Amino acid dipepetide frequency for Prevotella corporis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.908AlaAla: 4.908 ± 0.107	0.847AlaCys: 0.847 ± 0.035	4.233AlaAsp: 4.233 ± 0.073	4.315AlaGlu: 4.315 ± 0.09	3.11AlaPhe: 3.11 ± 0.071	4.244AlaGly: 4.244 ± 0.084	1.306AlaHis: 1.306 ± 0.036	4.994AlaIle: 4.994 ± 0.086	4.741AlaLys: 4.741 ± 0.086	6.066AlaLeu: 6.066 ± 0.094	2.008AlaMet: 2.008 ± 0.058	3.349AlaAsn: 3.349 ± 0.068	1.961AlaPro: 1.961 ± 0.055	2.781AlaGln: 2.781 ± 0.07	3.016AlaArg: 3.016 ± 0.066	4.005AlaSer: 4.005 ± 0.082	3.81AlaThr: 3.81 ± 0.084	4.347AlaVal: 4.347 ± 0.075	0.587AlaTrp: 0.587 ± 0.028	2.793AlaTyr: 2.793 ± 0.064	0.0AlaXaa: 0.0 ± 0.0
Cys	0.78CysAla: 0.78 ± 0.029	0.231CysCys: 0.231 ± 0.02	0.72CysAsp: 0.72 ± 0.028	0.682CysGlu: 0.682 ± 0.029	0.628CysPhe: 0.628 ± 0.028	1.04CysGly: 1.04 ± 0.039	0.368CysHis: 0.368 ± 0.022	0.872CysIle: 0.872 ± 0.036	0.86CysLys: 0.86 ± 0.035	1.091CysLeu: 1.091 ± 0.034	0.31CysMet: 0.31 ± 0.019	0.664CysAsn: 0.664 ± 0.027	0.528CysPro: 0.528 ± 0.03	0.419CysGln: 0.419 ± 0.023	0.67CysArg: 0.67 ± 0.03	0.801CysSer: 0.801 ± 0.03	0.635CysThr: 0.635 ± 0.027	0.773CysVal: 0.773 ± 0.031	0.158CysTrp: 0.158 ± 0.014	0.528CysTyr: 0.528 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.724AspAla: 3.724 ± 0.065	0.696AspCys: 0.696 ± 0.027	3.115AspAsp: 3.115 ± 0.07	4.086AspGlu: 4.086 ± 0.084	3.181AspPhe: 3.181 ± 0.07	3.994AspGly: 3.994 ± 0.088	0.957AspHis: 0.957 ± 0.039	4.254AspIle: 4.254 ± 0.071	4.229AspLys: 4.229 ± 0.077	4.464AspLeu: 4.464 ± 0.095	1.584AspMet: 1.584 ± 0.039	3.165AspAsn: 3.165 ± 0.07	1.731AspPro: 1.731 ± 0.042	1.245AspGln: 1.245 ± 0.041	2.449AspArg: 2.449 ± 0.058	3.193AspSer: 3.193 ± 0.065	2.806AspThr: 2.806 ± 0.059	3.532AspVal: 3.532 ± 0.064	0.749AspTrp: 0.749 ± 0.028	2.919AspTyr: 2.919 ± 0.072	0.0AspXaa: 0.0 ± 0.0
Glu	4.37GluAla: 4.37 ± 0.089	0.675GluCys: 0.675 ± 0.028	3.17GluAsp: 3.17 ± 0.063	4.897GluGlu: 4.897 ± 0.111	2.364GluPhe: 2.364 ± 0.053	3.792GluGly: 3.792 ± 0.065	1.3GluHis: 1.3 ± 0.04	4.644GluIle: 4.644 ± 0.093	5.279GluLys: 5.279 ± 0.081	5.733GluLeu: 5.733 ± 0.087	1.944GluMet: 1.944 ± 0.048	3.525GluAsn: 3.525 ± 0.064	1.769GluPro: 1.769 ± 0.055	2.886GluGln: 2.886 ± 0.075	3.476GluArg: 3.476 ± 0.07	3.08GluSer: 3.08 ± 0.062	3.291GluThr: 3.291 ± 0.067	3.999GluVal: 3.999 ± 0.083	0.728GluTrp: 0.728 ± 0.027	2.554GluTyr: 2.554 