Amino acid dipepetide frequency for Streptococcus phage Javan585

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.863AlaAla: 4.863 ± 0.966
0.634AlaCys: 0.634 ± 0.315
4.44AlaAsp: 4.44 ± 0.729
5.92AlaGlu: 5.92 ± 0.785
3.594AlaPhe: 3.594 ± 0.605
4.123AlaGly: 4.123 ± 0.944
0.634AlaHis: 0.634 ± 0.287
5.92AlaIle: 5.92 ± 1.214
4.123AlaLys: 4.123 ± 0.583
7.083AlaLeu: 7.083 ± 1.099
2.854AlaMet: 2.854 ± 0.524
3.489AlaAsn: 3.489 ± 0.743
2.009AlaPro: 2.009 ± 0.564
3.489AlaGln: 3.489 ± 0.748
3.806AlaArg: 3.806 ± 0.609
4.652AlaSer: 4.652 ± 0.589
3.066AlaThr: 3.066 ± 0.648
4.44AlaVal: 4.44 ± 0.978
0.317AlaTrp: 0.317 ± 0.211
2.326AlaTyr: 2.326 ± 0.572
0.0AlaXaa: 0.0 ± 0.0
Cys
0.317CysAla: 0.317 ± 0.162
0.0CysCys: 0.0 ± 0.0
0.317CysAsp: 0.317 ± 0.23
0.529CysGlu: 0.529 ± 0.247
0.106CysPhe: 0.106 ± 0.104
0.211CysGly: 0.211 ± 0.157
0.211CysHis: 0.211 ± 0.136
0.634CysIle: 0.634 ± 0.258
0.317CysLys: 0.317 ± 0.18
0.423CysLeu: 0.423 ± 0.202
0.0CysMet: 0.0 ± 0.0
0.211CysAsn: 0.211 ± 0.138
0.106CysPro: 0.106 ± 0.099
0.423CysGln: 0.423 ± 0.243
0.211CysArg: 0.211 ± 0.147
0.423CysSer: 0.423 ± 0.207
0.423CysThr: 0.423 ± 0.21
0.529CysVal: 0.529 ± 0.241
0.106CysTrp: 0.106 ± 0.092
0.106CysTyr: 0.106 ± 0.099
0.0CysXaa: 0.0 ± 0.0
Asp
3.912AspAla: 3.912 ± 0.784
0.423AspCys: 0.423 ± 0.206
3.172AspAsp: 3.172 ± 0.786
4.863AspGlu: 4.863 ± 0.802
4.546AspPhe: 4.546 ± 0.711
4.652AspGly: 4.652 ± 0.986
0.317AspHis: 0.317 ± 0.159
3.594AspIle: 3.594 ± 0.694
4.757AspLys: 4.757 ± 0.688
4.44AspLeu: 4.44 ± 0.681
1.903AspMet: 1.903 ± 0.455
3.806AspAsn: 3.806 ± 0.706
2.114AspPro: 2.114 ± 0.351
1.163AspGln: 1.163 ± 0.379
2.22AspArg: 2.22 ± 0.481
2.432AspSer: 2.432 ± 0.507
2.537AspThr: 2.537 ± 0.471
3.277AspVal: 3.277 ± 0.55
1.692AspTrp: 1.692 ± 0.434
3.172AspTyr: 3.172 ± 0.568
0.0AspXaa: 0.0 ± 0.0
Glu
5.603GluAla: 5.603 ± 0.922
0.211GluCys: 0.211 ± 0.139
3.912GluAsp: 3.912 ± 0.667
5.815GluGlu: 5.815 ± 0.855
2.854GluPhe: 2.854 ± 0.557
4.969GluGly: 4.969 ± 0.613
1.057GluHis: 1.057 ± 0.295
6.555GluIle: 6.555 ± 0.934
7.083GluLys: 7.083 ± 1.097
8.563GluLeu: 8.563 ± 1.159
2.326GluMet: 2.326 ± 0.443
4.017GluAsn: 4.017 ± 0.549
1.903GluPro: 1.903 ± 0.467
4.546GluGln: 4.546 ± 0.703
3.277GluArg: 3.277 ± 0.788
2.854GluSer: 2.854 ± 0.514
3.489GluThr: 3.489 ± 0.753
6.026GluVal: 6.026 ± 0.727
0.846GluTrp: 0.846 ± 0.248
2.749GluTyr: 2.749 ± 0.543
0.0GluXaa: 0.0 ± 0.0
Phe
3.277PheAla: 3.277 ± 0.508
0.317PheCys: 0.317 ± 0.166
3.383PheAsp: 3.383 ± 0.518
3.806PheGlu: 3.806 ± 0.789
1.903PhePhe: 1.903 ± 0.618
3.172PheGly: 3.172 ± 0.653
0.74PheHis: 0.74 ± 0.247
2.749PheIle: 2.749 ± 0.731
3.277PheLys: 3.277 ± 0.514
2.96PheLeu: 2.96 ± 0.607
1.057PheMet: 1.057 ± 0.327
3.489PheAsn: 3.489 ± 0.44
1.163PhePro: 1.163 ± 0.433
2.009PheGln: 2.009 ± 0.456
1.692PheArg: 1.692 ± 0.417
2.96PheSer: 2.96 ± 0.455
1.586PheThr: 1.586 ± 0.472
2.432PheVal: 2.432 ± 0.436
0.423PheTrp: 0.423 ± 0.174
1.163PheTyr: 1.163 ± 0.37
0.0PheXaa: 0.0 ± 0.0
Gly
3.489GlyAla: 3.489 ± 0.779
0.423GlyCys: 0.423 ± 0.301
3.277GlyAsp: 3.277 ± 0.636
2.537GlyGlu: 2.537 ± 0.498
2.643GlyPhe: 2.643 ± 0.625
4.44GlyGly: 4.44 ± 0.954
0.951GlyHis: 0.951 ± 0.295
5.392GlyIle: 5.392 ± 0.749
5.709GlyLys: 5.709 ± 0.761
5.497GlyLeu: 5.497 ± 0.83
2.009GlyMet: 2.009 ± 0.496
2.854GlyAsn: 2.854 ± 0.456
0.634GlyPro: 0.634 ± 0.323
2.854GlyGln: 2.854 ± 0.515
3.066GlyArg: 3.066 ± 0.598
2.96GlySer: 2.96 ± 0.567
3.7GlyThr: 3.7 ± 0.775
3.7GlyVal: 3.7 ± 0.444
0.423GlyTrp: 0.423 ± 0.206
3.383GlyTyr: 3.383 ± 0.527
0.0GlyXaa: 0.0 ± 0.0
His
0.634HisAla: 0.634 ± 0.243
0.211HisCys: 0.211 ± 0.134
1.163HisAsp: 1.163 ± 0.413
1.163HisGlu: 1.163 ± 0.314
0.529HisPhe: 0.529 ± 0.259
1.163HisGly: 1.163 ± 0.339
0.317HisHis: 0.317 ± 0.186
2.22HisIle: 2.22 ± 0.417
0.317HisLys: 0.317 ± 0.18
1.48HisLeu: 1.48 ± 0.529
0.317HisMet: 0.317 ± 0.18
0.846HisAsn: 0.846 ± 0.281
0.634HisPro: 0.634 ± 0.26
0.74HisGln: 0.74 ± 0.271
0.317HisArg: 0.317 ± 0.155
1.057HisSer: 1.057 ± 0.335
0.634HisThr: 0.634 ± 0.233
0.951HisVal: 0.951 ± 0.299
0.106HisTrp: 0.106 ± 0.104
1.163HisTyr: 1.163 ± 0.401
0.0HisXaa: 0.0 ± 0.0
Ile
5.815IleAla: 5.815 ± 0.997
0.317IleCys: 0.317 ± 0.216
4.969IleAsp: 4.969 ± 0.691
5.709IleGlu: 5.709 ± 0.794
2.009IlePhe: 2.009 ± 0.396
3.7IleGly: 3.7 ± 0.598
1.48IleHis: 1.48 ± 0.372
4.863IleIle: 4.863 ± 0.754
7.189IleLys: 7.189 ± 0.818
5.709IleLeu: 5.709 ± 0.717
1.692IleMet: 1.692 ± 0.371
4.969IleAsn: 4.969 ± 0.776
2.326IlePro: 2.326 ± 0.509
3.066IleGln: 3.066 ± 0.699
3.172IleArg: 3.172 ± 0.604
2.643IleSer: 2.643 ± 0.694
4.123IleThr: 4.123 ± 0.657
5.92IleVal: 5.92 ± 0.981
0.74IleTrp: 0.74 ± 0.352
1.692IleTyr: 1.692 ± 0.488
0.0IleXaa: 0.0 ± 0.0
Lys
4.863LysAla: 4.863 ± 0.724
0.317LysCys: 0.317 ± 0.182
4.123LysAsp: 4.123 ± 0.608
6.555LysGlu: 6.555 ± 0.913
2.749LysPhe: 2.749 ± 0.482
4.757LysGly: 4.757 ± 0.648
1.48LysHis: 1.48 ± 0.458
4.969LysIle: 4.969 ± 0.49
6.343LysLys: 6.343 ± 1.081
6.766LysLeu: 6.766 ± 0.884
1.692LysMet: 1.692 ± 0.423
4.863LysAsn: 4.863 ± 0.891
3.7LysPro: 3.7 ± 0.745
4.44LysGln: 4.44 ± 0.782
4.123LysArg: 4.123 ± 0.822
4.863LysSer: 4.863 ± 0.756
4.757LysThr: 4.757 ± 0.623
4.017LysVal: 4.017 ± 0.806
1.057LysTrp: 1.057 ± 0.366
2.854LysTyr: 2.854 ± 0.632
0.0LysXaa: 0.0 ± 0.0
Leu
7.929LeuAla: 7.929 ± 0.931
0.317LeuCys: 0.317 ± 0.187
4.969LeuAsp: 4.969 ± 0.784
9.409LeuGlu: 9.409 ± 1.066
2.326LeuPhe: 2.326 ± 0.576
4.123LeuGly: 4.123 ± 0.631
1.48LeuHis: 1.48 ± 0.356
6.237LeuIle: 6.237 ± 0.987
8.563LeuLys: 8.563 ± 0.783
6.026LeuLeu: 6.026 ± 0.862
2.432LeuMet: 2.432 ± 0.388
4.44LeuAsn: 4.44 ± 0.755
3.066LeuPro: 3.066 ± 0.57
2.749LeuGln: 2.749 ± 0.573
2.432LeuArg: 2.432 ± 0.522
5.075LeuSer: 5.075 ± 0.859
5.92LeuThr: 5.92 ± 0.735
5.18LeuVal: 5.18 ± 0.875
0.846LeuTrp: 0.846 ± 0.31
2.537LeuTyr: 2.537 ± 0.462
0.0LeuXaa: 0.0 ± 0.0
Met
2.643MetAla: 2.643 ± 0.403
0.106MetCys: 0.106 ± 0.099
1.374MetAsp: 1.374 ± 0.332
1.903MetGlu: 1.903 ± 0.486
1.269MetPhe: 1.269 ± 0.34
1.163MetGly: 1.163 ± 0.339
0.423MetHis: 0.423 ± 0.224
2.22MetIle: 2.22 ± 0.495
2.326MetLys: 2.326 ± 0.472
2.22MetLeu: 2.22 ± 0.609
0.634MetMet: 0.634 ± 0.253
1.586MetAsn: 1.586 ± 0.462
0.74MetPro: 0.74 ± 0.298
0.634MetGln: 0.634 ± 0.248
0.951MetArg: 0.951 ± 0.261
3.383MetSer: 3.383 ± 0.709
2.854MetThr: 2.854 ± 0.49
0.951MetVal: 0.951 ± 0.306
0.211MetTrp: 0.211 ± 0.175
0.634MetTyr: 0.634 ± 0.214
0.0MetXaa: 0.0 ± 0.0
Asn
3.7AsnAla: 3.7 ± 0.819
0.211AsnCys: 0.211 ± 0.129
2.432AsnAsp: 2.432 ± 0.538
3.7AsnGlu: 3.7 ± 0.718
3.066AsnPhe: 3.066 ± 0.573
5.709AsnGly: 5.709 ± 0.746
1.057AsnHis: 1.057 ± 0.309
2.96AsnIle: 2.96 ± 0.546
4.969AsnLys: 4.969 ± 0.699
5.497AsnLeu: 5.497 ± 0.594
1.586AsnMet: 1.586 ± 0.362
2.643AsnAsn: 2.643 ± 0.36
1.692AsnPro: 1.692 ± 0.483
2.432AsnGln: 2.432 ± 0.515
2.009AsnArg: 2.009 ± 0.683
3.066AsnSer: 3.066 ± 0.501
3.383AsnThr: 3.383 ± 0.587
3.7AsnVal: 3.7 ± 0.629
1.057AsnTrp: 1.057 ± 0.31
1.903AsnTyr: 1.903 ± 0.472
0.0AsnXaa: 0.0 ± 0.0
Pro
2.009ProAla: 2.009 ± 0.472
0.211ProCys: 0.211 ± 0.15
1.586ProAsp: 1.586 ± 0.38
2.326ProGlu: 2.326 ± 0.484
1.057ProPhe: 1.057 ± 0.355
1.586ProGly: 1.586 ± 0.302
0.634ProHis: 0.634 ± 0.269
2.854ProIle: 2.854 ± 0.498
2.009ProLys: 2.009 ± 0.393
1.797ProLeu: 1.797 ± 0.353
0.317ProMet: 0.317 ± 0.174
1.797ProAsn: 1.797 ± 0.441
0.529ProPro: 0.529 ± 0.242
1.692ProGln: 1.692 ± 0.378
1.374ProArg: 1.374 ± 0.421
2.432ProSer: 2.432 ± 0.581
1.797ProThr: 1.797 ± 0.44
1.903ProVal: 1.903 ± 0.477
0.423ProTrp: 0.423 ± 0.246
1.057ProTyr: 1.057 ± 0.33
0.0ProXaa: 0.0 ± 0.0
Gln
4.44GlnAla: 4.44 ± 0.62
0.317GlnCys: 0.317 ± 0.187
2.114GlnAsp: 2.114 ± 0.486
3.912GlnGlu: 3.912 ± 0.779
2.432GlnPhe: 2.432 ± 0.484
1.797GlnGly: 1.797 ± 0.487
0.529GlnHis: 0.529 ± 0.213
2.854GlnIle: 2.854 ± 0.592
2.854GlnLys: 2.854 ± 0.414
4.229GlnLeu: 4.229 ± 0.788
0.951GlnMet: 0.951 ± 0.324
2.432GlnAsn: 2.432 ± 0.659
1.374GlnPro: 1.374 ± 0.32
2.432GlnGln: 2.432 ± 0.437
2.22GlnArg: 2.22 ± 0.486
2.22GlnSer: 2.22 ± 0.406
2.22GlnThr: 2.22 ± 0.404
2.854GlnVal: 2.854 ± 0.483
0.106GlnTrp: 0.106 ± 0.1
1.586GlnTyr: 1.586 ± 0.48
0.0GlnXaa: 0.0 ± 0.0
Arg
2.22ArgAla: 2.22 ± 0.529
0.106ArgCys: 0.106 ± 0.113
1.903ArgAsp: 1.903 ± 0.406
4.44ArgGlu: 4.44 ± 0.896
1.374ArgPhe: 1.374 ± 0.375
2.22ArgGly: 2.22 ± 0.443
1.269ArgHis: 1.269 ± 0.353
3.277ArgIle: 3.277 ± 0.583
4.334ArgLys: 4.334 ± 0.678
3.489ArgLeu: 3.489 ± 0.901
1.057ArgMet: 1.057 ± 0.37
2.537ArgAsn: 2.537 ± 0.464
1.48ArgPro: 1.48 ± 0.41
1.586ArgGln: 1.586 ± 0.524
2.009ArgArg: 2.009 ± 0.69
2.009ArgSer: 2.009 ± 0.463
2.749ArgThr: 2.749 ± 0.572
2.22ArgVal: 2.22 ± 0.538
0.634ArgTrp: 0.634 ± 0.257
1.903ArgTyr: 1.903 ± 0.453
0.0ArgXaa: 0.0 ± 0.0
Ser
3.383SerAla: 3.383 ± 0.624
0.106SerCys: 0.106 ± 0.11
4.969SerAsp: 4.969 ± 0.554
5.497SerGlu: 5.497 ± 0.735
3.277SerPhe: 3.277 ± 0.491
3.383SerGly: 3.383 ± 0.516
0.634SerHis: 0.634 ± 0.268
3.172SerIle: 3.172 ± 0.577
3.806SerLys: 3.806 ± 0.498
5.075SerLeu: 5.075 ± 0.694
2.643SerMet: 2.643 ± 0.527
3.912SerAsn: 3.912 ± 0.635
1.374SerPro: 1.374 ± 0.345
3.277SerGln: 3.277 ± 0.67
2.009SerArg: 2.009 ± 0.438
3.7SerSer: 3.7 ± 0.684
3.277SerThr: 3.277 ± 0.562
3.489SerVal: 3.489 ± 0.687
0.423SerTrp: 0.423 ± 0.212
1.586SerTyr: 1.586 ± 0.566
0.0SerXaa: 0.0 ± 0.0
Thr
4.757ThrAla: 4.757 ± 1.105
0.106ThrCys: 0.106 ± 0.116
2.749ThrAsp: 2.749 ± 0.504
3.7ThrGlu: 3.7 ± 0.539
2.96ThrPhe: 2.96 ± 0.462
2.537ThrGly: 2.537 ± 0.419
1.057ThrHis: 1.057 ± 0.304
5.709ThrIle: 5.709 ± 0.817
4.017ThrLys: 4.017 ± 0.65
5.075ThrLeu: 5.075 ± 0.828
1.903ThrMet: 1.903 ± 0.458
2.854ThrAsn: 2.854 ± 0.45
1.269ThrPro: 1.269 ± 0.36
1.269ThrGln: 1.269 ± 0.342
2.537ThrArg: 2.537 ± 0.447
2.749ThrSer: 2.749 ± 0.619
3.277ThrThr: 3.277 ± 0.766
4.757ThrVal: 4.757 ± 0.776
1.057ThrTrp: 1.057 ± 0.46
2.537ThrTyr: 2.537 ± 0.563
0.0ThrXaa: 0.0 ± 0.0
Val
4.757ValAla: 4.757 ± 0.74
0.317ValCys: 0.317 ± 0.156
4.969ValAsp: 4.969 ± 0.616
3.806ValGlu: 3.806 ± 0.644
2.432ValPhe: 2.432 ± 0.487
3.277ValGly: 3.277 ± 0.616
0.951ValHis: 0.951 ± 0.385
3.489ValIle: 3.489 ± 0.446
4.334ValLys: 4.334 ± 0.614
4.546ValLeu: 4.546 ± 0.756
1.797ValMet: 1.797 ± 0.454
3.383ValAsn: 3.383 ± 0.646
2.22ValPro: 2.22 ± 0.534
2.22ValGln: 2.22 ± 0.457
2.749ValArg: 2.749 ± 0.618
6.026ValSer: 6.026 ± 0.752
4.546ValThr: 4.546 ± 0.812
4.017ValVal: 4.017 ± 0.613
1.057ValTrp: 1.057 ± 0.357
2.009ValTyr: 2.009 ± 0.454
0.0ValXaa: 0.0 ± 0.0
Trp
0.951TrpAla: 0.951 ± 0.405
0.106TrpCys: 0.106 ± 0.099
0.529TrpAsp: 0.529 ± 0.297
0.951TrpGlu: 0.951 ± 0.36
0.634TrpPhe: 0.634 ± 0.267
0.634TrpGly: 0.634 ± 0.274
0.0TrpHis: 0.0 ± 0.0
0.423TrpIle: 0.423 ± 0.235
0.529TrpLys: 0.529 ± 0.281
1.48TrpLeu: 1.48 ± 0.351
0.423TrpMet: 0.423 ± 0.181
1.163TrpAsn: 1.163 ± 0.499
0.211TrpPro: 0.211 ± 0.147
0.846TrpGln: 0.846 ± 0.278
0.0TrpArg: 0.0 ± 0.0
1.163TrpSer: 1.163 ± 0.311
1.057TrpThr: 1.057 ± 0.33
0.74TrpVal: 0.74 ± 0.25
0.106TrpTrp: 0.106 ± 0.1
0.211TrpTyr: 0.211 ± 0.144
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.22TyrAla: 2.22 ± 0.514
0.846TyrCys: 0.846 ± 0.437
2.643TyrAsp: 2.643 ± 0.541
2.114TyrGlu: 2.114 ± 0.53
1.797TyrPhe: 1.797 ± 0.39
2.326TyrGly: 2.326 ± 0.578
0.74TyrHis: 0.74 ± 0.309
2.009TyrIle: 2.009 ± 0.496
2.432TyrLys: 2.432 ± 0.512
3.7TyrLeu: 3.7 ± 0.691
0.529TyrMet: 0.529 ± 0.235
1.48TyrAsn: 1.48 ± 0.364
0.846TyrPro: 0.846 ± 0.314
2.114TyrGln: 2.114 ± 0.573
2.643TyrArg: 2.643 ± 0.617
2.326TyrSer: 2.326 ± 0.53
1.48TyrThr: 1.48 ± 0.428
1.797TyrVal: 1.797 ± 0.415
0.529TyrTrp: 0.529 ± 0.27
1.48TyrTyr: 1.48 ± 0.434
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (9460 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski