Amino acid dipepetide frequency for Campylobacter ureolyticus ACS-301-V-Sch3b

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.385AlaAla: 3.385 ± 0.096
0.723AlaCys: 0.723 ± 0.046
2.817AlaAsp: 2.817 ± 0.073
2.229AlaGlu: 2.229 ± 0.081
3.413AlaPhe: 3.413 ± 0.086
3.803AlaGly: 3.803 ± 0.101
0.944AlaHis: 0.944 ± 0.043
6.06AlaIle: 6.06 ± 0.12
7.027AlaLys: 7.027 ± 0.136
6.792AlaLeu: 6.792 ± 0.134
1.724AlaMet: 1.724 ± 0.067
3.926AlaAsn: 3.926 ± 0.096
1.454AlaPro: 1.454 ± 0.059
1.61AlaGln: 1.61 ± 0.057
2.061AlaArg: 2.061 ± 0.062
3.885AlaSer: 3.885 ± 0.099
2.958AlaThr: 2.958 ± 0.08
3.791AlaVal: 3.791 ± 0.102
0.357AlaTrp: 0.357 ± 0.033
2.278AlaTyr: 2.278 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.758CysAla: 0.758 ± 0.035
0.092CysCys: 0.092 ± 0.017
0.809CysAsp: 0.809 ± 0.052
0.923CysGlu: 0.923 ± 0.053
0.572CysPhe: 0.572 ± 0.037
0.905CysGly: 0.905 ± 0.044
0.245CysHis: 0.245 ± 0.036
0.795CysIle: 0.795 ± 0.042
0.936CysLys: 0.936 ± 0.044
0.854CysLeu: 0.854 ± 0.038
0.239CysMet: 0.239 ± 0.022
0.443CysAsn: 0.443 ± 0.029
0.36CysPro: 0.36 ± 0.03
0.276CysGln: 0.276 ± 0.025
0.239CysArg: 0.239 ± 0.023
0.643CysSer: 0.643 ± 0.036
0.308CysThr: 0.308 ± 0.023
0.688CysVal: 0.688 ± 0.039
0.072CysTrp: 0.072 ± 0.012
0.38CysTyr: 0.38 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
3.227AspAla: 3.227 ± 0.086
0.484AspCys: 0.484 ± 0.033
3.863AspAsp: 3.863 ± 0.106
7.166AspGlu: 7.166 ± 0.146
3.795AspPhe: 3.795 ± 0.095
3.489AspGly: 3.489 ± 0.093
0.5AspHis: 0.5 ± 0.03
5.709AspIle: 5.709 ± 0.114
6.348AspLys: 6.348 ± 0.125
5.368AspLeu: 5.368 ± 0.121
1.295AspMet: 1.295 ± 0.051
2.862AspAsn: 2.862 ± 0.09
1.344AspPro: 1.344 ± 0.055
0.839AspGln: 0.839 ± 0.041
1.677AspArg: 1.677 ± 0.053
2.978AspSer: 2.978 ± 0.085
2.159AspThr: 2.159 ± 0.067
2.874AspVal: 2.874 ± 0.076
0.31AspTrp: 0.31 ± 0.026
2.202AspTyr: 2.202 ± 0.069
0.0AspXaa: 0.0 ± 0.0
Glu
4.018GluAla: 4.018 ± 0.092
0.731GluCys: 0.731 ± 0.042
3.09GluAsp: 3.09 ± 0.089
3.807GluGlu: 3.807 ± 0.111
4.516GluPhe: 4.516 ± 0.112
2.376GluGly: 2.376 ± 0.078
0.793GluHis: 0.793 ± 0.043
8.663GluIle: 8.663 ± 0.166
7.202GluLys: 7.202 ± 0.157
6.575GluLeu: 6.575 ± 0.132
1.559GluMet: 1.559 ± 0.057
5.944GluAsn: 5.944 ± 0.124
1.542GluPro: 1.542 ± 0.07
1.375GluGln: 1.375 ± 0.059
1.898GluArg: 1.898 ± 0.059
3.086GluSer: 3.086 ± 0.093
2.218GluThr: 2.218 ± 0.063
4.222GluVal: 4.222 ± 0.105
0.443GluTrp: 0.443 ± 0.027
2.472GluTyr: 2.472 ± 0.07
0.0GluXaa: 0.0 ± 0.0
Phe
3.376PheAla: 3.376 ± 0.096
0.811PheCys: 0.811 ± 0.041
3.993PheAsp: 3.993 ± 0.098
3.936PheGlu: 3.936 ± 0.098
3.315PhePhe: 3.315 ± 0.102
3.848PheGly: 3.848 ± 0.1
0.643PheHis: 0.643 ± 0.034
5.92PheIle: 5.92 ± 0.134
5.603PheLys: 5.603 ± 0.134
6.477PheLeu: 6.477 ± 0.161
1.383PheMet: 1.383 ± 0.054
3.415PheAsn: 3.415 ± 0.088
1.148PhePro: 1.148 ± 0.048
0.903PheGln: 0.903 ± 0.038
1.456PheArg: 1.456 ± 0.057
4.259PheSer: 4.259 ± 0.112
2.353PheThr: 2.353 ± 0.064
3.323PheVal: 3.323 ± 0.096
0.492PheTrp: 0.492 ± 0.03
2.574PheTyr: 2.574 ± 0.079
0.0PheXaa: 0.0 ± 0.0
Gly
4.087GlyAla: 4.087 ± 0.106
0.776GlyCys: 0.776 ± 0.047
3.238GlyAsp: 3.238 ± 0.083
3.664GlyGlu: 3.664 ± 0.1
3.824GlyPhe: 3.824 ± 0.094
4.234GlyGly: 4.234 ± 0.131
0.935GlyHis: 0.935 ± 0.06
5.435GlyIle: 5.435 ± 0.107
4.951GlyLys: 4.951 ± 0.114
5.284GlyLeu: 5.284 ± 0.122
1.414GlyMet: 1.414 ± 0.059
2.725GlyAsn: 2.725 ± 0.091
0.823GlyPro: 0.823 ± 0.047
1.064GlyGln: 1.064 ± 0.051
1.777GlyArg: 1.777 ± 0.067
3.599GlySer: 3.599 ± 0.096
2.416GlyThr: 2.416 ± 0.079
4.753GlyVal: 4.753 ± 0.101
0.409GlyTrp: 0.409 ± 0.033
2.666GlyTyr: 2.666 ± 0.087
0.0GlyXaa: 0.0 ± 0.0
His
0.835HisAla: 0.835 ± 0.043
0.186HisCys: 0.186 ± 0.02
0.654HisAsp: 0.654 ± 0.039
0.733HisGlu: 0.733 ± 0.036
0.803HisPhe: 0.803 ± 0.04
0.852HisGly: 0.852 ± 0.042
0.264HisHis: 0.264 ± 0.025
1.207HisIle: 1.207 ± 0.047
1.162HisLys: 1.162 ± 0.044
1.405HisLeu: 1.405 ± 0.051
0.245HisMet: 0.245 ± 0.023
0.725HisAsn: 0.725 ± 0.044
0.613HisPro: 0.613 ± 0.036
0.372HisGln: 0.372 ± 0.027
0.449HisArg: 0.449 ± 0.033
0.964HisSer: 0.964 ± 0.04
0.713HisThr: 0.713 ± 0.04
0.511HisVal: 0.511 ± 0.032
0.11HisTrp: 0.11 ± 0.017
0.564HisTyr: 0.564 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
5.791IleAla: 5.791 ± 0.129
1.209IleCys: 1.209 ± 0.052
5.486IleAsp: 5.486 ± 0.111
5.372IleGlu: 5.372 ± 0.126
5.448IlePhe: 5.448 ± 0.129
5.209IleGly: 5.209 ± 0.115
1.097IleHis: 1.097 ± 0.046
7.623IleIle: 7.623 ± 0.177
9.658IleLys: 9.658 ± 0.166
9.758IleLeu: 9.758 ± 0.181
1.859IleMet: 1.859 ± 0.066
6.212IleAsn: 6.212 ± 0.15
2.602IlePro: 2.602 ± 0.072
1.755IleGln: 1.755 ± 0.062
2.423IleArg: 2.423 ± 0.08
7.143IleSer: 7.143 ± 0.13
4.328IleThr: 4.328 ± 0.094
4.849IleVal: 4.849 ± 0.114
0.586IleTrp: 0.586 ± 0.038
4.124IleTyr: 4.124 ± 0.105
0.0IleXaa: 0.0 ± 0.0
Lys
5.909LysAla: 5.909 ± 0.103
0.793LysCys: 0.793 ± 0.041
7.392LysAsp: 7.392 ± 0.159
8.781LysGlu: 8.781 ± 0.144
6.273LysPhe: 6.273 ± 0.131
4.433LysGly: 4.433 ± 0.095
1.093LysHis: 1.093 ± 0.05
9.803LysIle: 9.803 ± 0.144
10.146LysLys: 10.146 ± 0.189
7.231LysLeu: 7.231 ± 0.119
2.388LysMet: 2.388 ± 0.069
9.849LysAsn: 9.849 ± 0.203
2.645LysPro: 2.645 ± 0.075
2.414LysGln: 2.414 ± 0.084
3.123LysArg: 3.123 ± 0.091
6.156LysSer: 6.156 ± 0.117
5.429LysThr: 5.429 ± 0.11
4.802LysVal: 4.802 ± 0.092
0.545LysTrp: 0.545 ± 0.034
3.248LysTyr: 3.248 ± 0.091
0.0LysXaa: 0.0 ± 0.0
Leu
6.218LeuAla: 6.218 ± 0.115
1.048LeuCys: 1.048 ± 0.049
5.836LeuAsp: 5.836 ± 0.111
6.632LeuGlu: 6.632 ± 0.118
5.176LeuPhe: 5.176 ± 0.141
5.995LeuGly: 5.995 ± 0.126
1.125LeuHis: 1.125 ± 0.058
8.115LeuIle: 8.115 ± 0.13
11.51LeuLys: 11.51 ± 0.188
8.009LeuLeu: 8.009 ± 0.137
2.171LeuMet: 2.171 ± 0.077
8.019LeuAsn: 8.019 ± 0.153
2.896LeuPro: 2.896 ± 0.079
2.171LeuGln: 2.171 ± 0.064
2.952LeuArg: 2.952 ± 0.08
7.427LeuSer: 7.427 ± 0.14
4.187LeuThr: 4.187 ± 0.101
5.051LeuVal: 5.051 ± 0.118
0.574LeuTrp: 0.574 ± 0.036
3.193LeuTyr: 3.193 ± 0.085
0.0LeuXaa: 0.0 ± 0.0
Met
1.618MetAla: 1.618 ± 0.061
0.214MetCys: 0.214 ± 0.02
1.203MetAsp: 1.203 ± 0.046
1.207MetGlu: 1.207 ± 0.051
1.056MetPhe: 1.056 ± 0.055
1.428MetGly: 1.428 ± 0.057
0.364MetHis: 0.364 ± 0.028
1.94MetIle: 1.94 ± 0.07
2.302MetLys: 2.302 ± 0.07
2.306MetLeu: 2.306 ± 0.068
0.57MetMet: 0.57 ± 0.036
1.152MetAsn: 1.152 ± 0.047
0.999MetPro: 0.999 ± 0.042
0.917MetGln: 0.917 ± 0.046
0.758MetArg: 0.758 ± 0.036
1.657MetSer: 1.657 ± 0.058
0.764MetThr: 0.764 ± 0.036
1.256MetVal: 1.256 ± 0.053
0.153MetTrp: 0.153 ± 0.019
0.505MetTyr: 0.505 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
4.065AsnAla: 4.065 ± 0.1
0.521AsnCys: 0.521 ± 0.032
3.617AsnAsp: 3.617 ± 0.087
5.294AsnGlu: 5.294 ± 0.116
4.169AsnPhe: 4.169 ± 0.113
3.687AsnGly: 3.687 ± 0.109
0.891AsnHis: 0.891 ± 0.047
6.016AsnIle: 6.016 ± 0.128
6.224AsnLys: 6.224 ± 0.133
9.449AsnLeu: 9.449 ± 0.19
1.175AsnMet: 1.175 ± 0.045
3.556AsnAsn: 3.556 ± 0.13
2.251AsnPro: 2.251 ± 0.074
1.71AsnGln: 1.71 ± 0.061
1.732AsnArg: 1.732 ± 0.066
5.245AsnSer: 5.245 ± 0.145
2.672AsnThr: 2.672 ± 0.084
2.88AsnVal: 2.88 ± 0.075
0.372AsnTrp: 0.372 ± 0.025
2.594AsnTyr: 2.594 ± 0.077
0.0AsnXaa: 0.0 ± 0.0
Pro
1.463ProAla: 1.463 ± 0.052
0.27ProCys: 0.27 ± 0.026
1.313ProAsp: 1.313 ± 0.053
1.456ProGlu: 1.456 ± 0.063
1.642ProPhe: 1.642 ± 0.059
1.289ProGly: 1.289 ± 0.06
0.492ProHis: 0.492 ± 0.035
2.21ProIle: 2.21 ± 0.075
2.952ProLys: 2.952 ± 0.085
2.825ProLeu: 2.825 ± 0.08
0.507ProMet: 0.507 ± 0.036
2.122ProAsn: 2.122 ± 0.074
0.625ProPro: 0.625 ± 0.034
0.731ProGln: 0.731 ± 0.041
0.737ProArg: 0.737 ± 0.039
1.71ProSer: 1.71 ± 0.064
1.509ProThr: 1.509 ± 0.056
1.701ProVal: 1.701 ± 0.06
0.217ProTrp: 0.217 ± 0.018
1.232ProTyr: 1.232 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
1.324GlnAla: 1.324 ± 0.058
0.141GlnCys: 0.141 ± 0.016
1.199GlnAsp: 1.199 ± 0.052
1.293GlnGlu: 1.293 ± 0.056
0.762GlnPhe: 0.762 ± 0.04
1.152GlnGly: 1.152 ± 0.051
0.282GlnHis: 0.282 ± 0.022
2.676GlnIle: 2.676 ± 0.075
2.941GlnLys: 2.941 ± 0.074
1.342GlnLeu: 1.342 ± 0.054
0.547GlnMet: 0.547 ± 0.036
2.841GlnAsn: 2.841 ± 0.098
0.511GlnPro: 0.511 ± 0.036
0.406GlnGln: 0.406 ± 0.031
0.889GlnArg: 0.889 ± 0.044
1.512GlnSer: 1.512 ± 0.06
1.418GlnThr: 1.418 ± 0.059
1.023GlnVal: 1.023 ± 0.05
0.141GlnTrp: 0.141 ± 0.019
0.505GlnTyr: 0.505 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
2.037ArgAla: 2.037 ± 0.062
0.264ArgCys: 0.264 ± 0.024
1.81ArgAsp: 1.81 ± 0.071
1.881ArgGlu: 1.881 ± 0.058
1.749ArgPhe: 1.749 ± 0.053
1.585ArgGly: 1.585 ± 0.065
0.488ArgHis: 0.488 ± 0.03
2.425ArgIle: 2.425 ± 0.079
2.372ArgLys: 2.372 ± 0.084
2.845ArgLeu: 2.845 ± 0.077
0.637ArgMet: 0.637 ± 0.034
1.767ArgAsn: 1.767 ± 0.066
0.799ArgPro: 0.799 ± 0.046
0.866ArgGln: 0.866 ± 0.039
1.052ArgArg: 1.052 ± 0.052
1.726ArgSer: 1.726 ± 0.059
1.148ArgThr: 1.148 ± 0.053
2.302ArgVal: 2.302 ± 0.077
0.192ArgTrp: 0.192 ± 0.021
1.275ArgTyr: 1.275 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
3.554SerAla: 3.554 ± 0.089
0.629SerCys: 0.629 ± 0.04
3.875SerAsp: 3.875 ± 0.1
3.458SerGlu: 3.458 ± 0.092
4.343SerPhe: 4.343 ± 0.117
4.496SerGly: 4.496 ± 0.095
1.027SerHis: 1.027 ± 0.043
5.47SerIle: 5.47 ± 0.104
6.8SerLys: 6.8 ± 0.117
6.973SerLeu: 6.973 ± 0.115
1.409SerMet: 1.409 ± 0.049
4.218SerAsn: 4.218 ± 0.113
1.704SerPro: 1.704 ± 0.059
1.989SerGln: 1.989 ± 0.056
1.755SerArg: 1.755 ± 0.065
4.72SerSer: 4.72 ± 0.101
2.563SerThr: 2.563 ± 0.089
4.079SerVal: 4.079 ± 0.091
0.474SerTrp: 0.474 ± 0.029
2.643SerTyr: 2.643 ± 0.088
0.0SerXaa: 0.0 ± 0.0
Thr
2.68ThrAla: 2.68 ± 0.084
0.396ThrCys: 0.396 ± 0.027
2.083ThrAsp: 2.083 ± 0.065
1.8ThrGlu: 1.8 ± 0.061
2.179ThrPhe: 2.179 ± 0.079
2.711ThrGly: 2.711 ± 0.083
0.927ThrHis: 0.927 ± 0.045
3.979ThrIle: 3.979 ± 0.099
4.537ThrLys: 4.537 ± 0.09
4.706ThrLeu: 4.706 ± 0.082
0.917ThrMet: 0.917 ± 0.044
3.009ThrAsn: 3.009 ± 0.086
2.02ThrPro: 2.02 ± 0.065
1.293ThrGln: 1.293 ± 0.053
1.32ThrArg: 1.32 ± 0.058
2.935ThrSer: 2.935 ± 0.078
2.372ThrThr: 2.372 ± 0.073
1.757ThrVal: 1.757 ± 0.056
0.247ThrTrp: 0.247 ± 0.022
1.585ThrTyr: 1.585 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
4.03ValAla: 4.03 ± 0.104
0.825ValCys: 0.825 ± 0.044
3.344ValAsp: 3.344 ± 0.081
3.401ValGlu: 3.401 ± 0.09
3.268ValPhe: 3.268 ± 0.096
3.985ValGly: 3.985 ± 0.096
0.552ValHis: 0.552 ± 0.036
4.921ValIle: 4.921 ± 0.11
5.27ValLys: 5.27 ± 0.11
5.74ValLeu: 5.74 ± 0.122
1.36ValMet: 1.36 ± 0.051
3.033ValAsn: 3.033 ± 0.09
1.462ValPro: 1.462 ± 0.051
0.972ValGln: 0.972 ± 0.046
1.659ValArg: 1.659 ± 0.056
3.66ValSer: 3.66 ± 0.095
2.063ValThr: 2.063 ± 0.076
4.183ValVal: 4.183 ± 0.129
0.396ValTrp: 0.396 ± 0.031
1.857ValTyr: 1.857 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.458TrpAla: 0.458 ± 0.034
0.08TrpCys: 0.08 ± 0.012
0.376TrpAsp: 0.376 ± 0.024
0.333TrpGlu: 0.333 ± 0.029
0.394TrpPhe: 0.394 ± 0.029
0.46TrpGly: 0.46 ± 0.034
0.157TrpHis: 0.157 ± 0.017
0.58TrpIle: 0.58 ± 0.035
0.419TrpLys: 0.419 ± 0.026
0.701TrpLeu: 0.701 ± 0.041
0.196TrpMet: 0.196 ± 0.022
0.317TrpAsn: 0.317 ± 0.026
0.086TrpPro: 0.086 ± 0.014
0.27TrpGln: 0.27 ± 0.025
0.216TrpArg: 0.216 ± 0.023
0.343TrpSer: 0.343 ± 0.027
0.214TrpThr: 0.214 ± 0.022
0.39TrpVal: 0.39 ± 0.029
0.102TrpTrp: 0.102 ± 0.014
0.274TrpTyr: 0.274 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.404TyrAla: 2.404 ± 0.072
0.345TyrCys: 0.345 ± 0.027
2.49TyrAsp: 2.49 ± 0.075
3.168TyrGlu: 3.168 ± 0.095
2.529TyrPhe: 2.529 ± 0.078
2.133TyrGly: 2.133 ± 0.074
0.549TyrHis: 0.549 ± 0.029
2.986TyrIle: 2.986 ± 0.085
4.091TyrLys: 4.091 ± 0.084
3.664TyrLeu: 3.664 ± 0.081
0.772TyrMet: 0.772 ± 0.036
1.987TyrAsn: 1.987 ± 0.073
1.119TyrPro: 1.119 ± 0.047
0.974TyrGln: 0.974 ± 0.045
1.048TyrArg: 1.048 ± 0.044
2.531TyrSer: 2.531 ± 0.067
1.663TyrThr: 1.663 ± 0.065
1.548TyrVal: 1.548 ± 0.054
0.176TyrTrp: 0.176 ± 0.019
1.479TyrTyr: 1.479 ± 0.062
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1686 proteins (510434 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski