Amino acid dipepetide frequency for Anaerotignum neopropionicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.831AlaAla: 6.831 ± 0.131	1.056AlaCys: 1.056 ± 0.041	3.888AlaAsp: 3.888 ± 0.065	5.582AlaGlu: 5.582 ± 0.085	3.366AlaPhe: 3.366 ± 0.075	5.384AlaGly: 5.384 ± 0.104	1.034AlaHis: 1.034 ± 0.038	5.76AlaIle: 5.76 ± 0.096	5.56AlaLys: 5.56 ± 0.087	7.581AlaLeu: 7.581 ± 0.111	2.505AlaMet: 2.505 ± 0.055	2.796AlaAsn: 2.796 ± 0.069	2.165AlaPro: 2.165 ± 0.057	2.595AlaGln: 2.595 ± 0.056	2.502AlaArg: 2.502 ± 0.062	3.751AlaSer: 3.751 ± 0.076	3.936AlaThr: 3.936 ± 0.092	6.098AlaVal: 6.098 ± 0.096	0.545AlaTrp: 0.545 ± 0.028	2.685AlaTyr: 2.685 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	1.023CysAla: 1.023 ± 0.037	0.284CysCys: 0.284 ± 0.021	0.738CysAsp: 0.738 ± 0.031	0.884CysGlu: 0.884 ± 0.034	0.703CysPhe: 0.703 ± 0.031	1.429CysGly: 1.429 ± 0.038	0.292CysHis: 0.292 ± 0.019	1.182CysIle: 1.182 ± 0.04	0.834CysLys: 0.834 ± 0.034	1.063CysLeu: 1.063 ± 0.035	0.375CysMet: 0.375 ± 0.02	0.6CysAsn: 0.6 ± 0.025	0.573CysPro: 0.573 ± 0.028	0.372CysGln: 0.372 ± 0.019	0.559CysArg: 0.559 ± 0.025	0.841CysSer: 0.841 ± 0.034	0.719CysThr: 0.719 ± 0.033	0.939CysVal: 0.939 ± 0.033	0.12CysTrp: 0.12 ± 0.011	0.508CysTyr: 0.508 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	3.843AspAla: 3.843 ± 0.067	0.802AspCys: 0.802 ± 0.035	2.495AspAsp: 2.495 ± 0.07	4.302AspGlu: 4.302 ± 0.083	2.841AspPhe: 2.841 ± 0.053	4.272AspGly: 4.272 ± 0.094	0.804AspHis: 0.804 ± 0.032	4.456AspIle: 4.456 ± 0.073	3.335AspLys: 3.335 ± 0.066	4.42AspLeu: 4.42 ± 0.074	1.691AspMet: 1.691 ± 0.046	2.096AspAsn: 2.096 ± 0.064	1.44AspPro: 1.44 ± 0.049	1.161AspGln: 1.161 ± 0.035	1.985AspArg: 1.985 ± 0.049	2.917AspSer: 2.917 ± 0.056	2.828AspThr: 2.828 ± 0.069	3.674AspVal: 3.674 ± 0.067	0.564AspTrp: 0.564 ± 0.027	2.218AspTyr: 2.218 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	5.353GluAla: 5.353 ± 0.09	0.686GluCys: 0.686 ± 0.03	3.898GluAsp: 3.898 ± 0.079	6.669GluGlu: 6.669 ± 0.132	2.668GluPhe: 2.668 ± 0.059	4.584GluGly: 4.584 ± 0.082	1.124GluHis: 1.124 ± 0.039	6.358GluIle: 6.358 ± 0.106	7.268GluLys: 7.268 ± 0.108	6.418GluLeu: 6.418 ± 0.098	2.606GluMet: 2.606 ± 0.064	4.639GluAsn: 4.639 ± 0.086	1.713GluPro: 1.713 ± 0.051	2.712GluGln: 2.712 ± 0.062	3.281GluArg: 3.281 ± 0.082	3.143GluSer: 3.143 ± 0.061	3.641GluThr: 3.641 ± 0.071	4.679GluVal: 4.679 ± 0.083	0.599GluTrp: 0.599 ± 0.029	2.74GluTyr: 2.74 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	3.365PheAla: 3.365 ± 0.066	0.86PheCys: 0.86 ± 0.033	2.527PheAsp: 2.527 ± 0.054	2.837PheGlu: 2.837 ± 0.063	2.335PhePhe: 2.335 ± 0.072	3.392PheGly: 3.392 ± 0.077	0.866PheHis: 0.866 ± 0.031	3.255PheIle: 3.255 ± 0.069	2.063PheLys: 2.063 ± 0.058	4.503PheLeu: 4.503 ± 0.09	1.363PheMet: 1.363 ± 0.043	1.682PheAsn: 1.682 ± 0.046	1.552PhePro: 1.552 ± 0.043	1.508PheGln: 1.508 ± 0.045	1.565PheArg: 1.565 ± 0.045	3.255PheSer: 3.255 ± 0.067	2.523PheThr: 2.523 ± 0.061	3.072PheVal: 3.072 ± 0.063	0.439PheTrp: 0.439 ± 0.024	1.675PheTyr: 1.675 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	5.231GlyAla: 5.231 ± 0.096	1.267GlyCys: 1.267 ± 0.047	3.527GlyAsp: 3.527 ± 0.072	5.116GlyGlu: 5.116 ± 0.083	3.398GlyPhe: 3.398 ± 0.06	5.367GlyGly: 5.367 ± 0.09	1.145GlyHis: 1.145 ± 0.041	6.372GlyIle: 6.372 ± 0.092	5.637GlyLys: 5.637 ± 0.088	6.101GlyLeu: 6.101 ± 0.092	2.329GlyMet: 2.329 ± 0.059	3.281GlyAsn: 3.281 ± 0.07	1.224GlyPro: 1.224 ± 0.061	2.159GlyGln: 2.159 ± 0.056	2.846GlyArg: 2.846 ± 0.059	3.971GlySer: 3.971 ± 0.082	4.356GlyThr: 4.356 ± 0.106	5.402GlyVal: 5.402 ± 0.094	0.618GlyTrp: 0.618 ± 0.03	2.921GlyTyr: 2.921 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	0.988HisAla: 0.988 ± 0.033	0.316HisCys: 0.316 ± 0.021	0.761HisAsp: 0.761 ± 0.036	1.017HisGlu: 1.017 ± 0.036	0.821HisPhe: 0.821 ± 0.034	1.193HisGly: 1.193 ± 0.033	0.415HisHis: 0.415 ± 0.029	1.386HisIle: 1.386 ± 0.042	0.99HisLys: 0.99 ± 0.037	1.461HisLeu: 1.461 ± 0.047	0.506HisMet: 0.506 ± 0.025	0.739HisAsn: 0.739 ± 0.034	0.747HisPro: 0.747 ± 0.028	0.507HisGln: 0.507 ± 0.024	0.694HisArg: 0.694 ± 0.03	1.034HisSer: 1.034 ± 0.037	0.878HisThr: 0.878 ± 0.037	0.96HisVal: 0.96 ± 0.034	0.188HisTrp: 0.188 ± 0.018	0.661HisTyr: 0.661 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.144IleAla: 6.144 ± 0.089	1.293IleCys: 1.293 ± 0.038	4.142IleAsp: 4.142 ± 0.067	5.04IleGlu: 5.04 ± 0.087	3.416IlePhe: 3.416 ± 0.082	5.41IleGly: 5.41 ± 0.087	1.366IleHis: 1.366 ± 0.04	5.909IleIle: 5.909 ± 0.103	4.634IleLys: 4.634 ± 0.084	7.632IleLeu: 7.632 ± 0.129	2.086IleMet: 2.086 ± 0.05	3.324IleAsn: 3.324 ± 0.073	3.256IlePro: 3.256 ± 0.063	2.506IleGln: 2.506 ± 0.059	3.154IleArg: 3.154 ± 0.066	5.693IleSer: 5.693 ± 0.091	4.649IleThr: 4.649 ± 0.094	5.132IleVal: 5.132 ± 0.096	0.562IleTrp: 0.562 ± 0.027	2.792IleTyr: 2.792 ± 0.068	0.0IleXaa: 0.0 ± 0.0
Lys	5.16LysAla: 5.16 ± 0.086	0.666LysCys: 0.666 ± 0.032	3.961LysAsp: 3.961 ± 0.074	7.006LysGlu: 7.006 ± 0.097	2.082LysPhe: 2.082 ± 0.052	4.671LysGly: 4.671 ± 0.077	0.986LysHis: 0.986 ± 0.034	5.513LysIle: 5.513 ± 0.096	6.423LysLys: 6.423 ± 0.095	5.786LysLeu: 5.786 ± 0.084	2.426LysMet: 2.426 ± 0.054	4.016LysAsn: 4.016 ± 0.075	1.937LysPro: 1.937 ± 0.05	2.462LysGln: 2.462 ± 0.063	2.963LysArg: 2.963 ± 0.067	3.462LysSer: 3.462 ± 0.074	4.047LysThr: 4.047 ± 0.063	4.235LysVal: 4.235 ± 0.07	0.546LysTrp: 0.546 ± 0.029	2.651LysTyr: 2.651 ± 0.058	0.0LysXaa: 0.0 ± 0.0
Leu	7.081LeuAla: 7.081 ± 0.1	1.437LeuCys: 1.437 ± 0.047	4.732LeuAsp: 4.732 ± 0.072	6.872LeuGlu: 6.872 ± 0.099	4.401LeuPhe: 4.401 ± 0.086	6.333LeuGly: 6.333 ± 0.106	1.425LeuHis: 1.425 ± 0.045	6.133LeuIle: 6.133 ± 0.107	6.281LeuLys: 6.281 ± 0.101	8.963LeuLeu: 8.963 ± 0.141	2.588LeuMet: 2.588 ± 0.06	4.004LeuAsn: 4.004 ± 0.063	3.631LeuPro: 3.631 ± 0.061	3.16LeuGln: 3.16 ± 0.06	3.691LeuArg: 3.691 ± 0.063	6.513LeuSer: 6.513 ± 0.104	5.355LeuThr: 5.355 ± 0.088	5.525LeuVal: 5.525 ± 0.086	0.85LeuTrp: 0.85 ± 0.035	3.047LeuTyr: 3.047 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.551MetAla: 2.551 ± 0.069	0.301MetCys: 0.301 ± 0.018	1.809MetAsp: 1.809 ± 0.044	2.719MetGlu: 2.719 ± 0.06	0.973MetPhe: 0.973 ± 0.032	2.434MetGly: 2.434 ± 0.066	0.419MetHis: 0.419 ± 0.022	2.185MetIle: 2.185 ± 0.052	2.519MetLys: 2.519 ± 0.051	2.716MetLeu: 2.716 ± 0.056	0.904MetMet: 0.904 ± 0.034	1.547MetAsn: 1.547 ± 0.046	1.147MetPro: 1.147 ± 0.037	1.067MetGln: 1.067 ± 0.031	1.19MetArg: 1.19 ± 0.039	1.701MetSer: 1.701 ± 0.045	1.601MetThr: 1.601 ± 0.042	2.042MetVal: 2.042 ± 0.049	0.157MetTrp: 0.157 ± 0.013	0.748MetTyr: 0.748 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.318AsnAla: 3.318 ± 0.057	0.668AsnCys: 0.668 ± 0.032	2.23AsnAsp: 2.23 ± 0.051	3.131AsnGlu: 3.131 ± 0.058	1.845AsnPhe: 1.845 ± 0.051	3.724AsnGly: 3.724 ± 0.088	0.858AsnHis: 0.858 ± 0.032	3.864AsnIle: 3.864 ± 0.069	3.033AsnLys: 3.033 ± 0.07	4.015AsnLeu: 4.015 ± 0.068	1.342AsnMet: 1.342 ± 0.045	2.091AsnAsn: 2.091 ± 0.065	2.048AsnPro: 2.048 ± 0.048	1.634AsnGln: 1.634 ± 0.048	1.832AsnArg: 1.832 ± 0.05	2.568AsnSer: 2.568 ± 0.062	2.566AsnThr: 2.566 ± 0.065	2.939AsnVal: 2.939 ± 0.059	0.416AsnTrp: 0.416 ± 0.023	1.732AsnTyr: 1.732 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	2.135ProAla: 2.135 ± 0.072	0.429ProCys: 0.429 ± 0.023	1.752ProAsp: 1.752 ± 0.046	2.692ProGlu: 2.692 ± 0.067	1.687ProPhe: 1.687 ± 0.045	1.865ProGly: 1.865 ± 0.051	0.562ProHis: 0.562 ± 0.025	2.535ProIle: 2.535 ± 0.056	2.166ProLys: 2.166 ± 0.051	2.883ProLeu: 2.883 ± 0.059	1.001ProMet: 1.001 ± 0.037	1.529ProAsn: 1.529 ± 0.044	0.933ProPro: 0.933 ± 0.034	1.276ProGln: 1.276 ± 0.034	1.058ProArg: 1.058 ± 0.035	1.905ProSer: 1.905 ± 0.052	1.857ProThr: 1.857 ± 0.051	2.645ProVal: 2.645 ± 0.058	0.301ProTrp: 0.301 ± 0.019	1.423ProTyr: 1.423 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.515GlnAla: 2.515 ± 0.054	0.359GlnCys: 0.359 ± 0.022	1.496GlnAsp: 1.496 ± 0.043	2.723GlnGlu: 2.723 ± 0.057	1.195GlnPhe: 1.195 ± 0.04	2.302GlnGly: 2.302 ± 0.055	0.438GlnHis: 0.438 ± 0.02	2.575GlnIle: 2.575 ± 0.053	2.954GlnLys: 2.954 ± 0.057	2.951GlnLeu: 2.951 ± 0.065	1.166GlnMet: 1.166 ± 0.044	1.814GlnAsn: 1.814 ± 0.052	0.897GlnPro: 0.897 ± 0.031	1.236GlnGln: 1.236 ± 0.046	1.511GlnArg: 1.511 ± 0.049	1.664GlnSer: 1.664 ± 0.049	1.753GlnThr: 1.753 ± 0.045	1.983GlnVal: 1.983 ± 0.049	0.363GlnTrp: 0.363 ± 0.023	1.229GlnTyr: 1.229 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	2.526ArgAla: 2.526 ± 0.052	0.516ArgCys: 0.516 ± 0.025	1.904ArgAsp: 1.904 ± 0.055	3.134ArgGlu: 3.134 ± 0.068	1.793ArgPhe: 1.793 ± 0.057	2.443ArgGly: 2.443 ± 0.058	0.654ArgHis: 0.654 ± 0.025	3.223ArgIle: 3.223 ± 0.069	3.031ArgLys: 3.031 ± 0.07	3.835ArgLeu: 3.835 ± 0.073	1.316ArgMet: 1.316 ± 0.037	1.906ArgAsn: 1.906 ± 0.056	1.188ArgPro: 1.188 ± 0.039	1.418ArgGln: 1.418 ± 0.043	1.937ArgArg: 1.937 ± 0.053	1.899ArgSer: 1.899 ± 0.054	2.007ArgThr: 2.007 ± 0.056	2.557ArgVal: 2.557 ± 0.066	0.345ArgTrp: 0.345 ± 0.019	1.579ArgTyr: 1.579 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.371SerAla: 4.371 ± 0.085	0.755SerCys: 0.755 ± 0.032	2.834SerAsp: 2.834 ± 0.071	3.476SerGlu: 3.476 ± 0.07	3.008SerPhe: 3.008 ± 0.058	4.828SerGly: 4.828 ± 0.098	1.027SerHis: 1.027 ± 0.037	4.528SerIle: 4.528 ± 0.081	3.711SerLys: 3.711 ± 0.077	5.457SerLeu: 5.457 ± 0.09	1.766SerMet: 1.766 ± 0.047	2.512SerAsn: 2.512 ± 0.055	1.91SerPro: 1.91 ± 0.051	1.972SerGln: 1.972 ± 0.049	2.208SerArg: 2.208 ± 0.057	3.411SerSer: 3.411 ± 0.08	3.047SerThr: 3.047 ± 0.068	4.295SerVal: 4.295 ± 0.072	0.485SerTrp: 0.485 ± 0.023	2.258SerTyr: 2.258 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.783ThrAla: 4.783 ± 0.103	0.546ThrCys: 0.546 ± 0.024	2.981ThrAsp: 2.981 ± 0.079	3.67ThrGlu: 3.67 ± 0.061	2.377ThrPhe: 2.377 ± 0.063	4.472ThrGly: 4.472 ± 0.096	0.873ThrHis: 0.873 ± 0.028	4.284ThrIle: 4.284 ± 0.073	3.48ThrLys: 3.48 ± 0.072	5.285ThrLeu: 5.285 ± 0.093	1.523ThrMet: 1.523 ± 0.045	2.224ThrAsn: 2.224 ± 0.056	2.358ThrPro: 2.358 ± 0.061	1.799ThrGln: 1.799 ± 0.048	1.89ThrArg: 1.89 ± 0.053	2.879ThrSer: 2.879 ± 0.07	3.185ThrThr: 3.185 ± 0.084	4.556ThrVal: 4.556 ± 0.104	0.407ThrTrp: 0.407 ± 0.023	1.885ThrTyr: 1.885 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	5.252ValAla: 5.252 ± 0.096	1.06ValCys: 1.06 ± 0.038	3.68ValAsp: 3.68 ± 0.071	4.739ValGlu: 4.739 ± 0.078	3.49ValPhe: 3.49 ± 0.069	4.752ValGly: 4.752 ± 0.088	1.028ValHis: 1.028 ± 0.036	5.153ValIle: 5.153 ± 0.088	4.275ValLys: 4.275 ± 0.079	6.731ValLeu: 6.731 ± 0.101	2.007ValMet: 2.007 ± 0.059	2.88ValAsn: 2.88 ± 0.07	2.431ValPro: 2.431 ± 0.063	1.885ValGln: 1.885 ± 0.05	2.457ValArg: 2.457 ± 0.049	4.55ValSer: 4.55 ± 0.077	4.077ValThr: 4.077 ± 0.109	5.089ValVal: 5.089 ± 0.076	0.571ValTrp: 0.571 ± 0.028	2.451ValTyr: 2.451 ± 0.063	0.0ValXaa: 0.0 ± 0.0
Trp	0.625TrpAla: 0.625 ± 0.03	0.131TrpCys: 0.131 ± 0.013	0.531TrpAsp: 0.531 ± 0.027	0.617TrpGlu: 0.617 ± 0.028	0.36TrpPhe: 0.36 ± 0.023	0.629TrpGly: 0.629 ± 0.028	0.144TrpHis: 0.144 ± 0.015	0.595TrpIle: 0.595 ± 0.031	0.635TrpLys: 0.635 ± 0.03	0.805TrpLeu: 0.805 ± 0.034	0.242TrpMet: 0.242 ± 0.016	0.477TrpAsn: 0.477 ± 0.027	0.16TrpPro: 0.16 ± 0.015	0.363TrpGln: 0.363 ± 0.022	0.332TrpArg: 0.332 ± 0.022	0.464TrpSer: 0.464 ± 0.026	0.406TrpThr: 0.406 ± 0.022	0.55TrpVal: 0.55 ± 0.025	0.1TrpTrp: 0.1 ± 0.012	0.32TrpTyr: 0.32 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.525TyrAla: 2.525 ± 0.061	0.606TyrCys: 0.606 ± 0.029	2.258TyrAsp: 2.258 ± 0.056	2.551TyrGlu: 2.551 ± 0.056	1.877TyrPhe: 1.877 ± 0.053	2.783TyrGly: 2.783 ± 0.066	0.803TyrHis: 0.803 ± 0.03	2.876TyrIle: 2.876 ± 0.057	2.172TyrLys: 2.172 ± 0.057	3.421TyrLeu: 3.421 ± 0.068	0.988TyrMet: 0.988 ± 0.033	1.696TyrAsn: 1.696 ± 0.046	1.326TyrPro: 1.326 ± 0.04	1.335TyrGln: 1.335 ± 0.04	1.554TyrArg: 1.554 ± 0.04	2.236TyrSer: 2.236 ± 0.053	2.026TyrThr: 2.026 ± 0.053	2.183TyrVal: 2.183 ± 0.049	0.307TyrTrp: 0.307 ± 0.02	1.665TyrTyr: 1.665 ± 0.054	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2804 proteins (838418 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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