Amino acid dipepetide frequency for Ureaplasma diversum NCTC 246

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.593AlaAla: 3.593 ± 0.158
0.57AlaCys: 0.57 ± 0.05
2.999AlaAsp: 2.999 ± 0.112
2.738AlaGlu: 2.738 ± 0.122
2.861AlaPhe: 2.861 ± 0.119
2.604AlaGly: 2.604 ± 0.126
0.969AlaHis: 0.969 ± 0.059
5.184AlaIle: 5.184 ± 0.147
6.058AlaLys: 6.058 ± 0.182
5.611AlaLeu: 5.611 ± 0.192
1.037AlaMet: 1.037 ± 0.074
5.041AlaAsn: 5.041 ± 0.197
1.516AlaPro: 1.516 ± 0.09
1.919AlaGln: 1.919 ± 0.102
1.808AlaArg: 1.808 ± 0.09
3.66AlaSer: 3.66 ± 0.127
3.482AlaThr: 3.482 ± 0.128
3.039AlaVal: 3.039 ± 0.107
0.451AlaTrp: 0.451 ± 0.044
2.489AlaTyr: 2.489 ± 0.11
0.0AlaXaa: 0.0 ± 0.0
Cys
0.455CysAla: 0.455 ± 0.047
0.099CysCys: 0.099 ± 0.028
0.384CysAsp: 0.384 ± 0.043
0.419CysGlu: 0.419 ± 0.055
0.526CysPhe: 0.526 ± 0.054
0.415CysGly: 0.415 ± 0.047
0.123CysHis: 0.123 ± 0.025
0.601CysIle: 0.601 ± 0.053
0.352CysLys: 0.352 ± 0.038
0.76CysLeu: 0.76 ± 0.062
0.103CysMet: 0.103 ± 0.021
0.423CysAsn: 0.423 ± 0.044
0.15CysPro: 0.15 ± 0.025
0.214CysGln: 0.214 ± 0.028
0.131CysArg: 0.131 ± 0.022
0.447CysSer: 0.447 ± 0.044
0.36CysThr: 0.36 ± 0.032
0.455CysVal: 0.455 ± 0.046
0.032CysTrp: 0.032 ± 0.011
0.265CysTyr: 0.265 ± 0.034
0.0CysXaa: 0.0 ± 0.0
Asp
2.762AspAla: 2.762 ± 0.114
0.408AspCys: 0.408 ± 0.044
3.502AspAsp: 3.502 ± 0.114
3.918AspGlu: 3.918 ± 0.157
3.637AspPhe: 3.637 ± 0.139
2.635AspGly: 2.635 ± 0.115
1.195AspHis: 1.195 ± 0.069
4.072AspIle: 4.072 ± 0.118
5.421AspLys: 5.421 ± 0.173
6.391AspLeu: 6.391 ± 0.169
0.629AspMet: 0.629 ± 0.056
4.012AspAsn: 4.012 ± 0.125
2.362AspPro: 2.362 ± 0.095
4.262AspGln: 4.262 ± 0.172
1.452AspArg: 1.452 ± 0.073
3.522AspSer: 3.522 ± 0.109
2.354AspThr: 2.354 ± 0.108
3.391AspVal: 3.391 ± 0.119
0.554AspTrp: 0.554 ± 0.047
2.802AspTyr: 2.802 ± 0.116
0.0AspXaa: 0.0 ± 0.0
Glu
3.779GluAla: 3.779 ± 0.152
0.348GluCys: 0.348 ± 0.038
3.205GluAsp: 3.205 ± 0.135
3.933GluGlu: 3.933 ± 0.214
2.873GluPhe: 2.873 ± 0.112
1.824GluGly: 1.824 ± 0.105
1.231GluHis: 1.231 ± 0.068
5.718GluIle: 5.718 ± 0.184
5.31GluLys: 5.31 ± 0.199
6.866GluLeu: 6.866 ± 0.208
1.092GluMet: 1.092 ± 0.072
4.721GluAsn: 4.721 ± 0.154
1.682GluPro: 1.682 ± 0.116
4.052GluGln: 4.052 ± 0.167
1.935GluArg: 1.935 ± 0.109
3.083GluSer: 3.083 ± 0.136
3.257GluThr: 3.257 ± 0.121
3.641GluVal: 3.641 ± 0.132
0.475GluTrp: 0.475 ± 0.041
2.707GluTyr: 2.707 ± 0.12
0.0GluXaa: 0.0 ± 0.0
Phe
2.837PheAla: 2.837 ± 0.127
0.344PheCys: 0.344 ± 0.034
3.874PheAsp: 3.874 ± 0.118
2.96PheGlu: 2.96 ± 0.128
2.137PhePhe: 2.137 ± 0.128
2.212PheGly: 2.212 ± 0.109
0.562PheHis: 0.562 ± 0.047
4.127PheIle: 4.127 ± 0.169
4.669PheLys: 4.669 ± 0.167
4.214PheLeu: 4.214 ± 0.153
0.78PheMet: 0.78 ± 0.061
4.179PheAsn: 4.179 ± 0.173
0.902PhePro: 0.902 ± 0.059
0.89PheGln: 0.89 ± 0.063
1.231PheArg: 1.231 ± 0.081
3.815PheSer: 3.815 ± 0.141
2.168PheThr: 2.168 ± 0.098
3.205PheVal: 3.205 ± 0.118
0.356PheTrp: 0.356 ± 0.033
2.01PheTyr: 2.01 ± 0.091
0.0PheXaa: 0.0 ± 0.0
Gly
2.643GlyAla: 2.643 ± 0.118
0.324GlyCys: 0.324 ± 0.036
1.99GlyAsp: 1.99 ± 0.109
1.911GlyGlu: 1.911 ± 0.103
2.643GlyPhe: 2.643 ± 0.123
2.473GlyGly: 2.473 ± 0.152
0.689GlyHis: 0.689 ± 0.053
4.088GlyIle: 4.088 ± 0.155
3.067GlyLys: 3.067 ± 0.166
4.606GlyLeu: 4.606 ± 0.164
0.847GlyMet: 0.847 ± 0.063
2.232GlyAsn: 2.232 ± 0.108
0.807GlyPro: 0.807 ± 0.058
1.31GlyGln: 1.31 ± 0.077
1.25GlyArg: 1.25 ± 0.077
3.961GlySer: 3.961 ± 0.217
2.386GlyThr: 2.386 ± 0.121
3.023GlyVal: 3.023 ± 0.14
0.396GlyTrp: 0.396 ± 0.04
1.959GlyTyr: 1.959 ± 0.086
0.0GlyXaa: 0.0 ± 0.0
His
0.886HisAla: 0.886 ± 0.067
0.107HisCys: 0.107 ± 0.023
0.784HisAsp: 0.784 ± 0.05
0.819HisGlu: 0.819 ± 0.063
0.95HisPhe: 0.95 ± 0.068
0.724HisGly: 0.724 ± 0.053
0.412HisHis: 0.412 ± 0.045
1.409HisIle: 1.409 ± 0.067
1.508HisLys: 1.508 ± 0.075
1.65HisLeu: 1.65 ± 0.091
0.269HisMet: 0.269 ± 0.033
1.314HisAsn: 1.314 ± 0.074
0.609HisPro: 0.609 ± 0.049
0.89HisGln: 0.89 ± 0.063
0.451HisArg: 0.451 ± 0.042
1.013HisSer: 1.013 ± 0.072
0.843HisThr: 0.843 ± 0.051
0.736HisVal: 0.736 ± 0.052
0.206HisTrp: 0.206 ± 0.027
0.831HisTyr: 0.831 ± 0.062
0.0HisXaa: 0.0 ± 0.0
Ile
5.215IleAla: 5.215 ± 0.157
0.641IleCys: 0.641 ± 0.056
5.762IleAsp: 5.762 ± 0.154
4.907IleGlu: 4.907 ± 0.15
3.633IlePhe: 3.633 ± 0.143
4.052IleGly: 4.052 ± 0.156
1.239IleHis: 1.239 ± 0.065
7.408IleIle: 7.408 ± 0.253
9.564IleLys: 9.564 ± 0.211
6.98IleLeu: 6.98 ± 0.22
1.294IleMet: 1.294 ± 0.065
8.674IleAsn: 8.674 ± 0.24
2.56IlePro: 2.56 ± 0.108
2.422IleGln: 2.422 ± 0.098
2.362IleArg: 2.362 ± 0.119
5.924IleSer: 5.924 ± 0.152
4.563IleThr: 4.563 ± 0.144
5.152IleVal: 5.152 ± 0.172
0.621IleTrp: 0.621 ± 0.051
3.118IleTyr: 3.118 ± 0.126
0.0IleXaa: 0.0 ± 0.0
Lys
5.607LysAla: 5.607 ± 0.176
0.388LysCys: 0.388 ± 0.042
6.355LysAsp: 6.355 ± 0.198
7.606LysGlu: 7.606 ± 0.258
3.371LysPhe: 3.371 ± 0.116
3.189LysGly: 3.189 ± 0.139
1.765LysHis: 1.765 ± 0.083
7.609LysIle: 7.609 ± 0.224
9.244LysLys: 9.244 ± 0.207
8.5LysLeu: 8.5 ± 0.191
1.911LysMet: 1.911 ± 0.091
7.558LysAsn: 7.558 ± 0.203
3.534LysPro: 3.534 ± 0.144
5.453LysGln: 5.453 ± 0.177
3.205LysArg: 3.205 ± 0.125
4.978LysSer: 4.978 ± 0.14
6.316LysThr: 6.316 ± 0.167
5.54LysVal: 5.54 ± 0.166
0.871LysTrp: 0.871 ± 0.067
4.42LysTyr: 4.42 ± 0.143
0.0LysXaa: 0.0 ± 0.0
Leu
6.367LeuAla: 6.367 ± 0.185
0.59LeuCys: 0.59 ± 0.054
6.185LeuAsp: 6.185 ± 0.152
6.399LeuGlu: 6.399 ± 0.175
4.135LeuPhe: 4.135 ± 0.166
3.625LeuGly: 3.625 ± 0.14
1.266LeuHis: 1.266 ± 0.081
8.872LeuIle: 8.872 ± 0.247
9.315LeuLys: 9.315 ± 0.204
8.634LeuLeu: 8.634 ± 0.23
1.642LeuMet: 1.642 ± 0.09
8.072LeuAsn: 8.072 ± 0.244
2.453LeuPro: 2.453 ± 0.122
2.386LeuGln: 2.386 ± 0.098
2.655LeuArg: 2.655 ± 0.118
6.505LeuSer: 6.505 ± 0.153
5.029LeuThr: 5.029 ± 0.14
6.937LeuVal: 6.937 ± 0.202
0.692LeuTrp: 0.692 ± 0.058
3.419LeuTyr: 3.419 ± 0.142
0.0LeuXaa: 0.0 ± 0.0
Met
1.072MetAla: 1.072 ± 0.071
0.107MetCys: 0.107 ± 0.022
0.712MetAsp: 0.712 ± 0.059
0.689MetGlu: 0.689 ± 0.051
0.827MetPhe: 0.827 ± 0.056
0.712MetGly: 0.712 ± 0.055
0.324MetHis: 0.324 ± 0.038
1.587MetIle: 1.587 ± 0.084
1.539MetLys: 1.539 ± 0.074
1.448MetLeu: 1.448 ± 0.078
0.364MetMet: 0.364 ± 0.037
1.421MetAsn: 1.421 ± 0.08
0.435MetPro: 0.435 ± 0.044
0.692MetGln: 0.692 ± 0.053
0.669MetArg: 0.669 ± 0.056
1.112MetSer: 1.112 ± 0.066
0.586MetThr: 0.586 ± 0.045
0.966MetVal: 0.966 ± 0.068
0.135MetTrp: 0.135 ± 0.027
0.554MetTyr: 0.554 ± 0.046
0.0MetXaa: 0.0 ± 0.0
Asn
3.953AsnAla: 3.953 ± 0.127
0.332AsnCys: 0.332 ± 0.037
4.934AsnAsp: 4.934 ± 0.144
5.963AsnGlu: 5.963 ± 0.198
3.217AsnPhe: 3.217 ± 0.128
3.185AsnGly: 3.185 ± 0.127
1.508AsnHis: 1.508 ± 0.085
5.754AsnIle: 5.754 ± 0.153
9.723AsnLys: 9.723 ± 0.247
7.245AsnLeu: 7.245 ± 0.19
1.033AsnMet: 1.033 ± 0.063
7.867AsnAsn: 7.867 ± 0.244
3.276AsnPro: 3.276 ± 0.153
5.481AsnGln: 5.481 ± 0.191
2.117AsnArg: 2.117 ± 0.099
5.061AsnSer: 5.061 ± 0.171
3.799AsnThr: 3.799 ± 0.138
3.815AsnVal: 3.815 ± 0.122
0.728AsnTrp: 0.728 ± 0.051
3.316AsnTyr: 3.316 ± 0.149
0.0AsnXaa: 0.0 ± 0.0
Pro
1.571ProAla: 1.571 ± 0.091
0.162ProCys: 0.162 ± 0.028
1.444ProAsp: 1.444 ± 0.094
1.884ProGlu: 1.884 ± 0.111
1.468ProPhe: 1.468 ± 0.07
1.322ProGly: 1.322 ± 0.086
0.514ProHis: 0.514 ± 0.043
2.679ProIle: 2.679 ± 0.109
3.015ProLys: 3.015 ± 0.141
2.521ProLeu: 2.521 ± 0.11
0.348ProMet: 0.348 ± 0.034
2.517ProAsn: 2.517 ± 0.117
0.649ProPro: 0.649 ± 0.055
1.06ProGln: 1.06 ± 0.083
0.673ProArg: 0.673 ± 0.056
2.327ProSer: 2.327 ± 0.134
2.263ProThr: 2.263 ± 0.119
1.781ProVal: 1.781 ± 0.084
0.21ProTrp: 0.21 ± 0.033
1.243ProTyr: 1.243 ± 0.073
0.0ProXaa: 0.0 ± 0.0
Gln
2.568GlnAla: 2.568 ± 0.117
0.146GlnCys: 0.146 ± 0.025
1.832GlnAsp: 1.832 ± 0.091
2.631GlnGlu: 2.631 ± 0.136
1.836GlnPhe: 1.836 ± 0.085
1.365GlnGly: 1.365 ± 0.088
0.562GlnHis: 0.562 ± 0.04
4.262GlnIle: 4.262 ± 0.134
4.139GlnLys: 4.139 ± 0.178
4.598GlnLeu: 4.598 ± 0.15
0.748GlnMet: 0.748 ± 0.06
3.094GlnAsn: 3.094 ± 0.137
1.587GlnPro: 1.587 ± 0.13
2.711GlnGln: 2.711 ± 0.162
1.243GlnArg: 1.243 ± 0.081
2.386GlnSer: 2.386 ± 0.103
2.81GlnThr: 2.81 ± 0.118
2.113GlnVal: 2.113 ± 0.094
0.36GlnTrp: 0.36 ± 0.032
1.88GlnTyr: 1.88 ± 0.087
0.0GlnXaa: 0.0 ± 0.0
Arg
1.729ArgAla: 1.729 ± 0.075
0.21ArgCys: 0.21 ± 0.028
1.535ArgAsp: 1.535 ± 0.084
1.674ArgGlu: 1.674 ± 0.094
1.713ArgPhe: 1.713 ± 0.081
1.191ArgGly: 1.191 ± 0.075
0.463ArgHis: 0.463 ± 0.046
2.667ArgIle: 2.667 ± 0.108
2.354ArgLys: 2.354 ± 0.101
2.885ArgLeu: 2.885 ± 0.095
0.629ArgMet: 0.629 ± 0.053
2.097ArgAsn: 2.097 ± 0.106
0.764ArgPro: 0.764 ± 0.058
0.95ArgGln: 0.95 ± 0.074
1.179ArgArg: 1.179 ± 0.075
1.899ArgSer: 1.899 ± 0.083
1.523ArgThr: 1.523 ± 0.08
1.812ArgVal: 1.812 ± 0.078
0.321ArgTrp: 0.321 ± 0.034
1.306ArgTyr: 1.306 ± 0.084
0.0ArgXaa: 0.0 ± 0.0
Ser
3.071SerAla: 3.071 ± 0.118
0.637SerCys: 0.637 ± 0.069
3.32SerAsp: 3.32 ± 0.109
3.692SerGlu: 3.692 ± 0.134
3.518SerPhe: 3.518 ± 0.126
3.375SerGly: 3.375 ± 0.182
1.001SerHis: 1.001 ± 0.085
5.777SerIle: 5.777 ± 0.171
6.672SerLys: 6.672 ± 0.184
6.529SerLeu: 6.529 ± 0.18
1.009SerMet: 1.009 ± 0.061
5.188SerAsn: 5.188 ± 0.157
1.405SerPro: 1.405 ± 0.089
2.279SerGln: 2.279 ± 0.115
1.812SerArg: 1.812 ± 0.082
5.251SerSer: 5.251 ± 0.195
3.85SerThr: 3.85 ± 0.139
3.842SerVal: 3.842 ± 0.131
0.685SerTrp: 0.685 ± 0.055
2.722SerTyr: 2.722 ± 0.113
0.0SerXaa: 0.0 ± 0.0
Thr
2.671ThrAla: 2.671 ± 0.106
0.226ThrCys: 0.226 ± 0.036
2.529ThrAsp: 2.529 ± 0.103
2.679ThrGlu: 2.679 ± 0.133
2.252ThrPhe: 2.252 ± 0.103
2.271ThrGly: 2.271 ± 0.106
0.847ThrHis: 0.847 ± 0.062
5.168ThrIle: 5.168 ± 0.148
6.414ThrLys: 6.414 ± 0.195
4.84ThrLeu: 4.84 ± 0.122
0.613ThrMet: 0.613 ± 0.045
5.576ThrAsn: 5.576 ± 0.168
2.192ThrPro: 2.192 ± 0.12
1.808ThrGln: 1.808 ± 0.103
1.5ThrArg: 1.5 ± 0.078
3.751ThrSer: 3.751 ± 0.131
3.684ThrThr: 3.684 ± 0.156
2.631ThrVal: 2.631 ± 0.104
0.392ThrTrp: 0.392 ± 0.037
2.121ThrTyr: 2.121 ± 0.099
0.0ThrXaa: 0.0 ± 0.0
Val
4.226ValAla: 4.226 ± 0.137
0.669ValCys: 0.669 ± 0.052
4.566ValAsp: 4.566 ± 0.132
3.621ValGlu: 3.621 ± 0.131
2.968ValPhe: 2.968 ± 0.132
3.273ValGly: 3.273 ± 0.141
0.859ValHis: 0.859 ± 0.058
5.144ValIle: 5.144 ± 0.17
4.479ValLys: 4.479 ± 0.136
5.322ValLeu: 5.322 ± 0.162
0.922ValMet: 0.922 ± 0.06
4.468ValAsn: 4.468 ± 0.143
1.496ValPro: 1.496 ± 0.079
1.975ValGln: 1.975 ± 0.109
1.626ValArg: 1.626 ± 0.09
3.803ValSer: 3.803 ± 0.124
2.41ValThr: 2.41 ± 0.127
4.408ValVal: 4.408 ± 0.154
0.487ValTrp: 0.487 ± 0.045
2.655ValTyr: 2.655 ± 0.114
0.0ValXaa: 0.0 ± 0.0
Trp
0.451TrpAla: 0.451 ± 0.043
0.075TrpCys: 0.075 ± 0.016
0.443TrpAsp: 0.443 ± 0.04
0.415TrpGlu: 0.415 ± 0.036
0.613TrpPhe: 0.613 ± 0.05
0.301TrpGly: 0.301 ± 0.039
0.131TrpHis: 0.131 ± 0.021
0.894TrpIle: 0.894 ± 0.062
0.673TrpLys: 0.673 ± 0.05
0.962TrpLeu: 0.962 ± 0.069
0.19TrpMet: 0.19 ± 0.023
0.673TrpAsn: 0.673 ± 0.051
0.17TrpPro: 0.17 ± 0.032
0.214TrpGln: 0.214 ± 0.031
0.269TrpArg: 0.269 ± 0.034
0.546TrpSer: 0.546 ± 0.05
0.483TrpThr: 0.483 ± 0.05
0.475TrpVal: 0.475 ± 0.047
0.119TrpTrp: 0.119 ± 0.022
0.412TrpTyr: 0.412 ± 0.045
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.172TyrAla: 2.172 ± 0.11
0.332TyrCys: 0.332 ± 0.037
2.924TyrAsp: 2.924 ± 0.117
2.873TyrGlu: 2.873 ± 0.104
2.295TyrPhe: 2.295 ± 0.107
1.856TyrGly: 1.856 ± 0.091
0.752TyrHis: 0.752 ± 0.053
3.071TyrIle: 3.071 ± 0.126
3.902TyrLys: 3.902 ± 0.135
4.622TyrLeu: 4.622 ± 0.152
0.487TyrMet: 0.487 ± 0.042
3.181TyrAsn: 3.181 ± 0.125
1.1TyrPro: 1.1 ± 0.065
1.903TyrGln: 1.903 ± 0.092
1.334TyrArg: 1.334 ± 0.073
2.592TyrSer: 2.592 ± 0.117
1.998TyrThr: 1.998 ± 0.093
2.414TyrVal: 2.414 ± 0.088
0.419TyrTrp: 0.419 ± 0.039
1.868TyrTyr: 1.868 ± 0.109
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 666 proteins (252712 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski