Amino acid dipepetide frequency for Actinoplanes utahensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.032AlaAla: 23.032 ± 0.163	0.933AlaCys: 0.933 ± 0.022	8.614AlaAsp: 8.614 ± 0.072	8.457AlaGlu: 8.457 ± 0.073	3.494AlaPhe: 3.494 ± 0.037	14.824AlaGly: 14.824 ± 0.09	2.434AlaHis: 2.434 ± 0.035	4.451AlaIle: 4.451 ± 0.05	2.562AlaLys: 2.562 ± 0.043	13.773AlaLeu: 13.773 ± 0.104	2.553AlaMet: 2.553 ± 0.034	2.15AlaAsn: 2.15 ± 0.04	6.564AlaPro: 6.564 ± 0.071	3.366AlaGln: 3.366 ± 0.042	9.843AlaArg: 9.843 ± 0.082	5.652AlaSer: 5.652 ± 0.057	7.805AlaThr: 7.805 ± 0.073	12.613AlaVal: 12.613 ± 0.088	1.93AlaTrp: 1.93 ± 0.03	2.718AlaTyr: 2.718 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.909CysAla: 0.909 ± 0.022	0.084CysCys: 0.084 ± 0.007	0.452CysAsp: 0.452 ± 0.015	0.304CysGlu: 0.304 ± 0.012	0.191CysPhe: 0.191 ± 0.01	0.883CysGly: 0.883 ± 0.02	0.178CysHis: 0.178 ± 0.011	0.156CysIle: 0.156 ± 0.008	0.095CysLys: 0.095 ± 0.006	0.674CysLeu: 0.674 ± 0.021	0.105CysMet: 0.105 ± 0.006	0.139CysAsn: 0.139 ± 0.008	0.442CysPro: 0.442 ± 0.014	0.16CysGln: 0.16 ± 0.009	0.591CysArg: 0.591 ± 0.018	0.388CysSer: 0.388 ± 0.014	0.445CysThr: 0.445 ± 0.014	0.575CysVal: 0.575 ± 0.016	0.109CysTrp: 0.109 ± 0.007	0.15CysTyr: 0.15 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.127AspAla: 7.127 ± 0.061	0.385AspCys: 0.385 ± 0.014	3.983AspAsp: 3.983 ± 0.05	3.84AspGlu: 3.84 ± 0.045	1.675AspPhe: 1.675 ± 0.026	6.448AspGly: 6.448 ± 0.063	1.349AspHis: 1.349 ± 0.026	1.934AspIle: 1.934 ± 0.032	0.993AspLys: 0.993 ± 0.022	6.864AspLeu: 6.864 ± 0.056	0.834AspMet: 0.834 ± 0.021	0.965AspAsn: 0.965 ± 0.023	4.688AspPro: 4.688 ± 0.046	1.711AspGln: 1.711 ± 0.029	5.245AspArg: 5.245 ± 0.052	2.459AspSer: 2.459 ± 0.033	3.031AspThr: 3.031 ± 0.041	5.092AspVal: 5.092 ± 0.048	1.007AspTrp: 1.007 ± 0.024	1.201AspTyr: 1.201 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	6.562GluAla: 6.562 ± 0.068	0.299GluCys: 0.299 ± 0.012	2.39GluAsp: 2.39 ± 0.037	2.676GluGlu: 2.676 ± 0.043	1.616GluPhe: 1.616 ± 0.028	3.163GluGly: 3.163 ± 0.038	1.427GluHis: 1.427 ± 0.027	2.724GluIle: 2.724 ± 0.038	1.33GluLys: 1.33 ± 0.026	6.099GluLeu: 6.099 ± 0.059	0.989GluMet: 0.989 ± 0.022	1.022GluAsn: 1.022 ± 0.023	3.444GluPro: 3.444 ± 0.043	2.185GluGln: 2.185 ± 0.034	4.781GluArg: 4.781 ± 0.054	2.384GluSer: 2.384 ± 0.034	2.903GluThr: 2.903 ± 0.04	4.458GluVal: 4.458 ± 0.048	0.713GluTrp: 0.713 ± 0.017	1.054GluTyr: 1.054 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.913PheAla: 3.913 ± 0.045	0.261PheCys: 0.261 ± 0.011	2.089PheAsp: 2.089 ± 0.031	1.362PheGlu: 1.362 ± 0.028	0.893PhePhe: 0.893 ± 0.022	3.133PheGly: 3.133 ± 0.043	0.618PheHis: 0.618 ± 0.014	0.766PheIle: 0.766 ± 0.02	0.509PheLys: 0.509 ± 0.014	2.663PheLeu: 2.663 ± 0.034	0.385PheMet: 0.385 ± 0.013	0.605PheAsn: 0.605 ± 0.018	1.416PhePro: 1.416 ± 0.025	0.758PheGln: 0.758 ± 0.018	1.951PheArg: 1.951 ± 0.032	1.43PheSer: 1.43 ± 0.026	2.178PheThr: 2.178 ± 0.031	2.339PheVal: 2.339 ± 0.035	0.457PheTrp: 0.457 ± 0.014	0.651PheTyr: 0.651 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	10.724GlyAla: 10.724 ± 0.077	0.759GlyCys: 0.759 ± 0.018	5.692GlyAsp: 5.692 ± 0.066	4.705GlyGlu: 4.705 ± 0.053	3.03GlyPhe: 3.03 ± 0.041	8.462GlyGly: 8.462 ± 0.076	2.219GlyHis: 2.219 ± 0.034	3.565GlyIle: 3.565 ± 0.043	2.197GlyLys: 2.197 ± 0.033	9.499GlyLeu: 9.499 ± 0.074	1.905GlyMet: 1.905 ± 0.033	1.82GlyAsn: 1.82 ± 0.029	5.03GlyPro: 5.03 ± 0.061	2.511GlyGln: 2.511 ± 0.039	7.609GlyArg: 7.609 ± 0.066	5.043GlySer: 5.043 ± 0.06	5.991GlyThr: 5.991 ± 0.063	7.69GlyVal: 7.69 ± 0.063	1.823GlyTrp: 1.823 ± 0.03	2.39GlyTyr: 2.39 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	2.487HisAla: 2.487 ± 0.038	0.178HisCys: 0.178 ± 0.01	1.406HisAsp: 1.406 ± 0.024	1.107HisGlu: 1.107 ± 0.021	0.582HisPhe: 0.582 ± 0.015	2.153HisGly: 2.153 ± 0.038	0.661HisHis: 0.661 ± 0.021	0.634HisIle: 0.634 ± 0.018	0.268HisLys: 0.268 ± 0.012	2.495HisLeu: 2.495 ± 0.038	0.319HisMet: 0.319 ± 0.011	0.379HisAsn: 0.379 ± 0.014	1.684HisPro: 1.684 ± 0.03	0.65HisGln: 0.65 ± 0.015	2.041HisArg: 2.041 ± 0.028	0.858HisSer: 0.858 ± 0.02	1.185HisThr: 1.185 ± 0.023	1.638HisVal: 1.638 ± 0.029	0.339HisTrp: 0.339 ± 0.013	0.461HisTyr: 0.461 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	5.576IleAla: 5.576 ± 0.057	0.327IleCys: 0.327 ± 0.012	2.735IleAsp: 2.735 ± 0.037	2.286IleGlu: 2.286 ± 0.035	0.915IlePhe: 0.915 ± 0.023	4.03IleGly: 4.03 ± 0.05	0.628IleHis: 0.628 ± 0.016	1.166IleIle: 1.166 ± 0.031	0.776IleLys: 0.776 ± 0.021	2.997IleLeu: 2.997 ± 0.043	0.536IleMet: 0.536 ± 0.017	0.859IleAsn: 0.859 ± 0.021	2.019IlePro: 2.019 ± 0.029	0.841IleGln: 0.841 ± 0.02	2.813IleArg: 2.813 ± 0.033	1.962IleSer: 1.962 ± 0.031	2.684IleThr: 2.684 ± 0.041	3.278IleVal: 3.278 ± 0.041	0.475IleTrp: 0.475 ± 0.013	0.653IleTyr: 0.653 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	2.542LysAla: 2.542 ± 0.044	0.108LysCys: 0.108 ± 0.008	0.99LysAsp: 0.99 ± 0.027	0.905LysGlu: 0.905 ± 0.025	0.45LysPhe: 0.45 ± 0.015	1.445LysGly: 1.445 ± 0.026	0.401LysHis: 0.401 ± 0.013	0.957LysIle: 0.957 ± 0.025	0.609LysLys: 0.609 ± 0.02	1.902LysLeu: 1.902 ± 0.032	0.349LysMet: 0.349 ± 0.014	0.463LysAsn: 0.463 ± 0.017	1.311LysPro: 1.311 ± 0.029	0.641LysGln: 0.641 ± 0.018	1.403LysArg: 1.403 ± 0.026	1.051LysSer: 1.051 ± 0.026	1.218LysThr: 1.218 ± 0.025	1.762LysVal: 1.762 ± 0.033	0.248LysTrp: 0.248 ± 0.011	0.417LysTyr: 0.417 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.47LeuAla: 15.47 ± 0.099	0.698LeuCys: 0.698 ± 0.019	6.729LeuAsp: 6.729 ± 0.061	4.234LeuGlu: 4.234 ± 0.048	2.744LeuPhe: 2.744 ± 0.041	8.963LeuGly: 8.963 ± 0.077	2.268LeuHis: 2.268 ± 0.029	4.288LeuIle: 4.288 ± 0.049	1.734LeuLys: 1.734 ± 0.033	11.247LeuLeu: 11.247 ± 0.098	1.533LeuMet: 1.533 ± 0.027	1.816LeuAsn: 1.816 ± 0.029	6.453LeuPro: 6.453 ± 0.062	2.215LeuGln: 2.215 ± 0.035	8.825LeuArg: 8.825 ± 0.078	5.258LeuSer: 5.258 ± 0.054	7.302LeuThr: 7.302 ± 0.056	8.572LeuVal: 8.572 ± 0.069	1.266LeuTrp: 1.266 ± 0.027	1.753LeuTyr: 1.753 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.218MetAla: 2.218 ± 0.038	0.107MetCys: 0.107 ± 0.007	0.772MetAsp: 0.772 ± 0.019	0.657MetGlu: 0.657 ± 0.019	0.509MetPhe: 0.509 ± 0.015	1.145MetGly: 1.145 ± 0.024	0.349MetHis: 0.349 ± 0.015	0.886MetIle: 0.886 ± 0.02	0.373MetLys: 0.373 ± 0.012	1.951MetLeu: 1.951 ± 0.032	0.327MetMet: 0.327 ± 0.012	0.412MetAsn: 0.412 ± 0.013	1.179MetPro: 1.179 ± 0.024	0.433MetGln: 0.433 ± 0.014	1.568MetArg: 1.568 ± 0.027	1.268MetSer: 1.268 ± 0.026	1.656MetThr: 1.656 ± 0.027	1.335MetVal: 1.335 ± 0.026	0.21MetTrp: 0.21 ± 0.01	0.304MetTyr: 0.304 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.279AsnAla: 2.279 ± 0.033	0.156AsnCys: 0.156 ± 0.008	1.027AsnAsp: 1.027 ± 0.024	0.853AsnGlu: 0.853 ± 0.02	0.506AsnPhe: 0.506 ± 0.015	1.987AsnGly: 1.987 ± 0.034	0.394AsnHis: 0.394 ± 0.013	0.669AsnIle: 0.669 ± 0.019	0.394AsnLys: 0.394 ± 0.014	1.871AsnLeu: 1.871 ± 0.028	0.328AsnMet: 0.328 ± 0.013	0.466AsnAsn: 0.466 ± 0.015	1.474AsnPro: 1.474 ± 0.028	0.542AsnGln: 0.542 ± 0.019	1.506AsnArg: 1.506 ± 0.026	0.907AsnSer: 0.907 ± 0.022	1.136AsnThr: 1.136 ± 0.022	1.538AsnVal: 1.538 ± 0.029	0.321AsnTrp: 0.321 ± 0.013	0.432AsnTyr: 0.432 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	9.6ProAla: 9.6 ± 0.091	0.28ProCys: 0.28 ± 0.013	4.487ProAsp: 4.487 ± 0.056	3.902ProGlu: 3.902 ± 0.045	1.567ProPhe: 1.567 ± 0.029	6.636ProGly: 6.636 ± 0.073	1.21ProHis: 1.21 ± 0.023	1.861ProIle: 1.861 ± 0.032	1.028ProLys: 1.028 ± 0.021	5.031ProLeu: 5.031 ± 0.048	1.034ProMet: 1.034 ± 0.022	1.011ProAsn: 1.011 ± 0.022	3.713ProPro: 3.713 ± 0.068	1.513ProGln: 1.513 ± 0.028	3.774ProArg: 3.774 ± 0.049	3.149ProSer: 3.149 ± 0.047	3.023ProThr: 3.023 ± 0.044	5.637ProVal: 5.637 ± 0.052	0.918ProTrp: 0.918 ± 0.022	1.216ProTyr: 1.216 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.716GlnAla: 3.716 ± 0.044	0.15GlnCys: 0.15 ± 0.008	1.159GlnAsp: 1.159 ± 0.024	1.238GlnGlu: 1.238 ± 0.027	0.762GlnPhe: 0.762 ± 0.019	1.849GlnGly: 1.849 ± 0.029	0.633GlnHis: 0.633 ± 0.016	1.245GlnIle: 1.245 ± 0.026	0.57GlnLys: 0.57 ± 0.02	2.853GlnLeu: 2.853 ± 0.036	0.498GlnMet: 0.498 ± 0.017	0.559GlnAsn: 0.559 ± 0.017	1.776GlnPro: 1.776 ± 0.033	1.186GlnGln: 1.186 ± 0.029	2.582GlnArg: 2.582 ± 0.038	1.184GlnSer: 1.184 ± 0.024	1.431GlnThr: 1.431 ± 0.025	2.49GlnVal: 2.49 ± 0.037	0.473GlnTrp: 0.473 ± 0.016	0.549GlnTyr: 0.549 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.56ArgAla: 9.56 ± 0.087	0.532ArgCys: 0.532 ± 0.016	4.778ArgAsp: 4.778 ± 0.054	4.231ArgGlu: 4.231 ± 0.044	2.529ArgPhe: 2.529 ± 0.032	5.416ArgGly: 5.416 ± 0.046	2.147ArgHis: 2.147 ± 0.038	3.637ArgIle: 3.637 ± 0.036	1.509ArgLys: 1.509 ± 0.031	9.214ArgLeu: 9.214 ± 0.091	1.934ArgMet: 1.934 ± 0.027	1.54ArgAsn: 1.54 ± 0.029	4.868ArgPro: 4.868 ± 0.061	2.448ArgGln: 2.448 ± 0.038	7.949ArgArg: 7.949 ± 0.085	3.996ArgSer: 3.996 ± 0.047	4.93ArgThr: 4.93 ± 0.05	5.998ArgVal: 5.998 ± 0.052	1.513ArgTrp: 1.513 ± 0.029	1.963ArgTyr: 1.963 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.587SerAla: 6.587 ± 0.058	0.347SerCys: 0.347 ± 0.013	2.557SerAsp: 2.557 ± 0.036	2.204SerGlu: 2.204 ± 0.031	1.512SerPhe: 1.512 ± 0.028	5.824SerGly: 5.824 ± 0.058	0.876SerHis: 0.876 ± 0.019	1.795SerIle: 1.795 ± 0.031	0.844SerLys: 0.844 ± 0.021	4.531SerLeu: 4.531 ± 0.041	1.076SerMet: 1.076 ± 0.021	0.896SerAsn: 0.896 ± 0.024	3.161SerPro: 3.161 ± 0.041	1.125SerGln: 1.125 ± 0.023	3.889SerArg: 3.889 ± 0.042	2.778SerSer: 2.778 ± 0.052	3.041SerThr: 3.041 ± 0.04	4.034SerVal: 4.034 ± 0.05	0.956SerTrp: 0.956 ± 0.022	1.141SerTyr: 1.141 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	9.183ThrAla: 9.183 ± 0.079	0.439ThrCys: 0.439 ± 0.014	3.603ThrAsp: 3.603 ± 0.047	3.061ThrGlu: 3.061 ± 0.038	1.834ThrPhe: 1.834 ± 0.032	7.054ThrGly: 7.054 ± 0.076	1.088ThrHis: 1.088 ± 0.024	2.276ThrIle: 2.276 ± 0.036	1.068ThrLys: 1.068 ± 0.029	5.869ThrLeu: 5.869 ± 0.051	1.097ThrMet: 1.097 ± 0.025	1.059ThrAsn: 1.059 ± 0.023	4.004ThrPro: 4.004 ± 0.045	1.144ThrGln: 1.144 ± 0.024	3.999ThrArg: 3.999 ± 0.042	3.08ThrSer: 3.08 ± 0.041	4.037ThrThr: 4.037 ± 0.054	6.696ThrVal: 6.696 ± 0.064	0.961ThrTrp: 0.961 ± 0.022	1.283ThrTyr: 1.283 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	11.847ValAla: 11.847 ± 0.086	0.677ValCys: 0.677 ± 0.018	5.219ValAsp: 5.219 ± 0.047	4.45ValGlu: 4.45 ± 0.052	2.396ValPhe: 2.396 ± 0.037	6.266ValGly: 6.266 ± 0.05	1.804ValHis: 1.804 ± 0.027	3.404ValIle: 3.404 ± 0.041	1.67ValLys: 1.67 ± 0.031	9.646ValLeu: 9.646 ± 0.088	1.319ValMet: 1.319 ± 0.025	1.748ValAsn: 1.748 ± 0.027	5.354ValPro: 5.354 ± 0.051	2.101ValGln: 2.101 ± 0.031	6.903ValArg: 6.903 ± 0.066	4.388ValSer: 4.388 ± 0.046	6.514ValThr: 6.514 ± 0.064	8.109ValVal: 8.109 ± 0.07	1.14ValTrp: 1.14 ± 0.024	1.564ValTyr: 1.564 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.782TrpAla: 1.782 ± 0.029	0.135TrpCys: 0.135 ± 0.008	0.819TrpAsp: 0.819 ± 0.02	0.655TrpGlu: 0.655 ± 0.017	0.526TrpPhe: 0.526 ± 0.017	0.948TrpGly: 0.948 ± 0.026	0.384TrpHis: 0.384 ± 0.014	0.631TrpIle: 0.631 ± 0.018	0.301TrpLys: 0.301 ± 0.011	1.815TrpLeu: 1.815 ± 0.031	0.293TrpMet: 0.293 ± 0.011	0.465TrpAsn: 0.465 ± 0.017	0.875TrpPro: 0.875 ± 0.024	0.648TrpGln: 0.648 ± 0.017	1.481TrpArg: 1.481 ± 0.031	1.0TrpSer: 1.0 ± 0.025	1.068TrpThr: 1.068 ± 0.024	1.022TrpVal: 1.022 ± 0.023	0.402TrpTrp: 0.402 ± 0.015	0.36TrpTyr: 0.36 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.652TyrAla: 2.652 ± 0.034	0.171TyrCys: 0.171 ± 0.01	1.329TyrAsp: 1.329 ± 0.025	1.094TyrGlu: 1.094 ± 0.025	0.647TyrPhe: 0.647 ± 0.016	2.031TyrGly: 2.031 ± 0.027	0.456TyrHis: 0.456 ± 0.014	0.512TyrIle: 0.512 ± 0.017	0.343TyrLys: 0.343 ± 0.015	2.373TyrLeu: 2.373 ± 0.036	0.244TyrMet: 0.244 ± 0.011	0.416TyrAsn: 0.416 ± 0.016	1.135TyrPro: 1.135 ± 0.024	0.725TyrGln: 0.725 ± 0.02	1.939TyrArg: 1.939 ± 0.033	0.941TyrSer: 0.941 ± 0.023	1.259TyrThr: 1.259 ± 0.026	1.643TyrVal: 1.643 ± 0.029	0.35TyrTrp: 0.35 ± 0.014	0.468TyrTyr: 0.468 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7275 proteins (2280864 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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