Amino acid dipepetide frequency for Sediminitomix flava

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.816AlaAla: 3.816 ± 0.069
0.617AlaCys: 0.617 ± 0.02
3.542AlaAsp: 3.542 ± 0.063
4.551AlaGlu: 4.551 ± 0.064
3.363AlaPhe: 3.363 ± 0.049
3.974AlaGly: 3.974 ± 0.056
1.103AlaHis: 1.103 ± 0.029
4.585AlaIle: 4.585 ± 0.056
4.18AlaLys: 4.18 ± 0.066
6.01AlaLeu: 6.01 ± 0.069
1.54AlaMet: 1.54 ± 0.03
3.144AlaAsn: 3.144 ± 0.04
2.007AlaPro: 2.007 ± 0.037
2.689AlaGln: 2.689 ± 0.039
1.909AlaArg: 1.909 ± 0.031
4.35AlaSer: 4.35 ± 0.052
3.315AlaThr: 3.315 ± 0.048
3.95AlaVal: 3.95 ± 0.05
0.718AlaTrp: 0.718 ± 0.021
2.687AlaTyr: 2.687 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.459CysAla: 0.459 ± 0.017
0.095CysCys: 0.095 ± 0.007
0.451CysAsp: 0.451 ± 0.021
0.515CysGlu: 0.515 ± 0.02
0.451CysPhe: 0.451 ± 0.016
0.561CysGly: 0.561 ± 0.018
0.196CysHis: 0.196 ± 0.013
0.56CysIle: 0.56 ± 0.018
0.409CysLys: 0.409 ± 0.016
0.694CysLeu: 0.694 ± 0.023
0.157CysMet: 0.157 ± 0.008
0.356CysAsn: 0.356 ± 0.014
0.308CysPro: 0.308 ± 0.014
0.264CysGln: 0.264 ± 0.011
0.25CysArg: 0.25 ± 0.011
0.54CysSer: 0.54 ± 0.021
0.474CysThr: 0.474 ± 0.021
0.427CysVal: 0.427 ± 0.018
0.073CysTrp: 0.073 ± 0.005
0.306CysTyr: 0.306 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.656AspAla: 3.656 ± 0.061
0.435AspCys: 0.435 ± 0.017
2.965AspAsp: 2.965 ± 0.054
4.264AspGlu: 4.264 ± 0.051
3.602AspPhe: 3.602 ± 0.047
4.167AspGly: 4.167 ± 0.074
1.146AspHis: 1.146 ± 0.026
4.352AspIle: 4.352 ± 0.053
3.806AspLys: 3.806 ± 0.066
5.606AspLeu: 5.606 ± 0.066
1.255AspMet: 1.255 ± 0.03
2.74AspAsn: 2.74 ± 0.049
1.978AspPro: 1.978 ± 0.038
2.286AspGln: 2.286 ± 0.041
2.169AspArg: 2.169 ± 0.034
3.364AspSer: 3.364 ± 0.068
2.755AspThr: 2.755 ± 0.058
3.481AspVal: 3.481 ± 0.057
0.902AspTrp: 0.902 ± 0.022
2.687AspTyr: 2.687 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
4.771GluAla: 4.771 ± 0.057
0.395GluCys: 0.395 ± 0.015
4.146GluAsp: 4.146 ± 0.053
6.505GluGlu: 6.505 ± 0.077
3.191GluPhe: 3.191 ± 0.046
5.107GluGly: 5.107 ± 0.057
1.255GluHis: 1.255 ± 0.026
5.561GluIle: 5.561 ± 0.06
6.159GluLys: 6.159 ± 0.095
7.242GluLeu: 7.242 ± 0.078
1.824GluMet: 1.824 ± 0.03
4.694GluAsn: 4.694 ± 0.052
1.6GluPro: 1.6 ± 0.035
2.709GluGln: 2.709 ± 0.043
2.687GluArg: 2.687 ± 0.041
3.961GluSer: 3.961 ± 0.048
3.489GluThr: 3.489 ± 0.044
5.341GluVal: 5.341 ± 0.07
0.904GluTrp: 0.904 ± 0.025
2.729GluTyr: 2.729 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
2.883PheAla: 2.883 ± 0.039
0.459PheCys: 0.459 ± 0.017
3.247PheAsp: 3.247 ± 0.041
3.751PheGlu: 3.751 ± 0.053
2.792PhePhe: 2.792 ± 0.053
3.448PheGly: 3.448 ± 0.047
0.962PheHis: 0.962 ± 0.021
3.614PheIle: 3.614 ± 0.053
3.318PheLys: 3.318 ± 0.051
4.728PheLeu: 4.728 ± 0.072
1.206PheMet: 1.206 ± 0.028
2.887PheAsn: 2.887 ± 0.041
1.71PhePro: 1.71 ± 0.035
1.78PheGln: 1.78 ± 0.03
1.889PheArg: 1.889 ± 0.032
4.256PheSer: 4.256 ± 0.054
3.191PheThr: 3.191 ± 0.053
2.914PheVal: 2.914 ± 0.041
0.606PheTrp: 0.606 ± 0.022
2.314PheTyr: 2.314 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
4.173GlyAla: 4.173 ± 0.063
0.572GlyCys: 0.572 ± 0.024
3.69GlyAsp: 3.69 ± 0.064
4.504GlyGlu: 4.504 ± 0.058
3.473GlyPhe: 3.473 ± 0.049
4.778GlyGly: 4.778 ± 0.068
1.242GlyHis: 1.242 ± 0.028
5.107GlyIle: 5.107 ± 0.06
4.786GlyLys: 4.786 ± 0.062
6.018GlyLeu: 6.018 ± 0.078
1.685GlyMet: 1.685 ± 0.033
3.481GlyAsn: 3.481 ± 0.061
1.254GlyPro: 1.254 ± 0.031
2.177GlyGln: 2.177 ± 0.042
2.098GlyArg: 2.098 ± 0.037
4.078GlySer: 4.078 ± 0.077
3.754GlyThr: 3.754 ± 0.078
4.696GlyVal: 4.696 ± 0.066
0.847GlyTrp: 0.847 ± 0.023
3.003GlyTyr: 3.003 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
0.954HisAla: 0.954 ± 0.024
0.177HisCys: 0.177 ± 0.009
0.934HisAsp: 0.934 ± 0.023
1.176HisGlu: 1.176 ± 0.03
1.221HisPhe: 1.221 ± 0.026
1.139HisGly: 1.139 ± 0.024
0.525HisHis: 0.525 ± 0.017
1.402HisIle: 1.402 ± 0.026
1.246HisLys: 1.246 ± 0.03
1.935HisLeu: 1.935 ± 0.036
0.385HisMet: 0.385 ± 0.014
0.894HisAsn: 0.894 ± 0.022
0.884HisPro: 0.884 ± 0.025
0.865HisGln: 0.865 ± 0.021
0.724HisArg: 0.724 ± 0.02
1.236HisSer: 1.236 ± 0.028
1.027HisThr: 1.027 ± 0.025
0.892HisVal: 0.892 ± 0.024
0.273HisTrp: 0.273 ± 0.012
0.87HisTyr: 0.87 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
4.625IleAla: 4.625 ± 0.058
0.655IleCys: 0.655 ± 0.019
4.636IleAsp: 4.636 ± 0.056
5.53IleGlu: 5.53 ± 0.058
3.476IlePhe: 3.476 ± 0.056
4.922IleGly: 4.922 ± 0.071
1.478IleHis: 1.478 ± 0.032
4.72IleIle: 4.72 ± 0.056
4.498IleLys: 4.498 ± 0.058
6.623IleLeu: 6.623 ± 0.077
1.294IleMet: 1.294 ± 0.032
3.87IleAsn: 3.87 ± 0.052
3.025IlePro: 3.025 ± 0.043
2.723IleGln: 2.723 ± 0.04
2.714IleArg: 2.714 ± 0.042
5.813IleSer: 5.813 ± 0.07
4.117IleThr: 4.117 ± 0.067
4.092IleVal: 4.092 ± 0.055
0.754IleTrp: 0.754 ± 0.024
2.815IleTyr: 2.815 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
4.738LysAla: 4.738 ± 0.066
0.336LysCys: 0.336 ± 0.014
4.247LysAsp: 4.247 ± 0.061
6.355LysGlu: 6.355 ± 0.091
2.665LysPhe: 2.665 ± 0.041
4.743LysGly: 4.743 ± 0.063
1.347LysHis: 1.347 ± 0.034
4.81LysIle: 4.81 ± 0.055
5.798LysLys: 5.798 ± 0.092
6.232LysLeu: 6.232 ± 0.087
1.795LysMet: 1.795 ± 0.037
3.969LysAsn: 3.969 ± 0.058
2.087LysPro: 2.087 ± 0.036
2.445LysGln: 2.445 ± 0.043
2.663LysArg: 2.663 ± 0.054
4.325LysSer: 4.325 ± 0.058
3.475LysThr: 3.475 ± 0.05
4.925LysVal: 4.925 ± 0.064
0.845LysTrp: 0.845 ± 0.024
3.085LysTyr: 3.085 ± 0.053
0.0LysXaa: 0.0 ± 0.0
Leu
5.788LeuAla: 5.788 ± 0.065
0.726LeuCys: 0.726 ± 0.022
5.455LeuAsp: 5.455 ± 0.06
6.913LeuGlu: 6.913 ± 0.067
4.899LeuPhe: 4.899 ± 0.066
6.027LeuGly: 6.027 ± 0.075
1.655LeuHis: 1.655 ± 0.032
6.45LeuIle: 6.45 ± 0.08
7.238LeuLys: 7.238 ± 0.089
8.614LeuLeu: 8.614 ± 0.109
2.137LeuMet: 2.137 ± 0.041
5.369LeuAsn: 5.369 ± 0.06
3.675LeuPro: 3.675 ± 0.045
3.362LeuGln: 3.362 ± 0.05
3.324LeuArg: 3.324 ± 0.048
7.519LeuSer: 7.519 ± 0.087
5.12LeuThr: 5.12 ± 0.068
5.319LeuVal: 5.319 ± 0.055
0.963LeuTrp: 0.963 ± 0.025
3.385LeuTyr: 3.385 ± 0.052
0.0LeuXaa: 0.0 ± 0.0
Met
1.527MetAla: 1.527 ± 0.035
0.131MetCys: 0.131 ± 0.009
1.267MetAsp: 1.267 ± 0.028
1.562MetGlu: 1.562 ± 0.032
0.843MetPhe: 0.843 ± 0.023
1.521MetGly: 1.521 ± 0.028
0.423MetHis: 0.423 ± 0.015
1.67MetIle: 1.67 ± 0.03
2.111MetLys: 2.111 ± 0.04
2.086MetLeu: 2.086 ± 0.04
0.677MetMet: 0.677 ± 0.023
1.398MetAsn: 1.398 ± 0.03
0.884MetPro: 0.884 ± 0.023
0.737MetGln: 0.737 ± 0.02
0.903MetArg: 0.903 ± 0.027
1.564MetSer: 1.564 ± 0.032
1.26MetThr: 1.26 ± 0.027
1.34MetVal: 1.34 ± 0.029
0.237MetTrp: 0.237 ± 0.012
0.793MetTyr: 0.793 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.379AsnAla: 3.379 ± 0.046
0.426AsnCys: 0.426 ± 0.019
2.94AsnAsp: 2.94 ± 0.049
3.743AsnGlu: 3.743 ± 0.041
2.75AsnPhe: 2.75 ± 0.044
3.83AsnGly: 3.83 ± 0.064
1.104AsnHis: 1.104 ± 0.025
4.132AsnIle: 4.132 ± 0.047
3.436AsnLys: 3.436 ± 0.055
4.966AsnLeu: 4.966 ± 0.052
1.194AsnMet: 1.194 ± 0.024
2.882AsnAsn: 2.882 ± 0.05
2.451AsnPro: 2.451 ± 0.038
2.247AsnGln: 2.247 ± 0.04
2.031AsnArg: 2.031 ± 0.038
3.678AsnSer: 3.678 ± 0.059
3.38AsnThr: 3.38 ± 0.049
3.254AsnVal: 3.254 ± 0.053
0.795AsnTrp: 0.795 ± 0.022
2.58AsnTyr: 2.58 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
1.837ProAla: 1.837 ± 0.035
0.189ProCys: 0.189 ± 0.013
1.929ProAsp: 1.929 ± 0.038
2.708ProGlu: 2.708 ± 0.043
1.918ProPhe: 1.918 ± 0.032
1.486ProGly: 1.486 ± 0.038
0.669ProHis: 0.669 ± 0.02
2.564ProIle: 2.564 ± 0.038
2.404ProLys: 2.404 ± 0.042
3.014ProLeu: 3.014 ± 0.045
0.79ProMet: 0.79 ± 0.02
2.221ProAsn: 2.221 ± 0.037
0.858ProPro: 0.858 ± 0.025
1.285ProGln: 1.285 ± 0.023
0.934ProArg: 0.934 ± 0.026
2.723ProSer: 2.723 ± 0.042
2.009ProThr: 2.009 ± 0.036
2.241ProVal: 2.241 ± 0.044
0.38ProTrp: 0.38 ± 0.013
1.529ProTyr: 1.529 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
2.195GlnAla: 2.195 ± 0.043
0.172GlnCys: 0.172 ± 0.01
1.869GlnAsp: 1.869 ± 0.031
2.849GlnGlu: 2.849 ± 0.047
1.797GlnPhe: 1.797 ± 0.031
1.978GlnGly: 1.978 ± 0.033
0.664GlnHis: 0.664 ± 0.021
2.803GlnIle: 2.803 ± 0.04
3.133GlnLys: 3.133 ± 0.053
3.835GlnLeu: 3.835 ± 0.056
0.963GlnMet: 0.963 ± 0.025
2.257GlnAsn: 2.257 ± 0.038
0.983GlnPro: 0.983 ± 0.023
1.498GlnGln: 1.498 ± 0.034
1.399GlnArg: 1.399 ± 0.031
2.336GlnSer: 2.336 ± 0.041
2.003GlnThr: 2.003 ± 0.029
2.229GlnVal: 2.229 ± 0.036
0.455GlnTrp: 0.455 ± 0.018
1.446GlnTyr: 1.446 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
2.082ArgAla: 2.082 ± 0.042
0.193ArgCys: 0.193 ± 0.01
1.816ArgAsp: 1.816 ± 0.037
2.351ArgGlu: 2.351 ± 0.046
1.969ArgPhe: 1.969 ± 0.034
1.965ArgGly: 1.965 ± 0.035
0.601ArgHis: 0.601 ± 0.017
2.81ArgIle: 2.81 ± 0.039
2.851ArgLys: 2.851 ± 0.047
3.414ArgLeu: 3.414 ± 0.047
1.015ArgMet: 1.015 ± 0.027
1.971ArgAsn: 1.971 ± 0.036
1.162ArgPro: 1.162 ± 0.029
1.192ArgGln: 1.192 ± 0.026
1.396ArgArg: 1.396 ± 0.03
2.047ArgSer: 2.047 ± 0.034
1.855ArgThr: 1.855 ± 0.033
2.306ArgVal: 2.306 ± 0.036
0.472ArgTrp: 0.472 ± 0.018
1.574ArgTyr: 1.574 ± 0.03
0.0ArgXaa: 0.0 ± 0.0
Ser
4.054SerAla: 4.054 ± 0.046
0.698SerCys: 0.698 ± 0.03
4.068SerAsp: 4.068 ± 0.062
4.948SerGlu: 4.948 ± 0.054
4.209SerPhe: 4.209 ± 0.062
4.344SerGly: 4.344 ± 0.084
1.221SerHis: 1.221 ± 0.025
5.389SerIle: 5.389 ± 0.059
4.407SerLys: 4.407 ± 0.053
6.772SerLeu: 6.772 ± 0.072
1.514SerMet: 1.514 ± 0.03
3.784SerAsn: 3.784 ± 0.067
2.368SerPro: 2.368 ± 0.042
2.237SerGln: 2.237 ± 0.038
2.106SerArg: 2.106 ± 0.035
5.215SerSer: 5.215 ± 0.085
3.87SerThr: 3.87 ± 0.064
4.296SerVal: 4.296 ± 0.071
0.835SerTrp: 0.835 ± 0.022
3.094SerTyr: 3.094 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
3.689ThrAla: 3.689 ± 0.053
0.329ThrCys: 0.329 ± 0.015
3.369ThrAsp: 3.369 ± 0.057
3.742ThrGlu: 3.742 ± 0.056
3.085ThrPhe: 3.085 ± 0.046
3.754ThrGly: 3.754 ± 0.066
0.965ThrHis: 0.965 ± 0.022
3.988ThrIle: 3.988 ± 0.061
3.157ThrLys: 3.157 ± 0.048
5.393ThrLeu: 5.393 ± 0.071
0.926ThrMet: 0.926 ± 0.021
2.764ThrAsn: 2.764 ± 0.043
2.427ThrPro: 2.427 ± 0.04
1.892ThrGln: 1.892 ± 0.033
1.511ThrArg: 1.511 ± 0.028
3.936ThrSer: 3.936 ± 0.062
3.084ThrThr: 3.084 ± 0.06
3.678ThrVal: 3.678 ± 0.086
0.686ThrTrp: 0.686 ± 0.021
2.418ThrTyr: 2.418 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
4.072ValAla: 4.072 ± 0.055
0.538ValCys: 0.538 ± 0.02
3.734ValAsp: 3.734 ± 0.057
4.585ValGlu: 4.585 ± 0.063
3.241ValPhe: 3.241 ± 0.046
4.091ValGly: 4.091 ± 0.07
1.05ValHis: 1.05 ± 0.024
4.413ValIle: 4.413 ± 0.052
4.334ValLys: 4.334 ± 0.059
5.705ValLeu: 5.705 ± 0.065
1.403ValMet: 1.403 ± 0.031
3.439ValAsn: 3.439 ± 0.051
2.114ValPro: 2.114 ± 0.036
2.063ValGln: 2.063 ± 0.033
2.181ValArg: 2.181 ± 0.034
4.831ValSer: 4.831 ± 0.072
3.392ValThr: 3.392 ± 0.068
4.19ValVal: 4.19 ± 0.057
0.737ValTrp: 0.737 ± 0.019
2.516ValTyr: 2.516 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
0.804TrpAla: 0.804 ± 0.021
0.099TrpCys: 0.099 ± 0.007
0.815TrpAsp: 0.815 ± 0.027
0.931TrpGlu: 0.931 ± 0.022
0.558TrpPhe: 0.558 ± 0.019
0.904TrpGly: 0.904 ± 0.022
0.247TrpHis: 0.247 ± 0.011
0.773TrpIle: 0.773 ± 0.024
0.876TrpLys: 0.876 ± 0.025
1.033TrpLeu: 1.033 ± 0.024
0.341TrpMet: 0.341 ± 0.013
0.748TrpAsn: 0.748 ± 0.021
0.229TrpPro: 0.229 ± 0.011
0.468TrpGln: 0.468 ± 0.018
0.434TrpArg: 0.434 ± 0.015
0.792TrpSer: 0.792 ± 0.029
0.702TrpThr: 0.702 ± 0.023
0.821TrpVal: 0.821 ± 0.022
0.191TrpTrp: 0.191 ± 0.009
0.504TrpTyr: 0.504 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.546TyrAla: 2.546 ± 0.042
0.305TyrCys: 0.305 ± 0.015
2.496TyrAsp: 2.496 ± 0.05
2.786TyrGlu: 2.786 ± 0.047
2.451TyrPhe: 2.451 ± 0.04
2.677TyrGly: 2.677 ± 0.051
0.907TyrHis: 0.907 ± 0.025
2.68TyrIle: 2.68 ± 0.041
2.737TyrLys: 2.737 ± 0.044
4.017TyrLeu: 4.017 ± 0.057
0.835TyrMet: 0.835 ± 0.023
2.329TyrAsn: 2.329 ± 0.039
1.684TyrPro: 1.684 ± 0.032
1.945TyrGln: 1.945 ± 0.036
1.718TyrArg: 1.718 ± 0.033
2.863TyrSer: 2.863 ± 0.049
2.523TyrThr: 2.523 ± 0.052
2.24TyrVal: 2.24 ± 0.036
0.598TyrTrp: 0.598 ± 0.019
1.989TyrTyr: 1.989 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5031 proteins (1924432 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski