Amino acid dipepetide frequency for Microbispora triticiradicis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.579AlaAla: 21.579 ± 0.161
1.141AlaCys: 1.141 ± 0.025
7.866AlaAsp: 7.866 ± 0.072
8.552AlaGlu: 8.552 ± 0.084
3.582AlaPhe: 3.582 ± 0.046
14.215AlaGly: 14.215 ± 0.107
2.66AlaHis: 2.66 ± 0.029
3.758AlaIle: 3.758 ± 0.05
2.395AlaLys: 2.395 ± 0.043
14.309AlaLeu: 14.309 ± 0.107
2.52AlaMet: 2.52 ± 0.031
1.957AlaAsn: 1.957 ± 0.034
6.64AlaPro: 6.64 ± 0.071
3.217AlaGln: 3.217 ± 0.045
10.888AlaArg: 10.888 ± 0.092
5.932AlaSer: 5.932 ± 0.056
6.904AlaThr: 6.904 ± 0.064
12.325AlaVal: 12.325 ± 0.088
1.95AlaTrp: 1.95 ± 0.029
2.823AlaTyr: 2.823 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
1.088CysAla: 1.088 ± 0.022
0.109CysCys: 0.109 ± 0.007
0.505CysAsp: 0.505 ± 0.016
0.406CysGlu: 0.406 ± 0.013
0.224CysPhe: 0.224 ± 0.01
0.933CysGly: 0.933 ± 0.023
0.212CysHis: 0.212 ± 0.009
0.122CysIle: 0.122 ± 0.007
0.104CysLys: 0.104 ± 0.008
0.812CysLeu: 0.812 ± 0.019
0.113CysMet: 0.113 ± 0.008
0.138CysAsn: 0.138 ± 0.009
0.539CysPro: 0.539 ± 0.015
0.164CysGln: 0.164 ± 0.009
0.678CysArg: 0.678 ± 0.019
0.459CysSer: 0.459 ± 0.017
0.45CysThr: 0.45 ± 0.014
0.711CysVal: 0.711 ± 0.019
0.127CysTrp: 0.127 ± 0.008
0.173CysTyr: 0.173 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.244AspAla: 7.244 ± 0.068
0.421AspCys: 0.421 ± 0.014
3.629AspAsp: 3.629 ± 0.051
3.678AspGlu: 3.678 ± 0.048
1.522AspPhe: 1.522 ± 0.026
6.229AspGly: 6.229 ± 0.059
1.42AspHis: 1.42 ± 0.027
1.66AspIle: 1.66 ± 0.031
0.947AspLys: 0.947 ± 0.024
6.734AspLeu: 6.734 ± 0.069
0.815AspMet: 0.815 ± 0.017
0.913AspAsn: 0.913 ± 0.019
4.575AspPro: 4.575 ± 0.046
1.434AspGln: 1.434 ± 0.024
4.976AspArg: 4.976 ± 0.053
2.203AspSer: 2.203 ± 0.031
2.593AspThr: 2.593 ± 0.039
5.074AspVal: 5.074 ± 0.052
0.961AspTrp: 0.961 ± 0.022
1.256AspTyr: 1.256 ± 0.026
0.0AspXaa: 0.0 ± 0.0
Glu
7.219GluAla: 7.219 ± 0.071
0.397GluCys: 0.397 ± 0.012
2.779GluAsp: 2.779 ± 0.045
3.567GluGlu: 3.567 ± 0.053
1.461GluPhe: 1.461 ± 0.025
4.143GluGly: 4.143 ± 0.047
1.503GluHis: 1.503 ± 0.029
2.636GluIle: 2.636 ± 0.038
1.11GluLys: 1.11 ± 0.024
5.992GluLeu: 5.992 ± 0.068
0.975GluMet: 0.975 ± 0.025
0.977GluAsn: 0.977 ± 0.023
3.42GluPro: 3.42 ± 0.05
1.877GluGln: 1.877 ± 0.035
5.661GluArg: 5.661 ± 0.07
2.476GluSer: 2.476 ± 0.039
2.933GluThr: 2.933 ± 0.045
4.701GluVal: 4.701 ± 0.05
0.86GluTrp: 0.86 ± 0.022
0.985GluTyr: 0.985 ± 0.021
0.0GluXaa: 0.0 ± 0.0
Phe
3.73PheAla: 3.73 ± 0.047
0.26PheCys: 0.26 ± 0.012
1.996PheAsp: 1.996 ± 0.03
1.402PheGlu: 1.402 ± 0.026
0.858PhePhe: 0.858 ± 0.022
3.079PheGly: 3.079 ± 0.04
0.616PheHis: 0.616 ± 0.019
0.647PheIle: 0.647 ± 0.017
0.454PheLys: 0.454 ± 0.017
2.647PheLeu: 2.647 ± 0.039
0.376PheMet: 0.376 ± 0.013
0.573PheAsn: 0.573 ± 0.019
1.454PhePro: 1.454 ± 0.024
0.675PheGln: 0.675 ± 0.016
1.913PheArg: 1.913 ± 0.031
1.448PheSer: 1.448 ± 0.026
1.995PheThr: 1.995 ± 0.032
2.353PheVal: 2.353 ± 0.036
0.425PheTrp: 0.425 ± 0.014
0.608PheTyr: 0.608 ± 0.018
0.0PheXaa: 0.0 ± 0.0
Gly
11.003GlyAla: 11.003 ± 0.08
0.852GlyCys: 0.852 ± 0.023
5.665GlyAsp: 5.665 ± 0.062
5.369GlyGlu: 5.369 ± 0.053
2.875GlyPhe: 2.875 ± 0.04
9.383GlyGly: 9.383 ± 0.091
2.364GlyHis: 2.364 ± 0.038
3.16GlyIle: 3.16 ± 0.042
2.031GlyLys: 2.031 ± 0.035
9.969GlyLeu: 9.969 ± 0.083
1.978GlyMet: 1.978 ± 0.031
1.806GlyAsn: 1.806 ± 0.041
5.536GlyPro: 5.536 ± 0.056
2.648GlyGln: 2.648 ± 0.044
8.715GlyArg: 8.715 ± 0.084
5.12GlySer: 5.12 ± 0.057
5.981GlyThr: 5.981 ± 0.074
8.31GlyVal: 8.31 ± 0.066
1.74GlyTrp: 1.74 ± 0.029
2.403GlyTyr: 2.403 ± 0.036
0.0GlyXaa: 0.0 ± 0.0
His
2.582HisAla: 2.582 ± 0.034
0.192HisCys: 0.192 ± 0.008
1.355HisAsp: 1.355 ± 0.024
1.178HisGlu: 1.178 ± 0.023
0.569HisPhe: 0.569 ± 0.016
2.22HisGly: 2.22 ± 0.037
0.607HisHis: 0.607 ± 0.02
0.621HisIle: 0.621 ± 0.016
0.294HisLys: 0.294 ± 0.012
2.454HisLeu: 2.454 ± 0.036
0.313HisMet: 0.313 ± 0.012
0.368HisAsn: 0.368 ± 0.013
1.761HisPro: 1.761 ± 0.027
0.55HisGln: 0.55 ± 0.017
1.966HisArg: 1.966 ± 0.031
0.912HisSer: 0.912 ± 0.018
1.112HisThr: 1.112 ± 0.023
1.867HisVal: 1.867 ± 0.03
0.352HisTrp: 0.352 ± 0.012
0.487HisTyr: 0.487 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
4.79IleAla: 4.79 ± 0.044
0.284IleCys: 0.284 ± 0.011
2.269IleAsp: 2.269 ± 0.035
2.076IleGlu: 2.076 ± 0.033
0.755IlePhe: 0.755 ± 0.021
3.542IleGly: 3.542 ± 0.041
0.584IleHis: 0.584 ± 0.017
0.911IleIle: 0.911 ± 0.021
0.675IleLys: 0.675 ± 0.018
2.594IleLeu: 2.594 ± 0.036
0.504IleMet: 0.504 ± 0.015
0.68IleAsn: 0.68 ± 0.017
1.825IlePro: 1.825 ± 0.028
0.727IleGln: 0.727 ± 0.016
2.471IleArg: 2.471 ± 0.034
1.806IleSer: 1.806 ± 0.031
2.208IleThr: 2.208 ± 0.034
3.035IleVal: 3.035 ± 0.038
0.421IleTrp: 0.421 ± 0.015
0.576IleTyr: 0.576 ± 0.018
0.0IleXaa: 0.0 ± 0.0
Lys
2.377LysAla: 2.377 ± 0.042
0.12LysCys: 0.12 ± 0.009
1.014LysAsp: 1.014 ± 0.026
1.017LysGlu: 1.017 ± 0.023
0.406LysPhe: 0.406 ± 0.017
1.538LysGly: 1.538 ± 0.034
0.362LysHis: 0.362 ± 0.012
0.904LysIle: 0.904 ± 0.021
0.58LysLys: 0.58 ± 0.022
1.641LysLeu: 1.641 ± 0.031
0.335LysMet: 0.335 ± 0.013
0.44LysAsn: 0.44 ± 0.017
1.154LysPro: 1.154 ± 0.026
0.533LysGln: 0.533 ± 0.016
1.25LysArg: 1.25 ± 0.024
0.927LysSer: 0.927 ± 0.023
1.129LysThr: 1.129 ± 0.023
1.746LysVal: 1.746 ± 0.034
0.28LysTrp: 0.28 ± 0.012
0.425LysTyr: 0.425 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
15.64LeuAla: 15.64 ± 0.109
0.819LeuCys: 0.819 ± 0.02
6.59LeuAsp: 6.59 ± 0.054
4.655LeuGlu: 4.655 ± 0.053
2.623LeuPhe: 2.623 ± 0.039
9.436LeuGly: 9.436 ± 0.077
2.089LeuHis: 2.089 ± 0.034
3.218LeuIle: 3.218 ± 0.048
1.76LeuLys: 1.76 ± 0.032
11.228LeuLeu: 11.228 ± 0.1
1.597LeuMet: 1.597 ± 0.028
1.701LeuAsn: 1.701 ± 0.03
6.529LeuPro: 6.529 ± 0.06
1.943LeuGln: 1.943 ± 0.03
9.397LeuArg: 9.397 ± 0.07
5.435LeuSer: 5.435 ± 0.047
6.774LeuThr: 6.774 ± 0.056
9.321LeuVal: 9.321 ± 0.08
1.345LeuTrp: 1.345 ± 0.027
1.836LeuTyr: 1.836 ± 0.032
0.0LeuXaa: 0.0 ± 0.0
Met
2.203MetAla: 2.203 ± 0.029
0.137MetCys: 0.137 ± 0.007
0.87MetAsp: 0.87 ± 0.021
0.762MetGlu: 0.762 ± 0.02
0.462MetPhe: 0.462 ± 0.016
1.292MetGly: 1.292 ± 0.021
0.324MetHis: 0.324 ± 0.013
0.758MetIle: 0.758 ± 0.019
0.387MetLys: 0.387 ± 0.013
1.819MetLeu: 1.819 ± 0.028
0.273MetMet: 0.273 ± 0.012
0.406MetAsn: 0.406 ± 0.015
1.16MetPro: 1.16 ± 0.023
0.361MetGln: 0.361 ± 0.012
1.615MetArg: 1.615 ± 0.025
1.26MetSer: 1.26 ± 0.024
1.523MetThr: 1.523 ± 0.025
1.352MetVal: 1.352 ± 0.022
0.23MetTrp: 0.23 ± 0.01
0.291MetTyr: 0.291 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
2.161AsnAla: 2.161 ± 0.037
0.162AsnCys: 0.162 ± 0.008
0.9AsnAsp: 0.9 ± 0.02
0.775AsnGlu: 0.775 ± 0.02
0.459AsnPhe: 0.459 ± 0.016
2.094AsnGly: 2.094 ± 0.05
0.408AsnHis: 0.408 ± 0.015
0.596AsnIle: 0.596 ± 0.017
0.346AsnLys: 0.346 ± 0.016
1.822AsnLeu: 1.822 ± 0.036
0.279AsnMet: 0.279 ± 0.01
0.492AsnAsn: 0.492 ± 0.024
1.346AsnPro: 1.346 ± 0.03
0.517AsnGln: 0.517 ± 0.018
1.311AsnArg: 1.311 ± 0.026
0.869AsnSer: 0.869 ± 0.026
1.085AsnThr: 1.085 ± 0.026
1.526AsnVal: 1.526 ± 0.026
0.311AsnTrp: 0.311 ± 0.013
0.424AsnTyr: 0.424 ± 0.014
0.0AsnXaa: 0.0 ± 0.0
Pro
8.982ProAla: 8.982 ± 0.078
0.366ProCys: 0.366 ± 0.013
4.276ProAsp: 4.276 ± 0.044
4.302ProGlu: 4.302 ± 0.051
1.539ProPhe: 1.539 ± 0.027
7.422ProGly: 7.422 ± 0.075
1.231ProHis: 1.231 ± 0.022
1.624ProIle: 1.624 ± 0.03
1.066ProLys: 1.066 ± 0.024
5.299ProLeu: 5.299 ± 0.049
1.038ProMet: 1.038 ± 0.022
0.955ProAsn: 0.955 ± 0.022
3.979ProPro: 3.979 ± 0.063
1.466ProGln: 1.466 ± 0.03
4.158ProArg: 4.158 ± 0.055
3.604ProSer: 3.604 ± 0.058
2.769ProThr: 2.769 ± 0.039
5.53ProVal: 5.53 ± 0.054
0.938ProTrp: 0.938 ± 0.021
1.514ProTyr: 1.514 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
3.718GlnAla: 3.718 ± 0.048
0.142GlnCys: 0.142 ± 0.008
1.173GlnAsp: 1.173 ± 0.024
1.29GlnGlu: 1.29 ± 0.024
0.64GlnPhe: 0.64 ± 0.017
2.168GlnGly: 2.168 ± 0.041
0.49GlnHis: 0.49 ± 0.014
1.171GlnIle: 1.171 ± 0.025
0.499GlnLys: 0.499 ± 0.018
2.224GlnLeu: 2.224 ± 0.039
0.463GlnMet: 0.463 ± 0.015
0.478GlnAsn: 0.478 ± 0.016
1.498GlnPro: 1.498 ± 0.034
0.908GlnGln: 0.908 ± 0.035
2.169GlnArg: 2.169 ± 0.031
1.211GlnSer: 1.211 ± 0.027
1.278GlnThr: 1.278 ± 0.025
2.41GlnVal: 2.41 ± 0.036
0.461GlnTrp: 0.461 ± 0.015
0.495GlnTyr: 0.495 ± 0.015
0.0GlnXaa: 0.0 ± 0.0
Arg
10.235ArgAla: 10.235 ± 0.09
0.646ArgCys: 0.646 ± 0.018
4.747ArgAsp: 4.747 ± 0.056
5.048ArgGlu: 5.048 ± 0.061
2.612ArgPhe: 2.612 ± 0.032
6.251ArgGly: 6.251 ± 0.063
2.243ArgHis: 2.243 ± 0.036
3.154ArgIle: 3.154 ± 0.039
1.417ArgLys: 1.417 ± 0.027
10.058ArgLeu: 10.058 ± 0.08
1.873ArgMet: 1.873 ± 0.027
1.38ArgAsn: 1.38 ± 0.026
5.378ArgPro: 5.378 ± 0.059
2.36ArgGln: 2.36 ± 0.031
8.858ArgArg: 8.858 ± 0.097
4.159ArgSer: 4.159 ± 0.04
4.841ArgThr: 4.841 ± 0.053
6.67ArgVal: 6.67 ± 0.057
1.411ArgTrp: 1.411 ± 0.028
1.934ArgTyr: 1.934 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
6.612SerAla: 6.612 ± 0.064
0.413SerCys: 0.413 ± 0.015
2.519SerAsp: 2.519 ± 0.035
2.185SerGlu: 2.185 ± 0.032
1.527SerPhe: 1.527 ± 0.027
6.279SerGly: 6.279 ± 0.069
0.976SerHis: 0.976 ± 0.022
1.528SerIle: 1.528 ± 0.029
0.848SerLys: 0.848 ± 0.018
4.782SerLeu: 4.782 ± 0.054
1.055SerMet: 1.055 ± 0.02
0.874SerAsn: 0.874 ± 0.023
3.727SerPro: 3.727 ± 0.063
1.212SerGln: 1.212 ± 0.021
3.956SerArg: 3.956 ± 0.048
2.84SerSer: 2.84 ± 0.051
2.735SerThr: 2.735 ± 0.037
4.131SerVal: 4.131 ± 0.044
0.954SerTrp: 0.954 ± 0.023
1.233SerTyr: 1.233 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
8.052ThrAla: 8.052 ± 0.068
0.524ThrCys: 0.524 ± 0.017
2.848ThrAsp: 2.848 ± 0.042
2.698ThrGlu: 2.698 ± 0.037
1.651ThrPhe: 1.651 ± 0.031
6.782ThrGly: 6.782 ± 0.064
1.038ThrHis: 1.038 ± 0.024
2.048ThrIle: 2.048 ± 0.032
0.915ThrLys: 0.915 ± 0.024
5.774ThrLeu: 5.774 ± 0.055
0.983ThrMet: 0.983 ± 0.022
1.009ThrAsn: 1.009 ± 0.028
4.145ThrPro: 4.145 ± 0.056
1.263ThrGln: 1.263 ± 0.024
4.126ThrArg: 4.126 ± 0.045
3.029ThrSer: 3.029 ± 0.042
3.677ThrThr: 3.677 ± 0.055
5.594ThrVal: 5.594 ± 0.057
0.911ThrTrp: 0.911 ± 0.021
1.337ThrTyr: 1.337 ± 0.027
0.0ThrXaa: 0.0 ± 0.0
Val
11.632ValAla: 11.632 ± 0.089
0.755ValCys: 0.755 ± 0.02
4.938ValAsp: 4.938 ± 0.046
4.825ValGlu: 4.825 ± 0.054
2.574ValPhe: 2.574 ± 0.036
6.392ValGly: 6.392 ± 0.065
1.81ValHis: 1.81 ± 0.03
3.133ValIle: 3.133 ± 0.042
1.644ValLys: 1.644 ± 0.032
9.727ValLeu: 9.727 ± 0.08
1.442ValMet: 1.442 ± 0.024
1.813ValAsn: 1.813 ± 0.032
5.393ValPro: 5.393 ± 0.056
1.888ValGln: 1.888 ± 0.029
7.76ValArg: 7.76 ± 0.068
4.684ValSer: 4.684 ± 0.047
6.192ValThr: 6.192 ± 0.061
8.914ValVal: 8.914 ± 0.082
1.183ValTrp: 1.183 ± 0.023
1.696ValTyr: 1.696 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
1.668TrpAla: 1.668 ± 0.028
0.147TrpCys: 0.147 ± 0.008
0.894TrpAsp: 0.894 ± 0.021
0.702TrpGlu: 0.702 ± 0.016
0.522TrpPhe: 0.522 ± 0.014
1.068TrpGly: 1.068 ± 0.022
0.384TrpHis: 0.384 ± 0.014
0.589TrpIle: 0.589 ± 0.016
0.324TrpLys: 0.324 ± 0.013
1.825TrpLeu: 1.825 ± 0.032
0.299TrpMet: 0.299 ± 0.013
0.452TrpAsn: 0.452 ± 0.015
0.909TrpPro: 0.909 ± 0.022
0.536TrpGln: 0.536 ± 0.016
1.521TrpArg: 1.521 ± 0.028
0.999TrpSer: 0.999 ± 0.023
1.054TrpThr: 1.054 ± 0.025
1.0TrpVal: 1.0 ± 0.023
0.352TrpTrp: 0.352 ± 0.012
0.363TrpTyr: 0.363 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.695TyrAla: 2.695 ± 0.038
0.178TyrCys: 0.178 ± 0.008
1.453TyrAsp: 1.453 ± 0.03
1.185TyrGlu: 1.185 ± 0.026
0.648TyrPhe: 0.648 ± 0.016
2.44TyrGly: 2.44 ± 0.041
0.439TyrHis: 0.439 ± 0.014
0.497TyrIle: 0.497 ± 0.016
0.382TyrLys: 0.382 ± 0.016
2.226TyrLeu: 2.226 ± 0.034
0.255TyrMet: 0.255 ± 0.009
0.472TyrAsn: 0.472 ± 0.018
1.089TyrPro: 1.089 ± 0.023
0.61TyrGln: 0.61 ± 0.017
1.884TyrArg: 1.884 ± 0.034
1.011TyrSer: 1.011 ± 0.021
1.17TyrThr: 1.17 ± 0.024
1.826TyrVal: 1.826 ± 0.029
0.396TyrTrp: 0.396 ± 0.012
0.51TyrTyr: 0.51 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6852 proteins (2296812 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski