Amino acid dipepetide frequency for Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.565AlaAla: 4.565 ± 0.112
0.42AlaCys: 0.42 ± 0.026
3.044AlaAsp: 3.044 ± 0.078
5.931AlaGlu: 5.931 ± 0.117
3.814AlaPhe: 3.814 ± 0.076
5.591AlaGly: 5.591 ± 0.109
1.245AlaHis: 1.245 ± 0.047
5.456AlaIle: 5.456 ± 0.099
5.128AlaLys: 5.128 ± 0.103
9.483AlaLeu: 9.483 ± 0.144
2.054AlaMet: 2.054 ± 0.06
1.951AlaAsn: 1.951 ± 0.057
2.365AlaPro: 2.365 ± 0.062
1.465AlaGln: 1.465 ± 0.058
4.424AlaArg: 4.424 ± 0.084
3.561AlaSer: 3.561 ± 0.078
2.997AlaThr: 2.997 ± 0.075
6.649AlaVal: 6.649 ± 0.117
0.833AlaTrp: 0.833 ± 0.034
3.212AlaTyr: 3.212 ± 0.078
0.0AlaXaa: 0.0 ± 0.0
Cys
0.301CysAla: 0.301 ± 0.021
0.055CysCys: 0.055 ± 0.009
0.243CysAsp: 0.243 ± 0.019
0.334CysGlu: 0.334 ± 0.021
0.143CysPhe: 0.143 ± 0.015
0.725CysGly: 0.725 ± 0.038
0.107CysHis: 0.107 ± 0.014
0.249CysIle: 0.249 ± 0.02
0.207CysLys: 0.207 ± 0.021
0.372CysLeu: 0.372 ± 0.028
0.127CysMet: 0.127 ± 0.016
0.209CysAsn: 0.209 ± 0.019
0.643CysPro: 0.643 ± 0.04
0.113CysGln: 0.113 ± 0.015
0.347CysArg: 0.347 ± 0.024
0.336CysSer: 0.336 ± 0.026
0.245CysThr: 0.245 ± 0.02
0.325CysVal: 0.325 ± 0.024
0.074CysTrp: 0.074 ± 0.011
0.163CysTyr: 0.163 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.276AspAla: 3.276 ± 0.068
0.234AspCys: 0.234 ± 0.019
2.211AspAsp: 2.211 ± 0.07
4.783AspGlu: 4.783 ± 0.083
2.471AspPhe: 2.471 ± 0.067
3.692AspGly: 3.692 ± 0.115
0.638AspHis: 0.638 ± 0.028
3.361AspIle: 3.361 ± 0.073
2.312AspLys: 2.312 ± 0.062
4.51AspLeu: 4.51 ± 0.082
1.151AspMet: 1.151 ± 0.046
1.248AspAsn: 1.248 ± 0.048
2.512AspPro: 2.512 ± 0.065
0.626AspGln: 0.626 ± 0.029
2.439AspArg: 2.439 ± 0.068
2.036AspSer: 2.036 ± 0.056
2.04AspThr: 2.04 ± 0.059
4.731AspVal: 4.731 ± 0.09
0.764AspTrp: 0.764 ± 0.038
2.296AspTyr: 2.296 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
6.245GluAla: 6.245 ± 0.111
0.304GluCys: 0.304 ± 0.024
4.134GluAsp: 4.134 ± 0.094
9.266GluGlu: 9.266 ± 0.182
3.699GluPhe: 3.699 ± 0.078
5.84GluGly: 5.84 ± 0.106
1.311GluHis: 1.311 ± 0.046
6.444GluIle: 6.444 ± 0.111
7.659GluLys: 7.659 ± 0.156
9.963GluLeu: 9.963 ± 0.163
2.15GluMet: 2.15 ± 0.059
3.378GluAsn: 3.378 ± 0.066
2.773GluPro: 2.773 ± 0.073
1.255GluGln: 1.255 ± 0.049
5.614GluArg: 5.614 ± 0.12
3.296GluSer: 3.296 ± 0.083
3.35GluThr: 3.35 ± 0.069
7.549GluVal: 7.549 ± 0.125
1.17GluTrp: 1.17 ± 0.048
2.862GluTyr: 2.862 ± 0.067
0.0GluXaa: 0.0 ± 0.0
Phe
2.915PheAla: 2.915 ± 0.071
0.21PheCys: 0.21 ± 0.02
2.239PheAsp: 2.239 ± 0.065
3.604PheGlu: 3.604 ± 0.073
1.887PhePhe: 1.887 ± 0.067
3.663PheGly: 3.663 ± 0.078
0.729PheHis: 0.729 ± 0.037
2.896PheIle: 2.896 ± 0.055
2.428PheLys: 2.428 ± 0.06
4.897PheLeu: 4.897 ± 0.108
1.015PheMet: 1.015 ± 0.04
1.485PheAsn: 1.485 ± 0.05
1.781PhePro: 1.781 ± 0.051
0.911PheGln: 0.911 ± 0.039
2.379PheArg: 2.379 ± 0.057
2.611PheSer: 2.611 ± 0.072
2.073PheThr: 2.073 ± 0.061
3.226PheVal: 3.226 ± 0.061
0.59PheTrp: 0.59 ± 0.037
1.756PheTyr: 1.756 ± 0.058
0.0PheXaa: 0.0 ± 0.0
Gly
5.263GlyAla: 5.263 ± 0.112
0.51GlyCys: 0.51 ± 0.032
3.83GlyAsp: 3.83 ± 0.082
6.063GlyGlu: 6.063 ± 0.123
3.555GlyPhe: 3.555 ± 0.084
5.007GlyGly: 5.007 ± 0.116
1.233GlyHis: 1.233 ± 0.051
6.4GlyIle: 6.4 ± 0.126
6.19GlyLys: 6.19 ± 0.093
7.203GlyLeu: 7.203 ± 0.123
2.108GlyMet: 2.108 ± 0.057
2.44GlyAsn: 2.44 ± 0.082
2.079GlyPro: 2.079 ± 0.066
1.388GlyGln: 1.388 ± 0.047
4.355GlyArg: 4.355 ± 0.089
3.839GlySer: 3.839 ± 0.093
3.776GlyThr: 3.776 ± 0.093
6.359GlyVal: 6.359 ± 0.123
1.107GlyTrp: 1.107 ± 0.044
3.133GlyTyr: 3.133 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
1.077HisAla: 1.077 ± 0.043
0.149HisCys: 0.149 ± 0.016
0.718HisAsp: 0.718 ± 0.03
1.123HisGlu: 1.123 ± 0.042
0.756HisPhe: 0.756 ± 0.036
1.325HisGly: 1.325 ± 0.046
0.347HisHis: 0.347 ± 0.023
1.129HisIle: 1.129 ± 0.045
0.693HisLys: 0.693 ± 0.036
1.518HisLeu: 1.518 ± 0.049
0.323HisMet: 0.323 ± 0.023
0.489HisAsn: 0.489 ± 0.028
1.096HisPro: 1.096 ± 0.044
0.276HisGln: 0.276 ± 0.019
1.018HisArg: 1.018 ± 0.044
0.801HisSer: 0.801 ± 0.036
0.673HisThr: 0.673 ± 0.039
1.33HisVal: 1.33 ± 0.041
0.227HisTrp: 0.227 ± 0.018
0.855HisTyr: 0.855 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
6.07IleAla: 6.07 ± 0.102
0.303IleCys: 0.303 ± 0.024
3.525IleAsp: 3.525 ± 0.08
6.219IleGlu: 6.219 ± 0.11
2.578IlePhe: 2.578 ± 0.07
5.376IleGly: 5.376 ± 0.1
1.107IleHis: 1.107 ± 0.039
4.786IleIle: 4.786 ± 0.084
4.568IleLys: 4.568 ± 0.092
6.743IleLeu: 6.743 ± 0.113
1.363IleMet: 1.363 ± 0.049
2.318IleAsn: 2.318 ± 0.06
3.564IlePro: 3.564 ± 0.068
1.427IleGln: 1.427 ± 0.057
3.894IleArg: 3.894 ± 0.082
3.643IleSer: 3.643 ± 0.085
3.784IleThr: 3.784 ± 0.074
5.424IleVal: 5.424 ± 0.086
0.692IleTrp: 0.692 ± 0.036
2.228IleTyr: 2.228 ± 0.05
0.0IleXaa: 0.0 ± 0.0
Lys
6.252LysAla: 6.252 ± 0.114
0.397LysCys: 0.397 ± 0.028
3.152LysAsp: 3.152 ± 0.078
6.469LysGlu: 6.469 ± 0.135
2.471LysPhe: 2.471 ± 0.064
4.825LysGly: 4.825 ± 0.09
1.016LysHis: 1.016 ± 0.039
4.501LysIle: 4.501 ± 0.089
5.224LysLys: 5.224 ± 0.108
7.041LysLeu: 7.041 ± 0.11
1.433LysMet: 1.433 ± 0.05
2.233LysAsn: 2.233 ± 0.066
3.183LysPro: 3.183 ± 0.081
1.026LysGln: 1.026 ± 0.04
4.455LysArg: 4.455 ± 0.1
2.762LysSer: 2.762 ± 0.072
3.238LysThr: 3.238 ± 0.078
5.834LysVal: 5.834 ± 0.096
0.85LysTrp: 0.85 ± 0.037
2.321LysTyr: 2.321 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
8.539LeuAla: 8.539 ± 0.135
0.436LeuCys: 0.436 ± 0.026
4.919LeuAsp: 4.919 ± 0.087
8.576LeuGlu: 8.576 ± 0.149
4.082LeuPhe: 4.082 ± 0.098
8.416LeuGly: 8.416 ± 0.12
1.553LeuHis: 1.553 ± 0.049
6.942LeuIle: 6.942 ± 0.104
7.722LeuLys: 7.722 ± 0.128
10.709LeuLeu: 10.709 ± 0.186
2.636LeuMet: 2.636 ± 0.068
3.386LeuAsn: 3.386 ± 0.068
4.653LeuPro: 4.653 ± 0.088
2.042LeuGln: 2.042 ± 0.053
6.212LeuArg: 6.212 ± 0.098
6.188LeuSer: 6.188 ± 0.107
4.819LeuThr: 4.819 ± 0.108
7.902LeuVal: 7.902 ± 0.124
1.253LeuTrp: 1.253 ± 0.046
3.732LeuTyr: 3.732 ± 0.08
0.0LeuXaa: 0.0 ± 0.0
Met
2.073MetAla: 2.073 ± 0.06
0.099MetCys: 0.099 ± 0.014
1.101MetAsp: 1.101 ± 0.038
2.025MetGlu: 2.025 ± 0.056
0.762MetPhe: 0.762 ± 0.031
1.904MetGly: 1.904 ± 0.05
0.367MetHis: 0.367 ± 0.023
1.429MetIle: 1.429 ± 0.052
1.977MetLys: 1.977 ± 0.053
2.249MetLeu: 2.249 ± 0.069
0.608MetMet: 0.608 ± 0.033
0.853MetAsn: 0.853 ± 0.039
1.063MetPro: 1.063 ± 0.041
0.398MetGln: 0.398 ± 0.028
1.692MetArg: 1.692 ± 0.057
1.242MetSer: 1.242 ± 0.049
1.04MetThr: 1.04 ± 0.039
1.755MetVal: 1.755 ± 0.053
0.198MetTrp: 0.198 ± 0.016
0.541MetTyr: 0.541 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
2.439AsnAla: 2.439 ± 0.067
0.243AsnCys: 0.243 ± 0.021
1.418AsnAsp: 1.418 ± 0.05
2.484AsnGlu: 2.484 ± 0.073
1.349AsnPhe: 1.349 ± 0.043
3.049AsnGly: 3.049 ± 0.095
0.478AsnHis: 0.478 ± 0.028
2.014AsnIle: 2.014 ± 0.06
1.353AsnLys: 1.353 ± 0.054
3.405AsnLeu: 3.405 ± 0.072
0.552AsnMet: 0.552 ± 0.028
0.842AsnAsn: 0.842 ± 0.047
2.341AsnPro: 2.341 ± 0.062
0.601AsnGln: 0.601 ± 0.032
1.678AsnArg: 1.678 ± 0.056
1.579AsnSer: 1.579 ± 0.064
1.493AsnThr: 1.493 ± 0.05
2.989AsnVal: 2.989 ± 0.077
0.496AsnTrp: 0.496 ± 0.028
1.338AsnTyr: 1.338 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
2.776ProAla: 2.776 ± 0.061
0.256ProCys: 0.256 ± 0.019
2.327ProAsp: 2.327 ± 0.059
4.747ProGlu: 4.747 ± 0.089
2.018ProPhe: 2.018 ± 0.058
3.215ProGly: 3.215 ± 0.075
0.814ProHis: 0.814 ± 0.034
2.776ProIle: 2.776 ± 0.065
2.933ProLys: 2.933 ± 0.071
4.228ProLeu: 4.228 ± 0.085
0.96ProMet: 0.96 ± 0.04
1.56ProAsn: 1.56 ± 0.054
1.811ProPro: 1.811 ± 0.049
0.908ProGln: 0.908 ± 0.037
2.228ProArg: 2.228 ± 0.065
2.279ProSer: 2.279 ± 0.061
2.117ProThr: 2.117 ± 0.061
3.561ProVal: 3.561 ± 0.083
0.56ProTrp: 0.56 ± 0.032
1.81ProTyr: 1.81 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
1.443GlnAla: 1.443 ± 0.052
0.091GlnCys: 0.091 ± 0.011
0.77GlnAsp: 0.77 ± 0.034
1.458GlnGlu: 1.458 ± 0.056
0.775GlnPhe: 0.775 ± 0.034
1.197GlnGly: 1.197 ± 0.047
0.281GlnHis: 0.281 ± 0.021
1.278GlnIle: 1.278 ± 0.042
1.393GlnLys: 1.393 ± 0.053
1.833GlnLeu: 1.833 ± 0.059
0.5GlnMet: 0.5 ± 0.026
0.762GlnAsn: 0.762 ± 0.038
0.648GlnPro: 0.648 ± 0.032
0.39GlnGln: 0.39 ± 0.028
1.396GlnArg: 1.396 ± 0.045
0.784GlnSer: 0.784 ± 0.042
0.897GlnThr: 0.897 ± 0.038
1.447GlnVal: 1.447 ± 0.054
0.238GlnTrp: 0.238 ± 0.019
0.646GlnTyr: 0.646 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
4.322ArgAla: 4.322 ± 0.09
0.318ArgCys: 0.318 ± 0.028
2.831ArgAsp: 2.831 ± 0.063
6.654ArgGlu: 6.654 ± 0.133
2.569ArgPhe: 2.569 ± 0.074
4.082ArgGly: 4.082 ± 0.092
0.859ArgHis: 0.859 ± 0.042
4.259ArgIle: 4.259 ± 0.086
4.711ArgLys: 4.711 ± 0.099
5.614ArgLeu: 5.614 ± 0.105
1.408ArgMet: 1.408 ± 0.049
1.766ArgAsn: 1.766 ± 0.053
2.192ArgPro: 2.192 ± 0.066
0.91ArgGln: 0.91 ± 0.034
3.721ArgArg: 3.721 ± 0.096
2.188ArgSer: 2.188 ± 0.054
2.346ArgThr: 2.346 ± 0.063
4.761ArgVal: 4.761 ± 0.097
0.739ArgTrp: 0.739 ± 0.034
2.15ArgTyr: 2.15 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
3.522SerAla: 3.522 ± 0.084
0.278SerCys: 0.278 ± 0.022
2.333SerAsp: 2.333 ± 0.072
4.01SerGlu: 4.01 ± 0.079
2.398SerPhe: 2.398 ± 0.068
4.389SerGly: 4.389 ± 0.101
0.87SerHis: 0.87 ± 0.038
3.348SerIle: 3.348 ± 0.085
2.995SerLys: 2.995 ± 0.075
5.462SerLeu: 5.462 ± 0.114
1.135SerMet: 1.135 ± 0.045
1.57SerAsn: 1.57 ± 0.053
2.398SerPro: 2.398 ± 0.064
0.985SerGln: 0.985 ± 0.037
2.702SerArg: 2.702 ± 0.075
3.06SerSer: 3.06 ± 0.1
2.567SerThr: 2.567 ± 0.085
3.724SerVal: 3.724 ± 0.095
0.75SerTrp: 0.75 ± 0.037
1.97SerTyr: 1.97 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
3.613ThrAla: 3.613 ± 0.079
0.276ThrCys: 0.276 ± 0.021
1.885ThrAsp: 1.885 ± 0.055
2.898ThrGlu: 2.898 ± 0.072
2.141ThrPhe: 2.141 ± 0.066
3.935ThrGly: 3.935 ± 0.086
0.794ThrHis: 0.794 ± 0.035
3.243ThrIle: 3.243 ± 0.08
2.439ThrLys: 2.439 ± 0.061
5.173ThrLeu: 5.173 ± 0.096
0.985ThrMet: 0.985 ± 0.041
1.513ThrAsn: 1.513 ± 0.071
2.597ThrPro: 2.597 ± 0.078
0.866ThrGln: 0.866 ± 0.039
2.073ThrArg: 2.073 ± 0.055
2.573ThrSer: 2.573 ± 0.072
2.594ThrThr: 2.594 ± 0.079
4.113ThrVal: 4.113 ± 0.105
0.604ThrTrp: 0.604 ± 0.031
1.838ThrTyr: 1.838 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
5.796ValAla: 5.796 ± 0.094
0.461ValCys: 0.461 ± 0.031
3.922ValAsp: 3.922 ± 0.092
7.614ValGlu: 7.614 ± 0.111
3.624ValPhe: 3.624 ± 0.086
5.666ValGly: 5.666 ± 0.112
1.233ValHis: 1.233 ± 0.044
5.881ValIle: 5.881 ± 0.098
5.936ValLys: 5.936 ± 0.096
8.752ValLeu: 8.752 ± 0.122
1.818ValMet: 1.818 ± 0.051
2.417ValAsn: 2.417 ± 0.075
3.895ValPro: 3.895 ± 0.076
1.581ValGln: 1.581 ± 0.053
4.628ValArg: 4.628 ± 0.092
4.734ValSer: 4.734 ± 0.105
3.717ValThr: 3.717 ± 0.083
7.173ValVal: 7.173 ± 0.129
0.983ValTrp: 0.983 ± 0.037
3.089ValTyr: 3.089 ± 0.082
0.0ValXaa: 0.0 ± 0.0
Trp
0.93TrpAla: 0.93 ± 0.035
0.056TrpCys: 0.056 ± 0.01
0.775TrpAsp: 0.775 ± 0.039
1.192TrpGlu: 1.192 ± 0.044
0.496TrpPhe: 0.496 ± 0.03
0.936TrpGly: 0.936 ± 0.044
0.243TrpHis: 0.243 ± 0.021
0.8TrpIle: 0.8 ± 0.031
1.101TrpLys: 1.101 ± 0.041
1.256TrpLeu: 1.256 ± 0.049
0.307TrpMet: 0.307 ± 0.021
0.461TrpAsn: 0.461 ± 0.031
0.411TrpPro: 0.411 ± 0.026
0.273TrpGln: 0.273 ± 0.023
0.817TrpArg: 0.817 ± 0.037
0.565TrpSer: 0.565 ± 0.03
0.514TrpThr: 0.514 ± 0.027
1.096TrpVal: 1.096 ± 0.042
0.235TrpTrp: 0.235 ± 0.019
0.5TrpTyr: 0.5 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.769TyrAla: 2.769 ± 0.062
0.22TyrCys: 0.22 ± 0.022
1.952TyrAsp: 1.952 ± 0.057
2.812TyrGlu: 2.812 ± 0.071
1.709TyrPhe: 1.709 ± 0.051
3.005TyrGly: 3.005 ± 0.081
0.699TyrHis: 0.699 ± 0.037
2.423TyrIle: 2.423 ± 0.077
1.719TyrLys: 1.719 ± 0.057
4.306TyrLeu: 4.306 ± 0.103
0.74TyrMet: 0.74 ± 0.031
1.258TyrAsn: 1.258 ± 0.048
1.876TyrPro: 1.876 ± 0.053
0.789TyrGln: 0.789 ± 0.037
2.329TyrArg: 2.329 ± 0.061
2.39TyrSer: 2.39 ± 0.067
1.872TyrThr: 1.872 ± 0.056
2.969TyrVal: 2.969 ± 0.075
0.604TyrTrp: 0.604 ± 0.026
1.877TyrTyr: 1.877 ± 0.072
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2301 proteins (637680 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski