Amino acid dipepetide frequency for Planctomycetes bacterium K22_7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.164AlaAla: 12.164 ± 0.113	1.102AlaCys: 1.102 ± 0.028	7.279AlaAsp: 7.279 ± 0.069	5.714AlaGlu: 5.714 ± 0.06	3.16AlaPhe: 3.16 ± 0.039	8.256AlaGly: 8.256 ± 0.08	1.513AlaHis: 1.513 ± 0.033	6.189AlaIle: 6.189 ± 0.063	4.116AlaLys: 4.116 ± 0.065	7.305AlaLeu: 7.305 ± 0.068	2.982AlaMet: 2.982 ± 0.045	3.258AlaAsn: 3.258 ± 0.042	4.048AlaPro: 4.048 ± 0.051	3.207AlaGln: 3.207 ± 0.045	5.017AlaArg: 5.017 ± 0.056	7.082AlaSer: 7.082 ± 0.054	6.302AlaThr: 6.302 ± 0.064	7.179AlaVal: 7.179 ± 0.067	1.32AlaTrp: 1.32 ± 0.029	1.908AlaTyr: 1.908 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	0.719CysAla: 0.719 ± 0.019	0.223CysCys: 0.223 ± 0.011	0.796CysAsp: 0.796 ± 0.024	0.631CysGlu: 0.631 ± 0.017	0.421CysPhe: 0.421 ± 0.014	1.056CysGly: 1.056 ± 0.029	0.439CysHis: 0.439 ± 0.021	0.465CysIle: 0.465 ± 0.013	0.305CysLys: 0.305 ± 0.014	1.024CysLeu: 1.024 ± 0.024	0.206CysMet: 0.206 ± 0.009	0.308CysAsn: 0.308 ± 0.012	0.579CysPro: 0.579 ± 0.019	0.455CysGln: 0.455 ± 0.013	0.849CysArg: 0.849 ± 0.022	0.647CysSer: 0.647 ± 0.018	0.482CysThr: 0.482 ± 0.016	0.867CysVal: 0.867 ± 0.021	0.176CysTrp: 0.176 ± 0.009	0.292CysTyr: 0.292 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.33AspAla: 7.33 ± 0.067	0.634AspCys: 0.634 ± 0.019	5.089AspAsp: 5.089 ± 0.068	4.112AspGlu: 4.112 ± 0.044	2.529AspPhe: 2.529 ± 0.038	6.359AspGly: 6.359 ± 0.124	1.69AspHis: 1.69 ± 0.032	2.605AspIle: 2.605 ± 0.038	1.658AspLys: 1.658 ± 0.033	6.046AspLeu: 6.046 ± 0.064	1.066AspMet: 1.066 ± 0.023	1.724AspAsn: 1.724 ± 0.039	4.173AspPro: 4.173 ± 0.049	3.452AspGln: 3.452 ± 0.042	5.117AspArg: 5.117 ± 0.057	4.573AspSer: 4.573 ± 0.059	2.98AspThr: 2.98 ± 0.058	4.777AspVal: 4.777 ± 0.053	1.15AspTrp: 1.15 ± 0.024	1.514AspTyr: 1.514 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	4.936GluAla: 4.936 ± 0.064	0.438GluCys: 0.438 ± 0.014	2.637GluAsp: 2.637 ± 0.037	2.36GluGlu: 2.36 ± 0.048	2.138GluPhe: 2.138 ± 0.04	3.184GluGly: 3.184 ± 0.043	1.106GluHis: 1.106 ± 0.025	3.148GluIle: 3.148 ± 0.044	2.072GluLys: 2.072 ± 0.037	5.736GluLeu: 5.736 ± 0.057	1.563GluMet: 1.563 ± 0.035	1.796GluAsn: 1.796 ± 0.03	2.459GluPro: 2.459 ± 0.038	2.366GluGln: 2.366 ± 0.036	3.176GluArg: 3.176 ± 0.049	4.762GluSer: 4.762 ± 0.048	3.635GluThr: 3.635 ± 0.044	3.822GluVal: 3.822 ± 0.045	0.586GluTrp: 0.586 ± 0.016	1.134GluTyr: 1.134 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.913PheAla: 3.913 ± 0.042	0.449PheCys: 0.449 ± 0.014	3.059PheAsp: 3.059 ± 0.049	2.106PheGlu: 2.106 ± 0.047	1.331PhePhe: 1.331 ± 0.029	3.301PheGly: 3.301 ± 0.043	0.798PheHis: 0.798 ± 0.016	1.357PheIle: 1.357 ± 0.026	0.954PheLys: 0.954 ± 0.028	3.105PheLeu: 3.105 ± 0.04	0.648PheMet: 0.648 ± 0.017	1.093PheAsn: 1.093 ± 0.024	1.596PhePro: 1.596 ± 0.025	1.408PheGln: 1.408 ± 0.025	2.364PheArg: 2.364 ± 0.035	2.277PheSer: 2.277 ± 0.037	1.981PheThr: 1.981 ± 0.039	2.793PheVal: 2.793 ± 0.039	0.526PheTrp: 0.526 ± 0.015	0.911PheTyr: 0.911 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	5.873GlyAla: 5.873 ± 0.073	1.051GlyCys: 1.051 ± 0.03	5.606GlyAsp: 5.606 ± 0.111	4.092GlyGlu: 4.092 ± 0.044	3.055GlyPhe: 3.055 ± 0.039	7.132GlyGly: 7.132 ± 0.133	1.725GlyHis: 1.725 ± 0.028	4.138GlyIle: 4.138 ± 0.047	3.326GlyLys: 3.326 ± 0.049	6.769GlyLeu: 6.769 ± 0.067	2.009GlyMet: 2.009 ± 0.039	2.946GlyAsn: 2.946 ± 0.075	3.353GlyPro: 3.353 ± 0.043	3.413GlyGln: 3.413 ± 0.047	5.263GlyArg: 5.263 ± 0.059	5.598GlySer: 5.598 ± 0.085	4.737GlyThr: 4.737 ± 0.09	5.392GlyVal: 5.392 ± 0.054	1.39GlyTrp: 1.39 ± 0.026	2.096GlyTyr: 2.096 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	2.041HisAla: 2.041 ± 0.031	0.344HisCys: 0.344 ± 0.011	1.419HisAsp: 1.419 ± 0.027	1.074HisGlu: 1.074 ± 0.021	0.938HisPhe: 0.938 ± 0.021	1.798HisGly: 1.798 ± 0.031	0.747HisHis: 0.747 ± 0.021	0.799HisIle: 0.799 ± 0.021	0.468HisLys: 0.468 ± 0.015	2.072HisLeu: 2.072 ± 0.034	0.38HisMet: 0.38 ± 0.013	0.59HisAsn: 0.59 ± 0.016	1.507HisPro: 1.507 ± 0.026	1.05HisGln: 1.05 ± 0.021	1.749HisArg: 1.749 ± 0.034	1.447HisSer: 1.447 ± 0.029	0.95HisThr: 0.95 ± 0.021	1.475HisVal: 1.475 ± 0.029	0.454HisTrp: 0.454 ± 0.014	0.598HisTyr: 0.598 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	6.536IleAla: 6.536 ± 0.068	0.588IleCys: 0.588 ± 0.017	4.71IleAsp: 4.71 ± 0.059	3.802IleGlu: 3.802 ± 0.048	1.393IlePhe: 1.393 ± 0.025	4.559IleGly: 4.559 ± 0.051	1.205IleHis: 1.205 ± 0.024	1.919IleIle: 1.919 ± 0.03	1.317IleLys: 1.317 ± 0.026	3.773IleLeu: 3.773 ± 0.047	0.68IleMet: 0.68 ± 0.019	1.603IleAsn: 1.603 ± 0.041	2.514IlePro: 2.514 ± 0.034	2.225IleGln: 2.225 ± 0.034	3.678IleArg: 3.678 ± 0.045	3.225IleSer: 3.225 ± 0.046	2.755IleThr: 2.755 ± 0.045	3.975IleVal: 3.975 ± 0.047	0.583IleTrp: 0.583 ± 0.018	1.104IleTyr: 1.104 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.778LysAla: 2.778 ± 0.05	0.287LysCys: 0.287 ± 0.011	1.655LysAsp: 1.655 ± 0.03	1.461LysGlu: 1.461 ± 0.031	1.254LysPhe: 1.254 ± 0.029	1.794LysGly: 1.794 ± 0.038	0.794LysHis: 0.794 ± 0.019	1.857LysIle: 1.857 ± 0.034	1.504LysLys: 1.504 ± 0.04	3.436LysLeu: 3.436 ± 0.046	0.866LysMet: 0.866 ± 0.019	1.111LysAsn: 1.111 ± 0.028	2.135LysPro: 2.135 ± 0.038	1.606LysGln: 1.606 ± 0.03	2.433LysArg: 2.433 ± 0.042	2.422LysSer: 2.422 ± 0.036	2.094LysThr: 2.094 ± 0.033	2.29LysVal: 2.29 ± 0.037	0.477LysTrp: 0.477 ± 0.017	0.785LysTyr: 0.785 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	10.301LeuAla: 10.301 ± 0.08	1.046LeuCys: 1.046 ± 0.023	6.052LeuAsp: 6.052 ± 0.069	4.46LeuGlu: 4.46 ± 0.052	3.073LeuPhe: 3.073 ± 0.039	6.929LeuGly: 6.929 ± 0.067	1.855LeuHis: 1.855 ± 0.033	4.714LeuIle: 4.714 ± 0.052	3.022LeuLys: 3.022 ± 0.049	8.41LeuLeu: 8.41 ± 0.088	2.128LeuMet: 2.128 ± 0.037	2.681LeuAsn: 2.681 ± 0.042	5.183LeuPro: 5.183 ± 0.053	3.395LeuGln: 3.395 ± 0.042	6.188LeuArg: 6.188 ± 0.065	6.3LeuSer: 6.3 ± 0.064	5.314LeuThr: 5.314 ± 0.067	6.892LeuVal: 6.892 ± 0.059	1.201LeuTrp: 1.201 ± 0.025	1.849LeuTyr: 1.849 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.354MetAla: 2.354 ± 0.038	0.197MetCys: 0.197 ± 0.009	1.298MetAsp: 1.298 ± 0.026	0.991MetGlu: 0.991 ± 0.022	0.78MetPhe: 0.78 ± 0.019	1.64MetGly: 1.64 ± 0.032	0.544MetHis: 0.544 ± 0.016	1.435MetIle: 1.435 ± 0.028	0.981MetLys: 0.981 ± 0.023	2.429MetLeu: 2.429 ± 0.044	0.688MetMet: 0.688 ± 0.022	0.947MetAsn: 0.947 ± 0.02	1.449MetPro: 1.449 ± 0.029	0.995MetGln: 0.995 ± 0.022	1.486MetArg: 1.486 ± 0.03	1.543MetSer: 1.543 ± 0.027	1.681MetThr: 1.681 ± 0.029	1.695MetVal: 1.695 ± 0.03	0.241MetTrp: 0.241 ± 0.01	0.377MetTyr: 0.377 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.991AsnAla: 2.991 ± 0.042	0.314AsnCys: 0.314 ± 0.011	2.228AsnAsp: 2.228 ± 0.052	1.706AsnGlu: 1.706 ± 0.028	1.107AsnPhe: 1.107 ± 0.025	2.613AsnGly: 2.613 ± 0.056	0.822AsnHis: 0.822 ± 0.019	1.285AsnIle: 1.285 ± 0.025	0.755AsnLys: 0.755 ± 0.019	2.921AsnLeu: 2.921 ± 0.042	0.548AsnMet: 0.548 ± 0.016	0.977AsnAsn: 0.977 ± 0.031	2.071AsnPro: 2.071 ± 0.037	1.562AsnGln: 1.562 ± 0.025	2.464AsnArg: 2.464 ± 0.039	2.006AsnSer: 2.006 ± 0.045	1.498AsnThr: 1.498 ± 0.036	2.395AsnVal: 2.395 ± 0.047	0.492AsnTrp: 0.492 ± 0.015	0.79AsnTyr: 0.79 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	5.377ProAla: 5.377 ± 0.066	0.387ProCys: 0.387 ± 0.014	3.771ProAsp: 3.771 ± 0.047	3.193ProGlu: 3.193 ± 0.038	1.722ProPhe: 1.722 ± 0.03	3.886ProGly: 3.886 ± 0.052	1.065ProHis: 1.065 ± 0.023	2.993ProIle: 2.993 ± 0.039	1.84ProLys: 1.84 ± 0.035	4.358ProLeu: 4.358 ± 0.044	1.347ProMet: 1.347 ± 0.023	1.924ProAsn: 1.924 ± 0.032	2.999ProPro: 2.999 ± 0.057	1.978ProGln: 1.978 ± 0.03	2.764ProArg: 2.764 ± 0.04	4.089ProSer: 4.089 ± 0.048	3.487ProThr: 3.487 ± 0.04	3.86ProVal: 3.86 ± 0.053	0.722ProTrp: 0.722 ± 0.017	1.09ProTyr: 1.09 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.767GlnAla: 3.767 ± 0.044	0.418GlnCys: 0.418 ± 0.015	1.943GlnAsp: 1.943 ± 0.029	1.593GlnGlu: 1.593 ± 0.027	1.606GlnPhe: 1.606 ± 0.025	2.32GlnGly: 2.32 ± 0.034	0.979GlnHis: 0.979 ± 0.023	2.453GlnIle: 2.453 ± 0.036	1.342GlnLys: 1.342 ± 0.027	4.135GlnLeu: 4.135 ± 0.056	1.114GlnMet: 1.114 ± 0.023	1.25GlnAsn: 1.25 ± 0.028	2.477GlnPro: 2.477 ± 0.041	2.344GlnGln: 2.344 ± 0.038	3.329GlnArg: 3.329 ± 0.044	3.449GlnSer: 3.449 ± 0.039	2.685GlnThr: 2.685 ± 0.034	2.79GlnVal: 2.79 ± 0.041	0.881GlnTrp: 0.881 ± 0.022	1.015GlnTyr: 1.015 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	4.589ArgAla: 4.589 ± 0.049	0.832ArgCys: 0.832 ± 0.023	4.112ArgAsp: 4.112 ± 0.051	3.353ArgGlu: 3.353 ± 0.053	2.863ArgPhe: 2.863 ± 0.038	4.457ArgGly: 4.457 ± 0.055	1.477ArgHis: 1.477 ± 0.031	3.799ArgIle: 3.799 ± 0.041	2.202ArgLys: 2.202 ± 0.039	7.015ArgLeu: 7.015 ± 0.068	1.922ArgMet: 1.922 ± 0.035	2.006ArgAsn: 2.006 ± 0.029	3.315ArgPro: 3.315 ± 0.049	3.011ArgGln: 3.011 ± 0.04	5.33ArgArg: 5.33 ± 0.072	4.971ArgSer: 4.971 ± 0.055	3.499ArgThr: 3.499 ± 0.044	4.548ArgVal: 4.548 ± 0.046	1.352ArgTrp: 1.352 ± 0.024	1.866ArgTyr: 1.866 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	6.441SerAla: 6.441 ± 0.057	0.646SerCys: 0.646 ± 0.017	5.131SerAsp: 5.131 ± 0.059	3.771SerGlu: 3.771 ± 0.042	2.465SerPhe: 2.465 ± 0.036	6.382SerGly: 6.382 ± 0.088	1.456SerHis: 1.456 ± 0.027	3.883SerIle: 3.883 ± 0.052	2.281SerLys: 2.281 ± 0.039	6.733SerLeu: 6.733 ± 0.063	1.749SerMet: 1.749 ± 0.034	2.235SerAsn: 2.235 ± 0.042	4.036SerPro: 4.036 ± 0.05	2.727SerGln: 2.727 ± 0.034	4.262SerArg: 4.262 ± 0.05	4.897SerSer: 4.897 ± 0.071	3.942SerThr: 3.942 ± 0.066	5.27SerVal: 5.27 ± 0.058	0.889SerTrp: 0.889 ± 0.021	1.389SerTyr: 1.389 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	5.862ThrAla: 5.862 ± 0.061	0.542ThrCys: 0.542 ± 0.017	3.965ThrAsp: 3.965 ± 0.056	2.943ThrGlu: 2.943 ± 0.041	2.108ThrPhe: 2.108 ± 0.044	4.861ThrGly: 4.861 ± 0.076	1.132ThrHis: 1.132 ± 0.023	3.478ThrIle: 3.478 ± 0.068	1.786ThrLys: 1.786 ± 0.033	5.543ThrLeu: 5.543 ± 0.067	1.283ThrMet: 1.283 ± 0.025	1.808ThrAsn: 1.808 ± 0.038	3.415ThrPro: 3.415 ± 0.042	2.013ThrGln: 2.013 ± 0.036	3.278ThrArg: 3.278 ± 0.047	3.906ThrSer: 3.906 ± 0.058	3.526ThrThr: 3.526 ± 0.069	4.388ThrVal: 4.388 ± 0.069	0.809ThrTrp: 0.809 ± 0.021	1.328ThrTyr: 1.328 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	7.945ValAla: 7.945 ± 0.075	0.927ValCys: 0.927 ± 0.024	5.378ValAsp: 5.378 ± 0.054	3.83ValGlu: 3.83 ± 0.042	2.474ValPhe: 2.474 ± 0.032	5.624ValGly: 5.624 ± 0.06	1.565ValHis: 1.565 ± 0.026	3.891ValIle: 3.891 ± 0.039	1.972ValLys: 1.972 ± 0.033	6.372ValLeu: 6.372 ± 0.061	1.712ValMet: 1.712 ± 0.032	2.054ValAsn: 2.054 ± 0.04	3.695ValPro: 3.695 ± 0.042	2.748ValGln: 2.748 ± 0.04	4.774ValArg: 4.774 ± 0.053	4.972ValSer: 4.972 ± 0.05	4.399ValThr: 4.399 ± 0.066	5.748ValVal: 5.748 ± 0.055	1.028ValTrp: 1.028 ± 0.023	1.573ValTyr: 1.573 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.139TrpAla: 1.139 ± 0.026	0.205TrpCys: 0.205 ± 0.01	0.844TrpAsp: 0.844 ± 0.02	0.576TrpGlu: 0.576 ± 0.017	0.581TrpPhe: 0.581 ± 0.016	0.921TrpGly: 0.921 ± 0.021	0.408TrpHis: 0.408 ± 0.015	0.992TrpIle: 0.992 ± 0.022	0.611TrpLys: 0.611 ± 0.02	1.63TrpLeu: 1.63 ± 0.034	0.529TrpMet: 0.529 ± 0.015	0.578TrpAsn: 0.578 ± 0.018	0.694TrpPro: 0.694 ± 0.021	0.755TrpGln: 0.755 ± 0.019	0.961TrpArg: 0.961 ± 0.022	1.006TrpSer: 1.006 ± 0.022	0.931TrpThr: 0.931 ± 0.021	0.974TrpVal: 0.974 ± 0.024	0.278TrpTrp: 0.278 ± 0.012	0.331TrpTyr: 0.331 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.047TyrAla: 2.047 ± 0.028	0.312TyrCys: 0.312 ± 0.011	1.605TyrAsp: 1.605 ± 0.039	1.284TyrGlu: 1.284 ± 0.024	0.972TyrPhe: 0.972 ± 0.024	1.895TyrGly: 1.895 ± 0.035	0.579TyrHis: 0.579 ± 0.015	0.744TyrIle: 0.744 ± 0.018	0.531TyrLys: 0.531 ± 0.016	2.183TyrLeu: 2.183 ± 0.035	0.329TyrMet: 0.329 ± 0.012	0.655TyrAsn: 0.655 ± 0.017	1.153TyrPro: 1.153 ± 0.024	1.179TyrGln: 1.179 ± 0.026	2.037TyrArg: 2.037 ± 0.027	1.411TyrSer: 1.411 ± 0.026	1.095TyrThr: 1.095 ± 0.038	1.55TyrVal: 1.55 ± 0.025	0.388TyrTrp: 0.388 ± 0.012	0.636TyrTyr: 0.636 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6373 proteins (2431915 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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