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.095PheAla: 3.095 ± 0.062	0.776PheCys: 0.776 ± 0.035	2.865PheAsp: 2.865 ± 0.061	2.38PheGlu: 2.38 ± 0.052	2.34PhePhe: 2.34 ± 0.065	3.304PheGly: 3.304 ± 0.08	0.999PheHis: 0.999 ± 0.04	3.282PheIle: 3.282 ± 0.069	2.761PheLys: 2.761 ± 0.057	4.0PheLeu: 4.0 ± 0.072	1.238PheMet: 1.238 ± 0.04	2.507PheAsn: 2.507 ± 0.063	1.567PhePro: 1.567 ± 0.045	1.309PheGln: 1.309 ± 0.042	2.163PheArg: 2.163 ± 0.047	3.428PheSer: 3.428 ± 0.062	2.681PheThr: 2.681 ± 0.053	3.078PheVal: 3.078 ± 0.067	0.476PheTrp: 0.476 ± 0.024	1.964PheTyr: 1.964 ± 0.056	0.0PheXaa: 0.0 ± 0.0
Gly	4.128GlyAla: 4.128 ± 0.091	0.901GlyCys: 0.901 ± 0.04	3.394GlyAsp: 3.394 ± 0.071	3.92GlyGlu: 3.92 ± 0.073	3.108GlyPhe: 3.108 ± 0.069	4.519GlyGly: 4.519 ± 0.097	1.357GlyHis: 1.357 ± 0.041	5.206GlyIle: 5.206 ± 0.076	5.565GlyLys: 5.565 ± 0.08	5.637GlyLeu: 5.637 ± 0.091	1.976GlyMet: 1.976 ± 0.051	3.61GlyAsn: 3.61 ± 0.072	1.128GlyPro: 1.128 ± 0.04	2.257GlyGln: 2.257 ± 0.05	2.916GlyArg: 2.916 ± 0.066	3.656GlySer: 3.656 ± 0.078	3.876GlyThr: 3.876 ± 0.084	4.302GlyVal: 4.302 ± 0.079	0.819GlyTrp: 0.819 ± 0.031	2.982GlyTyr: 2.982 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	1.158HisAla: 1.158 ± 0.041	0.364HisCys: 0.364 ± 0.02	1.054HisAsp: 1.054 ± 0.043	1.079HisGlu: 1.079 ± 0.033	1.117HisPhe: 1.117 ± 0.04	1.231HisGly: 1.231 ± 0.034	0.56HisHis: 0.56 ± 0.023	1.563HisIle: 1.563 ± 0.041	1.262HisLys: 1.262 ± 0.037	1.922HisLeu: 1.922 ± 0.047	0.365HisMet: 0.365 ± 0.021	1.051HisAsn: 1.051 ± 0.036	1.054HisPro: 1.054 ± 0.038	0.78HisGln: 0.78 ± 0.033	1.132HisArg: 1.132 ± 0.035	1.234HisSer: 1.234 ± 0.045	1.091HisThr: 1.091 ± 0.036	1.139HisVal: 1.139 ± 0.039	0.276HisTrp: 0.276 ± 0.017	0.951HisTyr: 0.951 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.327IleAla: 5.327 ± 0.095	0.999IleCys: 0.999 ± 0.035	4.81IleAsp: 4.81 ± 0.074	4.787IleGlu: 4.787 ± 0.081	2.939IlePhe: 2.939 ± 0.08	4.847IleGly: 4.847 ± 0.085	1.415IleHis: 1.415 ± 0.04	5.266IleIle: 5.266 ± 0.098	4.656IleLys: 4.656 ± 0.085	5.79IleLeu: 5.79 ± 0.105	1.694IleMet: 1.694 ± 0.054	3.799IleAsn: 3.799 ± 0.071	3.093IlePro: 3.093 ± 0.063	2.236IleGln: 2.236 ± 0.052	3.397IleArg: 3.397 ± 0.063	4.762IleSer: 4.762 ± 0.083	4.132IleThr: 4.132 ± 0.074	4.772IleVal: 4.772 ± 0.082	0.608IleTrp: 0.608 ± 0.03	2.762IleTyr: 2.762 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	5.168LysAla: 5.168 ± 0.088	0.683LysCys: 0.683 ± 0.027	4.175LysAsp: 4.175 ± 0.076	5.623LysGlu: 5.623 ± 0.098	2.653LysPhe: 2.653 ± 0.057	4.704LysGly: 4.704 ± 0.079	1.379LysHis: 1.379 ± 0.036	4.775LysIle: 4.775 ± 0.072	5.604LysLys: 5.604 ± 0.1	5.7LysLeu: 5.7 ± 0.08	2.281LysMet: 2.281 ± 0.055	3.857LysAsn: 3.857 ± 0.068	2.418LysPro: 2.418 ± 0.059	2.903LysGln: 2.903 ± 0.06	3.512LysArg: 3.512 ± 0.08	3.964LysSer: 3.964 ± 0.082	4.098LysThr: 4.098 ± 0.079	4.602LysVal: 4.602 ± 0.082	0.778LysTrp: 0.778 ± 0.031	3.086LysTyr: 3.086 ± 0.065	0.0LysXaa: 0.0 ± 0.0
Leu	5.931LeuAla: 5.931 ± 0.085	1.262LeuCys: 1.262 ± 0.04	4.634LeuAsp: 4.634 ± 0.088	4.715LeuGlu: 4.715 ± 0.088	4.196LeuPhe: 4.196 ± 0.082	5.47LeuGly: 5.47 ± 0.09	1.823LeuHis: 1.823 ± 0.048	5.71LeuIle: 5.71 ± 0.09	6.123LeuLys: 6.123 ± 0.097	8.519LeuLeu: 8.519 ± 0.148	2.615LeuMet: 2.615 ± 0.063	4.706LeuAsn: 4.706 ± 0.094	3.753LeuPro: 3.753 ± 0.069	3.403LeuGln: 3.403 ± 0.061	4.511LeuArg: 4.511 ± 0.086	6.835LeuSer: 6.835 ± 0.092	5.188LeuThr: 5.188 ± 0.088	4.981LeuVal: 4.981 ± 0.077	0.944LeuTrp: 0.944 ± 0.033	3.491LeuTyr: 3.491 ± 0.074	0.0LeuXaa: 0.0 ± 0.0
Met	2.275MetAla: 2.275 ± 0.054	0.278MetCys: 0.278 ± 0.02	1.473MetAsp: 1.473 ± 0.044	1.892MetGlu: 1.892 ± 0.058	1.096MetPhe: 1.096 ± 0.038	1.913MetGly: 1.913 ± 0.049	0.482MetHis: 0.482 ± 0.022	1.74MetIle: 1.74 ± 0.043	2.597MetLys: 2.597 ± 0.048	2.537MetLeu: 2.537 ± 0.06	0.922MetMet: 0.922 ± 0.035	1.543MetAsn: 1.543 ± 0.046	1.248MetPro: 1.248 ± 0.042	1.194MetGln: 1.194 ± 0.037	1.501MetArg: 1.501 ± 0.048	1.709MetSer: 1.709 ± 0.048	1.571MetThr: 1.571 ± 0.04	1.633MetVal: 1.633 ± 0.045	0.208MetTrp: 0.208 ± 0.016	0.748MetTyr: 0.748 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.535AsnAla: 3.535 ± 0.084	0.599AsnCys: 0.599 ± 0.028	2.916AsnAsp: 2.916 ± 0.06	3.165AsnGlu: 3.165 ± 0.055	2.426AsnPhe: 2.426 ± 0.055	4.092AsnGly: 4.092 ± 0.073	1.136AsnHis: 1.136 ± 0.04	4.248AsnIle: 4.248 ± 0.086	3.733AsnLys: 3.733 ± 0.084	4.504AsnLeu: 4.504 ± 0.083	1.366AsnMet: 1.366 ± 0.048	3.127AsnAsn: 3.127 ± 0.075	2.355AsnPro: 2.355 ± 0.061	1.781AsnGln: 1.781 ± 0.044	2.608AsnArg: 2.608 ± 0.063	3.089AsnSer: 3.089 ± 0.062	2.775AsnThr: 2.775 ± 0.07	3.226AsnVal: 3.226 ± 0.066	0.572AsnTrp: 0.572 ± 0.032	2.268AsnTyr: 2.268 ± 0.059	0.0AsnXaa: 0.0 ± 0.0
Pro	2.17ProAla: 2.17 ± 0.055	0.396ProCys: 0.396 ± 0.024	2.262ProAsp: 2.262 ± 0.05	2.642ProGlu: 2.642 ± 0.055	1.829ProPhe: 1.829 ± 0.046	1.836ProGly: 1.836 ± 0.052	0.772ProHis: 0.772 ± 0.028	2.578ProIle: 2.578 ± 0.053	2.351ProLys: 2.351 ± 0.053	3.04ProLeu: 3.04 ± 0.058	1.055ProMet: 1.055 ± 0.036	1.806ProAsn: 1.806 ± 0.045	0.806ProPro: 0.806 ± 0.03	1.427ProGln: 1.427 ± 0.04	1.269ProArg: 1.269 ± 0.039	2.233ProSer: 2.233 ± 0.053	2.311ProThr: 2.311 ± 0.052	2.467ProVal: 2.467 ± 0.055	0.337ProTrp: 0.337 ± 0.021	1.615ProTyr: 1.615 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.369GlnAla: 2.369 ± 0.057	0.334GlnCys: 0.334 ± 0.023	1.595GlnAsp: 1.595 ± 0.045	2.324GlnGlu: 2.324 ± 0.06	1.476GlnPhe: 1.476 ± 0.037	2.15GlnGly: 2.15 ± 0.062	0.776GlnHis: 0.776 ± 0.036	2.603GlnIle: 2.603 ± 0.065	2.773GlnLys: 2.773 ± 0.058	3.608GlnLeu: 3.608 ± 0.069	1.196GlnMet: 1.196 ± 0.038	1.889GlnAsn: 1.889 ± 0.049	1.371GlnPro: 1.371 ± 0.047	1.834GlnGln: 1.834 ± 0.06	2.04GlnArg: 2.04 ± 0.048	2.105GlnSer: 2.105 ± 0.049	2.065GlnThr: 2.065 ± 0.055	2.074GlnVal: 2.074 ± 0.048	0.483GlnTrp: 0.483 ± 0.023	1.459GlnTyr: 1.459 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.68ArgAla: 2.68 ± 0.06	0.592ArgCys: 0.592 ± 0.028	2.136ArgAsp: 2.136 ± 0.058	2.985ArgGlu: 2.985 ± 0.063	2.205ArgPhe: 2.205 ± 0.043	2.559ArgGly: 2.559 ± 0.051	1.179ArgHis: 1.179 ± 0.035	3.659ArgIle: 3.659 ± 0.066	3.885ArgLys: 3.885 ± 0.071	4.574ArgLeu: 4.574 ± 0.081	1.684ArgMet: 1.684 ± 0.044	2.706ArgAsn: 2.706 ± 0.059	1.603ArgPro: 1.603 ± 0.039	2.196ArgGln: 2.196 ± 0.057	2.718ArgArg: 2.718 ± 0.07	2.619ArgSer: 2.619 ± 0.061	2.525ArgThr: 2.525 ± 0.054	2.491ArgVal: 2.491 ± 0.054	0.592ArgTrp: 0.592 ± 0.027	2.31ArgTyr: 2.31 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	4.026SerAla: 4.026 ± 0.078	0.818SerCys: 0.818 ± 0.033	3.4SerAsp: 3.4 ± 0.067	3.55SerGlu: 3.55 ± 0.077	3.353SerPhe: 3.353 ± 0.065	4.005SerGly: 4.005 ± 0.067	1.269SerHis: 1.269 ± 0.04	4.418SerIle: 4.418 ± 0.082	4.05SerLys: 4.05 ± 0.075	5.963SerLeu: 5.963 ± 0.097	1.702SerMet: 1.702 ± 0.041	3.08SerAsn: 3.08 ± 0.07	2.28SerPro: 2.28 ± 0.049	2.116SerGln: 2.116 ± 0.053	2.627SerArg: 2.627 ± 0.057	3.973SerSer: 3.973 ± 0.085	3.324SerThr: 3.324 ± 0.07	4.087SerVal: 4.087 ± 0.086	0.776SerTrp: 0.776 ± 0.029	2.752SerTyr: 2.752 ± 0.076	0.0SerXaa: 0.0 ± 0.0
Thr	3.942ThrAla: 3.942 ± 0.076	0.623ThrCys: 0.623 ± 0.03	3.463ThrAsp: 3.463 ± 0.07	3.358ThrGlu: 3.358 ± 0.073	2.735ThrPhe: 2.735 ± 0.061	3.808ThrGly: 3.808 ± 0.071	1.035ThrHis: 1.035 ± 0.038	4.341ThrIle: 4.341 ± 0.081	3.458ThrLys: 3.458 ± 0.061	5.214ThrLeu: 5.214 ± 0.081	1.403ThrMet: 1.403 ± 0.037	2.717ThrAsn: 2.717 ± 0.069	2.498ThrPro: 2.498 ± 0.059	1.781ThrGln: 1.781 ± 0.058	2.044ThrArg: 2.044 ± 0.048	3.367ThrSer: 3.367 ± 0.065	3.494ThrThr: 3.494 ± 0.081	3.738ThrVal: 3.738 ± 0.07	0.567ThrTrp: 0.567 ± 0.026	2.414ThrTyr: 2.414 ± 0.067	0.0ThrXaa: 0.0 ± 0.0
Val	4.543ValAla: 4.543 ± 0.08	0.945ValCys: 0.945 ± 0.035	3.489ValAsp: 3.489 ± 0.063	4.02ValGlu: 4.02 ± 0.082	2.858ValPhe: 2.858 ± 0.06	4.11ValGly: 4.11 ± 0.082	1.031ValHis: 1.031 ± 0.034	4.205ValIle: 4.205 ± 0.082	4.359ValLys: 4.359 ± 0.077	5.492ValLeu: 5.492 ± 0.095	1.815ValMet: 1.815 ± 0.05	3.242ValAsn: 3.242 ± 0.061	2.272ValPro: 2.272 ± 0.053	1.9ValGln: 1.9 ± 0.059	3.121ValArg: 3.121 ± 0.061	4.396ValSer: 4.396 ± 0.088	3.391ValThr: 3.391 ± 0.084	4.461ValVal: 4.461 ± 0.084	0.667ValTrp: 0.667 ± 0.029	2.449ValTyr: 2.449 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.652TrpAla: 0.652 ± 0.03	0.135TrpCys: 0.135 ± 0.011	0.591TrpAsp: 0.591 ± 0.025	0.597TrpGlu: 0.597 ± 0.025	0.518TrpPhe: 0.518 ± 0.028	0.76TrpGly: 0.76 ± 0.033	0.268TrpHis: 0.268 ± 0.018	0.818TrpIle: 0.818 ± 0.027	0.823TrpLys: 0.823 ± 0.03	1.164TrpLeu: 1.164 ± 0.036	0.384TrpMet: 0.384 ± 0.02	0.696TrpAsn: 0.696 ± 0.031	0.197TrpPro: 0.197 ± 0.014	0.543TrpGln: 0.543 ± 0.021	0.507TrpArg: 0.507 ± 0.026	0.537TrpSer: 0.537 ± 0.027	0.589TrpThr: 0.589 ± 0.03	0.618TrpVal: 0.618 ± 0.03	0.167TrpTrp: 0.167 ± 0.015	0.437TrpTyr: 0.437 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.644TyrAla: 2.644 ± 0.053	0.603TyrCys: 0.603 ± 0.028	2.578TyrAsp: 2.578 ± 0.058	2.458TyrGlu: 2.458 ± 0.06	2.083TyrPhe: 2.083 ± 0.051	2.879TyrGly: 2.879 ± 0.065	0.97TyrHis: 0.97 ± 0.04	2.914TyrIle: 2.914 ± 0.07	2.854TyrLys: 2.854 ± 0.064	3.792TyrLeu: 3.792 ± 0.071	1.017TyrMet: 1.017 ± 0.038	2.482TyrAsn: 2.482 ± 0.056	1.572TyrPro: 1.572 ± 0.045	1.531TyrGln: 1.531 ± 0.044	2.22TyrArg: 2.22 ± 0.056	2.584TyrSer: 2.584 ± 0.062	2.347TyrThr: 2.347 ± 0.06	2.446TyrVal: 2.446 ± 0.064	0.507TyrTrp: 0.507 ± 0.021	2.031TyrTyr: 2.031 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2956 proteins (835971 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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