Amino acid dipepetide frequency for Hymenobacter chitinivorans DSM 11115

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.05AlaAla: 14.05 ± 0.154
0.788AlaCys: 0.788 ± 0.024
5.583AlaAsp: 5.583 ± 0.061
5.948AlaGlu: 5.948 ± 0.076
3.613AlaPhe: 3.613 ± 0.045
8.88AlaGly: 8.88 ± 0.09
1.898AlaHis: 1.898 ± 0.036
3.748AlaIle: 3.748 ± 0.059
3.652AlaLys: 3.652 ± 0.056
11.059AlaLeu: 11.059 ± 0.113
1.677AlaMet: 1.677 ± 0.035
3.228AlaAsn: 3.228 ± 0.052
5.571AlaPro: 5.571 ± 0.081
5.315AlaGln: 5.315 ± 0.072
5.831AlaArg: 5.831 ± 0.07
5.436AlaSer: 5.436 ± 0.071
6.995AlaThr: 6.995 ± 0.1
7.255AlaVal: 7.255 ± 0.079
1.205AlaTrp: 1.205 ± 0.031
3.109AlaTyr: 3.109 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.647CysAla: 0.647 ± 0.019
0.112CysCys: 0.112 ± 0.009
0.35CysAsp: 0.35 ± 0.014
0.339CysGlu: 0.339 ± 0.013
0.295CysPhe: 0.295 ± 0.014
0.629CysGly: 0.629 ± 0.023
0.198CysHis: 0.198 ± 0.011
0.332CysIle: 0.332 ± 0.015
0.193CysLys: 0.193 ± 0.011
0.744CysLeu: 0.744 ± 0.021
0.119CysMet: 0.119 ± 0.007
0.252CysAsn: 0.252 ± 0.012
0.406CysPro: 0.406 ± 0.019
0.341CysGln: 0.341 ± 0.015
0.43CysArg: 0.43 ± 0.017
0.451CysSer: 0.451 ± 0.018
0.437CysThr: 0.437 ± 0.019
0.456CysVal: 0.456 ± 0.018
0.1CysTrp: 0.1 ± 0.007
0.283CysTyr: 0.283 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.748AspAla: 4.748 ± 0.056
0.339AspCys: 0.339 ± 0.013
2.21AspAsp: 2.21 ± 0.045
3.023AspGlu: 3.023 ± 0.051
2.527AspPhe: 2.527 ± 0.041
3.685AspGly: 3.685 ± 0.054
0.901AspHis: 0.901 ± 0.023
2.336AspIle: 2.336 ± 0.044
2.29AspLys: 2.29 ± 0.038
4.828AspLeu: 4.828 ± 0.056
0.934AspMet: 0.934 ± 0.025
2.012AspAsn: 2.012 ± 0.038
2.448AspPro: 2.448 ± 0.042
2.125AspGln: 2.125 ± 0.031
2.344AspArg: 2.344 ± 0.044
2.565AspSer: 2.565 ± 0.048
2.562AspThr: 2.562 ± 0.037
3.524AspVal: 3.524 ± 0.044
0.748AspTrp: 0.748 ± 0.023
2.177AspTyr: 2.177 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
5.719GluAla: 5.719 ± 0.076
0.296GluCys: 0.296 ± 0.014
2.116GluAsp: 2.116 ± 0.04
3.093GluGlu: 3.093 ± 0.054
2.09GluPhe: 2.09 ± 0.034
3.321GluGly: 3.321 ± 0.054
1.117GluHis: 1.117 ± 0.024
2.545GluIle: 2.545 ± 0.05
2.759GluLys: 2.759 ± 0.053
6.303GluLeu: 6.303 ± 0.082
1.179GluMet: 1.179 ± 0.023
1.934GluAsn: 1.934 ± 0.035
2.357GluPro: 2.357 ± 0.044
3.147GluGln: 3.147 ± 0.056
3.02GluArg: 3.02 ± 0.046
2.252GluSer: 2.252 ± 0.043
2.792GluThr: 2.792 ± 0.04
3.884GluVal: 3.884 ± 0.049
0.647GluTrp: 0.647 ± 0.021
1.777GluTyr: 1.777 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
3.718PheAla: 3.718 ± 0.046
0.351PheCys: 0.351 ± 0.015
2.35PheAsp: 2.35 ± 0.038
2.222PheGlu: 2.222 ± 0.04
1.821PhePhe: 1.821 ± 0.041
3.398PheGly: 3.398 ± 0.051
0.761PheHis: 0.761 ± 0.022
1.744PheIle: 1.744 ± 0.039
1.454PheLys: 1.454 ± 0.033
3.944PheLeu: 3.944 ± 0.061
0.729PheMet: 0.729 ± 0.023
1.669PheAsn: 1.669 ± 0.033
1.755PhePro: 1.755 ± 0.033
1.549PheGln: 1.549 ± 0.033
2.584PheArg: 2.584 ± 0.044
2.765PheSer: 2.765 ± 0.047
2.884PheThr: 2.884 ± 0.049
2.961PheVal: 2.961 ± 0.044
0.567PheTrp: 0.567 ± 0.021
1.599PheTyr: 1.599 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
6.924GlyAla: 6.924 ± 0.084
0.689GlyCys: 0.689 ± 0.024
2.879GlyAsp: 2.879 ± 0.049
3.403GlyGlu: 3.403 ± 0.047
3.341GlyPhe: 3.341 ± 0.043
6.146GlyGly: 6.146 ± 0.086
1.555GlyHis: 1.555 ± 0.029
3.763GlyIle: 3.763 ± 0.059
3.615GlyLys: 3.615 ± 0.052
8.404GlyLeu: 8.404 ± 0.091
1.455GlyMet: 1.455 ± 0.031
2.898GlyAsn: 2.898 ± 0.055
3.221GlyPro: 3.221 ± 0.044
4.062GlyGln: 4.062 ± 0.053
4.618GlyArg: 4.618 ± 0.06
4.899GlySer: 4.899 ± 0.074
5.403GlyThr: 5.403 ± 0.094
5.189GlyVal: 5.189 ± 0.061
1.114GlyTrp: 1.114 ± 0.028
2.936GlyTyr: 2.936 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
1.668HisAla: 1.668 ± 0.036
0.2HisCys: 0.2 ± 0.012
1.097HisAsp: 1.097 ± 0.026
1.098HisGlu: 1.098 ± 0.025
1.074HisPhe: 1.074 ± 0.024
1.455HisGly: 1.455 ± 0.033
0.619HisHis: 0.619 ± 0.024
0.867HisIle: 0.867 ± 0.021
0.648HisLys: 0.648 ± 0.02
2.353HisLeu: 2.353 ± 0.043
0.354HisMet: 0.354 ± 0.015
0.732HisAsn: 0.732 ± 0.021
1.222HisPro: 1.222 ± 0.029
0.916HisGln: 0.916 ± 0.024
1.196HisArg: 1.196 ± 0.029
1.023HisSer: 1.023 ± 0.026
1.12HisThr: 1.12 ± 0.027
1.263HisVal: 1.263 ± 0.027
0.321HisTrp: 0.321 ± 0.015
0.916HisTyr: 0.916 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
3.793IleAla: 3.793 ± 0.063
0.374IleCys: 0.374 ± 0.016
2.412IleAsp: 2.412 ± 0.039
2.442IleGlu: 2.442 ± 0.047
1.648IlePhe: 1.648 ± 0.037
3.563IleGly: 3.563 ± 0.052
0.836IleHis: 0.836 ± 0.025
2.211IleIle: 2.211 ± 0.042
1.837IleLys: 1.837 ± 0.04
3.94IleLeu: 3.94 ± 0.061
0.749IleMet: 0.749 ± 0.02
1.806IleAsn: 1.806 ± 0.042
2.137IlePro: 2.137 ± 0.038
1.709IleGln: 1.709 ± 0.034
2.772IleArg: 2.772 ± 0.042
2.856IleSer: 2.856 ± 0.041
3.019IleThr: 3.019 ± 0.046
2.943IleVal: 2.943 ± 0.047
0.503IleTrp: 0.503 ± 0.019
1.401IleTyr: 1.401 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
4.005LysAla: 4.005 ± 0.056
0.183LysCys: 0.183 ± 0.01
2.099LysAsp: 2.099 ± 0.042
2.26LysGlu: 2.26 ± 0.043
1.353LysPhe: 1.353 ± 0.034
2.791LysGly: 2.791 ± 0.051
0.753LysHis: 0.753 ± 0.022
1.904LysIle: 1.904 ± 0.041
2.272LysLys: 2.272 ± 0.055
4.33LysLeu: 4.33 ± 0.057
0.956LysMet: 0.956 ± 0.023
1.656LysAsn: 1.656 ± 0.034
2.239LysPro: 2.239 ± 0.044
1.854LysGln: 1.854 ± 0.041
2.034LysArg: 2.034 ± 0.037
2.101LysSer: 2.101 ± 0.037
2.497LysThr: 2.497 ± 0.038
2.882LysVal: 2.882 ± 0.058
0.429LysTrp: 0.429 ± 0.017
1.371LysTyr: 1.371 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
11.582LeuAla: 11.582 ± 0.112
0.738LeuCys: 0.738 ± 0.023
5.4LeuAsp: 5.4 ± 0.066
5.049LeuGlu: 5.049 ± 0.068
3.999LeuPhe: 3.999 ± 0.057
8.168LeuGly: 8.168 ± 0.081
2.335LeuHis: 2.335 ± 0.043
4.093LeuIle: 4.093 ± 0.055
3.912LeuLys: 3.912 ± 0.054
13.727LeuLeu: 13.727 ± 0.163
1.821LeuMet: 1.821 ± 0.036
4.169LeuAsn: 4.169 ± 0.053
6.476LeuPro: 6.476 ± 0.067
4.726LeuGln: 4.726 ± 0.06
7.593LeuArg: 7.593 ± 0.093
6.588LeuSer: 6.588 ± 0.067
7.543LeuThr: 7.543 ± 0.071
7.505LeuVal: 7.505 ± 0.068
1.15LeuTrp: 1.15 ± 0.028
3.307LeuTyr: 3.307 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
1.798MetAla: 1.798 ± 0.039
0.108MetCys: 0.108 ± 0.008
0.739MetAsp: 0.739 ± 0.022
0.849MetGlu: 0.849 ± 0.028
0.53MetPhe: 0.53 ± 0.018
1.255MetGly: 1.255 ± 0.031
0.394MetHis: 0.394 ± 0.016
0.701MetIle: 0.701 ± 0.022
1.085MetLys: 1.085 ± 0.024
1.998MetLeu: 1.998 ± 0.036
0.395MetMet: 0.395 ± 0.018
0.775MetAsn: 0.775 ± 0.022
1.143MetPro: 1.143 ± 0.027
0.942MetGln: 0.942 ± 0.023
1.189MetArg: 1.189 ± 0.026
1.136MetSer: 1.136 ± 0.032
1.058MetThr: 1.058 ± 0.026
1.185MetVal: 1.185 ± 0.028
0.159MetTrp: 0.159 ± 0.011
0.442MetTyr: 0.442 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.278AsnAla: 3.278 ± 0.05
0.283AsnCys: 0.283 ± 0.014
1.781AsnAsp: 1.781 ± 0.037
1.753AsnGlu: 1.753 ± 0.035
1.608AsnPhe: 1.608 ± 0.036
3.229AsnGly: 3.229 ± 0.059
0.694AsnHis: 0.694 ± 0.021
1.801AsnIle: 1.801 ± 0.033
1.466AsnLys: 1.466 ± 0.036
3.895AsnLeu: 3.895 ± 0.054
0.656AsnMet: 0.656 ± 0.021
1.638AsnAsn: 1.638 ± 0.048
2.536AsnPro: 2.536 ± 0.043
1.709AsnGln: 1.709 ± 0.037
2.129AsnArg: 2.129 ± 0.039
2.273AsnSer: 2.273 ± 0.045
2.454AsnThr: 2.454 ± 0.049
2.538AsnVal: 2.538 ± 0.045
0.535AsnTrp: 0.535 ± 0.02
1.48AsnTyr: 1.48 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
7.554ProAla: 7.554 ± 0.091
0.259ProCys: 0.259 ± 0.013
3.248ProAsp: 3.248 ± 0.046
3.524ProGlu: 3.524 ± 0.057
1.871ProPhe: 1.871 ± 0.031
4.319ProGly: 4.319 ± 0.054
0.959ProHis: 0.959 ± 0.024
1.95ProIle: 1.95 ± 0.03
1.808ProLys: 1.808 ± 0.039
4.981ProLeu: 4.981 ± 0.058
0.79ProMet: 0.79 ± 0.019
1.944ProAsn: 1.944 ± 0.035
2.119ProPro: 2.119 ± 0.045
2.027ProGln: 2.027 ± 0.038
2.536ProArg: 2.536 ± 0.042
2.536ProSer: 2.536 ± 0.038
3.617ProThr: 3.617 ± 0.06
4.334ProVal: 4.334 ± 0.058
0.588ProTrp: 0.588 ± 0.021
1.575ProTyr: 1.575 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
5.198GlnAla: 5.198 ± 0.06
0.229GlnCys: 0.229 ± 0.011
2.096GlnAsp: 2.096 ± 0.037
2.481GlnGlu: 2.481 ± 0.045
1.754GlnPhe: 1.754 ± 0.035
3.046GlnGly: 3.046 ± 0.046
1.25GlnHis: 1.25 ± 0.031
1.854GlnIle: 1.854 ± 0.037
1.821GlnLys: 1.821 ± 0.035
5.835GlnLeu: 5.835 ± 0.076
0.901GlnMet: 0.901 ± 0.025
1.819GlnAsn: 1.819 ± 0.039
3.022GlnPro: 3.022 ± 0.05
3.417GlnGln: 3.417 ± 0.066
3.153GlnArg: 3.153 ± 0.048
2.089GlnSer: 2.089 ± 0.037
2.63GlnThr: 2.63 ± 0.045
3.392GlnVal: 3.392 ± 0.051
0.67GlnTrp: 0.67 ± 0.028
1.612GlnTyr: 1.612 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
5.315ArgAla: 5.315 ± 0.063
0.364ArgCys: 0.364 ± 0.015
2.533ArgAsp: 2.533 ± 0.043
3.259ArgGlu: 3.259 ± 0.05
2.632ArgPhe: 2.632 ± 0.043
3.584ArgGly: 3.584 ± 0.042
1.479ArgHis: 1.479 ± 0.035
2.9ArgIle: 2.9 ± 0.047
2.287ArgLys: 2.287 ± 0.041
6.989ArgLeu: 6.989 ± 0.079
1.229ArgMet: 1.229 ± 0.028
2.25ArgAsn: 2.25 ± 0.036
3.22ArgPro: 3.22 ± 0.047
3.566ArgGln: 3.566 ± 0.065
4.376ArgArg: 4.376 ± 0.062
2.777ArgSer: 2.777 ± 0.046
3.525ArgThr: 3.525 ± 0.046
4.145ArgVal: 4.145 ± 0.049
0.904ArgTrp: 0.904 ± 0.023
2.549ArgTyr: 2.549 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
5.729SerAla: 5.729 ± 0.065
0.511SerCys: 0.511 ± 0.017
2.361SerAsp: 2.361 ± 0.039
2.38SerGlu: 2.38 ± 0.038
2.882SerPhe: 2.882 ± 0.046
4.92SerGly: 4.92 ± 0.083
0.979SerHis: 0.979 ± 0.024
2.7SerIle: 2.7 ± 0.044
2.11SerLys: 2.11 ± 0.04
5.92SerLeu: 5.92 ± 0.067
1.016SerMet: 1.016 ± 0.024
2.048SerAsn: 2.048 ± 0.05
2.841SerPro: 2.841 ± 0.04
2.222SerGln: 2.222 ± 0.045
3.211SerArg: 3.211 ± 0.045
3.76SerSer: 3.76 ± 0.073
3.809SerThr: 3.809 ± 0.056
4.017SerVal: 4.017 ± 0.054
0.811SerTrp: 0.811 ± 0.022
2.238SerTyr: 2.238 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
6.938ThrAla: 6.938 ± 0.092
0.369ThrCys: 0.369 ± 0.016
3.307ThrAsp: 3.307 ± 0.042
3.112ThrGlu: 3.112 ± 0.044
2.678ThrPhe: 2.678 ± 0.044
5.481ThrGly: 5.481 ± 0.079
1.108ThrHis: 1.108 ± 0.026
2.903ThrIle: 2.903 ± 0.048
2.21ThrLys: 2.21 ± 0.04
6.953ThrLeu: 6.953 ± 0.071
0.956ThrMet: 0.956 ± 0.025
2.32ThrAsn: 2.32 ± 0.046
4.005ThrPro: 4.005 ± 0.05
2.501ThrGln: 2.501 ± 0.042
3.129ThrArg: 3.129 ± 0.051
3.724ThrSer: 3.724 ± 0.067
4.732ThrThr: 4.732 ± 0.093
4.962ThrVal: 4.962 ± 0.067
0.809ThrTrp: 0.809 ± 0.026
2.384ThrTyr: 2.384 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
7.815ValAla: 7.815 ± 0.088
0.523ValCys: 0.523 ± 0.019
3.24ValAsp: 3.24 ± 0.041
3.743ValGlu: 3.743 ± 0.048
2.81ValPhe: 2.81 ± 0.045
5.169ValGly: 5.169 ± 0.065
1.199ValHis: 1.199 ± 0.028
2.905ValIle: 2.905 ± 0.049
2.794ValLys: 2.794 ± 0.047
8.163ValLeu: 8.163 ± 0.077
1.2ValMet: 1.2 ± 0.028
2.558ValAsn: 2.558 ± 0.048
3.679ValPro: 3.679 ± 0.052
3.326ValGln: 3.326 ± 0.046
4.539ValArg: 4.539 ± 0.058
4.232ValSer: 4.232 ± 0.047
4.542ValThr: 4.542 ± 0.06
5.895ValVal: 5.895 ± 0.07
0.824ValTrp: 0.824 ± 0.024
2.335ValTyr: 2.335 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.14TrpAla: 1.14 ± 0.03
0.091TrpCys: 0.091 ± 0.006
0.552TrpAsp: 0.552 ± 0.018
0.628TrpGlu: 0.628 ± 0.021
0.533TrpPhe: 0.533 ± 0.02
0.818TrpGly: 0.818 ± 0.024
0.324TrpHis: 0.324 ± 0.017
0.432TrpIle: 0.432 ± 0.017
0.466TrpLys: 0.466 ± 0.018
1.82TrpLeu: 1.82 ± 0.04
0.266TrpMet: 0.266 ± 0.013
0.527TrpAsn: 0.527 ± 0.018
0.571TrpPro: 0.571 ± 0.021
0.92TrpGln: 0.92 ± 0.027
0.803TrpArg: 0.803 ± 0.024
0.677TrpSer: 0.677 ± 0.02
0.718TrpThr: 0.718 ± 0.021
0.853TrpVal: 0.853 ± 0.023
0.205TrpTrp: 0.205 ± 0.012
0.415TrpTyr: 0.415 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.224TyrAla: 3.224 ± 0.049
0.305TyrCys: 0.305 ± 0.014
1.974TyrAsp: 1.974 ± 0.038
1.743TyrGlu: 1.743 ± 0.032
1.766TyrPhe: 1.766 ± 0.034
2.659TyrGly: 2.659 ± 0.041
0.781TyrHis: 0.781 ± 0.022
1.261TyrIle: 1.261 ± 0.028
1.291TyrLys: 1.291 ± 0.034
3.695TyrLeu: 3.695 ± 0.049
0.5TyrMet: 0.5 ± 0.016
1.499TyrAsn: 1.499 ± 0.033
1.571TyrPro: 1.571 ± 0.038
1.895TyrGln: 1.895 ± 0.043
2.394TyrArg: 2.394 ± 0.047
2.326TyrSer: 2.326 ± 0.04
2.241TyrThr: 2.241 ± 0.045
2.309TyrVal: 2.309 ± 0.038
0.472TyrTrp: 0.472 ± 0.015
1.569TyrTyr: 1.569 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4905 proteins (1690591 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski