Amino acid dipepetide frequency for Lake Sinai Virus SA1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.069AlaAla: 9.069 ± 2.591
0.605AlaCys: 0.605 ± 0.372
5.441AlaAsp: 5.441 ± 1.188
1.814AlaGlu: 1.814 ± 0.385
4.837AlaPhe: 4.837 ± 0.806
3.628AlaGly: 3.628 ± 1.461
1.814AlaHis: 1.814 ± 0.385
4.232AlaIle: 4.232 ± 0.489
2.418AlaLys: 2.418 ± 1.832
6.046AlaLeu: 6.046 ± 1.193
1.209AlaMet: 1.209 ± 0.563
1.209AlaAsn: 1.209 ± 0.745
6.046AlaPro: 6.046 ± 1.489
1.209AlaGln: 1.209 ± 0.965
3.628AlaArg: 3.628 ± 1.548
9.674AlaSer: 9.674 ± 1.785
5.441AlaThr: 5.441 ± 0.441
5.441AlaVal: 5.441 ± 1.224
0.605AlaTrp: 0.605 ± 0.458
3.628AlaTyr: 3.628 ± 0.475
0.0AlaXaa: 0.0 ± 0.0
Cys
3.628CysAla: 3.628 ± 1.203
1.814CysCys: 1.814 ± 0.602
1.814CysAsp: 1.814 ± 0.385
1.209CysGlu: 1.209 ± 0.201
1.209CysPhe: 1.209 ± 0.745
1.814CysGly: 1.814 ± 0.385
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
3.628CysLeu: 3.628 ± 1.548
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
1.814CysPro: 1.814 ± 0.385
0.605CysGln: 0.605 ± 0.372
3.023CysArg: 3.023 ± 0.795
3.023CysSer: 3.023 ± 0.772
0.605CysThr: 0.605 ± 0.372
0.605CysVal: 0.605 ± 0.458
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.232AspAla: 4.232 ± 0.61
1.209AspCys: 1.209 ± 0.916
4.232AspAsp: 4.232 ± 0.642
1.814AspGlu: 1.814 ± 0.986
2.418AspPhe: 2.418 ± 0.731
5.441AspGly: 5.441 ± 0.451
1.814AspHis: 1.814 ± 1.204
3.023AspIle: 3.023 ± 1.094
0.605AspLys: 0.605 ± 0.458
5.441AspLeu: 5.441 ± 1.805
0.605AspMet: 0.605 ± 0.372
0.605AspAsn: 0.605 ± 0.372
4.232AspPro: 4.232 ± 0.489
2.418AspGln: 2.418 ± 1.489
4.232AspArg: 4.232 ± 1.371
4.232AspSer: 4.232 ± 1.626
4.232AspThr: 4.232 ± 1.626
1.814AspVal: 1.814 ± 0.385
0.0AspTrp: 0.0 ± 0.0
3.023AspTyr: 3.023 ± 0.795
0.0AspXaa: 0.0 ± 0.0
Glu
3.023GluAla: 3.023 ± 1.861
1.209GluCys: 1.209 ± 0.874
1.209GluAsp: 1.209 ± 0.745
0.605GluGlu: 0.605 ± 0.372
1.209GluPhe: 1.209 ± 0.201
3.023GluGly: 3.023 ± 0.795
1.209GluHis: 1.209 ± 0.916
3.023GluIle: 3.023 ± 0.772
1.209GluLys: 1.209 ± 0.201
3.023GluLeu: 3.023 ± 0.597
0.0GluMet: 0.0 ± 0.0
1.209GluAsn: 1.209 ± 0.745
1.814GluPro: 1.814 ± 1.374
0.605GluGln: 0.605 ± 0.372
3.628GluArg: 3.628 ± 0.604
3.023GluSer: 3.023 ± 1.861
0.605GluThr: 0.605 ± 0.372
3.023GluVal: 3.023 ± 1.18
0.0GluTrp: 0.0 ± 0.0
4.837GluTyr: 4.837 ± 0.806
0.0GluXaa: 0.0 ± 0.0
Phe
1.814PheAla: 1.814 ± 0.385
2.418PheCys: 2.418 ± 0.403
3.023PheAsp: 3.023 ± 1.558
1.814PheGlu: 1.814 ± 0.385
1.814PhePhe: 1.814 ± 0.986
3.023PheGly: 3.023 ± 1.861
0.605PheHis: 0.605 ± 0.372
3.023PheIle: 3.023 ± 0.795
1.209PheLys: 1.209 ± 0.201
2.418PheLeu: 2.418 ± 1.832
2.418PheMet: 2.418 ± 0.731
0.605PheAsn: 0.605 ± 0.372
1.814PhePro: 1.814 ± 0.385
1.209PheGln: 1.209 ± 0.874
1.814PheArg: 1.814 ± 1.117
4.837PheSer: 4.837 ± 0.858
0.0PheThr: 0.0 ± 0.0
3.628PheVal: 3.628 ± 1.042
0.605PheTrp: 0.605 ± 0.458
1.814PheTyr: 1.814 ± 0.602
0.0PheXaa: 0.0 ± 0.0
Gly
4.232GlyAla: 4.232 ± 1.107
1.814GlyCys: 1.814 ± 0.602
2.418GlyAsp: 2.418 ± 0.403
2.418GlyGlu: 2.418 ± 0.403
3.628GlyPhe: 3.628 ± 0.475
2.418GlyGly: 2.418 ± 0.403
1.209GlyHis: 1.209 ± 0.874
3.023GlyIle: 3.023 ± 0.772
1.209GlyLys: 1.209 ± 0.201
4.232GlyLeu: 4.232 ± 1.558
1.814GlyMet: 1.814 ± 1.028
0.605GlyAsn: 0.605 ± 0.458
3.628GlyPro: 3.628 ± 1.461
1.209GlyGln: 1.209 ± 0.745
4.232GlyArg: 4.232 ± 1.348
4.232GlySer: 4.232 ± 0.61
0.605GlyThr: 0.605 ± 0.372
4.232GlyVal: 4.232 ± 1.831
1.209GlyTrp: 1.209 ± 0.201
1.814GlyTyr: 1.814 ± 1.117
0.0GlyXaa: 0.0 ± 0.0
His
2.418HisAla: 2.418 ± 0.731
0.0HisCys: 0.0 ± 0.0
1.814HisAsp: 1.814 ± 0.385
0.605HisGlu: 0.605 ± 0.372
0.605HisPhe: 0.605 ± 0.372
0.605HisGly: 0.605 ± 0.913
0.0HisHis: 0.0 ± 0.0
1.209HisIle: 1.209 ± 0.916
0.605HisLys: 0.605 ± 0.372
1.209HisLeu: 1.209 ± 0.745
1.209HisMet: 1.209 ± 0.201
0.605HisAsn: 0.605 ± 0.372
3.628HisPro: 3.628 ± 0.771
0.0HisGln: 0.0 ± 0.0
3.023HisArg: 3.023 ± 1.094
1.814HisSer: 1.814 ± 0.602
2.418HisThr: 2.418 ± 1.544
4.232HisVal: 4.232 ± 2.414
1.209HisTrp: 1.209 ± 0.745
1.209HisTyr: 1.209 ± 0.745
0.0HisXaa: 0.0 ± 0.0
Ile
3.023IleAla: 3.023 ± 1.49
0.605IleCys: 0.605 ± 0.372
3.628IleAsp: 3.628 ± 0.604
1.814IleGlu: 1.814 ± 0.602
0.605IlePhe: 0.605 ± 0.372
3.023IleGly: 3.023 ± 0.49
1.814IleHis: 1.814 ± 0.385
3.628IleIle: 3.628 ± 0.771
1.814IleLys: 1.814 ± 0.602
2.418IleLeu: 2.418 ± 0.874
0.0IleMet: 0.0 ± 0.0
0.605IleAsn: 0.605 ± 0.458
3.023IlePro: 3.023 ± 0.772
2.418IleGln: 2.418 ± 0.403
1.814IleArg: 1.814 ± 0.602
6.651IleSer: 6.651 ± 1.363
3.023IleThr: 3.023 ± 0.49
3.628IleVal: 3.628 ± 0.771
0.605IleTrp: 0.605 ± 0.372
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
2.418LysAla: 2.418 ± 0.403
0.605LysCys: 0.605 ± 0.458
1.814LysAsp: 1.814 ± 0.602
1.814LysGlu: 1.814 ± 1.374
0.0LysPhe: 0.0 ± 0.0
1.814LysGly: 1.814 ± 0.385
0.0LysHis: 0.0 ± 0.0
1.209LysIle: 1.209 ± 0.916
0.0LysLys: 0.0 ± 0.0
0.605LysLeu: 0.605 ± 0.458
0.605LysMet: 0.605 ± 0.458
0.0LysAsn: 0.0 ± 0.0
0.605LysPro: 0.605 ± 0.458
0.605LysGln: 0.605 ± 0.458
2.418LysArg: 2.418 ± 0.731
1.814LysSer: 1.814 ± 0.385
1.814LysThr: 1.814 ± 0.602
2.418LysVal: 2.418 ± 0.403
0.0LysTrp: 0.0 ± 0.0
2.418LysTyr: 2.418 ± 0.403
0.0LysXaa: 0.0 ± 0.0
Leu
7.86LeuAla: 7.86 ± 2.318
3.023LeuCys: 3.023 ± 0.597
5.441LeuAsp: 5.441 ± 0.441
3.023LeuGlu: 3.023 ± 0.597
3.023LeuPhe: 3.023 ± 1.861
4.837LeuGly: 4.837 ± 0.806
2.418LeuHis: 2.418 ± 0.674
4.232LeuIle: 4.232 ± 1.649
2.418LeuLys: 2.418 ± 1.832
12.696LeuLeu: 12.696 ± 1.361
1.814LeuMet: 1.814 ± 0.385
3.023LeuAsn: 3.023 ± 1.504
4.837LeuPro: 4.837 ± 1.606
1.814LeuGln: 1.814 ± 1.374
11.487LeuArg: 11.487 ± 0.449
15.115LeuSer: 15.115 ± 2.358
6.046LeuThr: 6.046 ± 3.009
8.464LeuVal: 8.464 ± 3.162
0.605LeuTrp: 0.605 ± 0.458
3.023LeuTyr: 3.023 ± 1.18
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.605MetCys: 0.605 ± 0.372
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
0.605MetPhe: 0.605 ± 0.458
1.814MetGly: 1.814 ± 0.385
0.605MetHis: 0.605 ± 0.458
0.605MetIle: 0.605 ± 0.458
0.605MetLys: 0.605 ± 0.372
3.023MetLeu: 3.023 ± 1.18
0.605MetMet: 0.605 ± 0.372
1.209MetAsn: 1.209 ± 0.201
1.209MetPro: 1.209 ± 0.874
0.0MetGln: 0.0 ± 0.0
1.814MetArg: 1.814 ± 0.744
2.418MetSer: 2.418 ± 1.05
0.0MetThr: 0.0 ± 0.0
0.605MetVal: 0.605 ± 0.372
0.0MetTrp: 0.0 ± 0.0
1.814MetTyr: 1.814 ± 0.602
0.0MetXaa: 0.0 ± 0.0
Asn
1.209AsnAla: 1.209 ± 0.965
0.605AsnCys: 0.605 ± 0.372
2.418AsnAsp: 2.418 ± 0.731
1.814AsnGlu: 1.814 ± 1.117
1.209AsnPhe: 1.209 ± 0.201
1.209AsnGly: 1.209 ± 0.916
1.814AsnHis: 1.814 ± 1.117
0.605AsnIle: 0.605 ± 0.458
0.605AsnLys: 0.605 ± 0.372
3.023AsnLeu: 3.023 ± 0.772
0.605AsnMet: 0.605 ± 0.458
1.814AsnAsn: 1.814 ± 0.385
1.814AsnPro: 1.814 ± 0.602
0.605AsnGln: 0.605 ± 0.372
3.628AsnArg: 3.628 ± 0.604
0.0AsnSer: 0.0 ± 0.0
1.209AsnThr: 1.209 ± 0.201
1.209AsnVal: 1.209 ± 0.874
0.605AsnTrp: 0.605 ± 0.372
1.209AsnTyr: 1.209 ± 0.916
0.0AsnXaa: 0.0 ± 0.0
Pro
3.628ProAla: 3.628 ± 0.604
0.605ProCys: 0.605 ± 0.372
2.418ProAsp: 2.418 ± 0.674
2.418ProGlu: 2.418 ± 1.489
1.814ProPhe: 1.814 ± 0.602
1.209ProGly: 1.209 ± 0.201
4.232ProHis: 4.232 ± 0.642
2.418ProIle: 2.418 ± 1.05
1.209ProLys: 1.209 ± 0.201
6.651ProLeu: 6.651 ± 2.699
1.814ProMet: 1.814 ± 0.709
2.418ProAsn: 2.418 ± 0.874
3.023ProPro: 3.023 ± 1.504
0.605ProGln: 0.605 ± 0.913
6.651ProArg: 6.651 ± 2.731
4.232ProSer: 4.232 ± 0.61
7.86ProThr: 7.86 ± 1.872
4.837ProVal: 4.837 ± 0.858
1.814ProTrp: 1.814 ± 0.385
3.023ProTyr: 3.023 ± 0.772
0.0ProXaa: 0.0 ± 0.0
Gln
0.605GlnAla: 0.605 ± 0.913
0.0GlnCys: 0.0 ± 0.0
0.0GlnAsp: 0.0 ± 0.0
0.0GlnGlu: 0.0 ± 0.0
0.605GlnPhe: 0.605 ± 0.458
0.605GlnGly: 0.605 ± 0.458
1.209GlnHis: 1.209 ± 0.745
1.209GlnIle: 1.209 ± 0.874
1.209GlnLys: 1.209 ± 0.916
4.837GlnLeu: 4.837 ± 0.279
0.0GlnMet: 0.0 ± 0.0
1.209GlnAsn: 1.209 ± 0.745
1.814GlnPro: 1.814 ± 0.744
1.209GlnGln: 1.209 ± 0.965
3.628GlnArg: 3.628 ± 1.203
1.814GlnSer: 1.814 ± 0.986
1.209GlnThr: 1.209 ± 0.916
0.605GlnVal: 0.605 ± 0.372
0.0GlnTrp: 0.0 ± 0.0
0.605GlnTyr: 0.605 ± 0.372
0.0GlnXaa: 0.0 ± 0.0
Arg
6.046ArgAla: 6.046 ± 0.107
3.023ArgCys: 3.023 ± 0.597
3.628ArgAsp: 3.628 ± 0.475
3.023ArgGlu: 3.023 ± 0.795
4.837ArgPhe: 4.837 ± 2.201
3.628ArgGly: 3.628 ± 1.548
1.814ArgHis: 1.814 ± 0.385
2.418ArgIle: 2.418 ± 0.731
1.209ArgLys: 1.209 ± 0.201
11.487ArgLeu: 11.487 ± 0.539
0.605ArgMet: 0.605 ± 0.458
5.441ArgAsn: 5.441 ± 1.805
3.023ArgPro: 3.023 ± 0.597
0.605ArgGln: 0.605 ± 0.458
6.046ArgArg: 6.046 ± 1.149
4.837ArgSer: 4.837 ± 2.201
4.837ArgThr: 4.837 ± 1.334
8.464ArgVal: 8.464 ± 1.22
1.209ArgTrp: 1.209 ± 0.201
4.232ArgTyr: 4.232 ± 1.977
0.0ArgXaa: 0.0 ± 0.0
Ser
9.069SerAla: 9.069 ± 1.649
1.814SerCys: 1.814 ± 0.385
5.441SerAsp: 5.441 ± 0.451
3.023SerGlu: 3.023 ± 1.094
2.418SerPhe: 2.418 ± 0.403
4.232SerGly: 4.232 ± 1.107
1.814SerHis: 1.814 ± 1.117
5.441SerIle: 5.441 ± 2.572
3.023SerLys: 3.023 ± 0.49
9.069SerLeu: 9.069 ± 1.383
1.814SerMet: 1.814 ± 1.204
1.209SerAsn: 1.209 ± 0.916
8.464SerPro: 8.464 ± 1.41
3.023SerGln: 3.023 ± 1.18
9.069SerArg: 9.069 ± 0.763
10.278SerSer: 10.278 ± 1.013
7.255SerThr: 7.255 ± 1.124
7.255SerVal: 7.255 ± 2.928
3.023SerTrp: 3.023 ± 1.094
4.232SerTyr: 4.232 ± 1.348
0.0SerXaa: 0.0 ± 0.0
Thr
4.232ThrAla: 4.232 ± 0.642
0.0ThrCys: 0.0 ± 0.0
1.814ThrAsp: 1.814 ± 0.986
2.418ThrGlu: 2.418 ± 0.874
3.023ThrPhe: 3.023 ± 1.094
3.023ThrGly: 3.023 ± 0.597
1.814ThrHis: 1.814 ± 0.986
2.418ThrIle: 2.418 ± 0.403
2.418ThrLys: 2.418 ± 1.05
9.674ThrLeu: 9.674 ± 2.096
1.209ThrMet: 1.209 ± 0.874
0.605ThrAsn: 0.605 ± 0.458
4.232ThrPro: 4.232 ± 1.977
1.209ThrGln: 1.209 ± 0.201
1.814ThrArg: 1.814 ± 1.204
7.86ThrSer: 7.86 ± 1.343
7.255ThrThr: 7.255 ± 1.072
3.023ThrVal: 3.023 ± 1.094
1.209ThrTrp: 1.209 ± 0.916
3.628ThrTyr: 3.628 ± 0.771
0.0ThrXaa: 0.0 ± 0.0
Val
8.464ValAla: 8.464 ± 1.22
2.418ValCys: 2.418 ± 0.731
5.441ValAsp: 5.441 ± 2.22
2.418ValGlu: 2.418 ± 0.731
3.628ValPhe: 3.628 ± 2.463
3.023ValGly: 3.023 ± 1.094
2.418ValHis: 2.418 ± 0.674
1.209ValIle: 1.209 ± 0.874
1.209ValLys: 1.209 ± 0.745
7.255ValLeu: 7.255 ± 1.759
0.0ValMet: 0.0 ± 0.0
1.814ValAsn: 1.814 ± 0.986
6.651ValPro: 6.651 ± 1.237
1.209ValGln: 1.209 ± 0.965
6.046ValArg: 6.046 ± 1.489
6.046ValSer: 6.046 ± 1.007
6.651ValThr: 6.651 ± 1.308
6.651ValVal: 6.651 ± 2.554
0.605ValTrp: 0.605 ± 0.913
3.023ValTyr: 3.023 ± 1.18
0.0ValXaa: 0.0 ± 0.0
Trp
1.209TrpAla: 1.209 ± 0.745
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.209TrpGlu: 1.209 ± 0.916
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
1.209TrpIle: 1.209 ± 0.745
0.0TrpLys: 0.0 ± 0.0
1.814TrpLeu: 1.814 ± 0.744
0.0TrpMet: 0.0 ± 0.0
1.209TrpAsn: 1.209 ± 0.745
0.0TrpPro: 0.0 ± 0.0
0.605TrpGln: 0.605 ± 0.458
0.0TrpArg: 0.0 ± 0.0
2.418TrpSer: 2.418 ± 0.403
0.605TrpThr: 0.605 ± 0.372
2.418TrpVal: 2.418 ± 1.05
0.0TrpTrp: 0.0 ± 0.0
0.605TrpTyr: 0.605 ± 0.372
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.418TyrAla: 2.418 ± 0.403
2.418TyrCys: 2.418 ± 0.731
3.628TyrAsp: 3.628 ± 0.771
4.232TyrGlu: 4.232 ± 0.954
2.418TyrPhe: 2.418 ± 0.874
1.814TyrGly: 1.814 ± 0.744
1.814TyrHis: 1.814 ± 0.385
0.0TyrIle: 0.0 ± 0.0
0.0TyrLys: 0.0 ± 0.0
6.651TyrLeu: 6.651 ± 3.738
0.605TyrMet: 0.605 ± 0.372
1.814TyrAsn: 1.814 ± 1.117
1.209TyrPro: 1.209 ± 0.916
1.209TyrGln: 1.209 ± 0.745
2.418TyrArg: 2.418 ± 1.207
6.651TyrSer: 6.651 ± 0.312
1.209TyrThr: 1.209 ± 0.201
3.628TyrVal: 3.628 ± 0.823
0.0TyrTrp: 0.0 ± 0.0
5.441TyrTyr: 5.441 ± 1.822
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1655 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski