Amino acid dipepetide frequency for Corynebacterium testudinoris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.721AlaAla: 15.721 ± 0.212	0.817AlaCys: 0.817 ± 0.034	7.129AlaAsp: 7.129 ± 0.107	7.757AlaGlu: 7.757 ± 0.13	3.598AlaPhe: 3.598 ± 0.074	10.211AlaGly: 10.211 ± 0.128	2.319AlaHis: 2.319 ± 0.052	5.812AlaIle: 5.812 ± 0.101	2.988AlaLys: 2.988 ± 0.075	11.953AlaLeu: 11.953 ± 0.153	2.799AlaMet: 2.799 ± 0.067	2.698AlaAsn: 2.698 ± 0.064	5.205AlaPro: 5.205 ± 0.108	3.851AlaGln: 3.851 ± 0.079	7.288AlaArg: 7.288 ± 0.117	6.226AlaSer: 6.226 ± 0.096	7.128AlaThr: 7.128 ± 0.092	9.971AlaVal: 9.971 ± 0.132	1.599AlaTrp: 1.599 ± 0.045	2.294AlaTyr: 2.294 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.709CysAla: 0.709 ± 0.033	0.068CysCys: 0.068 ± 0.01	0.414CysAsp: 0.414 ± 0.022	0.335CysGlu: 0.335 ± 0.022	0.192CysPhe: 0.192 ± 0.015	0.673CysGly: 0.673 ± 0.033	0.153CysHis: 0.153 ± 0.016	0.274CysIle: 0.274 ± 0.017	0.122CysLys: 0.122 ± 0.013	0.568CysLeu: 0.568 ± 0.031	0.105CysMet: 0.105 ± 0.011	0.131CysAsn: 0.131 ± 0.015	0.391CysPro: 0.391 ± 0.026	0.195CysGln: 0.195 ± 0.015	0.341CysArg: 0.341 ± 0.024	0.442CysSer: 0.442 ± 0.021	0.452CysThr: 0.452 ± 0.025	0.529CysVal: 0.529 ± 0.025	0.075CysTrp: 0.075 ± 0.009	0.12CysTyr: 0.12 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.17AspAla: 7.17 ± 0.105	0.32AspCys: 0.32 ± 0.021	3.785AspAsp: 3.785 ± 0.088	4.149AspGlu: 4.149 ± 0.09	2.028AspPhe: 2.028 ± 0.049	5.266AspGly: 5.266 ± 0.091	1.392AspHis: 1.392 ± 0.045	3.191AspIle: 3.191 ± 0.064	1.669AspLys: 1.669 ± 0.05	6.15AspLeu: 6.15 ± 0.088	1.217AspMet: 1.217 ± 0.039	1.652AspAsn: 1.652 ± 0.045	3.929AspPro: 3.929 ± 0.068	1.748AspGln: 1.748 ± 0.051	3.844AspArg: 3.844 ± 0.078	3.239AspSer: 3.239 ± 0.076	3.377AspThr: 3.377 ± 0.061	5.098AspVal: 5.098 ± 0.088	0.812AspTrp: 0.812 ± 0.035	1.465AspTyr: 1.465 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	6.572GluAla: 6.572 ± 0.102	0.313GluCys: 0.313 ± 0.02	3.349GluAsp: 3.349 ± 0.067	4.173GluGlu: 4.173 ± 0.108	2.006GluPhe: 2.006 ± 0.049	4.363GluGly: 4.363 ± 0.072	1.528GluHis: 1.528 ± 0.042	3.212GluIle: 3.212 ± 0.059	2.049GluLys: 2.049 ± 0.051	7.038GluLeu: 7.038 ± 0.113	1.289GluMet: 1.289 ± 0.043	1.586GluAsn: 1.586 ± 0.046	2.787GluPro: 2.787 ± 0.063	2.463GluGln: 2.463 ± 0.057	4.084GluArg: 4.084 ± 0.072	3.12GluSer: 3.12 ± 0.059	2.941GluThr: 2.941 ± 0.059	5.076GluVal: 5.076 ± 0.088	0.888GluTrp: 0.888 ± 0.036	1.207GluTyr: 1.207 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.813PheAla: 3.813 ± 0.076	0.242PheCys: 0.242 ± 0.018	2.413PheAsp: 2.413 ± 0.059	1.704PheGlu: 1.704 ± 0.048	1.247PhePhe: 1.247 ± 0.046	3.434PheGly: 3.434 ± 0.068	0.794PheHis: 0.794 ± 0.028	1.719PheIle: 1.719 ± 0.05	0.629PheLys: 0.629 ± 0.031	3.267PheLeu: 3.267 ± 0.071	0.635PheMet: 0.635 ± 0.032	0.964PheAsn: 0.964 ± 0.035	1.593PhePro: 1.593 ± 0.041	0.891PheGln: 0.891 ± 0.035	1.822PheArg: 1.822 ± 0.054	2.048PheSer: 2.048 ± 0.055	2.187PheThr: 2.187 ± 0.056	2.397PheVal: 2.397 ± 0.059	0.435PheTrp: 0.435 ± 0.028	0.803PheTyr: 0.803 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	8.805GlyAla: 8.805 ± 0.124	0.612GlyCys: 0.612 ± 0.03	4.54GlyAsp: 4.54 ± 0.078	4.999GlyGlu: 4.999 ± 0.079	3.242GlyPhe: 3.242 ± 0.062	6.875GlyGly: 6.875 ± 0.123	1.96GlyHis: 1.96 ± 0.051	4.825GlyIle: 4.825 ± 0.086	2.474GlyLys: 2.474 ± 0.055	8.597GlyLeu: 8.597 ± 0.115	2.313GlyMet: 2.313 ± 0.057	2.12GlyAsn: 2.12 ± 0.06	3.561GlyPro: 3.561 ± 0.069	2.74GlyGln: 2.74 ± 0.052	5.457GlyArg: 5.457 ± 0.088	5.111GlySer: 5.111 ± 0.086	5.505GlyThr: 5.505 ± 0.074	7.466GlyVal: 7.466 ± 0.104	1.533GlyTrp: 1.533 ± 0.045	2.156GlyTyr: 2.156 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.188HisAla: 2.188 ± 0.057	0.187HisCys: 0.187 ± 0.016	1.363HisAsp: 1.363 ± 0.045	1.175HisGlu: 1.175 ± 0.039	0.694HisPhe: 0.694 ± 0.026	1.905HisGly: 1.905 ± 0.049	0.67HisHis: 0.67 ± 0.029	0.973HisIle: 0.973 ± 0.037	0.379HisLys: 0.379 ± 0.023	2.363HisLeu: 2.363 ± 0.061	0.4HisMet: 0.4 ± 0.021	0.593HisAsn: 0.593 ± 0.028	1.565HisPro: 1.565 ± 0.05	0.682HisGln: 0.682 ± 0.03	1.571HisArg: 1.571 ± 0.043	1.249HisSer: 1.249 ± 0.04	1.219HisThr: 1.219 ± 0.041	1.613HisVal: 1.613 ± 0.043	0.286HisTrp: 0.286 ± 0.017	0.495HisTyr: 0.495 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.738IleAla: 6.738 ± 0.115	0.364IleCys: 0.364 ± 0.022	4.177IleAsp: 4.177 ± 0.082	2.897IleGlu: 2.897 ± 0.065	1.62IlePhe: 1.62 ± 0.053	4.601IleGly: 4.601 ± 0.092	1.015IleHis: 1.015 ± 0.034	2.966IleIle: 2.966 ± 0.07	1.163IleLys: 1.163 ± 0.045	4.461IleLeu: 4.461 ± 0.083	1.012IleMet: 1.012 ± 0.04	1.506IleAsn: 1.506 ± 0.046	2.726IlePro: 2.726 ± 0.069	1.217IleGln: 1.217 ± 0.042	2.815IleArg: 2.815 ± 0.064	2.979IleSer: 2.979 ± 0.068	3.436IleThr: 3.436 ± 0.074	4.489IleVal: 4.489 ± 0.079	0.527IleTrp: 0.527 ± 0.026	1.046IleTyr: 1.046 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	2.961LysAla: 2.961 ± 0.075	0.101LysCys: 0.101 ± 0.012	1.486LysAsp: 1.486 ± 0.047	1.622LysGlu: 1.622 ± 0.056	0.721LysPhe: 0.721 ± 0.029	1.878LysGly: 1.878 ± 0.06	0.599LysHis: 0.599 ± 0.027	1.335LysIle: 1.335 ± 0.042	1.274LysLys: 1.274 ± 0.051	2.49LysLeu: 2.49 ± 0.062	0.613LysMet: 0.613 ± 0.027	0.814LysAsn: 0.814 ± 0.031	1.268LysPro: 1.268 ± 0.043	0.948LysGln: 0.948 ± 0.037	1.718LysArg: 1.718 ± 0.051	1.372LysSer: 1.372 ± 0.043	1.426LysThr: 1.426 ± 0.041	2.189LysVal: 2.189 ± 0.053	0.331LysTrp: 0.331 ± 0.021	0.613LysTyr: 0.613 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	12.961LeuAla: 12.961 ± 0.181	0.628LeuCys: 0.628 ± 0.027	6.574LeuAsp: 6.574 ± 0.11	5.085LeuGlu: 5.085 ± 0.092	3.034LeuPhe: 3.034 ± 0.082	9.049LeuGly: 9.049 ± 0.121	2.018LeuHis: 2.018 ± 0.051	5.544LeuIle: 5.544 ± 0.097	2.352LeuLys: 2.352 ± 0.065	9.866LeuLeu: 9.866 ± 0.163	2.089LeuMet: 2.089 ± 0.051	2.617LeuAsn: 2.617 ± 0.058	5.586LeuPro: 5.586 ± 0.094	2.662LeuGln: 2.662 ± 0.056	6.634LeuArg: 6.634 ± 0.102	6.453LeuSer: 6.453 ± 0.096	6.459LeuThr: 6.459 ± 0.091	8.441LeuVal: 8.441 ± 0.11	1.246LeuTrp: 1.246 ± 0.043	1.783LeuTyr: 1.783 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.6MetAla: 2.6 ± 0.059	0.134MetCys: 0.134 ± 0.013	1.141MetAsp: 1.141 ± 0.045	1.084MetGlu: 1.084 ± 0.035	0.761MetPhe: 0.761 ± 0.029	1.725MetGly: 1.725 ± 0.06	0.404MetHis: 0.404 ± 0.02	1.172MetIle: 1.172 ± 0.041	0.619MetLys: 0.619 ± 0.025	2.224MetLeu: 2.224 ± 0.052	0.495MetMet: 0.495 ± 0.026	0.687MetAsn: 0.687 ± 0.03	1.168MetPro: 1.168 ± 0.037	0.595MetGln: 0.595 ± 0.025	1.355MetArg: 1.355 ± 0.039	1.836MetSer: 1.836 ± 0.044	1.779MetThr: 1.779 ± 0.045	1.822MetVal: 1.822 ± 0.053	0.314MetTrp: 0.314 ± 0.018	0.358MetTyr: 0.358 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.808AsnAla: 2.808 ± 0.059	0.173AsnCys: 0.173 ± 0.017	1.514AsnAsp: 1.514 ± 0.05	1.388AsnGlu: 1.388 ± 0.037	0.836AsnPhe: 0.836 ± 0.035	2.125AsnGly: 2.125 ± 0.051	0.555AsnHis: 0.555 ± 0.026	1.33AsnIle: 1.33 ± 0.045	0.699AsnLys: 0.699 ± 0.027	2.635AsnLeu: 2.635 ± 0.056	0.52AsnMet: 0.52 ± 0.027	0.853AsnAsn: 0.853 ± 0.034	1.874AsnPro: 1.874 ± 0.047	0.874AsnGln: 0.874 ± 0.036	1.702AsnArg: 1.702 ± 0.048	1.597AsnSer: 1.597 ± 0.051	1.384AsnThr: 1.384 ± 0.04	1.999AsnVal: 1.999 ± 0.049	0.398AsnTrp: 0.398 ± 0.021	0.716AsnTyr: 0.716 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.205ProAla: 6.205 ± 0.106	0.21ProCys: 0.21 ± 0.018	3.581ProAsp: 3.581 ± 0.078	4.076ProGlu: 4.076 ± 0.079	1.594ProPhe: 1.594 ± 0.046	4.804ProGly: 4.804 ± 0.089	1.113ProHis: 1.113 ± 0.036	2.17ProIle: 2.17 ± 0.057	1.238ProLys: 1.238 ± 0.045	4.821ProLeu: 4.821 ± 0.08	1.075ProMet: 1.075 ± 0.036	1.319ProAsn: 1.319 ± 0.04	2.111ProPro: 2.111 ± 0.073	1.712ProGln: 1.712 ± 0.042	2.95ProArg: 2.95 ± 0.06	2.997ProSer: 2.997 ± 0.06	3.488ProThr: 3.488 ± 0.075	4.614ProVal: 4.614 ± 0.078	0.753ProTrp: 0.753 ± 0.033	1.095ProTyr: 1.095 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.016GlnAla: 4.016 ± 0.075	0.136GlnCys: 0.136 ± 0.013	1.427GlnAsp: 1.427 ± 0.042	1.798GlnGlu: 1.798 ± 0.055	0.992GlnPhe: 0.992 ± 0.036	2.265GlnGly: 2.265 ± 0.055	0.622GlnHis: 0.622 ± 0.025	1.653GlnIle: 1.653 ± 0.048	0.755GlnLys: 0.755 ± 0.032	3.693GlnLeu: 3.693 ± 0.072	0.798GlnMet: 0.798 ± 0.032	0.652GlnAsn: 0.652 ± 0.029	1.64GlnPro: 1.64 ± 0.049	1.288GlnGln: 1.288 ± 0.045	2.522GlnArg: 2.522 ± 0.056	1.575GlnSer: 1.575 ± 0.043	1.432GlnThr: 1.432 ± 0.043	2.739GlnVal: 2.739 ± 0.064	0.553GlnTrp: 0.553 ± 0.027	0.583GlnTyr: 0.583 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	6.7ArgAla: 6.7 ± 0.089	0.321ArgCys: 0.321 ± 0.019	3.836ArgAsp: 3.836 ± 0.075	4.375ArgGlu: 4.375 ± 0.078	2.122ArgPhe: 2.122 ± 0.051	4.69ArgGly: 4.69 ± 0.081	1.483ArgHis: 1.483 ± 0.043	3.425ArgIle: 3.425 ± 0.06	1.765ArgLys: 1.765 ± 0.047	6.468ArgLeu: 6.468 ± 0.092	1.62ArgMet: 1.62 ± 0.049	1.686ArgAsn: 1.686 ± 0.048	3.158ArgPro: 3.158 ± 0.065	2.292ArgGln: 2.292 ± 0.046	5.379ArgArg: 5.379 ± 0.108	3.675ArgSer: 3.675 ± 0.066	3.901ArgThr: 3.901 ± 0.072	4.96ArgVal: 4.96 ± 0.077	1.025ArgTrp: 1.025 ± 0.036	1.56ArgTyr: 1.56 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	6.511SerAla: 6.511 ± 0.088	0.365SerCys: 0.365 ± 0.022	3.268SerAsp: 3.268 ± 0.07	3.076SerGlu: 3.076 ± 0.064	2.103SerPhe: 2.103 ± 0.047	5.591SerGly: 5.591 ± 0.078	1.228SerHis: 1.228 ± 0.037	2.803SerIle: 2.803 ± 0.064	1.411SerLys: 1.411 ± 0.046	5.977SerLeu: 5.977 ± 0.098	1.494SerMet: 1.494 ± 0.041	1.431SerAsn: 1.431 ± 0.041	3.223SerPro: 3.223 ± 0.066	1.969SerGln: 1.969 ± 0.048	3.719SerArg: 3.719 ± 0.072	3.753SerSer: 3.753 ± 0.076	4.068SerThr: 4.068 ± 0.076	4.566SerVal: 4.566 ± 0.067	0.958SerTrp: 0.958 ± 0.036	1.349SerTyr: 1.349 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.855ThrAla: 6.855 ± 0.091	0.426ThrCys: 0.426 ± 0.024	3.548ThrAsp: 3.548 ± 0.065	3.262ThrGlu: 3.262 ± 0.065	2.071ThrPhe: 2.071 ± 0.052	5.57ThrGly: 5.57 ± 0.072	1.277ThrHis: 1.277 ± 0.036	3.256ThrIle: 3.256 ± 0.062	1.482ThrLys: 1.482 ± 0.045	6.063ThrLeu: 6.063 ± 0.084	1.34ThrMet: 1.34 ± 0.043	1.477ThrAsn: 1.477 ± 0.044	4.001ThrPro: 4.001 ± 0.067	1.701ThrGln: 1.701 ± 0.048	3.596ThrArg: 3.596 ± 0.06	3.852ThrSer: 3.852 ± 0.078	4.103ThrThr: 4.103 ± 0.081	5.621ThrVal: 5.621 ± 0.088	1.068ThrTrp: 1.068 ± 0.039	1.352ThrTyr: 1.352 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	10.228ValAla: 10.228 ± 0.137	0.605ValCys: 0.605 ± 0.027	5.924ValAsp: 5.924 ± 0.088	5.135ValGlu: 5.135 ± 0.091	2.711ValPhe: 2.711 ± 0.065	6.928ValGly: 6.928 ± 0.109	1.684ValHis: 1.684 ± 0.047	4.509ValIle: 4.509 ± 0.085	1.894ValLys: 1.894 ± 0.055	8.255ValLeu: 8.255 ± 0.128	1.737ValMet: 1.737 ± 0.05	2.177ValAsn: 2.177 ± 0.055	4.291ValPro: 4.291 ± 0.093	1.95ValGln: 1.95 ± 0.05	4.964ValArg: 4.964 ± 0.075	5.119ValSer: 5.119 ± 0.085	5.611ValThr: 5.611 ± 0.08	7.749ValVal: 7.749 ± 0.112	1.114ValTrp: 1.114 ± 0.035	1.581ValTyr: 1.581 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.563TrpAla: 1.563 ± 0.047	0.117TrpCys: 0.117 ± 0.013	0.715TrpAsp: 0.715 ± 0.027	0.792TrpGlu: 0.792 ± 0.031	0.596TrpPhe: 0.596 ± 0.027	0.992TrpGly: 0.992 ± 0.037	0.293TrpHis: 0.293 ± 0.02	0.776TrpIle: 0.776 ± 0.033	0.424TrpLys: 0.424 ± 0.028	1.665TrpLeu: 1.665 ± 0.051	0.397TrpMet: 0.397 ± 0.023	0.432TrpAsn: 0.432 ± 0.027	0.704TrpPro: 0.704 ± 0.03	0.562TrpGln: 0.562 ± 0.024	1.031TrpArg: 1.031 ± 0.035	0.872TrpSer: 0.872 ± 0.03	0.843TrpThr: 0.843 ± 0.033	1.177TrpVal: 1.177 ± 0.043	0.382TrpTrp: 0.382 ± 0.023	0.288TrpTyr: 0.288 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.239TyrAla: 2.239 ± 0.051	0.147TyrCys: 0.147 ± 0.011	1.317TyrAsp: 1.317 ± 0.037	1.162TyrGlu: 1.162 ± 0.045	0.869TyrPhe: 0.869 ± 0.039	1.947TyrGly: 1.947 ± 0.054	0.463TyrHis: 0.463 ± 0.024	0.809TyrIle: 0.809 ± 0.033	0.374TyrLys: 0.374 ± 0.021	2.527TyrLeu: 2.527 ± 0.059	0.323TyrMet: 0.323 ± 0.019	0.585TyrAsn: 0.585 ± 0.021	1.146TyrPro: 1.146 ± 0.04	0.799TyrGln: 0.799 ± 0.035	1.652TyrArg: 1.652 ± 0.051	1.348TyrSer: 1.348 ± 0.047	1.183TyrThr: 1.183 ± 0.042	1.652TyrVal: 1.652 ± 0.044	0.324TyrTrp: 0.324 ± 0.019	0.517TyrTyr: 0.517 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2543 proteins (818509 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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