094
1.869PhePro: 1.869 ± 0.09
1.916PheGln: 1.916 ± 0.095
1.972PheArg: 1.972 ± 0.099
3.629PheSer: 3.629 ± 0.169
2.321PheThr: 2.321 ± 0.106
2.594PheVal: 2.594 ± 0.107
0.593PheTrp: 0.593 ± 0.057
1.37PheTyr: 1.37 ± 0.086
0.033PheXaa: 0.033 ± 0.016
Gly
4.161GlyAla: 4.161 ± 0.186
0.942GlyCys: 0.942 ± 0.073
3.432GlyAsp: 3.432 ± 0.181
4.241GlyGlu: 4.241 ± 0.134
3.163GlyPhe: 3.163 ± 0.134
5.847GlyGly: 5.847 ± 0.385
1.577GlyHis: 1.577 ± 0.106
4.74GlyIle: 4.74 ± 0.165
4.209GlyLys: 4.209 ± 0.164
6.501GlyLeu: 6.501 ± 0.187
1.869GlyMet: 1.869 ± 0.094
3.116GlyAsn: 3.116 ± 0.151
1.878GlyPro: 1.878 ± 0.104
3.253GlyGln: 3.253 ± 0.142
3.394GlyArg: 3.394 ± 0.164
3.837GlySer: 3.837 ± 0.166
3.775GlyThr: 3.775 ± 0.193
4.128GlyVal: 4.128 ± 0.159
0.984GlyTrp: 0.984 ± 0.065
2.175GlyTyr: 2.175 ± 0.095
0.066GlyXaa: 0.066 ± 0.03
His
1.488HisAla: 1.488 ± 0.085
0.424HisCys: 0.424 ± 0.04
1.158HisAsp: 1.158 ± 0.088
1.191HisGlu: 1.191 ± 0.08
1.53HisPhe: 1.53 ± 0.091
1.252HisGly: 1.252 ± 0.073
0.852HisHis: 0.852 ± 0.063
1.596HisIle: 1.596 ± 0.08
1.177HisLys: 1.177 ± 0.145
3.192HisLeu: 3.192 ± 0.129
0.334HisMet: 0.334 ± 0.036
0.97HisAsn: 0.97 ± 0.07
1.662HisPro: 1.662 ± 0.099
1.215HisGln: 1.215 ± 0.077
1.309HisArg: 1.309 ± 0.084
1.455HisSer: 1.455 ± 0.086
1.266HisThr: 1.266 ± 0.076
1.05HisVal: 1.05 ± 0.07
0.405HisTrp: 0.405 ± 0.044
1.191HisTyr: 1.191 ± 0.082
0.005HisXaa: 0.005 ± 0.005
Ile
5.136IleAla: 5.136 ± 0.156
0.763IleCys: 0.763 ± 0.058
3.653IleAsp: 3.653 ± 0.134
4.576IleGlu: 4.576 ± 0.146
2.65IlePhe: 2.65 ± 0.133
4.185IleGly: 4.185 ± 0.153
1.648IleHis: 1.648 ± 0.145
4.194IleIle: 4.194 ± 0.175
3.714IleLys: 3.714 ± 0.127
6.266IleLeu: 6.266 ± 0.182
1.525IleMet: 1.525 ± 0.079
3.239IleAsn: 3.239 ± 0.114
3.389IlePro: 3.389 ± 0.127
2.726IleGln: 2.726 ± 0.108
3.102IleArg: 3.102 ± 0.118
4.477IleSer: 4.477 ± 0.174
3.997IleThr: 3.997 ± 0.159
3.705IleVal: 3.705 ± 0.133
0.73IleTrp: 0.73 ± 0.062
2.057IleTyr: 2.057 ± 0.096
0.019IleXaa: 0.019 ± 0.009
Lys
4.623LysAla: 4.623 ± 0.152
0.475LysCys: 0.475 ± 0.051
2.198LysAsp: 2.198 ± 0.104
2.872LysGlu: 2.872 ± 0.126
1.634LysPhe: 1.634 ± 0.094
3.771LysGly: 3.771 ± 0.145
1.172LysHis: 1.172 ± 0.087
3.87LysIle: 3.87 ± 0.156
3.705LysLys: 3.705 ± 0.168
4.905LysLeu: 4.905 ± 0.153
1.737LysMet: 1.737 ± 0.084
2.806LysAsn: 2.806 ± 0.128
2.744LysPro: 2.744 ± 0.107
2.89LysGln: 2.89 ± 0.12
3.446LysArg: 3.446 ± 0.135
3.291LysSer: 3.291 ± 0.144
4.096LysThr: 4.096 ± 0.183
2.914LysVal: 2.914 ± 0.14
0.612LysTrp: 0.612 ± 0.051
1.304LysTyr: 1.304 ± 0.087
0.028LysXaa: 0.028 ± 0.014
Leu
8.375LeuAla: 8.375 ± 0.252
1.167LeuCys: 1.167 ± 0.076
4.924LeuAsp: 4.924 ± 0.22
6.383LeuGlu: 6.383 ± 0.188
5.108LeuPhe: 5.108 ± 0.201
6.398LeuGly: 6.398 ± 0.221
2.368LeuHis: 2.368 ± 0.106
6.977LeuIle: 6.977 ± 0.19
6.176LeuLys: 6.176 ± 0.204
10.738LeuLeu: 10.738 ± 0.339
2.382LeuMet: 2.382 ± 0.119
4.788LeuAsn: 4.788 ± 0.143
5.503LeuPro: 5.503 ± 0.179
4.477LeuGln: 4.477 ± 0.161
5.164LeuArg: 5.164 ± 0.177
8.539LeuSer: 8.539 ± 0.269
6.096LeuThr: 6.096 ± 0.181
5.701LeuVal: 5.701 ± 0.179
1.309LeuTrp: 1.309 ± 0.089
3.022LeuTyr: 3.022 ± 0.124
0.028LeuXaa: 0.028 ± 0.022
Met
2.081MetAla: 2.081 ± 0.093
0.202MetCys: 0.202 ± 0.035
1.083MetAsp: 1.083 ± 0.073
1.144MetGlu: 1.144 ± 0.081
0.753MetPhe: 0.753 ± 0.067
1.864MetGly: 1.864 ± 0.119
0.414MetHis: 0.414 ± 0.043
1.756MetIle: 1.756 ± 0.09
1.422MetLys: 1.422 ± 0.085
2.42MetLeu: 2.42 ± 0.116
0.664MetMet: 0.664 ± 0.057
1.13MetAsn: 1.13 ± 0.07
1.553MetPro: 1.553 ± 0.085
0.918MetGln: 0.918 ± 0.069
1.506MetArg: 1.506 ± 0.085
1.615MetSer: 1.615 ± 0.086
1.676MetThr: 1.676 ± 0.095
1.45MetVal: 1.45 ± 0.088
0.226MetTrp: 0.226 ± 0.034
0.508MetTyr: 0.508 ± 0.052
0.009MetXaa: 0.009 ± 0.01
Asn
3.187AsnAla: 3.187 ± 0.123
0.537AsnCys: 0.537 ± 0.055
2.118AsnAsp: 2.118 ± 0.105
2.481AsnGlu: 2.481 ± 0.11
1.648AsnPhe: 1.648 ± 0.093
3.107AsnGly: 3.107 ± 0.164
1.158AsnHis: 1.158 ± 0.078
2.589AsnIle: 2.589 ± 0.105
2.373AsnLys: 2.373 ± 0.112
4.665AsnLeu: 4.665 ± 0.183
1.149AsnMet: 1.149 ± 0.079
2.198AsnAsn: 2.198 ± 0.113
2.909AsnPro: 2.909 ± 0.112
2.632AsnGln: 2.632 ± 0.128
2.5AsnArg: 2.5 ± 0.13
2.839AsnSer: 2.839 ± 0.127
2.697AsnThr: 2.697 ± 0.123
2.269AsnVal: 2.269 ± 0.113
0.617AsnTrp: 0.617 ± 0.059
1.351AsnTyr: 1.351 ± 0.084
0.009AsnXaa: 0.009 ± 0.005
Pro
3.196ProAla: 3.196 ± 0.127
0.532ProCys: 0.532 ± 0.048
2.787ProAsp: 2.787 ± 0.117
2.886ProGlu: 2.886 ± 0.126
2.377ProPhe: 2.377 ± 0.113
2.632ProGly: 2.632 ± 0.146
1.323ProHis: 1.323 ± 0.082
3.225ProIle: 3.225 ± 0.107
2.542ProLys: 2.542 ± 0.101
5.729ProLeu: 5.729 ± 0.173
1.13ProMet: 1.13 ± 0.062
2.377ProAsn: 2.377 ± 0.11
3.276ProPro: 3.276 ± 0.194
2.137ProGln: 2.137 ± 0.105
2.024ProArg: 2.024 ± 0.154
3.361ProSer: 3.361 ± 0.163
2.857ProThr: 2.857 ± 0.131
2.97ProVal: 2.97 ± 0.125
0.565ProTrp: 0.565 ± 0.053
1.342ProTyr: 1.342 ± 0.074
0.056ProXaa: 0.056 ± 0.032
Gln
4.387GlnAla: 4.387 ± 0.141
0.475GlnCys: 0.475 ± 0.052
1.954GlnAsp: 1.954 ± 0.099
2.613GlnGlu: 2.613 ± 0.138
1.963GlnPhe: 1.963 ± 0.088
3.267GlnGly: 3.267 ± 0.125
1.229GlnHis: 1.229 ± 0.076
3.131GlnIle: 3.131 ± 0.126
2.857GlnLys: 2.857 ± 0.121
5.07GlnLeu: 5.07 ± 0.183
1.172GlnMet: 1.172 ± 0.072
2.264GlnAsn: 2.264 ± 0.13
2.278GlnPro: 2.278 ± 0.128
2.693GlnGln: 2.693 ± 0.123
2.594GlnArg: 2.594 ± 0.108
2.956GlnSer: 2.956 ± 0.116
2.956GlnThr: 2.956 ± 0.121
3.154GlnVal: 3.154 ± 0.111
0.654GlnTrp: 0.654 ± 0.055
1.37GlnTyr: 1.37 ± 0.09
0.0GlnXaa: 0.0 ± 0.001
Arg
3.159ArgAla: 3.159 ± 0.11
0.781ArgCys: 0.781 ± 0.062
2.358ArgAsp: 2.358 ± 0.121
3.003ArgGlu: 3.003 ± 0.118
2.509ArgPhe: 2.509 ± 0.105
3.211ArgGly: 3.211 ± 0.122
1.586ArgHis: 1.586 ± 0.09
3.211ArgIle: 3.211 ± 0.173
2.236ArgLys: 2.236 ± 0.106
6.026ArgLeu: 6.026 ± 0.187
1.257ArgMet: 1.257 ± 0.072
1.723ArgAsn: 1.723 ± 0.098
2.095ArgPro: 2.095 ± 0.109
2.744ArgGln: 2.744 ± 0.137
2.787ArgArg: 2.787 ± 0.139
2.697ArgSer: 2.697 ± 0.103
2.283ArgThr: 2.283 ± 0.112
2.98ArgVal: 2.98 ± 0.12
0.668ArgTrp: 0.668 ± 0.06
1.944ArgTyr: 1.944 ± 0.095
0.024ArgXaa: 0.024 ± 0.013
Ser
4.213SerAla: 4.213 ± 0.152
0.72SerCys: 0.72 ± 0.065
3.229SerAsp: 3.229 ± 0.137
3.484SerGlu: 3.484 ± 0.145
2.942SerPhe: 2.942 ± 0.131
4.858SerGly: 4.858 ± 0.186
1.794SerHis: 1.794 ± 0.104
3.7SerIle: 3.7 ± 0.151
3.008SerLys: 3.008 ± 0.113
7.273SerLeu: 7.273 ± 0.276
1.262SerMet: 1.262 ± 0.074
2.66SerAsn: 2.66 ± 0.126
3.964SerPro: 3.964 ± 0.182
3.338SerGln: 3.338 ± 0.137
2.985SerArg: 2.985 ± 0.122
4.331SerSer: 4.331 ± 0.176
3.3SerThr: 3.3 ± 0.15
4.515SerVal: 4.515 ± 0.16
0.668SerTrp: 0.668 ± 0.052
2.052SerTyr: 2.052 ± 0.118
0.028SerXaa: 0.028 ± 0.013
Thr
4.646ThrAla: 4.646 ± 0.176
0.65ThrCys: 0.65 ± 0.06
3.262ThrAsp: 3.262 ± 0.135
3.159ThrGlu: 3.159 ± 0.14
2.443ThrPhe: 2.443 ± 0.117
4.171ThrGly: 4.171 ± 0.138
1.436ThrHis: 1.436 ± 0.083
3.559ThrIle: 3.559 ± 0.152
2.293ThrLys: 2.293 ± 0.122
7.17ThrLeu: 7.17 ± 0.229
1.073ThrMet: 1.073 ± 0.08
1.916ThrAsn: 1.916 ± 0.095
3.404ThrPro: 3.404 ± 0.143
3.022ThrGln: 3.022 ± 0.138
2.462ThrArg: 2.462 ± 0.127
3.201ThrSer: 3.201 ± 0.126
3.305ThrThr: 3.305 ± 0.124
3.921ThrVal: 3.921 ± 0.144
0.654ThrTrp: 0.654 ± 0.063
1.553ThrTyr: 1.553 ± 0.098
0.014ThrXaa: 0.014 ± 0.009
Val
4.444ValAla: 4.444 ± 0.193
0.758ValCys: 0.758 ± 0.058
3.022ValAsp: 3.022 ± 0.119
3.578ValGlu: 3.578 ± 0.117
2.73ValPhe: 2.73 ± 0.129
3.879ValGly: 3.879 ± 0.157
1.328ValHis: 1.328 ± 0.081
4.256ValIle: 4.256 ± 0.148
3.229ValLys: 3.229 ± 0.122
6.054ValLeu: 6.054 ± 0.193
1.586ValMet: 1.586 ± 0.091
2.914ValAsn: 2.914 ± 0.153
2.57ValPro: 2.57 ± 0.115
2.476ValGln: 2.476 ± 0.135
2.547ValArg: 2.547 ± 0.134
4.058ValSer: 4.058 ± 0.14
3.554ValThr: 3.554 ± 0.171
4.373ValVal: 4.373 ± 0.199
0.763ValTrp: 0.763 ± 0.073
1.671ValTyr: 1.671 ± 0.093
0.028ValXaa: 0.028 ± 0.019
Trp
0.772TrpAla: 0.772 ± 0.06
0.174TrpCys: 0.174 ± 0.027
0.603TrpAsp: 0.603 ± 0.063
0.716TrpGlu: 0.716 ± 0.076
0.523TrpPhe: 0.523 ± 0.051
0.885TrpGly: 0.885 ± 0.072
0.466TrpHis: 0.466 ± 0.045
0.805TrpIle: 0.805 ± 0.063
0.626TrpLys: 0.626 ± 0.053
1.577TrpLeu: 1.577 ± 0.103
0.353TrpMet: 0.353 ± 0.043
0.461TrpAsn: 0.461 ± 0.048
0.555TrpPro: 0.555 ± 0.051
0.965TrpGln: 0.965 ± 0.072
0.65TrpArg: 0.65 ± 0.056
0.546TrpSer: 0.546 ± 0.046
0.546TrpThr: 0.546 ± 0.048
0.918TrpVal: 0.918 ± 0.068
0.24TrpTrp: 0.24 ± 0.034
0.386TrpTyr: 0.386 ± 0.045
0.005TrpXaa: 0.005 ± 0.005
Tyr
2.057TyrAla: 2.057 ± 0.101
0.395TyrCys: 0.395 ± 0.042
1.398TyrAsp: 1.398 ± 0.08
1.619TyrGlu: 1.619 ± 0.089
1.728TyrPhe: 1.728 ± 0.093
1.695TyrGly: 1.695 ± 0.098
0.932TyrHis: 0.932 ± 0.063
1.596TyrIle: 1.596 ± 0.083
1.266TyrLys: 1.266 ± 0.074
3.512TyrLeu: 3.512 ± 0.149
0.626TyrMet: 0.626 ± 0.049
1.257TyrAsn: 1.257 ± 0.075
1.949TyrPro: 1.949 ± 0.097
2.175TyrGln: 2.175 ± 0.115
1.681TyrArg: 1.681 ± 0.089
1.874TyrSer: 1.874 ± 0.092
1.732TyrThr: 1.732 ± 0.095
1.61TyrVal: 1.61 ± 0.098
0.532TyrTrp: 0.532 ± 0.046
1.13TyrTyr: 1.13 ± 0.084
0.005TyrXaa: 0.005 ± 0.005
Xaa
0.019XaaAla: 0.019 ± 0.012
0.019XaaCys: 0.019 ± 0.009
0.005XaaAsp: 0.005 ± 0.004
0.014XaaGlu: 0.014 ± 0.011
0.028XaaPhe: 0.028 ± 0.014
0.061XaaGly: 0.061 ± 0.028
0.0XaaHis: 0.0 ± 0.0
0.005XaaIle: 0.005 ± 0.005
0.038XaaLys: 0.038 ± 0.027
0.047XaaLeu: 0.047 ± 0.027
0.0XaaMet: 0.0 ± 0.0
0.005XaaAsn: 0.005 ± 0.004
0.056XaaPro: 0.056 ± 0.03
0.009XaaGln: 0.009 ± 0.006
0.024XaaArg: 0.024 ± 0.013
0.047XaaSer: 0.047 ± 0.022
0.009XaaThr: 0.009 ± 0.006
0.024XaaVal: 0.024 ± 0.01
0.009XaaTrp: 0.009 ± 0.006
0.0XaaTyr: 0.0 ± 0.0
0.49XaaXaa: 0.49 ± 0.245
Statistics based on 1437 proteins (212427 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski