Amino acid dipepetide frequency for Changuinola virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.43AlaAla: 4.43 ± 1.106
0.475AlaCys: 0.475 ± 0.23
2.373AlaAsp: 2.373 ± 0.458
3.006AlaGlu: 3.006 ± 0.49
1.741AlaPhe: 1.741 ± 0.712
3.006AlaGly: 3.006 ± 0.952
1.424AlaHis: 1.424 ± 0.313
4.272AlaIle: 4.272 ± 0.953
2.848AlaLys: 2.848 ± 0.765
6.487AlaLeu: 6.487 ± 1.076
2.532AlaMet: 2.532 ± 0.409
3.323AlaAsn: 3.323 ± 0.387
2.532AlaPro: 2.532 ± 0.592
2.057AlaGln: 2.057 ± 0.712
5.538AlaArg: 5.538 ± 0.958
3.006AlaSer: 3.006 ± 0.561
3.639AlaThr: 3.639 ± 0.566
5.222AlaVal: 5.222 ± 1.396
0.949AlaTrp: 0.949 ± 0.394
2.532AlaTyr: 2.532 ± 0.686
0.0AlaXaa: 0.0 ± 0.0
Cys
0.791CysAla: 0.791 ± 0.396
0.0CysCys: 0.0 ± 0.0
0.316CysAsp: 0.316 ± 0.215
0.791CysGlu: 0.791 ± 0.523
1.108CysPhe: 1.108 ± 0.642
0.949CysGly: 0.949 ± 0.331
0.316CysHis: 0.316 ± 0.192
0.633CysIle: 0.633 ± 0.366
0.633CysLys: 0.633 ± 0.385
0.791CysLeu: 0.791 ± 0.399
0.0CysMet: 0.0 ± 0.0
0.949CysAsn: 0.949 ± 0.301
0.633CysPro: 0.633 ± 0.315
0.316CysGln: 0.316 ± 0.192
0.949CysArg: 0.949 ± 0.414
0.791CysSer: 0.791 ± 0.362
0.158CysThr: 0.158 ± 0.134
0.949CysVal: 0.949 ± 0.466
0.158CysTrp: 0.158 ± 0.134
0.316CysTyr: 0.316 ± 0.153
0.0CysXaa: 0.0 ± 0.0
Asp
3.797AspAla: 3.797 ± 0.694
0.791AspCys: 0.791 ± 0.713
4.272AspAsp: 4.272 ± 1.196
3.323AspGlu: 3.323 ± 0.841
1.741AspPhe: 1.741 ± 0.359
3.165AspGly: 3.165 ± 0.705
1.266AspHis: 1.266 ± 0.327
5.854AspIle: 5.854 ± 1.484
2.69AspLys: 2.69 ± 0.679
5.222AspLeu: 5.222 ± 1.165
1.108AspMet: 1.108 ± 0.312
1.741AspAsn: 1.741 ± 0.485
1.899AspPro: 1.899 ± 0.77
2.057AspGln: 2.057 ± 0.509
3.797AspArg: 3.797 ± 0.63
2.532AspSer: 2.532 ± 0.652
2.69AspThr: 2.69 ± 0.543
6.962AspVal: 6.962 ± 0.554
0.791AspTrp: 0.791 ± 0.535
1.899AspTyr: 1.899 ± 0.756
0.0AspXaa: 0.0 ± 0.0
Glu
4.747GluAla: 4.747 ± 0.757
0.316GluCys: 0.316 ± 0.201
4.114GluAsp: 4.114 ± 0.746
8.07GluGlu: 8.07 ± 1.438
3.006GluPhe: 3.006 ± 0.811
3.956GluGly: 3.956 ± 1.075
0.949GluHis: 0.949 ± 0.477
6.171GluIle: 6.171 ± 0.959
4.747GluLys: 4.747 ± 1.008
6.013GluLeu: 6.013 ± 1.02
2.215GluMet: 2.215 ± 0.543
3.323GluAsn: 3.323 ± 0.717
2.057GluPro: 2.057 ± 0.615
2.532GluGln: 2.532 ± 0.739
4.272GluArg: 4.272 ± 0.895
5.063GluSer: 5.063 ± 0.421
3.165GluThr: 3.165 ± 0.544
4.747GluVal: 4.747 ± 0.379
0.791GluTrp: 0.791 ± 0.484
2.69GluTyr: 2.69 ± 0.458
0.0GluXaa: 0.0 ± 0.0
Phe
2.532PheAla: 2.532 ± 0.377
0.633PheCys: 0.633 ± 0.208
2.215PheAsp: 2.215 ± 0.306
2.215PheGlu: 2.215 ± 0.39
1.899PhePhe: 1.899 ± 0.447
3.006PheGly: 3.006 ± 0.434
0.316PheHis: 0.316 ± 0.227
1.582PheIle: 1.582 ± 0.759
2.373PheLys: 2.373 ± 0.623
4.114PheLeu: 4.114 ± 0.897
0.949PheMet: 0.949 ± 0.295
2.057PheAsn: 2.057 ± 0.492
1.108PhePro: 1.108 ± 0.356
1.266PheGln: 1.266 ± 0.503
2.057PheArg: 2.057 ± 0.577
3.165PheSer: 3.165 ± 1.034
3.006PheThr: 3.006 ± 0.841
2.373PheVal: 2.373 ± 0.579
0.316PheTrp: 0.316 ± 0.163
3.006PheTyr: 3.006 ± 0.98
0.0PheXaa: 0.0 ± 0.0
Gly
5.063GlyAla: 5.063 ± 0.78
0.633GlyCys: 0.633 ± 0.36
3.639GlyAsp: 3.639 ± 0.736
4.43GlyGlu: 4.43 ± 0.432
2.215GlyPhe: 2.215 ± 0.587
3.797GlyGly: 3.797 ± 1.576
1.424GlyHis: 1.424 ± 0.409
2.69GlyIle: 2.69 ± 0.444
4.905GlyLys: 4.905 ± 0.948
3.323GlyLeu: 3.323 ± 0.693
1.582GlyMet: 1.582 ± 0.427
2.69GlyAsn: 2.69 ± 0.412
1.582GlyPro: 1.582 ± 0.439
2.215GlyGln: 2.215 ± 0.618
4.43GlyArg: 4.43 ± 1.295
3.481GlySer: 3.481 ± 0.74
2.373GlyThr: 2.373 ± 0.613
4.589GlyVal: 4.589 ± 0.851
0.633GlyTrp: 0.633 ± 0.319
3.165GlyTyr: 3.165 ± 0.442
0.0GlyXaa: 0.0 ± 0.0
His
1.266HisAla: 1.266 ± 0.417
0.475HisCys: 0.475 ± 0.17
0.949HisAsp: 0.949 ± 0.268
1.108HisGlu: 1.108 ± 0.32
0.633HisPhe: 0.633 ± 0.193
1.582HisGly: 1.582 ± 0.526
0.791HisHis: 0.791 ± 0.219
1.741HisIle: 1.741 ± 0.481
1.424HisLys: 1.424 ± 0.464
2.848HisLeu: 2.848 ± 0.592
1.741HisMet: 1.741 ± 0.894
0.949HisAsn: 0.949 ± 0.311
1.424HisPro: 1.424 ± 0.465
0.633HisGln: 0.633 ± 0.279
1.266HisArg: 1.266 ± 0.411
0.791HisSer: 0.791 ± 0.277
0.949HisThr: 0.949 ± 0.353
2.69HisVal: 2.69 ± 0.433
0.316HisTrp: 0.316 ± 0.185
0.633HisTyr: 0.633 ± 0.492
0.0HisXaa: 0.0 ± 0.0
Ile
4.43IleAla: 4.43 ± 0.754
0.949IleCys: 0.949 ± 0.535
4.589IleAsp: 4.589 ± 0.728
6.329IleGlu: 6.329 ± 1.044
2.69IlePhe: 2.69 ± 0.47
3.006IleGly: 3.006 ± 0.614
2.69IleHis: 2.69 ± 0.927
4.43IleIle: 4.43 ± 0.733
4.589IleLys: 4.589 ± 0.692
5.063IleLeu: 5.063 ± 0.536
2.848IleMet: 2.848 ± 0.548
4.114IleAsn: 4.114 ± 0.791
2.69IlePro: 2.69 ± 0.563
3.006IleGln: 3.006 ± 0.635
2.215IleArg: 2.215 ± 0.444
4.272IleSer: 4.272 ± 0.672
4.114IleThr: 4.114 ± 0.839
4.589IleVal: 4.589 ± 1.233
0.791IleTrp: 0.791 ± 0.37
3.481IleTyr: 3.481 ± 0.452
0.0IleXaa: 0.0 ± 0.0
Lys
2.057LysAla: 2.057 ± 0.729
0.791LysCys: 0.791 ± 0.52
3.006LysAsp: 3.006 ± 0.74
5.854LysGlu: 5.854 ± 1.07
2.532LysPhe: 2.532 ± 0.465
2.215LysGly: 2.215 ± 0.433
1.108LysHis: 1.108 ± 0.312
6.329LysIle: 6.329 ± 0.932
4.43LysLys: 4.43 ± 1.128
5.538LysLeu: 5.538 ± 0.527
2.057LysMet: 2.057 ± 0.571
3.639LysAsn: 3.639 ± 0.838
2.215LysPro: 2.215 ± 0.424
1.899LysGln: 1.899 ± 0.606
5.063LysArg: 5.063 ± 1.035
2.215LysSer: 2.215 ± 0.481
3.006LysThr: 3.006 ± 0.641
4.114LysVal: 4.114 ± 1.171
1.266LysTrp: 1.266 ± 0.507
2.532LysTyr: 2.532 ± 0.841
0.0LysXaa: 0.0 ± 0.0
Leu
4.905LeuAla: 4.905 ± 0.631
1.108LeuCys: 1.108 ± 0.502
4.747LeuAsp: 4.747 ± 0.66
5.063LeuGlu: 5.063 ± 0.76
3.639LeuPhe: 3.639 ± 0.945
4.589LeuGly: 4.589 ± 1.241
1.899LeuHis: 1.899 ± 0.41
6.487LeuIle: 6.487 ± 0.677
5.222LeuLys: 5.222 ± 1.097
5.696LeuLeu: 5.696 ± 0.657
3.006LeuMet: 3.006 ± 0.705
4.589LeuAsn: 4.589 ± 0.554
3.797LeuPro: 3.797 ± 1.025
2.69LeuGln: 2.69 ± 0.777
7.753LeuArg: 7.753 ± 1.346
4.589LeuSer: 4.589 ± 0.555
5.38LeuThr: 5.38 ± 0.956
5.222LeuVal: 5.222 ± 0.649
1.424LeuTrp: 1.424 ± 0.627
2.69LeuTyr: 2.69 ± 0.745
0.0LeuXaa: 0.0 ± 0.0
Met
2.057MetAla: 2.057 ± 0.64
1.108MetCys: 1.108 ± 0.509
1.899MetAsp: 1.899 ± 0.505
1.899MetGlu: 1.899 ± 0.491
1.741MetPhe: 1.741 ± 0.606
2.215MetGly: 2.215 ± 0.91
0.949MetHis: 0.949 ± 0.321
2.215MetIle: 2.215 ± 0.584
1.741MetLys: 1.741 ± 0.445
4.905MetLeu: 4.905 ± 0.716
0.633MetMet: 0.633 ± 0.362
1.108MetAsn: 1.108 ± 0.181
1.582MetPro: 1.582 ± 0.391
0.633MetGln: 0.633 ± 0.276
3.165MetArg: 3.165 ± 0.686
3.006MetSer: 3.006 ± 0.692
1.741MetThr: 1.741 ± 0.437
2.532MetVal: 2.532 ± 0.683
0.633MetTrp: 0.633 ± 0.255
0.791MetTyr: 0.791 ± 0.279
0.0MetXaa: 0.0 ± 0.0
Asn
3.323AsnAla: 3.323 ± 0.937
0.316AsnCys: 0.316 ± 0.268
2.057AsnAsp: 2.057 ± 0.706
5.38AsnGlu: 5.38 ± 0.769
1.582AsnPhe: 1.582 ± 0.667
3.956AsnGly: 3.956 ± 0.695
1.108AsnHis: 1.108 ± 0.561
3.956AsnIle: 3.956 ± 0.449
2.848AsnLys: 2.848 ± 0.746
3.956AsnLeu: 3.956 ± 0.49
1.899AsnMet: 1.899 ± 0.523
1.741AsnAsn: 1.741 ± 0.407
1.741AsnPro: 1.741 ± 0.683
2.373AsnGln: 2.373 ± 0.579
1.741AsnArg: 1.741 ± 0.497
2.215AsnSer: 2.215 ± 0.677
1.741AsnThr: 1.741 ± 0.648
5.222AsnVal: 5.222 ± 0.862
0.316AsnTrp: 0.316 ± 0.209
1.424AsnTyr: 1.424 ± 0.563
0.0AsnXaa: 0.0 ± 0.0
Pro
2.532ProAla: 2.532 ± 0.493
0.0ProCys: 0.0 ± 0.0
2.848ProAsp: 2.848 ± 0.51
2.215ProGlu: 2.215 ± 0.551
1.582ProPhe: 1.582 ± 0.351
1.899ProGly: 1.899 ± 0.435
1.582ProHis: 1.582 ± 0.451
2.848ProIle: 2.848 ± 0.84
1.741ProLys: 1.741 ± 0.665
2.532ProLeu: 2.532 ± 0.595
0.949ProMet: 0.949 ± 0.339
1.108ProAsn: 1.108 ± 0.356
1.899ProPro: 1.899 ± 0.43
1.266ProGln: 1.266 ± 0.514
1.582ProArg: 1.582 ± 0.392
1.899ProSer: 1.899 ± 0.6
3.006ProThr: 3.006 ± 0.939
3.006ProVal: 3.006 ± 0.694
0.633ProTrp: 0.633 ± 0.271
2.215ProTyr: 2.215 ± 0.467
0.0ProXaa: 0.0 ± 0.0
Gln
2.532GlnAla: 2.532 ± 0.93
0.475GlnCys: 0.475 ± 0.23
1.266GlnAsp: 1.266 ± 0.392
2.215GlnGlu: 2.215 ± 0.656
1.741GlnPhe: 1.741 ± 0.393
2.373GlnGly: 2.373 ± 0.482
0.475GlnHis: 0.475 ± 0.243
3.323GlnIle: 3.323 ± 0.731
2.373GlnLys: 2.373 ± 0.742
3.006GlnLeu: 3.006 ± 0.614
1.741GlnMet: 1.741 ± 0.71
2.373GlnAsn: 2.373 ± 0.664
1.108GlnPro: 1.108 ± 0.425
1.424GlnGln: 1.424 ± 0.441
2.532GlnArg: 2.532 ± 0.676
1.741GlnSer: 1.741 ± 0.571
1.582GlnThr: 1.582 ± 0.383
1.899GlnVal: 1.899 ± 0.476
0.158GlnTrp: 0.158 ± 0.134
1.741GlnTyr: 1.741 ± 0.545
0.0GlnXaa: 0.0 ± 0.0
Arg
3.639ArgAla: 3.639 ± 0.923
0.475ArgCys: 0.475 ± 0.185
3.797ArgAsp: 3.797 ± 0.411
6.013ArgGlu: 6.013 ± 0.739
3.956ArgPhe: 3.956 ± 0.659
3.797ArgGly: 3.797 ± 0.819
1.266ArgHis: 1.266 ± 0.483
4.905ArgIle: 4.905 ± 1.025
3.323ArgLys: 3.323 ± 0.618
5.38ArgLeu: 5.38 ± 0.88
2.532ArgMet: 2.532 ± 0.705
3.639ArgAsn: 3.639 ± 0.459
1.424ArgPro: 1.424 ± 0.5
2.215ArgGln: 2.215 ± 0.561
4.272ArgArg: 4.272 ± 0.675
3.797ArgSer: 3.797 ± 0.408
3.956ArgThr: 3.956 ± 0.602
3.165ArgVal: 3.165 ± 0.535
0.949ArgTrp: 0.949 ± 0.304
1.741ArgTyr: 1.741 ± 0.411
0.0ArgXaa: 0.0 ± 0.0
Ser
2.532SerAla: 2.532 ± 0.402
0.316SerCys: 0.316 ± 0.234
3.481SerAsp: 3.481 ± 0.73
4.747SerGlu: 4.747 ± 0.566
2.215SerPhe: 2.215 ± 0.55
3.956SerGly: 3.956 ± 0.84
1.108SerHis: 1.108 ± 0.352
2.848SerIle: 2.848 ± 0.485
3.639SerLys: 3.639 ± 0.865
4.43SerLeu: 4.43 ± 0.668
2.69SerMet: 2.69 ± 0.6
1.582SerAsn: 1.582 ± 0.387
2.848SerPro: 2.848 ± 0.766
2.215SerGln: 2.215 ± 0.617
3.006SerArg: 3.006 ± 0.717
2.532SerSer: 2.532 ± 0.56
4.114SerThr: 4.114 ± 0.912
2.532SerVal: 2.532 ± 0.477
0.633SerTrp: 0.633 ± 0.461
3.323SerTyr: 3.323 ± 0.842
0.0SerXaa: 0.0 ± 0.0
Thr
3.639ThrAla: 3.639 ± 1.066
0.633ThrCys: 0.633 ± 0.265
3.165ThrAsp: 3.165 ± 0.526
2.69ThrGlu: 2.69 ± 0.67
1.899ThrPhe: 1.899 ± 0.293
3.639ThrGly: 3.639 ± 0.791
1.741ThrHis: 1.741 ± 0.527
3.165ThrIle: 3.165 ± 0.709
3.165ThrLys: 3.165 ± 0.661
5.063ThrLeu: 5.063 ± 1.105
2.215ThrMet: 2.215 ± 0.634
2.69ThrAsn: 2.69 ± 0.673
1.741ThrPro: 1.741 ± 0.39
1.899ThrGln: 1.899 ± 0.574
3.006ThrArg: 3.006 ± 0.632
3.481ThrSer: 3.481 ± 0.456
3.481ThrThr: 3.481 ± 0.469
3.323ThrVal: 3.323 ± 0.781
0.791ThrTrp: 0.791 ± 0.303
2.215ThrTyr: 2.215 ± 0.893
0.0ThrXaa: 0.0 ± 0.0
Val
3.956ValAla: 3.956 ± 0.896
1.266ValCys: 1.266 ± 0.371
4.747ValAsp: 4.747 ± 0.745
4.905ValGlu: 4.905 ± 0.932
2.057ValPhe: 2.057 ± 0.361
3.639ValGly: 3.639 ± 0.725
2.057ValHis: 2.057 ± 0.564
4.747ValIle: 4.747 ± 0.812
5.538ValLys: 5.538 ± 0.944
6.171ValLeu: 6.171 ± 0.916
3.481ValMet: 3.481 ± 0.776
3.323ValAsn: 3.323 ± 0.604
3.481ValPro: 3.481 ± 0.619
3.956ValGln: 3.956 ± 0.931
4.43ValArg: 4.43 ± 1.375
4.114ValSer: 4.114 ± 1.16
2.215ValThr: 2.215 ± 0.547
4.43ValVal: 4.43 ± 0.775
0.316ValTrp: 0.316 ± 0.202
3.006ValTyr: 3.006 ± 0.884
0.0ValXaa: 0.0 ± 0.0
Trp
0.475TrpAla: 0.475 ± 0.276
0.0TrpCys: 0.0 ± 0.0
0.791TrpAsp: 0.791 ± 0.362
0.316TrpGlu: 0.316 ± 0.353
0.791TrpPhe: 0.791 ± 0.216
0.791TrpGly: 0.791 ± 0.273
0.475TrpHis: 0.475 ± 0.359
0.475TrpIle: 0.475 ± 0.276
1.266TrpLys: 1.266 ± 0.456
0.949TrpLeu: 0.949 ± 0.368
0.316TrpMet: 0.316 ± 0.215
1.108TrpAsn: 1.108 ± 0.409
0.0TrpPro: 0.0 ± 0.0
0.158TrpGln: 0.158 ± 0.176
1.108TrpArg: 1.108 ± 0.394
0.633TrpSer: 0.633 ± 0.36
0.791TrpThr: 0.791 ± 0.34
1.108TrpVal: 1.108 ± 0.268
0.158TrpTrp: 0.158 ± 0.154
0.316TrpTyr: 0.316 ± 0.224
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.69TyrAla: 2.69 ± 0.524
0.791TyrCys: 0.791 ± 0.247
3.323TyrAsp: 3.323 ± 0.699
2.373TyrGlu: 2.373 ± 0.574
1.424TyrPhe: 1.424 ± 0.424
3.323TyrGly: 3.323 ± 0.61
1.266TyrHis: 1.266 ± 0.333
2.215TyrIle: 2.215 ± 0.525
2.373TyrLys: 2.373 ± 0.571
3.006TyrLeu: 3.006 ± 0.632
1.899TyrMet: 1.899 ± 0.336
2.848TyrAsn: 2.848 ± 0.671
1.582TyrPro: 1.582 ± 0.469
1.424TyrGln: 1.424 ± 0.312
2.057TyrArg: 2.057 ± 0.491
1.424TyrSer: 1.424 ± 0.585
2.532TyrThr: 2.532 ± 0.601
3.165TyrVal: 3.165 ± 0.514
0.0TyrTrp: 0.0 ± 0.0
0.949TyrTyr: 0.949 ± 0.488
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (6321 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski