Amino acid dipepetide frequency for Avian paramyxovirus 15

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.367AlaAla: 4.367 ± 1.81
1.092AlaCys: 1.092 ± 0.527
2.183AlaAsp: 2.183 ± 0.558
4.148AlaGlu: 4.148 ± 0.981
1.528AlaPhe: 1.528 ± 0.762
3.057AlaGly: 3.057 ± 0.898
1.092AlaHis: 1.092 ± 0.571
5.459AlaIle: 5.459 ± 1.768
2.838AlaLys: 2.838 ± 0.491
5.895AlaLeu: 5.895 ± 1.385
1.31AlaMet: 1.31 ± 0.608
1.747AlaAsn: 1.747 ± 0.5
1.747AlaPro: 1.747 ± 0.927
3.712AlaGln: 3.712 ± 0.609
3.493AlaArg: 3.493 ± 0.866
5.677AlaSer: 5.677 ± 1.016
4.803AlaThr: 4.803 ± 0.403
4.803AlaVal: 4.803 ± 1.074
0.0AlaTrp: 0.0 ± 0.0
2.183AlaTyr: 2.183 ± 0.689
0.0AlaXaa: 0.0 ± 0.0
Cys
1.31CysAla: 1.31 ± 0.634
0.218CysCys: 0.218 ± 0.137
1.092CysAsp: 1.092 ± 0.464
0.437CysGlu: 0.437 ± 0.21
0.218CysPhe: 0.218 ± 0.247
0.437CysGly: 0.437 ± 0.21
0.655CysHis: 0.655 ± 0.251
1.31CysIle: 1.31 ± 0.273
1.528CysLys: 1.528 ± 0.583
1.528CysLeu: 1.528 ± 0.671
0.218CysMet: 0.218 ± 0.137
0.655CysAsn: 0.655 ± 0.411
0.655CysPro: 0.655 ± 0.513
0.873CysGln: 0.873 ± 0.42
1.528CysArg: 1.528 ± 0.237
1.965CysSer: 1.965 ± 0.651
1.747CysThr: 1.747 ± 0.406
1.528CysVal: 1.528 ± 0.406
0.218CysTrp: 0.218 ± 0.137
0.655CysTyr: 0.655 ± 0.251
0.0CysXaa: 0.0 ± 0.0
Asp
3.712AspAla: 3.712 ± 1.111
0.437AspCys: 0.437 ± 0.406
2.183AspAsp: 2.183 ± 0.532
2.402AspGlu: 2.402 ± 0.416
1.747AspPhe: 1.747 ± 1.095
1.747AspGly: 1.747 ± 0.398
1.092AspHis: 1.092 ± 0.388
5.677AspIle: 5.677 ± 1.006
3.275AspLys: 3.275 ± 0.982
4.803AspLeu: 4.803 ± 1.046
0.655AspMet: 0.655 ± 0.353
3.493AspAsn: 3.493 ± 0.652
3.93AspPro: 3.93 ± 0.654
1.092AspGln: 1.092 ± 0.495
0.437AspArg: 0.437 ± 0.208
3.93AspSer: 3.93 ± 0.527
3.93AspThr: 3.93 ± 1.245
1.528AspVal: 1.528 ± 0.549
0.218AspTrp: 0.218 ± 0.288
1.965AspTyr: 1.965 ± 0.675
0.0AspXaa: 0.0 ± 0.0
Glu
2.183GluAla: 2.183 ± 0.375
0.655GluCys: 0.655 ± 0.288
2.183GluAsp: 2.183 ± 0.559
3.275GluGlu: 3.275 ± 0.797
3.493GluPhe: 3.493 ± 0.852
2.838GluGly: 2.838 ± 0.753
0.437GluHis: 0.437 ± 0.21
6.114GluIle: 6.114 ± 1.006
2.838GluLys: 2.838 ± 0.909
5.895GluLeu: 5.895 ± 1.082
1.092GluMet: 1.092 ± 0.571
2.62GluAsn: 2.62 ± 0.671
1.747GluPro: 1.747 ± 0.398
2.838GluGln: 2.838 ± 1.004
3.275GluArg: 3.275 ± 0.482
5.895GluSer: 5.895 ± 1.205
3.493GluThr: 3.493 ± 0.906
2.183GluVal: 2.183 ± 0.507
0.873GluTrp: 0.873 ± 0.347
1.31GluTyr: 1.31 ± 0.487
0.0GluXaa: 0.0 ± 0.0
Phe
1.747PheAla: 1.747 ± 0.572
0.437PheCys: 0.437 ± 0.208
1.747PheAsp: 1.747 ± 1.095
1.528PheGlu: 1.528 ± 0.736
1.747PhePhe: 1.747 ± 0.554
1.747PheGly: 1.747 ± 0.39
0.655PheHis: 0.655 ± 0.299
2.402PheIle: 2.402 ± 1.232
3.712PheLys: 3.712 ± 1.006
4.148PheLeu: 4.148 ± 1.194
0.655PheMet: 0.655 ± 0.324
1.31PheAsn: 1.31 ± 0.444
1.092PhePro: 1.092 ± 0.72
0.873PheGln: 0.873 ± 0.682
1.092PheArg: 1.092 ± 0.745
2.402PheSer: 2.402 ± 0.64
2.183PheThr: 2.183 ± 0.295
1.747PheVal: 1.747 ± 0.543
0.437PheTrp: 0.437 ± 0.208
0.437PheTyr: 0.437 ± 0.274
0.0PheXaa: 0.0 ± 0.0
Gly
3.712GlyAla: 3.712 ± 0.931
1.31GlyCys: 1.31 ± 0.662
3.712GlyAsp: 3.712 ± 0.778
3.057GlyGlu: 3.057 ± 0.596
1.747GlyPhe: 1.747 ± 0.965
2.62GlyGly: 2.62 ± 0.856
0.873GlyHis: 0.873 ± 0.296
3.712GlyIle: 3.712 ± 0.938
1.31GlyLys: 1.31 ± 0.845
6.987GlyLeu: 6.987 ± 1.417
0.437GlyMet: 0.437 ± 0.274
2.838GlyAsn: 2.838 ± 2.078
1.092GlyPro: 1.092 ± 0.616
1.965GlyGln: 1.965 ± 0.366
3.493GlyArg: 3.493 ± 0.661
3.493GlySer: 3.493 ± 0.843
2.183GlyThr: 2.183 ± 0.557
5.022GlyVal: 5.022 ± 1.885
0.218GlyTrp: 0.218 ± 0.137
1.747GlyTyr: 1.747 ± 0.441
0.0GlyXaa: 0.0 ± 0.0
His
0.218HisAla: 0.218 ± 0.288
0.655HisCys: 0.655 ± 0.256
0.655HisAsp: 0.655 ± 0.251
0.873HisGlu: 0.873 ± 0.42
0.437HisPhe: 0.437 ± 0.577
1.31HisGly: 1.31 ± 0.366
0.655HisHis: 0.655 ± 0.411
1.31HisIle: 1.31 ± 0.634
0.655HisLys: 0.655 ± 0.411
2.62HisLeu: 2.62 ± 0.973
0.218HisMet: 0.218 ± 0.244
1.31HisAsn: 1.31 ± 0.464
2.183HisPro: 2.183 ± 0.906
0.437HisGln: 0.437 ± 0.634
0.437HisArg: 0.437 ± 0.274
1.747HisSer: 1.747 ± 0.525
0.873HisThr: 0.873 ± 0.298
1.092HisVal: 1.092 ± 0.495
0.218HisTrp: 0.218 ± 0.247
0.873HisTyr: 0.873 ± 0.287
0.0HisXaa: 0.0 ± 0.0
Ile
4.148IleAla: 4.148 ± 0.668
1.747IleCys: 1.747 ± 0.485
3.493IleAsp: 3.493 ± 1.121
4.803IleGlu: 4.803 ± 0.8
2.402IlePhe: 2.402 ± 0.876
5.022IleGly: 5.022 ± 1.355
1.965IleHis: 1.965 ± 0.991
6.55IleIle: 6.55 ± 1.288
4.803IleLys: 4.803 ± 1.287
8.952IleLeu: 8.952 ± 1.236
0.873IleMet: 0.873 ± 0.548
6.114IleAsn: 6.114 ± 0.672
4.148IlePro: 4.148 ± 0.458
5.459IleGln: 5.459 ± 0.573
3.93IleArg: 3.93 ± 0.766
8.079IleSer: 8.079 ± 0.981
5.022IleThr: 5.022 ± 1.48
4.148IleVal: 4.148 ± 0.968
1.747IleTrp: 1.747 ± 0.406
2.183IleTyr: 2.183 ± 0.375
0.0IleXaa: 0.0 ± 0.0
Lys
2.402LysAla: 2.402 ± 0.809
0.655LysCys: 0.655 ± 0.256
2.838LysAsp: 2.838 ± 0.523
2.62LysGlu: 2.62 ± 0.724
2.402LysPhe: 2.402 ± 0.777
2.183LysGly: 2.183 ± 0.837
1.747LysHis: 1.747 ± 0.473
4.148LysIle: 4.148 ± 0.428
3.712LysLys: 3.712 ± 1.442
8.079LysLeu: 8.079 ± 1.394
0.873LysMet: 0.873 ± 0.393
2.402LysAsn: 2.402 ± 0.639
3.057LysPro: 3.057 ± 1.341
1.31LysGln: 1.31 ± 0.344
2.183LysArg: 2.183 ± 0.536
4.585LysSer: 4.585 ± 0.89
3.493LysThr: 3.493 ± 0.783
1.965LysVal: 1.965 ± 0.54
0.218LysTrp: 0.218 ± 0.137
1.965LysTyr: 1.965 ± 0.685
0.0LysXaa: 0.0 ± 0.0
Leu
6.55LeuAla: 6.55 ± 1.726
2.62LeuCys: 2.62 ± 0.818
5.677LeuAsp: 5.677 ± 1.015
6.332LeuGlu: 6.332 ± 0.667
4.367LeuPhe: 4.367 ± 1.643
4.803LeuGly: 4.803 ± 0.828
2.838LeuHis: 2.838 ± 0.557
9.825LeuIle: 9.825 ± 1.485
7.642LeuLys: 7.642 ± 2.139
10.917LeuLeu: 10.917 ± 1.855
3.057LeuMet: 3.057 ± 1.126
5.895LeuAsn: 5.895 ± 1.325
3.712LeuPro: 3.712 ± 0.586
4.148LeuGln: 4.148 ± 0.39
4.148LeuArg: 4.148 ± 1.623
11.135LeuSer: 11.135 ± 1.994
6.987LeuThr: 6.987 ± 1.283
4.585LeuVal: 4.585 ± 0.764
1.528LeuTrp: 1.528 ± 0.394
4.367LeuTyr: 4.367 ± 1.164
0.0LeuXaa: 0.0 ± 0.0
Met
1.747MetAla: 1.747 ± 0.667
0.437MetCys: 0.437 ± 0.274
1.31MetAsp: 1.31 ± 0.506
1.528MetGlu: 1.528 ± 0.694
0.437MetPhe: 0.437 ± 0.274
1.31MetGly: 1.31 ± 1.195
0.437MetHis: 0.437 ± 0.24
1.092MetIle: 1.092 ± 0.332
0.655MetLys: 0.655 ± 0.513
1.092MetLeu: 1.092 ± 0.286
0.437MetMet: 0.437 ± 0.208
1.747MetAsn: 1.747 ± 0.693
0.655MetPro: 0.655 ± 0.288
0.0MetGln: 0.0 ± 0.0
1.31MetArg: 1.31 ± 0.576
1.528MetSer: 1.528 ± 0.529
1.31MetThr: 1.31 ± 0.304
0.437MetVal: 0.437 ± 0.274
0.218MetTrp: 0.218 ± 0.137
1.092MetTyr: 1.092 ± 0.271
0.0MetXaa: 0.0 ± 0.0
Asn
2.183AsnAla: 2.183 ± 0.475
0.437AsnCys: 0.437 ± 0.489
2.402AsnAsp: 2.402 ± 0.81
2.183AsnGlu: 2.183 ± 0.295
1.31AsnPhe: 1.31 ± 0.426
2.183AsnGly: 2.183 ± 0.1
0.218AsnHis: 0.218 ± 0.137
5.895AsnIle: 5.895 ± 1.719
1.747AsnLys: 1.747 ± 0.634
6.332AsnLeu: 6.332 ± 0.845
0.873AsnMet: 0.873 ± 0.493
3.493AsnAsn: 3.493 ± 0.848
2.62AsnPro: 2.62 ± 1.155
3.712AsnGln: 3.712 ± 0.698
1.747AsnArg: 1.747 ± 0.917
4.803AsnSer: 4.803 ± 1.069
2.62AsnThr: 2.62 ± 1.211
2.62AsnVal: 2.62 ± 0.471
0.655AsnTrp: 0.655 ± 0.411
3.057AsnTyr: 3.057 ± 0.795
0.0AsnXaa: 0.0 ± 0.0
Pro
3.057ProAla: 3.057 ± 0.991
0.218ProCys: 0.218 ± 0.245
3.275ProAsp: 3.275 ± 1.091
1.528ProGlu: 1.528 ± 0.565
0.655ProPhe: 0.655 ± 0.317
2.838ProGly: 2.838 ± 1.023
0.655ProHis: 0.655 ± 0.251
2.838ProIle: 2.838 ± 0.615
2.62ProLys: 2.62 ± 0.909
5.022ProLeu: 5.022 ± 1.6
0.437ProMet: 0.437 ± 0.253
1.528ProAsn: 1.528 ± 0.68
2.838ProPro: 2.838 ± 0.888
2.62ProGln: 2.62 ± 1.23
2.838ProArg: 2.838 ± 0.468
4.148ProSer: 4.148 ± 1.028
3.493ProThr: 3.493 ± 0.86
2.402ProVal: 2.402 ± 0.3
0.0ProTrp: 0.0 ± 0.0
1.747ProTyr: 1.747 ± 0.858
0.0ProXaa: 0.0 ± 0.0
Gln
2.402GlnAla: 2.402 ± 0.517
0.0GlnCys: 0.0 ± 0.0
2.183GlnAsp: 2.183 ± 1.663
2.838GlnGlu: 2.838 ± 1.078
2.183GlnPhe: 2.183 ± 0.345
2.402GlnGly: 2.402 ± 0.682
0.873GlnHis: 0.873 ± 0.548
3.712GlnIle: 3.712 ± 0.685
1.528GlnLys: 1.528 ± 0.726
5.24GlnLeu: 5.24 ± 1.082
0.655GlnMet: 0.655 ± 0.329
1.31GlnAsn: 1.31 ± 0.463
1.528GlnPro: 1.528 ± 0.505
2.183GlnGln: 2.183 ± 1.081
1.747GlnArg: 1.747 ± 0.814
3.93GlnSer: 3.93 ± 1.381
3.275GlnThr: 3.275 ± 1.051
4.585GlnVal: 4.585 ± 1.196
0.218GlnTrp: 0.218 ± 0.137
1.528GlnTyr: 1.528 ± 0.409
0.0GlnXaa: 0.0 ± 0.0
Arg
3.275ArgAla: 3.275 ± 0.781
0.655ArgCys: 0.655 ± 0.411
1.092ArgAsp: 1.092 ± 0.482
3.275ArgGlu: 3.275 ± 0.982
0.873ArgPhe: 0.873 ± 0.367
2.402ArgGly: 2.402 ± 0.592
0.655ArgHis: 0.655 ± 0.288
4.803ArgIle: 4.803 ± 1.382
2.183ArgLys: 2.183 ± 0.67
6.332ArgLeu: 6.332 ± 0.797
1.092ArgMet: 1.092 ± 0.449
2.838ArgAsn: 2.838 ± 0.807
2.62ArgPro: 2.62 ± 1.033
1.965ArgGln: 1.965 ± 0.648
2.838ArgArg: 2.838 ± 1.332
2.402ArgSer: 2.402 ± 0.63
1.747ArgThr: 1.747 ± 0.456
3.93ArgVal: 3.93 ± 0.752
0.655ArgTrp: 0.655 ± 0.525
1.092ArgTyr: 1.092 ± 0.302
0.0ArgXaa: 0.0 ± 0.0
Ser
5.677SerAla: 5.677 ± 0.402
2.402SerCys: 2.402 ± 0.396
4.803SerAsp: 4.803 ± 0.942
6.114SerGlu: 6.114 ± 1.107
2.183SerPhe: 2.183 ± 0.776
5.022SerGly: 5.022 ± 0.292
1.528SerHis: 1.528 ± 0.59
6.769SerIle: 6.769 ± 1.276
4.585SerLys: 4.585 ± 0.765
8.515SerLeu: 8.515 ± 0.861
2.402SerMet: 2.402 ± 0.632
4.148SerAsn: 4.148 ± 0.635
3.712SerPro: 3.712 ± 0.991
3.057SerGln: 3.057 ± 1.268
3.712SerArg: 3.712 ± 0.546
10.044SerSer: 10.044 ± 0.908
7.205SerThr: 7.205 ± 1.095
5.459SerVal: 5.459 ± 1.324
1.31SerTrp: 1.31 ± 0.366
2.838SerTyr: 2.838 ± 0.441
0.0SerXaa: 0.0 ± 0.0
Thr
5.459ThrAla: 5.459 ± 1.082
1.965ThrCys: 1.965 ± 0.332
2.838ThrAsp: 2.838 ± 1.01
3.275ThrGlu: 3.275 ± 0.911
1.31ThrPhe: 1.31 ± 0.344
3.275ThrGly: 3.275 ± 0.607
1.528ThrHis: 1.528 ± 0.289
5.459ThrIle: 5.459 ± 0.87
2.402ThrLys: 2.402 ± 0.63
6.987ThrLeu: 6.987 ± 1.149
1.092ThrMet: 1.092 ± 0.528
3.93ThrAsn: 3.93 ± 1.417
2.62ThrPro: 2.62 ± 0.687
3.057ThrGln: 3.057 ± 1.051
5.022ThrArg: 5.022 ± 0.775
5.022ThrSer: 5.022 ± 0.536
6.55ThrThr: 6.55 ± 1.957
3.93ThrVal: 3.93 ± 1.694
0.437ThrTrp: 0.437 ± 0.208
0.873ThrTyr: 0.873 ± 0.416
0.0ThrXaa: 0.0 ± 0.0
Val
3.712ValAla: 3.712 ± 1.107
1.747ValCys: 1.747 ± 0.525
2.402ValAsp: 2.402 ± 0.416
2.838ValGlu: 2.838 ± 0.635
2.183ValPhe: 2.183 ± 0.716
4.367ValGly: 4.367 ± 0.846
0.655ValHis: 0.655 ± 0.313
6.114ValIle: 6.114 ± 0.518
2.838ValLys: 2.838 ± 0.424
6.114ValLeu: 6.114 ± 1.317
1.528ValMet: 1.528 ± 0.314
1.747ValAsn: 1.747 ± 0.862
3.057ValPro: 3.057 ± 1.131
2.402ValGln: 2.402 ± 0.825
1.092ValArg: 1.092 ± 0.314
6.55ValSer: 6.55 ± 1.618
3.275ValThr: 3.275 ± 0.971
2.838ValVal: 2.838 ± 0.743
0.873ValTrp: 0.873 ± 0.264
1.31ValTyr: 1.31 ± 0.383
0.0ValXaa: 0.0 ± 0.0
Trp
0.655TrpAla: 0.655 ± 0.251
0.437TrpCys: 0.437 ± 0.208
0.0TrpAsp: 0.0 ± 0.0
1.092TrpGlu: 1.092 ± 0.495
0.218TrpPhe: 0.218 ± 0.256
0.218TrpGly: 0.218 ± 0.256
0.0TrpHis: 0.0 ± 0.0
0.437TrpIle: 0.437 ± 0.274
0.437TrpLys: 0.437 ± 0.21
1.31TrpLeu: 1.31 ± 0.449
0.218TrpMet: 0.218 ± 0.215
0.437TrpAsn: 0.437 ± 0.253
0.655TrpPro: 0.655 ± 0.436
0.0TrpGln: 0.0 ± 0.0
1.092TrpArg: 1.092 ± 0.464
0.873TrpSer: 0.873 ± 0.393
0.218TrpThr: 0.218 ± 0.137
0.873TrpVal: 0.873 ± 0.519
0.218TrpTrp: 0.218 ± 0.247
0.655TrpTyr: 0.655 ± 0.411
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.62TyrAla: 2.62 ± 0.446
0.655TyrCys: 0.655 ± 0.256
2.183TyrAsp: 2.183 ± 0.571
1.092TyrGlu: 1.092 ± 0.592
0.655TyrPhe: 0.655 ± 0.324
1.747TyrGly: 1.747 ± 0.574
0.218TyrHis: 0.218 ± 0.247
1.965TyrIle: 1.965 ± 0.446
1.528TyrLys: 1.528 ± 0.803
4.367TyrLeu: 4.367 ± 1.52
0.437TyrMet: 0.437 ± 0.253
1.528TyrAsn: 1.528 ± 0.506
1.092TyrPro: 1.092 ± 0.552
2.62TyrGln: 2.62 ± 0.627
1.31TyrArg: 1.31 ± 0.444
3.275TyrSer: 3.275 ± 0.596
2.62TyrThr: 2.62 ± 0.732
1.965TyrVal: 1.965 ± 0.605
0.0TyrTrp: 0.0 ± 0.0
0.873TyrTyr: 0.873 ± 0.264
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (4581 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski