Amino acid dipepetide frequency for Sulfurihydrogenibium yellowstonense SS-5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.163AlaAla: 3.163 ± 0.123
0.496AlaCys: 0.496 ± 0.036
2.711AlaAsp: 2.711 ± 0.077
3.854AlaGlu: 3.854 ± 0.091
2.818AlaPhe: 2.818 ± 0.081
3.975AlaGly: 3.975 ± 0.11
0.808AlaHis: 0.808 ± 0.044
5.619AlaIle: 5.619 ± 0.128
5.862AlaLys: 5.862 ± 0.121
5.82AlaLeu: 5.82 ± 0.119
1.272AlaMet: 1.272 ± 0.061
2.261AlaAsn: 2.261 ± 0.087
1.473AlaPro: 1.473 ± 0.058
1.453AlaGln: 1.453 ± 0.062
2.045AlaArg: 2.045 ± 0.082
3.018AlaSer: 3.018 ± 0.089
2.573AlaThr: 2.573 ± 0.089
4.441AlaVal: 4.441 ± 0.11
0.411AlaTrp: 0.411 ± 0.033
2.488AlaTyr: 2.488 ± 0.085
0.0AlaXaa: 0.0 ± 0.0
Cys
0.314CysAla: 0.314 ± 0.026
0.101CysCys: 0.101 ± 0.019
0.438CysAsp: 0.438 ± 0.029
0.489CysGlu: 0.489 ± 0.037
0.296CysPhe: 0.296 ± 0.027
0.65CysGly: 0.65 ± 0.043
0.22CysHis: 0.22 ± 0.023
0.521CysIle: 0.521 ± 0.033
0.583CysLys: 0.583 ± 0.037
0.565CysLeu: 0.565 ± 0.042
0.149CysMet: 0.149 ± 0.02
0.349CysAsn: 0.349 ± 0.028
0.457CysPro: 0.457 ± 0.039
0.22CysGln: 0.22 ± 0.02
0.278CysArg: 0.278 ± 0.02
0.464CysSer: 0.464 ± 0.038
0.282CysThr: 0.282 ± 0.025
0.413CysVal: 0.413 ± 0.033
0.062CysTrp: 0.062 ± 0.012
0.326CysTyr: 0.326 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
2.69AspAla: 2.69 ± 0.085
0.317AspCys: 0.317 ± 0.026
2.208AspAsp: 2.208 ± 0.084
4.241AspGlu: 4.241 ± 0.118
3.459AspPhe: 3.459 ± 0.095
2.956AspGly: 2.956 ± 0.085
0.581AspHis: 0.581 ± 0.042
5.678AspIle: 5.678 ± 0.115
5.543AspLys: 5.543 ± 0.116
5.903AspLeu: 5.903 ± 0.133
0.987AspMet: 0.987 ± 0.053
2.401AspAsn: 2.401 ± 0.067
1.981AspPro: 1.981 ± 0.071
0.863AspGln: 0.863 ± 0.044
2.144AspArg: 2.144 ± 0.075
2.252AspSer: 2.252 ± 0.075
2.148AspThr: 2.148 ± 0.073
3.746AspVal: 3.746 ± 0.092
0.539AspTrp: 0.539 ± 0.035
2.839AspTyr: 2.839 ± 0.081
0.0AspXaa: 0.0 ± 0.0
Glu
4.349GluAla: 4.349 ± 0.111
0.459GluCys: 0.459 ± 0.034
4.595GluAsp: 4.595 ± 0.112
8.038GluGlu: 8.038 ± 0.202
3.693GluPhe: 3.693 ± 0.092
4.416GluGly: 4.416 ± 0.12
0.934GluHis: 0.934 ± 0.048
8.719GluIle: 8.719 ± 0.176
10.319GluLys: 10.319 ± 0.166
6.892GluLeu: 6.892 ± 0.14
1.581GluMet: 1.581 ± 0.059
5.802GluAsn: 5.802 ± 0.15
1.666GluPro: 1.666 ± 0.064
1.336GluGln: 1.336 ± 0.064
3.452GluArg: 3.452 ± 0.103
3.78GluSer: 3.78 ± 0.094
2.949GluThr: 2.949 ± 0.081
5.265GluVal: 5.265 ± 0.114
0.436GluTrp: 0.436 ± 0.035
3.048GluTyr: 3.048 ± 0.088
0.0GluXaa: 0.0 ± 0.0
Phe
2.536PheAla: 2.536 ± 0.087
0.434PheCys: 0.434 ± 0.03
2.727PheAsp: 2.727 ± 0.085
3.743PheGlu: 3.743 ± 0.098
2.529PhePhe: 2.529 ± 0.099
3.294PheGly: 3.294 ± 0.097
0.705PheHis: 0.705 ± 0.04
4.767PheIle: 4.767 ± 0.123
4.317PheLys: 4.317 ± 0.108
5.543PheLeu: 5.543 ± 0.145
1.065PheMet: 1.065 ± 0.051
2.488PheAsn: 2.488 ± 0.08
1.613PhePro: 1.613 ± 0.068
1.177PheGln: 1.177 ± 0.056
1.558PheArg: 1.558 ± 0.065
3.115PheSer: 3.115 ± 0.093
2.502PheThr: 2.502 ± 0.07
3.014PheVal: 3.014 ± 0.094
0.402PheTrp: 0.402 ± 0.033
2.447PheTyr: 2.447 ± 0.083
0.0PheXaa: 0.0 ± 0.0
Gly
3.406GlyAla: 3.406 ± 0.112
0.56GlyCys: 0.56 ± 0.034
2.88GlyAsp: 2.88 ± 0.098
3.837GlyGlu: 3.837 ± 0.1
3.507GlyPhe: 3.507 ± 0.095
3.798GlyGly: 3.798 ± 0.101
0.994GlyHis: 0.994 ± 0.058
5.763GlyIle: 5.763 ± 0.13
5.938GlyLys: 5.938 ± 0.117
5.625GlyLeu: 5.625 ± 0.114
1.473GlyMet: 1.473 ± 0.061
2.729GlyAsn: 2.729 ± 0.099
1.129GlyPro: 1.129 ± 0.052
1.412GlyGln: 1.412 ± 0.068
2.463GlyArg: 2.463 ± 0.072
3.326GlySer: 3.326 ± 0.096
2.795GlyThr: 2.795 ± 0.087
3.936GlyVal: 3.936 ± 0.105
0.56GlyTrp: 0.56 ± 0.039
3.048GlyTyr: 3.048 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
0.737HisAla: 0.737 ± 0.038
0.161HisCys: 0.161 ± 0.02
0.597HisAsp: 0.597 ± 0.035
0.842HisGlu: 0.842 ± 0.045
0.764HisPhe: 0.764 ± 0.039
1.074HisGly: 1.074 ± 0.056
0.36HisHis: 0.36 ± 0.036
1.285HisIle: 1.285 ± 0.047
1.205HisLys: 1.205 ± 0.054
1.602HisLeu: 1.602 ± 0.059
0.259HisMet: 0.259 ± 0.026
0.636HisAsn: 0.636 ± 0.046
0.817HisPro: 0.817 ± 0.04
0.454HisGln: 0.454 ± 0.033
0.592HisArg: 0.592 ± 0.038
0.831HisSer: 0.831 ± 0.043
0.739HisThr: 0.739 ± 0.051
0.773HisVal: 0.773 ± 0.047
0.117HisTrp: 0.117 ± 0.017
0.695HisTyr: 0.695 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
5.554IleAla: 5.554 ± 0.116
0.624IleCys: 0.624 ± 0.048
5.462IleAsp: 5.462 ± 0.123
7.712IleGlu: 7.712 ± 0.164
4.42IlePhe: 4.42 ± 0.14
5.577IleGly: 5.577 ± 0.117
1.306IleHis: 1.306 ± 0.054
8.054IleIle: 8.054 ± 0.173
9.803IleLys: 9.803 ± 0.163
9.573IleLeu: 9.573 ± 0.18
1.453IleMet: 1.453 ± 0.055
4.891IleAsn: 4.891 ± 0.115
3.858IlePro: 3.858 ± 0.084
2.401IleGln: 2.401 ± 0.073
3.048IleArg: 3.048 ± 0.078
5.8IleSer: 5.8 ± 0.139
4.884IleThr: 4.884 ± 0.117
5.889IleVal: 5.889 ± 0.122
0.544IleTrp: 0.544 ± 0.034
3.652IleTyr: 3.652 ± 0.1
0.0IleXaa: 0.0 ± 0.0
Lys
5.793LysAla: 5.793 ± 0.14
0.51LysCys: 0.51 ± 0.039
6.807LysAsp: 6.807 ± 0.141
10.902LysGlu: 10.902 ± 0.192
3.932LysPhe: 3.932 ± 0.103
5.001LysGly: 5.001 ± 0.127
1.437LysHis: 1.437 ± 0.063
9.729LysIle: 9.729 ± 0.167
9.277LysLys: 9.277 ± 0.153
8.862LysLeu: 8.862 ± 0.16
1.871LysMet: 1.871 ± 0.074
6.025LysAsn: 6.025 ± 0.126
3.429LysPro: 3.429 ± 0.092
2.701LysGln: 2.701 ± 0.088
3.532LysArg: 3.532 ± 0.098
5.176LysSer: 5.176 ± 0.119
4.349LysThr: 4.349 ± 0.107
6.332LysVal: 6.332 ± 0.131
0.707LysTrp: 0.707 ± 0.04
4.01LysTyr: 4.01 ± 0.107
0.0LysXaa: 0.0 ± 0.0
Leu
6.022LeuAla: 6.022 ± 0.117
0.569LeuCys: 0.569 ± 0.037
5.079LeuAsp: 5.079 ± 0.111
8.329LeuGlu: 8.329 ± 0.158
4.292LeuPhe: 4.292 ± 0.128
5.419LeuGly: 5.419 ± 0.136
1.232LeuHis: 1.232 ± 0.058
8.66LeuIle: 8.66 ± 0.171
11.276LeuLys: 11.276 ± 0.175
8.336LeuLeu: 8.336 ± 0.169
1.85LeuMet: 1.85 ± 0.071
5.639LeuAsn: 5.639 ± 0.139
3.893LeuPro: 3.893 ± 0.101
2.52LeuGln: 2.52 ± 0.095
3.748LeuArg: 3.748 ± 0.094
6.647LeuSer: 6.647 ± 0.12
4.969LeuThr: 4.969 ± 0.109
5.164LeuVal: 5.164 ± 0.109
0.751LeuTrp: 0.751 ± 0.045
3.902LeuTyr: 3.902 ± 0.11
0.0LeuXaa: 0.0 ± 0.0
Met
1.457MetAla: 1.457 ± 0.062
0.108MetCys: 0.108 ± 0.014
0.941MetAsp: 0.941 ± 0.053
1.632MetGlu: 1.632 ± 0.055
0.955MetPhe: 0.955 ± 0.052
1.18MetGly: 1.18 ± 0.052
0.234MetHis: 0.234 ± 0.02
1.689MetIle: 1.689 ± 0.064
1.96MetLys: 1.96 ± 0.063
1.958MetLeu: 1.958 ± 0.068
0.471MetMet: 0.471 ± 0.032
0.865MetAsn: 0.865 ± 0.045
0.76MetPro: 0.76 ± 0.043
0.425MetGln: 0.425 ± 0.029
0.833MetArg: 0.833 ± 0.045
0.996MetSer: 0.996 ± 0.046
0.897MetThr: 0.897 ± 0.043
1.294MetVal: 1.294 ± 0.049
0.161MetTrp: 0.161 ± 0.02
0.725MetTyr: 0.725 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
2.486AsnAla: 2.486 ± 0.078
0.409AsnCys: 0.409 ± 0.03
2.274AsnAsp: 2.274 ± 0.084
3.218AsnGlu: 3.218 ± 0.098
2.805AsnPhe: 2.805 ± 0.094
2.619AsnGly: 2.619 ± 0.087
0.796AsnHis: 0.796 ± 0.048
5.394AsnIle: 5.394 ± 0.133
4.818AsnLys: 4.818 ± 0.119
6.323AsnLeu: 6.323 ± 0.147
0.861AsnMet: 0.861 ± 0.043
2.38AsnAsn: 2.38 ± 0.09
2.915AsnPro: 2.915 ± 0.088
1.967AsnGln: 1.967 ± 0.082
1.664AsnArg: 1.664 ± 0.061
2.366AsnSer: 2.366 ± 0.077
2.375AsnThr: 2.375 ± 0.08
3.296AsnVal: 3.296 ± 0.085
0.434AsnTrp: 0.434 ± 0.03
2.483AsnTyr: 2.483 ± 0.078
0.0AsnXaa: 0.0 ± 0.0
Pro
1.942ProAla: 1.942 ± 0.074
0.241ProCys: 0.241 ± 0.024
2.031ProAsp: 2.031 ± 0.067
3.456ProGlu: 3.456 ± 0.104
2.038ProPhe: 2.038 ± 0.066
1.737ProGly: 1.737 ± 0.088
0.65ProHis: 0.65 ± 0.044
3.096ProIle: 3.096 ± 0.099
3.011ProLys: 3.011 ± 0.09
2.952ProLeu: 2.952 ± 0.088
0.663ProMet: 0.663 ± 0.043
1.818ProAsn: 1.818 ± 0.066
1.43ProPro: 1.43 ± 0.076
0.973ProGln: 0.973 ± 0.052
1.021ProArg: 1.021 ± 0.046
2.04ProSer: 2.04 ± 0.076
1.829ProThr: 1.829 ± 0.069
2.74ProVal: 2.74 ± 0.083
0.296ProTrp: 0.296 ± 0.03
1.721ProTyr: 1.721 ± 0.06
0.0ProXaa: 0.0 ± 0.0
Gln
1.694GlnAla: 1.694 ± 0.064
0.138GlnCys: 0.138 ± 0.018
1.276GlnAsp: 1.276 ± 0.058
2.497GlnGlu: 2.497 ± 0.077
0.923GlnPhe: 0.923 ± 0.049
1.246GlnGly: 1.246 ± 0.056
0.386GlnHis: 0.386 ± 0.028
2.577GlnIle: 2.577 ± 0.083
2.766GlnLys: 2.766 ± 0.084
2.295GlnLeu: 2.295 ± 0.074
0.569GlnMet: 0.569 ± 0.042
1.423GlnAsn: 1.423 ± 0.066
0.886GlnPro: 0.886 ± 0.048
0.835GlnGln: 0.835 ± 0.059
1.024GlnArg: 1.024 ± 0.047
1.276GlnSer: 1.276 ± 0.05
1.372GlnThr: 1.372 ± 0.06
1.522GlnVal: 1.522 ± 0.061
0.255GlnTrp: 0.255 ± 0.028
1.01GlnTyr: 1.01 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
1.758ArgAla: 1.758 ± 0.067
0.241ArgCys: 0.241 ± 0.026
1.896ArgAsp: 1.896 ± 0.062
3.466ArgGlu: 3.466 ± 0.082
2.05ArgPhe: 2.05 ± 0.069
1.933ArgGly: 1.933 ± 0.072
0.532ArgHis: 0.532 ± 0.033
3.25ArgIle: 3.25 ± 0.096
3.564ArgLys: 3.564 ± 0.102
3.661ArgLeu: 3.661 ± 0.085
0.868ArgMet: 0.868 ± 0.05
1.795ArgAsn: 1.795 ± 0.054
1.324ArgPro: 1.324 ± 0.056
1.102ArgGln: 1.102 ± 0.049
1.448ArgArg: 1.448 ± 0.06
1.506ArgSer: 1.506 ± 0.058
1.331ArgThr: 1.331 ± 0.067
2.44ArgVal: 2.44 ± 0.077
0.324ArgTrp: 0.324 ± 0.03
1.604ArgTyr: 1.604 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
2.791SerAla: 2.791 ± 0.084
0.484SerCys: 0.484 ± 0.035
2.754SerAsp: 2.754 ± 0.072
3.629SerGlu: 3.629 ± 0.095
3.264SerPhe: 3.264 ± 0.111
3.395SerGly: 3.395 ± 0.086
0.927SerHis: 0.927 ± 0.046
5.061SerIle: 5.061 ± 0.129
5.375SerLys: 5.375 ± 0.116
5.841SerLeu: 5.841 ± 0.137
1.106SerMet: 1.106 ± 0.053
2.685SerAsn: 2.685 ± 0.093
1.942SerPro: 1.942 ± 0.067
1.864SerGln: 1.864 ± 0.066
1.772SerArg: 1.772 ± 0.061
3.165SerSer: 3.165 ± 0.104
2.176SerThr: 2.176 ± 0.081
3.422SerVal: 3.422 ± 0.085
0.434SerTrp: 0.434 ± 0.037
2.532SerTyr: 2.532 ± 0.087
0.0SerXaa: 0.0 ± 0.0
Thr
3.064ThrAla: 3.064 ± 0.08
0.308ThrCys: 0.308 ± 0.026
2.424ThrAsp: 2.424 ± 0.073
2.915ThrGlu: 2.915 ± 0.085
2.371ThrPhe: 2.371 ± 0.064
3.383ThrGly: 3.383 ± 0.094
0.675ThrHis: 0.675 ± 0.042
3.92ThrIle: 3.92 ± 0.11
3.505ThrLys: 3.505 ± 0.093
4.393ThrLeu: 4.393 ± 0.111
0.748ThrMet: 0.748 ± 0.042
1.857ThrAsn: 1.857 ± 0.071
2.07ThrPro: 2.07 ± 0.076
1.171ThrGln: 1.171 ± 0.057
1.32ThrArg: 1.32 ± 0.055
2.256ThrSer: 2.256 ± 0.073
2.196ThrThr: 2.196 ± 0.088
3.3ThrVal: 3.3 ± 0.083
0.301ThrTrp: 0.301 ± 0.026
1.884ThrTyr: 1.884 ± 0.072
0.0ThrXaa: 0.0 ± 0.0
Val
4.083ValAla: 4.083 ± 0.118
0.562ValCys: 0.562 ± 0.035
3.645ValAsp: 3.645 ± 0.101
5.194ValGlu: 5.194 ± 0.128
3.142ValPhe: 3.142 ± 0.083
4.386ValGly: 4.386 ± 0.115
0.845ValHis: 0.845 ± 0.047
6.174ValIle: 6.174 ± 0.136
6.479ValLys: 6.479 ± 0.137
6.58ValLeu: 6.58 ± 0.106
1.391ValMet: 1.391 ± 0.058
3.075ValAsn: 3.075 ± 0.089
2.132ValPro: 2.132 ± 0.076
1.297ValGln: 1.297 ± 0.054
2.33ValArg: 2.33 ± 0.083
3.858ValSer: 3.858 ± 0.094
1.359ValThr: 1.359 ± 0.073
4.762ValVal: 4.762 ± 0.117
0.489ValTrp: 0.489 ± 0.035
3.025ValTyr: 3.025 ± 0.078
0.0ValXaa: 0.0 ± 0.0
Trp
0.418TrpAla: 0.418 ± 0.028
0.08TrpCys: 0.08 ± 0.016
0.436TrpAsp: 0.436 ± 0.032
0.574TrpGlu: 0.574 ± 0.042
0.392TrpPhe: 0.392 ± 0.032
0.425TrpGly: 0.425 ± 0.028
0.156TrpHis: 0.156 ± 0.02
0.849TrpIle: 0.849 ± 0.049
0.691TrpLys: 0.691 ± 0.046
0.767TrpLeu: 0.767 ± 0.043
0.19TrpMet: 0.19 ± 0.018
0.379TrpAsn: 0.379 ± 0.034
0.163TrpPro: 0.163 ± 0.021
0.372TrpGln: 0.372 ± 0.031
0.264TrpArg: 0.264 ± 0.023
0.356TrpSer: 0.356 ± 0.031
0.312TrpThr: 0.312 ± 0.033
0.441TrpVal: 0.441 ± 0.038
0.094TrpTrp: 0.094 ± 0.016
0.347TrpTyr: 0.347 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.302TyrAla: 2.302 ± 0.076
0.376TyrCys: 0.376 ± 0.033
2.293TyrAsp: 2.293 ± 0.078
3.163TyrGlu: 3.163 ± 0.081
2.325TyrPhe: 2.325 ± 0.085
2.717TyrGly: 2.717 ± 0.085
0.764TyrHis: 0.764 ± 0.044
3.7TyrIle: 3.7 ± 0.101
4.09TyrLys: 4.09 ± 0.116
4.806TyrLeu: 4.806 ± 0.118
0.711TyrMet: 0.711 ± 0.041
2.385TyrAsn: 2.385 ± 0.082
1.749TyrPro: 1.749 ± 0.062
1.428TyrGln: 1.428 ± 0.062
1.556TyrArg: 1.556 ± 0.063
2.394TyrSer: 2.394 ± 0.073
2.02TyrThr: 2.02 ± 0.073
2.616TyrVal: 2.616 ± 0.081
0.39TyrTrp: 0.39 ± 0.028
2.036TyrTyr: 2.036 ± 0.08
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1670 proteins (435704 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski