Amino acid dipepetide frequency for Nocardia arthritidis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.926AlaAla: 21.926 ± 0.157
0.973AlaCys: 0.973 ± 0.021
8.817AlaAsp: 8.817 ± 0.066
8.66AlaGlu: 8.66 ± 0.067
3.377AlaPhe: 3.377 ± 0.033
11.798AlaGly: 11.798 ± 0.074
2.74AlaHis: 2.74 ± 0.034
5.334AlaIle: 5.334 ± 0.045
2.791AlaLys: 2.791 ± 0.039
13.328AlaLeu: 13.328 ± 0.089
2.661AlaMet: 2.661 ± 0.034
2.577AlaAsn: 2.577 ± 0.029
6.499AlaPro: 6.499 ± 0.055
3.955AlaGln: 3.955 ± 0.038
9.595AlaArg: 9.595 ± 0.068
5.123AlaSer: 5.123 ± 0.044
7.41AlaThr: 7.41 ± 0.056
11.573AlaVal: 11.573 ± 0.079
1.669AlaTrp: 1.669 ± 0.027
2.442AlaTyr: 2.442 ± 0.033
0.0AlaXaa: 0.0 ± 0.0
Cys
1.231CysAla: 1.231 ± 0.022
0.122CysCys: 0.122 ± 0.006
0.513CysAsp: 0.513 ± 0.014
0.373CysGlu: 0.373 ± 0.012
0.228CysPhe: 0.228 ± 0.009
1.005CysGly: 1.005 ± 0.02
0.206CysHis: 0.206 ± 0.008
0.215CysIle: 0.215 ± 0.009
0.126CysLys: 0.126 ± 0.007
0.716CysLeu: 0.716 ± 0.015
0.127CysMet: 0.127 ± 0.007
0.142CysAsn: 0.142 ± 0.007
0.517CysPro: 0.517 ± 0.014
0.185CysGln: 0.185 ± 0.008
0.715CysArg: 0.715 ± 0.018
0.486CysSer: 0.486 ± 0.016
0.507CysThr: 0.507 ± 0.015
0.662CysVal: 0.662 ± 0.015
0.151CysTrp: 0.151 ± 0.006
0.183CysTyr: 0.183 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
7.422AspAla: 7.422 ± 0.055
0.453AspCys: 0.453 ± 0.012
3.521AspAsp: 3.521 ± 0.042
3.631AspGlu: 3.631 ± 0.041
1.763AspPhe: 1.763 ± 0.025
5.857AspGly: 5.857 ± 0.056
1.423AspHis: 1.423 ± 0.021
2.71AspIle: 2.71 ± 0.03
1.225AspLys: 1.225 ± 0.02
6.041AspLeu: 6.041 ± 0.052
0.959AspMet: 0.959 ± 0.02
1.257AspAsn: 1.257 ± 0.021
4.785AspPro: 4.785 ± 0.044
1.784AspGln: 1.784 ± 0.024
5.49AspArg: 5.49 ± 0.052
3.056AspSer: 3.056 ± 0.033
3.174AspThr: 3.174 ± 0.031
4.102AspVal: 4.102 ± 0.038
0.991AspTrp: 0.991 ± 0.017
1.428AspTyr: 1.428 ± 0.022
0.0AspXaa: 0.0 ± 0.0
Glu
5.215GluAla: 5.215 ± 0.052
0.372GluCys: 0.372 ± 0.012
1.974GluAsp: 1.974 ± 0.028
2.089GluGlu: 2.089 ± 0.032
2.103GluPhe: 2.103 ± 0.027
2.706GluGly: 2.706 ± 0.033
1.544GluHis: 1.544 ± 0.021
2.844GluIle: 2.844 ± 0.034
1.117GluLys: 1.117 ± 0.02
7.528GluLeu: 7.528 ± 0.076
1.006GluMet: 1.006 ± 0.02
1.103GluAsn: 1.103 ± 0.024
3.313GluPro: 3.313 ± 0.041
2.302GluGln: 2.302 ± 0.025
4.963GluArg: 4.963 ± 0.049
2.951GluSer: 2.951 ± 0.036
2.808GluThr: 2.808 ± 0.032
4.055GluVal: 4.055 ± 0.037
0.829GluTrp: 0.829 ± 0.018
1.304GluTyr: 1.304 ± 0.022
0.0GluXaa: 0.0 ± 0.0
Phe
4.232PheAla: 4.232 ± 0.042
0.264PheCys: 0.264 ± 0.009
2.553PheAsp: 2.553 ± 0.037
1.584PheGlu: 1.584 ± 0.029
0.858PhePhe: 0.858 ± 0.019
3.628PheGly: 3.628 ± 0.034
0.646PheHis: 0.646 ± 0.016
0.958PheIle: 0.958 ± 0.021
0.413PheLys: 0.413 ± 0.013
2.501PheLeu: 2.501 ± 0.032
0.407PheMet: 0.407 ± 0.012
0.606PheAsn: 0.606 ± 0.017
1.475PhePro: 1.475 ± 0.022
0.748PheGln: 0.748 ± 0.018
2.003PheArg: 2.003 ± 0.026
1.419PheSer: 1.419 ± 0.022
2.041PheThr: 2.041 ± 0.028
2.488PheVal: 2.488 ± 0.033
0.419PheTrp: 0.419 ± 0.012
0.639PheTyr: 0.639 ± 0.016
0.0PheXaa: 0.0 ± 0.0
Gly
10.556GlyAla: 10.556 ± 0.077
0.903GlyCys: 0.903 ± 0.02
4.741GlyAsp: 4.741 ± 0.041
4.253GlyGlu: 4.253 ± 0.046
3.038GlyPhe: 3.038 ± 0.034
7.648GlyGly: 7.648 ± 0.072
2.133GlyHis: 2.133 ± 0.029
4.442GlyIle: 4.442 ± 0.044
2.307GlyLys: 2.307 ± 0.033
8.641GlyLeu: 8.641 ± 0.064
2.007GlyMet: 2.007 ± 0.027
1.95GlyAsn: 1.95 ± 0.028
4.819GlyPro: 4.819 ± 0.047
2.599GlyGln: 2.599 ± 0.033
7.0GlyArg: 7.0 ± 0.059
5.071GlySer: 5.071 ± 0.044
5.385GlyThr: 5.385 ± 0.055
7.118GlyVal: 7.118 ± 0.053
1.638GlyTrp: 1.638 ± 0.025
2.501GlyTyr: 2.501 ± 0.031
0.0GlyXaa: 0.0 ± 0.0
His
2.493HisAla: 2.493 ± 0.028
0.231HisCys: 0.231 ± 0.009
1.294HisAsp: 1.294 ± 0.018
1.092HisGlu: 1.092 ± 0.021
0.677HisPhe: 0.677 ± 0.016
2.19HisGly: 2.19 ± 0.029
0.665HisHis: 0.665 ± 0.018
0.91HisIle: 0.91 ± 0.015
0.318HisLys: 0.318 ± 0.01
2.194HisLeu: 2.194 ± 0.028
0.343HisMet: 0.343 ± 0.012
0.499HisAsn: 0.499 ± 0.013
1.855HisPro: 1.855 ± 0.029
0.634HisGln: 0.634 ± 0.015
2.257HisArg: 2.257 ± 0.032
1.11HisSer: 1.11 ± 0.019
1.315HisThr: 1.315 ± 0.027
1.388HisVal: 1.388 ± 0.024
0.375HisTrp: 0.375 ± 0.01
0.527HisTyr: 0.527 ± 0.012
0.0HisXaa: 0.0 ± 0.0
Ile
6.693IleAla: 6.693 ± 0.05
0.39IleCys: 0.39 ± 0.012
3.494IleAsp: 3.494 ± 0.037
2.69IleGlu: 2.69 ± 0.037
1.088IlePhe: 1.088 ± 0.02
4.783IleGly: 4.783 ± 0.046
0.796IleHis: 0.796 ± 0.016
1.353IleIle: 1.353 ± 0.025
0.725IleLys: 0.725 ± 0.019
3.075IleLeu: 3.075 ± 0.038
0.604IleMet: 0.604 ± 0.015
0.881IleAsn: 0.881 ± 0.019
2.528IlePro: 2.528 ± 0.03
0.933IleGln: 0.933 ± 0.018
3.158IleArg: 3.158 ± 0.035
2.297IleSer: 2.297 ± 0.028
2.797IleThr: 2.797 ± 0.031
3.593IleVal: 3.593 ± 0.038
0.545IleTrp: 0.545 ± 0.015
0.785IleTyr: 0.785 ± 0.017
0.0IleXaa: 0.0 ± 0.0
Lys
2.29LysAla: 2.29 ± 0.037
0.131LysCys: 0.131 ± 0.007
0.993LysAsp: 0.993 ± 0.022
0.83LysGlu: 0.83 ± 0.019
0.614LysPhe: 0.614 ± 0.016
1.381LysGly: 1.381 ± 0.026
0.439LysHis: 0.439 ± 0.013
0.915LysIle: 0.915 ± 0.018
0.537LysLys: 0.537 ± 0.018
2.053LysLeu: 2.053 ± 0.029
0.417LysMet: 0.417 ± 0.012
0.49LysAsn: 0.49 ± 0.016
1.345LysPro: 1.345 ± 0.021
0.722LysGln: 0.722 ± 0.017
1.394LysArg: 1.394 ± 0.024
1.212LysSer: 1.212 ± 0.019
1.22LysThr: 1.22 ± 0.022
1.632LysVal: 1.632 ± 0.027
0.287LysTrp: 0.287 ± 0.01
0.501LysTyr: 0.501 ± 0.013
0.0LysXaa: 0.0 ± 0.0
Leu
14.678LeuAla: 14.678 ± 0.09
0.879LeuCys: 0.879 ± 0.018
6.708LeuAsp: 6.708 ± 0.065
4.38LeuGlu: 4.38 ± 0.042
2.802LeuPhe: 2.802 ± 0.032
8.834LeuGly: 8.834 ± 0.052
2.131LeuHis: 2.131 ± 0.029
4.246LeuIle: 4.246 ± 0.044
1.406LeuLys: 1.406 ± 0.025
10.442LeuLeu: 10.442 ± 0.08
1.516LeuMet: 1.516 ± 0.024
1.954LeuAsn: 1.954 ± 0.029
6.312LeuPro: 6.312 ± 0.05
2.046LeuGln: 2.046 ± 0.025
8.82LeuArg: 8.82 ± 0.067
5.362LeuSer: 5.362 ± 0.04
6.69LeuThr: 6.69 ± 0.049
8.204LeuVal: 8.204 ± 0.066
1.239LeuTrp: 1.239 ± 0.026
1.693LeuTyr: 1.693 ± 0.027
0.0LeuXaa: 0.0 ± 0.0
Met
2.253MetAla: 2.253 ± 0.028
0.175MetCys: 0.175 ± 0.008
0.874MetAsp: 0.874 ± 0.019
0.644MetGlu: 0.644 ± 0.017
0.588MetPhe: 0.588 ± 0.015
1.289MetGly: 1.289 ± 0.022
0.41MetHis: 0.41 ± 0.013
0.864MetIle: 0.864 ± 0.018
0.379MetLys: 0.379 ± 0.013
1.949MetLeu: 1.949 ± 0.026
0.336MetMet: 0.336 ± 0.011
0.526MetAsn: 0.526 ± 0.013
1.192MetPro: 1.192 ± 0.021
0.43MetGln: 0.43 ± 0.013
1.702MetArg: 1.702 ± 0.024
1.401MetSer: 1.401 ± 0.022
1.566MetThr: 1.566 ± 0.025
1.529MetVal: 1.529 ± 0.027
0.254MetTrp: 0.254 ± 0.009
0.361MetTyr: 0.361 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.516AsnAla: 2.516 ± 0.033
0.189AsnCys: 0.189 ± 0.008
1.088AsnAsp: 1.088 ± 0.021
0.914AsnGlu: 0.914 ± 0.017
0.621AsnPhe: 0.621 ± 0.015
2.205AsnGly: 2.205 ± 0.03
0.446AsnHis: 0.446 ± 0.012
0.948AsnIle: 0.948 ± 0.018
0.436AsnLys: 0.436 ± 0.014
1.903AsnLeu: 1.903 ± 0.027
0.414AsnMet: 0.414 ± 0.013
0.529AsnAsn: 0.529 ± 0.015
1.791AsnPro: 1.791 ± 0.031
0.625AsnGln: 0.625 ± 0.016
1.691AsnArg: 1.691 ± 0.024
1.298AsnSer: 1.298 ± 0.023
1.336AsnThr: 1.336 ± 0.02
1.496AsnVal: 1.496 ± 0.022
0.374AsnTrp: 0.374 ± 0.011
0.549AsnTyr: 0.549 ± 0.013
0.0AsnXaa: 0.0 ± 0.0
Pro
7.861ProAla: 7.861 ± 0.057
0.365ProCys: 0.365 ± 0.011
4.823ProAsp: 4.823 ± 0.049
4.045ProGlu: 4.045 ± 0.044
1.585ProPhe: 1.585 ± 0.028
6.071ProGly: 6.071 ± 0.057
1.302ProHis: 1.302 ± 0.025
2.427ProIle: 2.427 ± 0.028
1.292ProLys: 1.292 ± 0.022
4.992ProLeu: 4.992 ± 0.045
1.159ProMet: 1.159 ± 0.02
1.485ProAsn: 1.485 ± 0.026
3.5ProPro: 3.5 ± 0.051
1.786ProGln: 1.786 ± 0.031
3.898ProArg: 3.898 ± 0.043
3.096ProSer: 3.096 ± 0.044
3.586ProThr: 3.586 ± 0.04
5.337ProVal: 5.337 ± 0.053
0.862ProTrp: 0.862 ± 0.018
1.145ProTyr: 1.145 ± 0.023
0.0ProXaa: 0.0 ± 0.0
Gln
3.481GlnAla: 3.481 ± 0.032
0.207GlnCys: 0.207 ± 0.007
1.183GlnAsp: 1.183 ± 0.021
1.071GlnGlu: 1.071 ± 0.02
0.871GlnPhe: 0.871 ± 0.017
1.9GlnGly: 1.9 ± 0.031
0.732GlnHis: 0.732 ± 0.015
1.295GlnIle: 1.295 ± 0.018
0.473GlnLys: 0.473 ± 0.013
3.542GlnLeu: 3.542 ± 0.04
0.514GlnMet: 0.514 ± 0.011
0.563GlnAsn: 0.563 ± 0.014
2.023GlnPro: 2.023 ± 0.036
1.338GlnGln: 1.338 ± 0.035
2.791GlnArg: 2.791 ± 0.039
1.383GlnSer: 1.383 ± 0.022
1.418GlnThr: 1.418 ± 0.024
2.503GlnVal: 2.503 ± 0.035
0.499GlnTrp: 0.499 ± 0.014
0.609GlnTyr: 0.609 ± 0.014
0.0GlnXaa: 0.0 ± 0.0
Arg
9.668ArgAla: 9.668 ± 0.078
0.761ArgCys: 0.761 ± 0.019
4.566ArgAsp: 4.566 ± 0.041
4.234ArgGlu: 4.234 ± 0.045
2.61ArgPhe: 2.61 ± 0.028
5.672ArgGly: 5.672 ± 0.047
1.96ArgHis: 1.96 ± 0.028
4.244ArgIle: 4.244 ± 0.039
1.72ArgLys: 1.72 ± 0.027
8.351ArgLeu: 8.351 ± 0.067
2.024ArgMet: 2.024 ± 0.026
1.847ArgAsn: 1.847 ± 0.029
4.743ArgPro: 4.743 ± 0.048
2.419ArgGln: 2.419 ± 0.034
7.804ArgArg: 7.804 ± 0.08
4.25ArgSer: 4.25 ± 0.037
5.148ArgThr: 5.148 ± 0.046
5.698ArgVal: 5.698 ± 0.048
1.462ArgTrp: 1.462 ± 0.022
1.998ArgTyr: 1.998 ± 0.027
0.0ArgXaa: 0.0 ± 0.0
Ser
7.178SerAla: 7.178 ± 0.051
0.462SerCys: 0.462 ± 0.013
2.909SerAsp: 2.909 ± 0.029
2.375SerGlu: 2.375 ± 0.033
1.525SerPhe: 1.525 ± 0.022
6.071SerGly: 6.071 ± 0.051
0.948SerHis: 0.948 ± 0.018
2.171SerIle: 2.171 ± 0.028
1.025SerLys: 1.025 ± 0.021
4.254SerLeu: 4.254 ± 0.039
1.244SerMet: 1.244 ± 0.02
1.108SerAsn: 1.108 ± 0.02
2.938SerPro: 2.938 ± 0.032
1.21SerGln: 1.21 ± 0.02
3.73SerArg: 3.73 ± 0.035
2.88SerSer: 2.88 ± 0.039
3.297SerThr: 3.297 ± 0.04
4.311SerVal: 4.311 ± 0.041
0.879SerTrp: 0.879 ± 0.017
1.153SerTyr: 1.153 ± 0.021
0.0SerXaa: 0.0 ± 0.0
Thr
8.437ThrAla: 8.437 ± 0.054
0.438ThrCys: 0.438 ± 0.013
3.796ThrAsp: 3.796 ± 0.036
3.471ThrGlu: 3.471 ± 0.037
1.731ThrPhe: 1.731 ± 0.025
6.191ThrGly: 6.191 ± 0.057
1.188ThrHis: 1.188 ± 0.02
2.546ThrIle: 2.546 ± 0.034
1.2ThrLys: 1.2 ± 0.02
5.376ThrLeu: 5.376 ± 0.045
1.137ThrMet: 1.137 ± 0.019
1.234ThrAsn: 1.234 ± 0.025
3.945ThrPro: 3.945 ± 0.042
1.415ThrGln: 1.415 ± 0.026
3.937ThrArg: 3.937 ± 0.04
2.989ThrSer: 2.989 ± 0.029
3.845ThrThr: 3.845 ± 0.047
6.013ThrVal: 6.013 ± 0.045
0.797ThrTrp: 0.797 ± 0.019
1.255ThrTyr: 1.255 ± 0.02
0.0ThrXaa: 0.0 ± 0.0
Val
11.104ValAla: 11.104 ± 0.085
0.713ValCys: 0.713 ± 0.015
5.166ValAsp: 5.166 ± 0.041
4.12ValGlu: 4.12 ± 0.042
2.53ValPhe: 2.53 ± 0.034
6.526ValGly: 6.526 ± 0.045
1.816ValHis: 1.816 ± 0.026
3.488ValIle: 3.488 ± 0.038
1.309ValLys: 1.309 ± 0.025
9.14ValLeu: 9.14 ± 0.067
1.297ValMet: 1.297 ± 0.023
1.736ValAsn: 1.736 ± 0.022
4.877ValPro: 4.877 ± 0.049
1.931ValGln: 1.931 ± 0.026
6.683ValArg: 6.683 ± 0.053
4.139ValSer: 4.139 ± 0.043
5.25ValThr: 5.25 ± 0.044
7.545ValVal: 7.545 ± 0.066
0.998ValTrp: 0.998 ± 0.02
1.499ValTyr: 1.499 ± 0.025
0.0ValXaa: 0.0 ± 0.0
Trp
1.542TrpAla: 1.542 ± 0.024
0.17TrpCys: 0.17 ± 0.007
0.76TrpAsp: 0.76 ± 0.019
0.62TrpGlu: 0.62 ± 0.015
0.537TrpPhe: 0.537 ± 0.015
0.959TrpGly: 0.959 ± 0.017
0.373TrpHis: 0.373 ± 0.01
0.65TrpIle: 0.65 ± 0.015
0.294TrpLys: 0.294 ± 0.011
1.814TrpLeu: 1.814 ± 0.028
0.287TrpMet: 0.287 ± 0.009
0.441TrpAsn: 0.441 ± 0.013
0.828TrpPro: 0.828 ± 0.019
0.642TrpGln: 0.642 ± 0.016
1.408TrpArg: 1.408 ± 0.021
1.017TrpSer: 1.017 ± 0.019
0.937TrpThr: 0.937 ± 0.02
1.066TrpVal: 1.066 ± 0.02
0.359TrpTrp: 0.359 ± 0.014
0.331TrpTyr: 0.331 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.47TyrAla: 2.47 ± 0.032
0.214TyrCys: 0.214 ± 0.01
1.3TyrAsp: 1.3 ± 0.025
1.048TyrGlu: 1.048 ± 0.019
0.736TyrPhe: 0.736 ± 0.016
2.034TyrGly: 2.034 ± 0.031
0.47TyrHis: 0.47 ± 0.013
0.646TyrIle: 0.646 ± 0.015
0.311TyrLys: 0.311 ± 0.012
2.5TyrLeu: 2.5 ± 0.031
0.264TyrMet: 0.264 ± 0.01
0.443TyrAsn: 0.443 ± 0.014
1.331TyrPro: 1.331 ± 0.023
0.693TyrGln: 0.693 ± 0.018
2.139TyrArg: 2.139 ± 0.029
1.13TyrSer: 1.13 ± 0.023
1.211TyrThr: 1.211 ± 0.022
1.554TyrVal: 1.554 ± 0.03
0.409TyrTrp: 0.409 ± 0.012
0.49TyrTyr: 0.49 ± 0.015
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8970 proteins (3023542 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski