Amino acid dipepetide frequency for endosymbiont of Rhynchophorus ferrugineus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.595AlaAla: 0.595 ± 0.118
0.145AlaCys: 0.145 ± 0.048
0.45AlaAsp: 0.45 ± 0.084
0.644AlaGlu: 0.644 ± 0.143
0.611AlaPhe: 0.611 ± 0.112
0.885AlaGly: 0.885 ± 0.137
0.161AlaHis: 0.161 ± 0.053
1.882AlaIle: 1.882 ± 0.221
1.609AlaLys: 1.609 ± 0.186
1.48AlaLeu: 1.48 ± 0.179
0.306AlaMet: 0.306 ± 0.078
0.788AlaAsn: 0.788 ± 0.125
0.257AlaPro: 0.257 ± 0.068
0.274AlaGln: 0.274 ± 0.074
0.66AlaArg: 0.66 ± 0.118
0.885AlaSer: 0.885 ± 0.142
0.595AlaThr: 0.595 ± 0.114
0.627AlaVal: 0.627 ± 0.119
0.064AlaTrp: 0.064 ± 0.033
0.772AlaTyr: 0.772 ± 0.113
0.0AlaXaa: 0.0 ± 0.0
Cys
0.064CysAla: 0.064 ± 0.032
0.097CysCys: 0.097 ± 0.038
0.386CysAsp: 0.386 ± 0.08
0.338CysGlu: 0.338 ± 0.088
0.611CysPhe: 0.611 ± 0.089
0.515CysGly: 0.515 ± 0.089
0.161CysHis: 0.161 ± 0.045
1.609CysIle: 1.609 ± 0.166
1.351CysLys: 1.351 ± 0.147
0.885CysLeu: 0.885 ± 0.11
0.129CysMet: 0.129 ± 0.039
1.384CysAsn: 1.384 ± 0.138
0.257CysPro: 0.257 ± 0.07
0.113CysGln: 0.113 ± 0.04
0.338CysArg: 0.338 ± 0.079
0.74CysSer: 0.74 ± 0.135
0.338CysThr: 0.338 ± 0.063
0.338CysVal: 0.338 ± 0.077
0.048CysTrp: 0.048 ± 0.024
0.595CysTyr: 0.595 ± 0.1
0.0CysXaa: 0.0 ± 0.0
Asp
0.531AspAla: 0.531 ± 0.116
0.306AspCys: 0.306 ± 0.087
1.287AspAsp: 1.287 ± 0.162
1.48AspGlu: 1.48 ± 0.175
2.687AspPhe: 2.687 ± 0.164
1.303AspGly: 1.303 ± 0.173
0.402AspHis: 0.402 ± 0.083
7.98AspIle: 7.98 ± 0.421
4.489AspLys: 4.489 ± 0.272
4.231AspLeu: 4.231 ± 0.313
0.627AspMet: 0.627 ± 0.115
4.698AspAsn: 4.698 ± 0.282
0.708AspPro: 0.708 ± 0.098
0.386AspGln: 0.386 ± 0.064
0.772AspArg: 0.772 ± 0.126
2.301AspSer: 2.301 ± 0.198
1.094AspThr: 1.094 ± 0.139
1.416AspVal: 1.416 ± 0.15
0.29AspTrp: 0.29 ± 0.059
2.413AspTyr: 2.413 ± 0.219
0.0AspXaa: 0.0 ± 0.0
Glu
0.949GluAla: 0.949 ± 0.154
0.515GluCys: 0.515 ± 0.087
1.931GluAsp: 1.931 ± 0.224
1.866GluGlu: 1.866 ± 0.175
2.059GluPhe: 2.059 ± 0.213
1.142GluGly: 1.142 ± 0.166
0.338GluHis: 0.338 ± 0.067
7.256GluIle: 7.256 ± 0.344
5.293GluLys: 5.293 ± 0.275
4.006GluLeu: 4.006 ± 0.277
0.692GluMet: 0.692 ± 0.107
4.907GluAsn: 4.907 ± 0.285
0.627GluPro: 0.627 ± 0.112
0.434GluGln: 0.434 ± 0.094
0.885GluArg: 0.885 ± 0.128
2.397GluSer: 2.397 ± 0.228
1.11GluThr: 1.11 ± 0.123
1.496GluVal: 1.496 ± 0.198
0.209GluTrp: 0.209 ± 0.051
2.445GluTyr: 2.445 ± 0.181
0.0GluXaa: 0.0 ± 0.0
Phe
0.45PheAla: 0.45 ± 0.088
0.772PheCys: 0.772 ± 0.097
2.349PheAsp: 2.349 ± 0.19
1.915PheGlu: 1.915 ± 0.189
3.797PhePhe: 3.797 ± 0.35
2.043PheGly: 2.043 ± 0.196
0.418PheHis: 0.418 ± 0.077
10.57PheIle: 10.57 ± 0.574
6.725PheLys: 6.725 ± 0.336
5.55PheLeu: 5.55 ± 0.363
0.595PheMet: 0.595 ± 0.092
8.108PheAsn: 8.108 ± 0.387
1.191PhePro: 1.191 ± 0.144
0.37PheGln: 0.37 ± 0.067
1.142PheArg: 1.142 ± 0.127
3.379PheSer: 3.379 ± 0.204
1.303PheThr: 1.303 ± 0.17
1.384PheVal: 1.384 ± 0.147
0.225PheTrp: 0.225 ± 0.06
4.119PheTyr: 4.119 ± 0.361
0.0PheXaa: 0.0 ± 0.0
Gly
0.981GlyAla: 0.981 ± 0.135
0.386GlyCys: 0.386 ± 0.082
1.85GlyAsp: 1.85 ± 0.199
1.448GlyGlu: 1.448 ± 0.178
2.268GlyPhe: 2.268 ± 0.2
2.526GlyGly: 2.526 ± 0.297
0.885GlyHis: 0.885 ± 0.123
6.13GlyIle: 6.13 ± 0.388
3.877GlyLys: 3.877 ± 0.279
3.234GlyLeu: 3.234 ± 0.28
0.467GlyMet: 0.467 ± 0.094
3.121GlyAsn: 3.121 ± 0.252
0.821GlyPro: 0.821 ± 0.123
0.772GlyGln: 0.772 ± 0.106
1.416GlyArg: 1.416 ± 0.213
2.188GlySer: 2.188 ± 0.206
1.496GlyThr: 1.496 ± 0.166
1.641GlyVal: 1.641 ± 0.204
0.306GlyTrp: 0.306 ± 0.076
1.77GlyTyr: 1.77 ± 0.167
0.0GlyXaa: 0.0 ± 0.0
His
0.193HisAla: 0.193 ± 0.05
0.113HisCys: 0.113 ± 0.04
0.338HisAsp: 0.338 ± 0.063
0.467HisGlu: 0.467 ± 0.088
0.37HisPhe: 0.37 ± 0.083
0.467HisGly: 0.467 ± 0.082
0.129HisHis: 0.129 ± 0.046
2.075HisIle: 2.075 ± 0.199
1.014HisLys: 1.014 ± 0.121
0.627HisLeu: 0.627 ± 0.117
0.097HisMet: 0.097 ± 0.037
0.981HisAsn: 0.981 ± 0.125
0.499HisPro: 0.499 ± 0.081
0.225HisGln: 0.225 ± 0.062
0.37HisArg: 0.37 ± 0.084
0.644HisSer: 0.644 ± 0.109
0.354HisThr: 0.354 ± 0.079
0.386HisVal: 0.386 ± 0.092
0.048HisTrp: 0.048 ± 0.028
0.418HisTyr: 0.418 ± 0.085
0.0HisXaa: 0.0 ± 0.0
Ile
2.397IleAla: 2.397 ± 0.258
2.011IleCys: 2.011 ± 0.194
8.253IleAsp: 8.253 ± 0.413
7.561IleGlu: 7.561 ± 0.439
10.2IlePhe: 10.2 ± 0.516
6.355IleGly: 6.355 ± 0.381
1.593IleHis: 1.593 ± 0.161
26.739IleIle: 26.739 ± 0.762
25.596IleLys: 25.596 ± 0.876
17.359IleLeu: 17.359 ± 0.599
1.77IleMet: 1.77 ± 0.152
27.302IleAsn: 27.302 ± 0.936
3.411IlePro: 3.411 ± 0.257
1.625IleGln: 1.625 ± 0.157
3.491IleArg: 3.491 ± 0.242
11.374IleSer: 11.374 ± 0.439
4.231IleThr: 4.231 ± 0.257
4.312IleVal: 4.312 ± 0.249
0.804IleTrp: 0.804 ± 0.124
10.49IleTyr: 10.49 ± 0.524
0.0IleXaa: 0.0 ± 0.0
Lys
1.062LysAla: 1.062 ± 0.118
1.255LysCys: 1.255 ± 0.15
4.167LysAsp: 4.167 ± 0.272
5.76LysGlu: 5.76 ± 0.29
6.596LysPhe: 6.596 ± 0.338
3.057LysGly: 3.057 ± 0.266
0.949LysHis: 0.949 ± 0.12
26.208LysIle: 26.208 ± 0.802
23.071LysLys: 23.071 ± 0.906
9.669LysLeu: 9.669 ± 0.387
2.703LysMet: 2.703 ± 0.235
25.323LysAsn: 25.323 ± 0.861
1.786LysPro: 1.786 ± 0.185
0.821LysGln: 0.821 ± 0.113
2.574LysArg: 2.574 ± 0.227
6.628LysSer: 6.628 ± 0.347
3.395LysThr: 3.395 ± 0.234
3.475LysVal: 3.475 ± 0.225
0.644LysTrp: 0.644 ± 0.129
10.715LysTyr: 10.715 ± 0.491
0.0LysXaa: 0.0 ± 0.0
Leu
1.239LeuAla: 1.239 ± 0.136
0.933LeuCys: 0.933 ± 0.117
3.572LeuAsp: 3.572 ± 0.198
3.652LeuGlu: 3.652 ± 0.288
5.373LeuPhe: 5.373 ± 0.41
3.62LeuGly: 3.62 ± 0.286
1.03LeuHis: 1.03 ± 0.134
13.353LeuIle: 13.353 ± 0.515
11.23LeuLys: 11.23 ± 0.455
8.784LeuLeu: 8.784 ± 0.445
0.917LeuMet: 0.917 ± 0.123
11.841LeuAsn: 11.841 ± 0.473
1.593LeuPro: 1.593 ± 0.126
1.03LeuGln: 1.03 ± 0.138
2.108LeuArg: 2.108 ± 0.196
5.792LeuSer: 5.792 ± 0.449
2.349LeuThr: 2.349 ± 0.187
2.349LeuVal: 2.349 ± 0.216
0.338LeuTrp: 0.338 ± 0.076
6.258LeuTyr: 6.258 ± 0.387
0.0LeuXaa: 0.0 ± 0.0
Met
0.306MetAla: 0.306 ± 0.072
0.193MetCys: 0.193 ± 0.054
0.467MetAsp: 0.467 ± 0.098
0.531MetGlu: 0.531 ± 0.089
0.788MetPhe: 0.788 ± 0.108
0.627MetGly: 0.627 ± 0.103
0.177MetHis: 0.177 ± 0.054
2.091MetIle: 2.091 ± 0.19
1.866MetLys: 1.866 ± 0.171
1.287MetLeu: 1.287 ± 0.121
0.145MetMet: 0.145 ± 0.055
1.866MetAsn: 1.866 ± 0.156
0.306MetPro: 0.306 ± 0.07
0.145MetGln: 0.145 ± 0.044
0.274MetArg: 0.274 ± 0.059
0.949MetSer: 0.949 ± 0.131
0.338MetThr: 0.338 ± 0.072
0.274MetVal: 0.274 ± 0.076
0.048MetTrp: 0.048 ± 0.027
0.885MetTyr: 0.885 ± 0.113
0.0MetXaa: 0.0 ± 0.0
Asn
0.804AsnAla: 0.804 ± 0.141
0.997AsnCys: 0.997 ± 0.125
4.955AsnAsp: 4.955 ± 0.289
5.438AsnGlu: 5.438 ± 0.348
8.784AsnPhe: 8.784 ± 0.536
2.96AsnGly: 2.96 ± 0.263
0.901AsnHis: 0.901 ± 0.127
31.565AsnIle: 31.565 ± 0.938
24.535AsnLys: 24.535 ± 0.749
10.86AsnLeu: 10.86 ± 0.46
1.512AsnMet: 1.512 ± 0.163
24.905AsnAsn: 24.905 ± 0.932
1.625AsnPro: 1.625 ± 0.171
1.239AsnGln: 1.239 ± 0.14
2.494AsnArg: 2.494 ± 0.202
6.5AsnSer: 6.5 ± 0.278
3.282AsnThr: 3.282 ± 0.209
3.153AsnVal: 3.153 ± 0.211
0.483AsnTrp: 0.483 ± 0.105
7.996AsnTyr: 7.996 ± 0.424
0.0AsnXaa: 0.0 ± 0.0
Pro
0.29ProAla: 0.29 ± 0.073
0.354ProCys: 0.354 ± 0.066
0.692ProAsp: 0.692 ± 0.099
0.74ProGlu: 0.74 ± 0.121
1.062ProPhe: 1.062 ± 0.121
1.223ProGly: 1.223 ± 0.146
0.322ProHis: 0.322 ± 0.066
3.346ProIle: 3.346 ± 0.276
1.528ProLys: 1.528 ± 0.148
1.335ProLeu: 1.335 ± 0.136
0.322ProMet: 0.322 ± 0.075
2.075ProAsn: 2.075 ± 0.182
0.386ProPro: 0.386 ± 0.08
0.225ProGln: 0.225 ± 0.072
0.402ProArg: 0.402 ± 0.087
1.351ProSer: 1.351 ± 0.149
0.579ProThr: 0.579 ± 0.105
0.644ProVal: 0.644 ± 0.108
0.161ProTrp: 0.161 ± 0.063
1.11ProTyr: 1.11 ± 0.124
0.0ProXaa: 0.0 ± 0.0
Gln
0.354GlnAla: 0.354 ± 0.087
0.113GlnCys: 0.113 ± 0.043
0.37GlnAsp: 0.37 ± 0.081
0.483GlnGlu: 0.483 ± 0.098
0.611GlnPhe: 0.611 ± 0.101
0.483GlnGly: 0.483 ± 0.086
0.129GlnHis: 0.129 ± 0.062
1.786GlnIle: 1.786 ± 0.166
0.869GlnLys: 0.869 ± 0.102
0.933GlnLeu: 0.933 ± 0.129
0.241GlnMet: 0.241 ± 0.059
1.014GlnAsn: 1.014 ± 0.146
0.257GlnPro: 0.257 ± 0.062
0.145GlnGln: 0.145 ± 0.046
0.402GlnArg: 0.402 ± 0.086
0.644GlnSer: 0.644 ± 0.096
0.37GlnThr: 0.37 ± 0.073
0.37GlnVal: 0.37 ± 0.089
0.048GlnTrp: 0.048 ± 0.025
0.692GlnTyr: 0.692 ± 0.095
0.0GlnXaa: 0.0 ± 0.0
Arg
0.499ArgAla: 0.499 ± 0.103
0.193ArgCys: 0.193 ± 0.052
0.837ArgAsp: 0.837 ± 0.116
0.901ArgGlu: 0.901 ± 0.125
1.158ArgPhe: 1.158 ± 0.124
1.142ArgGly: 1.142 ± 0.163
0.257ArgHis: 0.257 ± 0.077
3.121ArgIle: 3.121 ± 0.276
3.427ArgLys: 3.427 ± 0.259
1.947ArgLeu: 1.947 ± 0.185
0.483ArgMet: 0.483 ± 0.098
2.59ArgAsn: 2.59 ± 0.205
0.547ArgPro: 0.547 ± 0.094
0.45ArgGln: 0.45 ± 0.087
0.644ArgArg: 0.644 ± 0.108
1.528ArgSer: 1.528 ± 0.16
0.692ArgThr: 0.692 ± 0.116
0.74ArgVal: 0.74 ± 0.117
0.113ArgTrp: 0.113 ± 0.036
1.239ArgTyr: 1.239 ± 0.146
0.0ArgXaa: 0.0 ± 0.0
Ser
1.062SerAla: 1.062 ± 0.159
0.563SerCys: 0.563 ± 0.091
2.349SerAsp: 2.349 ± 0.215
2.108SerGlu: 2.108 ± 0.217
2.96SerPhe: 2.96 ± 0.263
3.073SerGly: 3.073 ± 0.231
0.644SerHis: 0.644 ± 0.116
10.425SerIle: 10.425 ± 0.466
7.738SerLys: 7.738 ± 0.344
5.052SerLeu: 5.052 ± 0.391
0.853SerMet: 0.853 ± 0.106
6.628SerAsn: 6.628 ± 0.319
1.191SerPro: 1.191 ± 0.157
0.644SerGln: 0.644 ± 0.116
1.738SerArg: 1.738 ± 0.174
3.523SerSer: 3.523 ± 0.254
1.931SerThr: 1.931 ± 0.149
1.48SerVal: 1.48 ± 0.168
0.257SerTrp: 0.257 ± 0.07
3.089SerTyr: 3.089 ± 0.23
0.0SerXaa: 0.0 ± 0.0
Thr
0.676ThrAla: 0.676 ± 0.123
0.354ThrCys: 0.354 ± 0.078
1.384ThrAsp: 1.384 ± 0.149
1.303ThrGlu: 1.303 ± 0.158
1.416ThrPhe: 1.416 ± 0.153
1.915ThrGly: 1.915 ± 0.201
0.467ThrHis: 0.467 ± 0.079
3.668ThrIle: 3.668 ± 0.238
2.848ThrLys: 2.848 ± 0.259
2.413ThrLeu: 2.413 ± 0.205
0.467ThrMet: 0.467 ± 0.08
3.089ThrAsn: 3.089 ± 0.25
0.869ThrPro: 0.869 ± 0.114
0.354ThrGln: 0.354 ± 0.069
0.676ThrArg: 0.676 ± 0.116
1.673ThrSer: 1.673 ± 0.196
1.239ThrThr: 1.239 ± 0.189
0.837ThrVal: 0.837 ± 0.139
0.113ThrTrp: 0.113 ± 0.038
1.384ThrTyr: 1.384 ± 0.108
0.0ThrXaa: 0.0 ± 0.0
Val
0.579ValAla: 0.579 ± 0.137
0.322ValCys: 0.322 ± 0.073
0.997ValAsp: 0.997 ± 0.137
1.464ValGlu: 1.464 ± 0.183
1.48ValPhe: 1.48 ± 0.137
1.561ValGly: 1.561 ± 0.172
0.37ValHis: 0.37 ± 0.073
3.732ValIle: 3.732 ± 0.247
3.137ValLys: 3.137 ± 0.243
2.622ValLeu: 2.622 ± 0.215
0.322ValMet: 0.322 ± 0.069
3.427ValAsn: 3.427 ± 0.285
0.788ValPro: 0.788 ± 0.135
0.402ValGln: 0.402 ± 0.094
0.804ValArg: 0.804 ± 0.106
1.915ValSer: 1.915 ± 0.211
1.014ValThr: 1.014 ± 0.134
1.062ValVal: 1.062 ± 0.154
0.129ValTrp: 0.129 ± 0.038
1.625ValTyr: 1.625 ± 0.15
0.0ValXaa: 0.0 ± 0.0
Trp
0.048TrpAla: 0.048 ± 0.027
0.113TrpCys: 0.113 ± 0.051
0.193TrpAsp: 0.193 ± 0.061
0.225TrpGlu: 0.225 ± 0.056
0.338TrpPhe: 0.338 ± 0.084
0.193TrpGly: 0.193 ± 0.054
0.064TrpHis: 0.064 ± 0.026
0.837TrpIle: 0.837 ± 0.1
0.402TrpLys: 0.402 ± 0.085
0.37TrpLeu: 0.37 ± 0.08
0.129TrpMet: 0.129 ± 0.042
0.692TrpAsn: 0.692 ± 0.119
0.097TrpPro: 0.097 ± 0.036
0.032TrpGln: 0.032 ± 0.025
0.145TrpArg: 0.145 ± 0.052
0.193TrpSer: 0.193 ± 0.05
0.097TrpThr: 0.097 ± 0.04
0.145TrpVal: 0.145 ± 0.05
0.048TrpTrp: 0.048 ± 0.025
0.274TrpTyr: 0.274 ± 0.068
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.611TyrAla: 0.611 ± 0.094
0.563TyrCys: 0.563 ± 0.096
2.574TyrAsp: 2.574 ± 0.212
2.236TyrGlu: 2.236 ± 0.185
3.234TyrPhe: 3.234 ± 0.285
2.494TyrGly: 2.494 ± 0.2
0.418TyrHis: 0.418 ± 0.089
12.501TyrIle: 12.501 ± 0.572
9.267TyrLys: 9.267 ± 0.454
4.714TyrLeu: 4.714 ± 0.299
0.772TyrMet: 0.772 ± 0.116
10.248TyrAsn: 10.248 ± 0.497
0.933TyrPro: 0.933 ± 0.142
0.627TyrGln: 0.627 ± 0.103
1.174TyrArg: 1.174 ± 0.147
2.703TyrSer: 2.703 ± 0.218
1.335TyrThr: 1.335 ± 0.14
1.625TyrVal: 1.625 ± 0.178
0.257TyrTrp: 0.257 ± 0.082
3.523TyrTyr: 3.523 ± 0.31
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 196 proteins (62158 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski