Amino acid dipepetide frequency for Cotesia congregata bracovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.586AlaAla: 2.586 ± 0.296
0.677AlaCys: 0.677 ± 0.128
2.731AlaAsp: 2.731 ± 0.217
3.553AlaGlu: 3.553 ± 0.306
1.668AlaPhe: 1.668 ± 0.181
1.982AlaGly: 1.982 ± 0.226
0.943AlaHis: 0.943 ± 0.143
3.021AlaIle: 3.021 ± 0.25
2.78AlaLys: 2.78 ± 0.29
3.529AlaLeu: 3.529 ± 0.281
0.677AlaMet: 0.677 ± 0.144
2.9AlaAsn: 2.9 ± 0.278
2.61AlaPro: 2.61 ± 0.379
2.344AlaGln: 2.344 ± 0.295
2.32AlaArg: 2.32 ± 0.229
4.834AlaSer: 4.834 ± 0.355
3.408AlaThr: 3.408 ± 0.293
3.384AlaVal: 3.384 ± 0.213
0.532AlaTrp: 0.532 ± 0.098
1.764AlaTyr: 1.764 ± 0.22
0.0AlaXaa: 0.0 ± 0.0
Cys
0.749CysAla: 0.749 ± 0.116
0.435CysCys: 0.435 ± 0.116
0.798CysAsp: 0.798 ± 0.15
0.798CysGlu: 0.798 ± 0.174
0.701CysPhe: 0.701 ± 0.122
0.653CysGly: 0.653 ± 0.122
0.338CysHis: 0.338 ± 0.092
1.039CysIle: 1.039 ± 0.139
1.136CysLys: 1.136 ± 0.157
1.474CysLeu: 1.474 ± 0.178
0.653CysMet: 0.653 ± 0.114
0.798CysAsn: 0.798 ± 0.135
0.58CysPro: 0.58 ± 0.114
0.991CysGln: 0.991 ± 0.151
0.894CysArg: 0.894 ± 0.157
1.547CysSer: 1.547 ± 0.206
0.918CysThr: 0.918 ± 0.17
1.305CysVal: 1.305 ± 0.172
0.435CysTrp: 0.435 ± 0.101
1.136CysTyr: 1.136 ± 0.204
0.0CysXaa: 0.0 ± 0.0
Asp
2.272AspAla: 2.272 ± 0.208
0.653AspCys: 0.653 ± 0.124
3.36AspAsp: 3.36 ± 0.285
3.239AspGlu: 3.239 ± 0.331
2.175AspPhe: 2.175 ± 0.27
3.142AspGly: 3.142 ± 0.427
1.934AspHis: 1.934 ± 0.227
3.094AspIle: 3.094 ± 0.276
2.78AspLys: 2.78 ± 0.313
4.447AspLeu: 4.447 ± 0.329
1.112AspMet: 1.112 ± 0.171
4.036AspAsn: 4.036 ± 0.304
2.224AspPro: 2.224 ± 0.273
2.006AspGln: 2.006 ± 0.193
2.248AspArg: 2.248 ± 0.261
3.916AspSer: 3.916 ± 0.36
2.127AspThr: 2.127 ± 0.23
3.287AspVal: 3.287 ± 0.32
0.508AspTrp: 0.508 ± 0.128
1.958AspTyr: 1.958 ± 0.209
0.0AspXaa: 0.0 ± 0.0
Glu
2.925GluAla: 2.925 ± 0.237
0.725GluCys: 0.725 ± 0.128
2.804GluAsp: 2.804 ± 0.283
4.447GluGlu: 4.447 ± 0.405
2.054GluPhe: 2.054 ± 0.196
2.199GluGly: 2.199 ± 0.261
1.837GluHis: 1.837 ± 0.218
3.819GluIle: 3.819 ± 0.351
4.375GluLys: 4.375 ± 0.375
5.269GluLeu: 5.269 ± 0.438
1.474GluMet: 1.474 ± 0.2
4.665GluAsn: 4.665 ± 0.412
2.03GluPro: 2.03 ± 0.231
3.601GluGln: 3.601 ± 0.33
3.48GluArg: 3.48 ± 0.315
4.931GluSer: 4.931 ± 0.316
3.142GluThr: 3.142 ± 0.273
3.553GluVal: 3.553 ± 0.305
0.846GluTrp: 0.846 ± 0.151
2.369GluTyr: 2.369 ± 0.231
0.0GluXaa: 0.0 ± 0.0
Phe
1.837PheAla: 1.837 ± 0.186
1.281PheCys: 1.281 ± 0.182
2.538PheAsp: 2.538 ± 0.25
2.538PheGlu: 2.538 ± 0.322
2.151PhePhe: 2.151 ± 0.275
1.982PheGly: 1.982 ± 0.291
0.798PheHis: 0.798 ± 0.144
2.876PheIle: 2.876 ± 0.302
2.586PheLys: 2.586 ± 0.273
3.916PheLeu: 3.916 ± 0.347
0.943PheMet: 0.943 ± 0.14
2.224PheAsn: 2.224 ± 0.236
1.595PhePro: 1.595 ± 0.187
1.499PheGln: 1.499 ± 0.189
1.571PheArg: 1.571 ± 0.203
2.393PheSer: 2.393 ± 0.297
2.127PheThr: 2.127 ± 0.264
2.828PheVal: 2.828 ± 0.247
0.749PheTrp: 0.749 ± 0.116
1.378PheTyr: 1.378 ± 0.158
0.0PheXaa: 0.0 ± 0.0
Gly
3.045GlyAla: 3.045 ± 0.352
0.532GlyCys: 0.532 ± 0.121
2.248GlyAsp: 2.248 ± 0.256
1.909GlyGlu: 1.909 ± 0.231
1.644GlyPhe: 1.644 ± 0.39
2.248GlyGly: 2.248 ± 0.402
0.725GlyHis: 0.725 ± 0.144
2.248GlyIle: 2.248 ± 0.251
3.166GlyLys: 3.166 ± 0.373
3.577GlyLeu: 3.577 ± 0.316
1.16GlyMet: 1.16 ± 0.228
4.061GlyAsn: 4.061 ± 0.453
2.369GlyPro: 2.369 ± 0.333
1.982GlyGln: 1.982 ± 0.334
2.103GlyArg: 2.103 ± 0.251
6.864GlySer: 6.864 ± 0.516
4.109GlyThr: 4.109 ± 0.569
2.32GlyVal: 2.32 ± 0.274
0.411GlyTrp: 0.411 ± 0.101
1.595GlyTyr: 1.595 ± 0.26
0.0GlyXaa: 0.0 ± 0.0
His
0.822HisAla: 0.822 ± 0.123
0.967HisCys: 0.967 ± 0.146
0.701HisAsp: 0.701 ± 0.165
1.571HisGlu: 1.571 ± 0.192
1.088HisPhe: 1.088 ± 0.158
1.184HisGly: 1.184 ± 0.206
0.967HisHis: 0.967 ± 0.137
1.281HisIle: 1.281 ± 0.196
1.112HisLys: 1.112 ± 0.154
1.789HisLeu: 1.789 ± 0.228
0.701HisMet: 0.701 ± 0.12
1.547HisAsn: 1.547 ± 0.162
0.822HisPro: 0.822 ± 0.134
1.668HisGln: 1.668 ± 0.189
1.088HisArg: 1.088 ± 0.163
2.441HisSer: 2.441 ± 0.249
1.305HisThr: 1.305 ± 0.153
1.015HisVal: 1.015 ± 0.176
0.169HisTrp: 0.169 ± 0.065
1.426HisTyr: 1.426 ± 0.186
0.0HisXaa: 0.0 ± 0.0
Ile
2.997IleAla: 2.997 ± 0.265
1.354IleCys: 1.354 ± 0.203
3.505IleAsp: 3.505 ± 0.327
3.408IleGlu: 3.408 ± 0.262
2.127IlePhe: 2.127 ± 0.227
2.828IleGly: 2.828 ± 0.235
1.402IleHis: 1.402 ± 0.18
5.583IleIle: 5.583 ± 0.677
4.471IleLys: 4.471 ± 0.433
4.834IleLeu: 4.834 ± 0.365
1.329IleMet: 1.329 ± 0.18
4.931IleAsn: 4.931 ± 0.34
2.441IlePro: 2.441 ± 0.238
2.997IleGln: 2.997 ± 0.28
3.021IleArg: 3.021 ± 0.281
4.592IleSer: 4.592 ± 0.348
3.311IleThr: 3.311 ± 0.262
5.39IleVal: 5.39 ± 0.455
0.508IleTrp: 0.508 ± 0.123
2.296IleTyr: 2.296 ± 0.272
0.0IleXaa: 0.0 ± 0.0
Lys
2.683LysAla: 2.683 ± 0.253
0.991LysCys: 0.991 ± 0.153
2.465LysAsp: 2.465 ± 0.24
4.737LysGlu: 4.737 ± 0.41
3.456LysPhe: 3.456 ± 0.364
2.489LysGly: 2.489 ± 0.389
1.16LysHis: 1.16 ± 0.163
4.471LysIle: 4.471 ± 0.366
5.003LysLys: 5.003 ± 0.434
5.414LysLeu: 5.414 ± 0.389
1.378LysMet: 1.378 ± 0.161
4.955LysAsn: 4.955 ± 0.326
3.287LysPro: 3.287 ± 0.326
1.982LysGln: 1.982 ± 0.274
3.239LysArg: 3.239 ± 0.257
4.592LysSer: 4.592 ± 0.373
3.964LysThr: 3.964 ± 0.332
3.529LysVal: 3.529 ± 0.291
0.58LysTrp: 0.58 ± 0.147
3.263LysTyr: 3.263 ± 0.265
0.0LysXaa: 0.0 ± 0.0
Leu
3.287LeuAla: 3.287 ± 0.283
1.45LeuCys: 1.45 ± 0.203
4.085LeuAsp: 4.085 ± 0.35
4.326LeuGlu: 4.326 ± 0.347
3.19LeuPhe: 3.19 ± 0.297
2.852LeuGly: 2.852 ± 0.269
1.789LeuHis: 1.789 ± 0.206
4.641LeuIle: 4.641 ± 0.364
5.922LeuLys: 5.922 ± 0.41
6.84LeuLeu: 6.84 ± 0.43
1.547LeuMet: 1.547 ± 0.158
5.221LeuAsn: 5.221 ± 0.319
4.931LeuPro: 4.931 ± 0.467
4.061LeuGln: 4.061 ± 0.35
4.979LeuArg: 4.979 ± 0.395
7.589LeuSer: 7.589 ± 0.721
4.544LeuThr: 4.544 ± 0.359
4.592LeuVal: 4.592 ± 0.307
0.773LeuTrp: 0.773 ± 0.145
2.707LeuTyr: 2.707 ± 0.285
0.0LeuXaa: 0.0 ± 0.0
Met
1.378MetAla: 1.378 ± 0.186
0.145MetCys: 0.145 ± 0.055
1.039MetAsp: 1.039 ± 0.162
1.305MetGlu: 1.305 ± 0.168
0.773MetPhe: 0.773 ± 0.136
1.281MetGly: 1.281 ± 0.18
0.483MetHis: 0.483 ± 0.105
1.233MetIle: 1.233 ± 0.191
1.547MetLys: 1.547 ± 0.203
2.175MetLeu: 2.175 ± 0.25
0.532MetMet: 0.532 ± 0.11
1.764MetAsn: 1.764 ± 0.191
0.943MetPro: 0.943 ± 0.138
0.653MetGln: 0.653 ± 0.154
1.208MetArg: 1.208 ± 0.172
1.789MetSer: 1.789 ± 0.221
1.233MetThr: 1.233 ± 0.164
1.402MetVal: 1.402 ± 0.181
0.145MetTrp: 0.145 ± 0.062
0.604MetTyr: 0.604 ± 0.097
0.0MetXaa: 0.0 ± 0.0
Asn
3.48AsnAla: 3.48 ± 0.301
1.112AsnCys: 1.112 ± 0.188
3.77AsnAsp: 3.77 ± 0.312
3.795AsnGlu: 3.795 ± 0.339
3.311AsnPhe: 3.311 ± 0.27
4.375AsnGly: 4.375 ± 0.627
1.764AsnHis: 1.764 ± 0.196
4.085AsnIle: 4.085 ± 0.321
4.181AsnLys: 4.181 ± 0.348
4.544AsnLeu: 4.544 ± 0.294
1.329AsnMet: 1.329 ± 0.159
6.502AsnAsn: 6.502 ± 0.63
3.021AsnPro: 3.021 ± 0.365
3.722AsnGln: 3.722 ± 0.348
3.964AsnArg: 3.964 ± 0.26
6.357AsnSer: 6.357 ± 0.553
5.221AsnThr: 5.221 ± 0.435
3.795AsnVal: 3.795 ± 0.404
0.483AsnTrp: 0.483 ± 0.1
3.529AsnTyr: 3.529 ± 0.592
0.0AsnXaa: 0.0 ± 0.0
Pro
2.393ProAla: 2.393 ± 0.298
0.894ProCys: 0.894 ± 0.141
2.272ProAsp: 2.272 ± 0.217
3.094ProGlu: 3.094 ± 0.253
1.426ProPhe: 1.426 ± 0.205
3.432ProGly: 3.432 ± 0.506
0.798ProHis: 0.798 ± 0.146
3.021ProIle: 3.021 ± 0.242
3.239ProLys: 3.239 ± 0.318
2.9ProLeu: 2.9 ± 0.327
1.305ProMet: 1.305 ± 0.21
3.505ProAsn: 3.505 ± 0.413
2.151ProPro: 2.151 ± 0.33
2.997ProGln: 2.997 ± 0.43
2.369ProArg: 2.369 ± 0.276
4.447ProSer: 4.447 ± 0.482
2.852ProThr: 2.852 ± 0.352
2.514ProVal: 2.514 ± 0.288
0.242ProTrp: 0.242 ± 0.09
1.426ProTyr: 1.426 ± 0.211
0.0ProXaa: 0.0 ± 0.0
Gln
2.538GlnAla: 2.538 ± 0.23
0.725GlnCys: 0.725 ± 0.142
2.441GlnAsp: 2.441 ± 0.35
3.891GlnGlu: 3.891 ± 0.358
1.764GlnPhe: 1.764 ± 0.221
2.224GlnGly: 2.224 ± 0.399
1.257GlnHis: 1.257 ± 0.246
2.852GlnIle: 2.852 ± 0.26
3.456GlnLys: 3.456 ± 0.314
3.263GlnLeu: 3.263 ± 0.335
0.967GlnMet: 0.967 ± 0.147
3.964GlnAsn: 3.964 ± 0.429
2.949GlnPro: 2.949 ± 0.431
3.311GlnGln: 3.311 ± 0.474
2.707GlnArg: 2.707 ± 0.29
4.592GlnSer: 4.592 ± 0.518
3.094GlnThr: 3.094 ± 0.402
2.369GlnVal: 2.369 ± 0.294
0.145GlnTrp: 0.145 ± 0.057
2.369GlnTyr: 2.369 ± 0.297
0.0GlnXaa: 0.0 ± 0.0
Arg
2.514ArgAla: 2.514 ± 0.313
0.749ArgCys: 0.749 ± 0.155
1.837ArgAsp: 1.837 ± 0.239
2.828ArgGlu: 2.828 ± 0.323
2.079ArgPhe: 2.079 ± 0.256
1.789ArgGly: 1.789 ± 0.187
1.499ArgHis: 1.499 ± 0.181
3.07ArgIle: 3.07 ± 0.276
3.867ArgLys: 3.867 ± 0.304
4.036ArgLeu: 4.036 ± 0.381
0.943ArgMet: 0.943 ± 0.145
3.335ArgAsn: 3.335 ± 0.313
2.683ArgPro: 2.683 ± 0.373
3.311ArgGln: 3.311 ± 0.371
3.19ArgArg: 3.19 ± 0.288
4.326ArgSer: 4.326 ± 0.345
3.19ArgThr: 3.19 ± 0.248
3.311ArgVal: 3.311 ± 0.303
0.483ArgTrp: 0.483 ± 0.085
1.934ArgTyr: 1.934 ± 0.197
0.0ArgXaa: 0.0 ± 0.0
Ser
4.689SerAla: 4.689 ± 0.393
1.354SerCys: 1.354 ± 0.185
4.858SerAsp: 4.858 ± 0.439
5.172SerGlu: 5.172 ± 0.398
3.432SerPhe: 3.432 ± 0.336
4.641SerGly: 4.641 ± 0.51
1.668SerHis: 1.668 ± 0.165
5.873SerIle: 5.873 ± 0.405
5.197SerLys: 5.197 ± 0.347
6.502SerLeu: 6.502 ± 0.379
1.861SerMet: 1.861 ± 0.267
6.477SerAsn: 6.477 ± 0.68
3.263SerPro: 3.263 ± 0.413
4.713SerGln: 4.713 ± 0.495
4.568SerArg: 4.568 ± 0.391
10.538SerSer: 10.538 ± 0.763
6.695SerThr: 6.695 ± 0.453
4.737SerVal: 4.737 ± 0.331
0.701SerTrp: 0.701 ± 0.151
2.9SerTyr: 2.9 ± 0.284
0.0SerXaa: 0.0 ± 0.0
Thr
3.311ThrAla: 3.311 ± 0.307
0.943ThrCys: 0.943 ± 0.191
3.239ThrAsp: 3.239 ± 0.291
3.722ThrGlu: 3.722 ± 0.334
2.224ThrPhe: 2.224 ± 0.286
3.263ThrGly: 3.263 ± 0.246
1.547ThrHis: 1.547 ± 0.222
4.23ThrIle: 4.23 ± 0.355
3.311ThrLys: 3.311 ± 0.34
5.535ThrLeu: 5.535 ± 0.6
0.798ThrMet: 0.798 ± 0.17
3.916ThrAsn: 3.916 ± 0.346
3.118ThrPro: 3.118 ± 0.385
3.384ThrGln: 3.384 ± 0.398
3.094ThrArg: 3.094 ± 0.276
5.801ThrSer: 5.801 ± 0.452
3.746ThrThr: 3.746 ± 0.294
3.601ThrVal: 3.601 ± 0.328
0.508ThrTrp: 0.508 ± 0.104
3.094ThrTyr: 3.094 ± 0.481
0.0ThrXaa: 0.0 ± 0.0
Val
2.925ValAla: 2.925 ± 0.302
1.281ValCys: 1.281 ± 0.165
2.925ValAsp: 2.925 ± 0.253
3.529ValGlu: 3.529 ± 0.354
2.344ValPhe: 2.344 ± 0.256
2.393ValGly: 2.393 ± 0.287
1.716ValHis: 1.716 ± 0.201
3.964ValIle: 3.964 ± 0.327
3.287ValLys: 3.287 ± 0.315
4.979ValLeu: 4.979 ± 0.413
1.789ValMet: 1.789 ± 0.171
4.278ValAsn: 4.278 ± 0.403
2.876ValPro: 2.876 ± 0.272
2.586ValGln: 2.586 ± 0.242
2.586ValArg: 2.586 ± 0.249
4.471ValSer: 4.471 ± 0.312
4.737ValThr: 4.737 ± 0.358
3.843ValVal: 3.843 ± 0.324
0.556ValTrp: 0.556 ± 0.131
2.707ValTyr: 2.707 ± 0.283
0.0ValXaa: 0.0 ± 0.0
Trp
0.218TrpAla: 0.218 ± 0.092
0.193TrpCys: 0.193 ± 0.06
0.532TrpAsp: 0.532 ± 0.099
0.677TrpGlu: 0.677 ± 0.107
0.411TrpPhe: 0.411 ± 0.097
0.314TrpGly: 0.314 ± 0.087
0.121TrpHis: 0.121 ± 0.053
0.556TrpIle: 0.556 ± 0.1
0.483TrpLys: 0.483 ± 0.113
1.063TrpLeu: 1.063 ± 0.169
0.242TrpMet: 0.242 ± 0.085
0.749TrpAsn: 0.749 ± 0.142
0.701TrpPro: 0.701 ± 0.136
0.628TrpGln: 0.628 ± 0.116
0.508TrpArg: 0.508 ± 0.124
0.943TrpSer: 0.943 ± 0.176
0.58TrpThr: 0.58 ± 0.121
0.314TrpVal: 0.314 ± 0.101
0.073TrpTrp: 0.073 ± 0.046
0.29TrpTyr: 0.29 ± 0.079
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.595TyrAla: 1.595 ± 0.19
0.918TyrCys: 0.918 ± 0.143
2.369TyrAsp: 2.369 ± 0.283
2.006TyrGlu: 2.006 ± 0.212
1.789TyrPhe: 1.789 ± 0.235
3.045TyrGly: 3.045 ± 0.311
0.918TyrHis: 0.918 ± 0.138
2.369TyrIle: 2.369 ± 0.269
1.74TyrLys: 1.74 ± 0.22
3.239TyrLeu: 3.239 ± 0.279
0.87TyrMet: 0.87 ± 0.106
2.514TyrAsn: 2.514 ± 0.416
2.683TyrPro: 2.683 ± 0.36
2.441TyrGln: 2.441 ± 0.289
1.837TyrArg: 1.837 ± 0.211
2.876TyrSer: 2.876 ± 0.302
2.079TyrThr: 2.079 ± 0.28
2.707TyrVal: 2.707 ± 0.239
0.749TyrTrp: 0.749 ± 0.134
1.813TyrTyr: 1.813 ± 0.262
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 150 proteins (41375 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski