Amino acid dipepetide frequency for Mucilaginibacter psychrotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.419AlaAla: 7.419 ± 0.085	0.74AlaCys: 0.74 ± 0.021	5.175AlaAsp: 5.175 ± 0.061	4.591AlaGlu: 4.591 ± 0.057	3.793AlaPhe: 3.793 ± 0.051	6.297AlaGly: 6.297 ± 0.077	1.344AlaHis: 1.344 ± 0.03	5.819AlaIle: 5.819 ± 0.062	5.003AlaLys: 5.003 ± 0.057	7.586AlaLeu: 7.586 ± 0.07	1.913AlaMet: 1.913 ± 0.035	4.034AlaAsn: 4.034 ± 0.06	2.672AlaPro: 2.672 ± 0.045	3.185AlaGln: 3.185 ± 0.046	2.812AlaArg: 2.812 ± 0.039	4.584AlaSer: 4.584 ± 0.053	4.575AlaThr: 4.575 ± 0.067	5.29AlaVal: 5.29 ± 0.058	0.87AlaTrp: 0.87 ± 0.024	3.24AlaTyr: 3.24 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.57CysAla: 0.57 ± 0.019	0.157CysCys: 0.157 ± 0.01	0.389CysAsp: 0.389 ± 0.016	0.354CysGlu: 0.354 ± 0.014	0.451CysPhe: 0.451 ± 0.016	0.65CysGly: 0.65 ± 0.019	0.184CysHis: 0.184 ± 0.011	0.644CysIle: 0.644 ± 0.019	0.509CysLys: 0.509 ± 0.018	0.844CysLeu: 0.844 ± 0.022	0.191CysMet: 0.191 ± 0.01	0.369CysAsn: 0.369 ± 0.014	0.309CysPro: 0.309 ± 0.013	0.226CysGln: 0.226 ± 0.011	0.325CysArg: 0.325 ± 0.014	0.48CysSer: 0.48 ± 0.016	0.459CysThr: 0.459 ± 0.015	0.474CysVal: 0.474 ± 0.015	0.095CysTrp: 0.095 ± 0.007	0.349CysTyr: 0.349 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.637AspAla: 4.637 ± 0.054	0.387AspCys: 0.387 ± 0.015	2.799AspAsp: 2.799 ± 0.047	3.412AspGlu: 3.412 ± 0.048	3.083AspPhe: 3.083 ± 0.045	4.098AspGly: 4.098 ± 0.05	0.913AspHis: 0.913 ± 0.022	4.035AspIle: 4.035 ± 0.045	4.112AspLys: 4.112 ± 0.049	4.697AspLeu: 4.697 ± 0.054	1.292AspMet: 1.292 ± 0.03	2.952AspAsn: 2.952 ± 0.04	2.003AspPro: 2.003 ± 0.038	1.525AspGln: 1.525 ± 0.028	2.109AspArg: 2.109 ± 0.033	3.042AspSer: 3.042 ± 0.046	2.945AspThr: 2.945 ± 0.047	3.475AspVal: 3.475 ± 0.047	0.778AspTrp: 0.778 ± 0.023	2.586AspTyr: 2.586 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	4.113GluAla: 4.113 ± 0.056	0.299GluCys: 0.299 ± 0.013	2.605GluAsp: 2.605 ± 0.039	3.166GluGlu: 3.166 ± 0.059	2.313GluPhe: 2.313 ± 0.038	3.162GluGly: 3.162 ± 0.044	1.099GluHis: 1.099 ± 0.027	3.851GluIle: 3.851 ± 0.048	4.002GluLys: 4.002 ± 0.062	5.572GluLeu: 5.572 ± 0.063	1.346GluMet: 1.346 ± 0.027	2.736GluAsn: 2.736 ± 0.046	1.729GluPro: 1.729 ± 0.036	2.345GluGln: 2.345 ± 0.042	2.423GluArg: 2.423 ± 0.04	2.527GluSer: 2.527 ± 0.039	2.781GluThr: 2.781 ± 0.041	3.557GluVal: 3.557 ± 0.047	0.621GluTrp: 0.621 ± 0.021	2.041GluTyr: 2.041 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.75PheAla: 3.75 ± 0.052	0.487PheCys: 0.487 ± 0.016	2.968PheAsp: 2.968 ± 0.039	2.527PheGlu: 2.527 ± 0.038	2.458PhePhe: 2.458 ± 0.044	3.469PheGly: 3.469 ± 0.05	0.813PheHis: 0.813 ± 0.023	3.422PheIle: 3.422 ± 0.05	3.361PheLys: 3.361 ± 0.047	4.164PheLeu: 4.164 ± 0.06	1.151PheMet: 1.151 ± 0.025	2.946PheAsn: 2.946 ± 0.045	1.673PhePro: 1.673 ± 0.031	1.292PheGln: 1.292 ± 0.026	1.794PheArg: 1.794 ± 0.033	3.446PheSer: 3.446 ± 0.04	3.262PheThr: 3.262 ± 0.043	2.92PheVal: 2.92 ± 0.045	0.586PheTrp: 0.586 ± 0.02	2.19PheTyr: 2.19 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	4.848GlyAla: 4.848 ± 0.064	0.618GlyCys: 0.618 ± 0.019	3.64GlyAsp: 3.64 ± 0.054	3.214GlyGlu: 3.214 ± 0.05	3.668GlyPhe: 3.668 ± 0.045	5.102GlyGly: 5.102 ± 0.085	1.336GlyHis: 1.336 ± 0.03	5.302GlyIle: 5.302 ± 0.057	5.307GlyLys: 5.307 ± 0.061	6.45GlyLeu: 6.45 ± 0.061	1.699GlyMet: 1.699 ± 0.033	3.796GlyAsn: 3.796 ± 0.049	1.785GlyPro: 1.785 ± 0.037	2.381GlyGln: 2.381 ± 0.039	2.673GlyArg: 2.673 ± 0.04	4.298GlySer: 4.298 ± 0.061	4.358GlyThr: 4.358 ± 0.074	4.504GlyVal: 4.504 ± 0.059	1.038GlyTrp: 1.038 ± 0.027	3.244GlyTyr: 3.244 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.259HisAla: 1.259 ± 0.03	0.189HisCys: 0.189 ± 0.011	0.993HisAsp: 0.993 ± 0.026	0.972HisGlu: 0.972 ± 0.027	1.108HisPhe: 1.108 ± 0.025	1.191HisGly: 1.191 ± 0.028	0.512HisHis: 0.512 ± 0.019	1.403HisIle: 1.403 ± 0.03	1.069HisLys: 1.069 ± 0.023	1.913HisLeu: 1.913 ± 0.033	0.385HisMet: 0.385 ± 0.016	0.895HisAsn: 0.895 ± 0.023	1.043HisPro: 1.043 ± 0.026	0.778HisGln: 0.778 ± 0.02	0.772HisArg: 0.772 ± 0.022	1.053HisSer: 1.053 ± 0.024	1.053HisThr: 1.053 ± 0.022	0.993HisVal: 0.993 ± 0.022	0.264HisTrp: 0.264 ± 0.012	0.946HisTyr: 0.946 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.384IleAla: 6.384 ± 0.063	0.68IleCys: 0.68 ± 0.02	4.224IleAsp: 4.224 ± 0.054	3.716IleGlu: 3.716 ± 0.05	3.001IlePhe: 3.001 ± 0.048	4.818IleGly: 4.818 ± 0.058	1.247IleHis: 1.247 ± 0.028	4.93IleIle: 4.93 ± 0.061	4.955IleLys: 4.955 ± 0.056	5.913IleLeu: 5.913 ± 0.067	1.321IleMet: 1.321 ± 0.027	4.12IleAsn: 4.12 ± 0.055	3.01IlePro: 3.01 ± 0.037	2.106IleGln: 2.106 ± 0.04	2.947IleArg: 2.947 ± 0.042	4.834IleSer: 4.834 ± 0.052	4.786IleThr: 4.786 ± 0.065	4.168IleVal: 4.168 ± 0.046	0.745IleTrp: 0.745 ± 0.021	2.661IleTyr: 2.661 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	5.692LysAla: 5.692 ± 0.065	0.323LysCys: 0.323 ± 0.015	3.84LysAsp: 3.84 ± 0.049	3.907LysGlu: 3.907 ± 0.052	2.678LysPhe: 2.678 ± 0.039	4.465LysGly: 4.465 ± 0.052	1.332LysHis: 1.332 ± 0.027	4.694LysIle: 4.694 ± 0.049	5.116LysLys: 5.116 ± 0.06	6.483LysLeu: 6.483 ± 0.065	1.829LysMet: 1.829 ± 0.034	3.884LysAsn: 3.884 ± 0.048	3.016LysPro: 3.016 ± 0.041	2.948LysGln: 2.948 ± 0.047	2.77LysArg: 2.77 ± 0.044	3.687LysSer: 3.687 ± 0.048	4.168LysThr: 4.168 ± 0.051	4.268LysVal: 4.268 ± 0.051	0.793LysTrp: 0.793 ± 0.021	2.885LysTyr: 2.885 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	7.575LeuAla: 7.575 ± 0.066	0.85LeuCys: 0.85 ± 0.021	4.74LeuAsp: 4.74 ± 0.055	4.37LeuGlu: 4.37 ± 0.058	4.734LeuPhe: 4.734 ± 0.06	5.753LeuGly: 5.753 ± 0.056	1.774LeuHis: 1.774 ± 0.034	6.421LeuIle: 6.421 ± 0.067	7.218LeuLys: 7.218 ± 0.066	9.758LeuLeu: 9.758 ± 0.102	2.216LeuMet: 2.216 ± 0.036	5.498LeuAsn: 5.498 ± 0.055	4.32LeuPro: 4.32 ± 0.056	3.82LeuGln: 3.82 ± 0.049	3.756LeuArg: 3.756 ± 0.051	6.778LeuSer: 6.778 ± 0.069	5.544LeuThr: 5.544 ± 0.052	5.822LeuVal: 5.822 ± 0.064	1.018LeuTrp: 1.018 ± 0.023	3.434LeuTyr: 3.434 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.043MetAla: 2.043 ± 0.031	0.161MetCys: 0.161 ± 0.009	1.238MetAsp: 1.238 ± 0.025	1.243MetGlu: 1.243 ± 0.028	0.854MetPhe: 0.854 ± 0.022	1.527MetGly: 1.527 ± 0.029	0.466MetHis: 0.466 ± 0.014	1.383MetIle: 1.383 ± 0.025	1.865MetLys: 1.865 ± 0.033	2.3MetLeu: 2.3 ± 0.035	0.636MetMet: 0.636 ± 0.019	1.139MetAsn: 1.139 ± 0.027	1.202MetPro: 1.202 ± 0.026	1.025MetGln: 1.025 ± 0.023	0.974MetArg: 0.974 ± 0.022	1.229MetSer: 1.229 ± 0.03	1.035MetThr: 1.035 ± 0.023	1.586MetVal: 1.586 ± 0.028	0.185MetTrp: 0.185 ± 0.011	0.65MetTyr: 0.65 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	4.11AsnAla: 4.11 ± 0.05	0.407AsnCys: 0.407 ± 0.016	2.815AsnAsp: 2.815 ± 0.043	2.71AsnGlu: 2.71 ± 0.045	2.577AsnPhe: 2.577 ± 0.042	4.136AsnGly: 4.136 ± 0.055	1.044AsnHis: 1.044 ± 0.024	4.039AsnIle: 4.039 ± 0.054	3.548AsnLys: 3.548 ± 0.045	4.92AsnLeu: 4.92 ± 0.054	1.129AsnMet: 1.129 ± 0.026	3.248AsnAsn: 3.248 ± 0.053	2.684AsnPro: 2.684 ± 0.038	2.05AsnGln: 2.05 ± 0.035	2.234AsnArg: 2.234 ± 0.033	3.222AsnSer: 3.222 ± 0.05	3.279AsnThr: 3.279 ± 0.043	3.126AsnVal: 3.126 ± 0.043	0.758AsnTrp: 0.758 ± 0.018	2.717AsnTyr: 2.717 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	3.742ProAla: 3.742 ± 0.052	0.226ProCys: 0.226 ± 0.009	2.639ProAsp: 2.639 ± 0.042	2.675ProGlu: 2.675 ± 0.044	1.966ProPhe: 1.966 ± 0.031	3.086ProGly: 3.086 ± 0.045	0.709ProHis: 0.709 ± 0.022	2.385ProIle: 2.385 ± 0.032	2.327ProLys: 2.327 ± 0.034	3.495ProLeu: 3.495 ± 0.044	0.792ProMet: 0.792 ± 0.02	2.061ProAsn: 2.061 ± 0.031	1.296ProPro: 1.296 ± 0.034	1.542ProGln: 1.542 ± 0.031	1.184ProArg: 1.184 ± 0.027	2.103ProSer: 2.103 ± 0.031	2.107ProThr: 2.107 ± 0.037	3.34ProVal: 3.34 ± 0.048	0.438ProTrp: 0.438 ± 0.017	1.65ProTyr: 1.65 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	2.797GlnAla: 2.797 ± 0.042	0.199GlnCys: 0.199 ± 0.011	1.576GlnAsp: 1.576 ± 0.028	1.846GlnGlu: 1.846 ± 0.034	1.695GlnPhe: 1.695 ± 0.027	2.081GlnGly: 2.081 ± 0.038	0.822GlnHis: 0.822 ± 0.024	2.432GlnIle: 2.432 ± 0.038	2.607GlnLys: 2.607 ± 0.042	3.953GlnLeu: 3.953 ± 0.044	0.923GlnMet: 0.923 ± 0.022	1.994GlnAsn: 1.994 ± 0.031	1.662GlnPro: 1.662 ± 0.028	2.211GlnGln: 2.211 ± 0.06	1.603GlnArg: 1.603 ± 0.031	2.217GlnSer: 2.217 ± 0.039	2.229GlnThr: 2.229 ± 0.035	2.41GlnVal: 2.41 ± 0.037	0.439GlnTrp: 0.439 ± 0.016	1.585GlnTyr: 1.585 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.74ArgAla: 2.74 ± 0.038	0.233ArgCys: 0.233 ± 0.012	2.092ArgAsp: 2.092 ± 0.036	2.186ArgGlu: 2.186 ± 0.036	2.061ArgPhe: 2.061 ± 0.036	2.176ArgGly: 2.176 ± 0.037	0.784ArgHis: 0.784 ± 0.019	3.012ArgIle: 3.012 ± 0.043	2.842ArgLys: 2.842 ± 0.045	3.942ArgLeu: 3.942 ± 0.047	1.044ArgMet: 1.044 ± 0.022	2.242ArgAsn: 2.242 ± 0.035	1.451ArgPro: 1.451 ± 0.031	1.598ArgGln: 1.598 ± 0.034	1.724ArgArg: 1.724 ± 0.032	2.322ArgSer: 2.322 ± 0.034	2.002ArgThr: 2.002 ± 0.032	2.515ArgVal: 2.515 ± 0.039	0.506ArgTrp: 0.506 ± 0.018	1.887ArgTyr: 1.887 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	4.998SerAla: 4.998 ± 0.06	0.546SerCys: 0.546 ± 0.018	2.962SerAsp: 2.962 ± 0.043	2.733SerGlu: 2.733 ± 0.045	3.343SerPhe: 3.343 ± 0.045	4.806SerGly: 4.806 ± 0.063	1.101SerHis: 1.101 ± 0.026	4.401SerIle: 4.401 ± 0.05	3.654SerLys: 3.654 ± 0.048	6.018SerLeu: 6.018 ± 0.064	1.196SerMet: 1.196 ± 0.024	3.059SerAsn: 3.059 ± 0.048	2.589SerPro: 2.589 ± 0.035	1.94SerGln: 1.94 ± 0.03	2.408SerArg: 2.408 ± 0.039	3.657SerSer: 3.657 ± 0.05	3.547SerThr: 3.547 ± 0.051	4.13SerVal: 4.13 ± 0.047	0.713SerTrp: 0.713 ± 0.02	2.685SerTyr: 2.685 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	5.183ThrAla: 5.183 ± 0.077	0.419ThrCys: 0.419 ± 0.017	3.652ThrAsp: 3.652 ± 0.051	2.934ThrGlu: 2.934 ± 0.042	2.779ThrPhe: 2.779 ± 0.046	4.988ThrGly: 4.988 ± 0.075	1.026ThrHis: 1.026 ± 0.026	4.245ThrIle: 4.245 ± 0.051	3.181ThrLys: 3.181 ± 0.045	5.57ThrLeu: 5.57 ± 0.057	1.027ThrMet: 1.027 ± 0.025	2.943ThrAsn: 2.943 ± 0.042	2.72ThrPro: 2.72 ± 0.041	1.922ThrGln: 1.922 ± 0.028	2.029ThrArg: 2.029 ± 0.035	3.39ThrSer: 3.39 ± 0.051	3.665ThrThr: 3.665 ± 0.064	4.281ThrVal: 4.281 ± 0.071	0.677ThrTrp: 0.677 ± 0.02	2.545ThrTyr: 2.545 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	5.229ValAla: 5.229 ± 0.054	0.588ValCys: 0.588 ± 0.018	3.462ValAsp: 3.462 ± 0.042	3.154ValGlu: 3.154 ± 0.051	3.197ValPhe: 3.197 ± 0.045	3.819ValGly: 3.819 ± 0.048	1.036ValHis: 1.036 ± 0.023	4.79ValIle: 4.79 ± 0.053	4.543ValLys: 4.543 ± 0.049	6.269ValLeu: 6.269 ± 0.059	1.496ValMet: 1.496 ± 0.028	3.667ValAsn: 3.667 ± 0.049	2.487ValPro: 2.487 ± 0.037	1.999ValGln: 1.999 ± 0.034	2.355ValArg: 2.355 ± 0.035	4.317ValSer: 4.317 ± 0.052	4.161ValThr: 4.161 ± 0.078	4.365ValVal: 4.365 ± 0.06	0.726ValTrp: 0.726 ± 0.019	2.666ValTyr: 2.666 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.851TrpAla: 0.851 ± 0.025	0.127TrpCys: 0.127 ± 0.008	0.682TrpAsp: 0.682 ± 0.02	0.621TrpGlu: 0.621 ± 0.018	0.638TrpPhe: 0.638 ± 0.022	0.845TrpGly: 0.845 ± 0.023	0.294TrpHis: 0.294 ± 0.012	0.715TrpIle: 0.715 ± 0.019	0.78TrpLys: 0.78 ± 0.023	1.276TrpLeu: 1.276 ± 0.032	0.356TrpMet: 0.356 ± 0.013	0.61TrpAsn: 0.61 ± 0.018	0.377TrpPro: 0.377 ± 0.015	0.584TrpGln: 0.584 ± 0.019	0.515TrpArg: 0.515 ± 0.016	0.655TrpSer: 0.655 ± 0.021	0.57TrpThr: 0.57 ± 0.021	0.814TrpVal: 0.814 ± 0.024	0.222TrpTrp: 0.222 ± 0.011	0.497TrpTyr: 0.497 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.003TyrAla: 3.003 ± 0.044	0.395TyrCys: 0.395 ± 0.015	2.386TyrAsp: 2.386 ± 0.037	1.958TyrGlu: 1.958 ± 0.031	2.285TyrPhe: 2.285 ± 0.037	2.792TyrGly: 2.792 ± 0.046	0.953TyrHis: 0.953 ± 0.022	2.644TyrIle: 2.644 ± 0.041	2.781TyrLys: 2.781 ± 0.036	4.275TyrLeu: 4.275 ± 0.049	0.798TyrMet: 0.798 ± 0.018	2.559TyrAsn: 2.559 ± 0.042	1.734TyrPro: 1.734 ± 0.033	1.803TyrGln: 1.803 ± 0.034	1.951TyrArg: 1.951 ± 0.033	2.644TyrSer: 2.644 ± 0.041	2.65TyrThr: 2.65 ± 0.042	2.29TyrVal: 2.29 ± 0.037	0.557TyrTrp: 0.557 ± 0.019	2.014TyrTyr: 2.014 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5520 proteins (1844079 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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