Amino acid dipepetide frequency for Mycobacterium virus Che12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.39AlaAla: 11.39 ± 0.973
0.681AlaCys: 0.681 ± 0.209
5.447AlaAsp: 5.447 ± 0.69
7.366AlaGlu: 7.366 ± 0.729
3.405AlaPhe: 3.405 ± 0.507
8.295AlaGly: 8.295 ± 1.017
1.671AlaHis: 1.671 ± 0.369
4.085AlaIle: 4.085 ± 0.414
5.447AlaLys: 5.447 ± 0.682
8.976AlaLeu: 8.976 ± 0.971
3.343AlaMet: 3.343 ± 0.356
3.838AlaAsn: 3.838 ± 0.541
4.828AlaPro: 4.828 ± 0.741
3.962AlaGln: 3.962 ± 0.636
5.509AlaArg: 5.509 ± 0.654
5.076AlaSer: 5.076 ± 0.623
4.271AlaThr: 4.271 ± 0.515
6.376AlaVal: 6.376 ± 0.704
1.795AlaTrp: 1.795 ± 0.338
3.033AlaTyr: 3.033 ± 0.494
0.0AlaXaa: 0.0 ± 0.0
Cys
0.557CysAla: 0.557 ± 0.167
0.0CysCys: 0.0 ± 0.0
0.557CysAsp: 0.557 ± 0.182
0.495CysGlu: 0.495 ± 0.175
0.557CysPhe: 0.557 ± 0.144
0.743CysGly: 0.743 ± 0.204
0.371CysHis: 0.371 ± 0.163
0.248CysIle: 0.248 ± 0.133
0.619CysLys: 0.619 ± 0.191
0.743CysLeu: 0.743 ± 0.213
0.248CysMet: 0.248 ± 0.129
0.433CysAsn: 0.433 ± 0.157
0.557CysPro: 0.557 ± 0.204
0.186CysGln: 0.186 ± 0.121
0.433CysArg: 0.433 ± 0.165
0.619CysSer: 0.619 ± 0.179
0.31CysThr: 0.31 ± 0.143
0.557CysVal: 0.557 ± 0.182
0.371CysTrp: 0.371 ± 0.163
0.433CysTyr: 0.433 ± 0.195
0.0CysXaa: 0.0 ± 0.0
Asp
5.695AspAla: 5.695 ± 0.683
0.743AspCys: 0.743 ± 0.223
3.157AspAsp: 3.157 ± 0.407
4.395AspGlu: 4.395 ± 0.621
2.228AspPhe: 2.228 ± 0.434
5.447AspGly: 5.447 ± 0.595
1.609AspHis: 1.609 ± 0.345
3.838AspIle: 3.838 ± 0.46
2.786AspLys: 2.786 ± 0.442
5.571AspLeu: 5.571 ± 0.637
1.176AspMet: 1.176 ± 0.239
1.424AspAsn: 1.424 ± 0.272
4.828AspPro: 4.828 ± 0.572
2.414AspGln: 2.414 ± 0.498
3.466AspArg: 3.466 ± 0.534
2.971AspSer: 2.971 ± 0.389
3.343AspThr: 3.343 ± 0.465
4.333AspVal: 4.333 ± 0.459
1.052AspTrp: 1.052 ± 0.276
2.352AspTyr: 2.352 ± 0.364
0.0AspXaa: 0.0 ± 0.0
Glu
7.304GluAla: 7.304 ± 0.858
0.371GluCys: 0.371 ± 0.135
3.652GluAsp: 3.652 ± 0.51
4.704GluGlu: 4.704 ± 0.646
2.847GluPhe: 2.847 ± 0.309
5.076GluGly: 5.076 ± 0.809
1.3GluHis: 1.3 ± 0.294
3.652GluIle: 3.652 ± 0.533
2.352GluLys: 2.352 ± 0.332
6.623GluLeu: 6.623 ± 0.886
2.352GluMet: 2.352 ± 0.376
2.352GluAsn: 2.352 ± 0.342
3.095GluPro: 3.095 ± 0.513
1.795GluGln: 1.795 ± 0.256
5.138GluArg: 5.138 ± 0.509
3.59GluSer: 3.59 ± 0.485
2.971GluThr: 2.971 ± 0.399
5.014GluVal: 5.014 ± 0.569
1.424GluTrp: 1.424 ± 0.295
1.981GluTyr: 1.981 ± 0.354
0.0GluXaa: 0.0 ± 0.0
Phe
3.095PheAla: 3.095 ± 0.446
0.248PheCys: 0.248 ± 0.125
2.538PheAsp: 2.538 ± 0.423
2.476PheGlu: 2.476 ± 0.352
0.681PhePhe: 0.681 ± 0.225
2.724PheGly: 2.724 ± 0.392
0.557PheHis: 0.557 ± 0.17
1.3PheIle: 1.3 ± 0.247
1.733PheLys: 1.733 ± 0.309
2.228PheLeu: 2.228 ± 0.361
0.31PheMet: 0.31 ± 0.145
1.548PheAsn: 1.548 ± 0.351
1.733PhePro: 1.733 ± 0.318
1.362PheGln: 1.362 ± 0.357
1.671PheArg: 1.671 ± 0.304
1.733PheSer: 1.733 ± 0.306
2.228PheThr: 2.228 ± 0.388
2.724PheVal: 2.724 ± 0.343
0.619PheTrp: 0.619 ± 0.196
0.99PheTyr: 0.99 ± 0.284
0.0PheXaa: 0.0 ± 0.0
Gly
7.057GlyAla: 7.057 ± 0.893
0.619GlyCys: 0.619 ± 0.191
5.633GlyAsp: 5.633 ± 0.635
4.828GlyGlu: 4.828 ± 0.493
2.909GlyPhe: 2.909 ± 0.491
8.109GlyGly: 8.109 ± 1.19
1.795GlyHis: 1.795 ± 0.333
4.395GlyIle: 4.395 ± 0.575
3.466GlyLys: 3.466 ± 0.47
6.314GlyLeu: 6.314 ± 0.836
1.857GlyMet: 1.857 ± 0.34
2.909GlyAsn: 2.909 ± 0.502
3.033GlyPro: 3.033 ± 0.43
3.405GlyGln: 3.405 ± 0.473
4.395GlyArg: 4.395 ± 0.387
3.962GlySer: 3.962 ± 0.752
5.757GlyThr: 5.757 ± 0.658
6.376GlyVal: 6.376 ± 0.687
1.857GlyTrp: 1.857 ± 0.337
2.228GlyTyr: 2.228 ± 0.401
0.0GlyXaa: 0.0 ± 0.0
His
1.671HisAla: 1.671 ± 0.448
0.248HisCys: 0.248 ± 0.108
1.486HisAsp: 1.486 ± 0.3
1.671HisGlu: 1.671 ± 0.344
0.495HisPhe: 0.495 ± 0.189
1.548HisGly: 1.548 ± 0.362
0.557HisHis: 0.557 ± 0.193
1.176HisIle: 1.176 ± 0.258
1.362HisLys: 1.362 ± 0.369
1.919HisLeu: 1.919 ± 0.337
0.31HisMet: 0.31 ± 0.143
0.433HisAsn: 0.433 ± 0.164
1.362HisPro: 1.362 ± 0.267
0.929HisGln: 0.929 ± 0.255
1.486HisArg: 1.486 ± 0.34
0.743HisSer: 0.743 ± 0.2
1.486HisThr: 1.486 ± 0.321
1.362HisVal: 1.362 ± 0.291
0.31HisTrp: 0.31 ± 0.157
0.805HisTyr: 0.805 ± 0.294
0.0HisXaa: 0.0 ± 0.0
Ile
5.881IleAla: 5.881 ± 0.504
0.495IleCys: 0.495 ± 0.204
3.652IleAsp: 3.652 ± 0.437
3.962IleGlu: 3.962 ± 0.457
1.238IlePhe: 1.238 ± 0.297
3.838IleGly: 3.838 ± 0.595
1.114IleHis: 1.114 ± 0.222
1.857IleIle: 1.857 ± 0.355
2.6IleLys: 2.6 ± 0.361
3.9IleLeu: 3.9 ± 0.461
0.495IleMet: 0.495 ± 0.137
2.105IleAsn: 2.105 ± 0.372
3.652IlePro: 3.652 ± 0.423
1.795IleGln: 1.795 ± 0.297
3.281IleArg: 3.281 ± 0.439
2.786IleSer: 2.786 ± 0.533
3.405IleThr: 3.405 ± 0.419
3.528IleVal: 3.528 ± 0.406
0.743IleTrp: 0.743 ± 0.166
1.176IleTyr: 1.176 ± 0.261
0.0IleXaa: 0.0 ± 0.0
Lys
4.828LysAla: 4.828 ± 0.66
0.31LysCys: 0.31 ± 0.139
2.847LysAsp: 2.847 ± 0.514
2.476LysGlu: 2.476 ± 0.455
0.929LysPhe: 0.929 ± 0.267
3.528LysGly: 3.528 ± 0.425
1.052LysHis: 1.052 ± 0.223
2.29LysIle: 2.29 ± 0.34
3.033LysLys: 3.033 ± 0.518
3.776LysLeu: 3.776 ± 0.481
0.99LysMet: 0.99 ± 0.27
1.795LysAsn: 1.795 ± 0.368
3.343LysPro: 3.343 ± 0.552
1.981LysGln: 1.981 ± 0.38
3.528LysArg: 3.528 ± 0.508
2.538LysSer: 2.538 ± 0.411
3.219LysThr: 3.219 ± 0.551
3.714LysVal: 3.714 ± 0.485
0.681LysTrp: 0.681 ± 0.208
1.238LysTyr: 1.238 ± 0.313
0.0LysXaa: 0.0 ± 0.0
Leu
8.418LeuAla: 8.418 ± 0.73
0.929LeuCys: 0.929 ± 0.269
4.704LeuAsp: 4.704 ± 0.462
5.695LeuGlu: 5.695 ± 0.656
2.167LeuPhe: 2.167 ± 0.281
6.561LeuGly: 6.561 ± 0.845
2.043LeuHis: 2.043 ± 0.404
4.952LeuIle: 4.952 ± 0.43
3.652LeuLys: 3.652 ± 0.431
4.89LeuLeu: 4.89 ± 0.591
2.662LeuMet: 2.662 ± 0.416
2.786LeuAsn: 2.786 ± 0.446
4.271LeuPro: 4.271 ± 0.534
2.538LeuGln: 2.538 ± 0.565
4.643LeuArg: 4.643 ± 0.53
5.881LeuSer: 5.881 ± 0.679
4.766LeuThr: 4.766 ± 0.608
5.323LeuVal: 5.323 ± 0.729
1.3LeuTrp: 1.3 ± 0.26
2.352LeuTyr: 2.352 ± 0.387
0.0LeuXaa: 0.0 ± 0.0
Met
2.105MetAla: 2.105 ± 0.436
0.062MetCys: 0.062 ± 0.065
1.3MetAsp: 1.3 ± 0.234
1.238MetGlu: 1.238 ± 0.228
0.619MetPhe: 0.619 ± 0.244
1.362MetGly: 1.362 ± 0.333
0.31MetHis: 0.31 ± 0.131
1.3MetIle: 1.3 ± 0.286
1.671MetLys: 1.671 ± 0.288
2.105MetLeu: 2.105 ± 0.348
0.557MetMet: 0.557 ± 0.218
0.929MetAsn: 0.929 ± 0.218
1.3MetPro: 1.3 ± 0.296
0.99MetGln: 0.99 ± 0.303
1.548MetArg: 1.548 ± 0.271
2.414MetSer: 2.414 ± 0.345
2.786MetThr: 2.786 ± 0.335
1.362MetVal: 1.362 ± 0.284
0.371MetTrp: 0.371 ± 0.142
0.371MetTyr: 0.371 ± 0.121
0.0MetXaa: 0.0 ± 0.0
Asn
3.405AsnAla: 3.405 ± 0.494
0.31AsnCys: 0.31 ± 0.166
2.105AsnAsp: 2.105 ± 0.317
2.167AsnGlu: 2.167 ± 0.356
0.929AsnPhe: 0.929 ± 0.279
3.157AsnGly: 3.157 ± 0.391
0.805AsnHis: 0.805 ± 0.242
1.548AsnIle: 1.548 ± 0.361
1.052AsnLys: 1.052 ± 0.263
2.724AsnLeu: 2.724 ± 0.396
0.929AsnMet: 0.929 ± 0.238
1.176AsnAsn: 1.176 ± 0.312
2.476AsnPro: 2.476 ± 0.38
1.114AsnGln: 1.114 ± 0.248
2.724AsnArg: 2.724 ± 0.417
1.671AsnSer: 1.671 ± 0.412
1.671AsnThr: 1.671 ± 0.376
2.909AsnVal: 2.909 ± 0.39
0.619AsnTrp: 0.619 ± 0.182
1.176AsnTyr: 1.176 ± 0.233
0.0AsnXaa: 0.0 ± 0.0
Pro
5.138ProAla: 5.138 ± 0.754
0.31ProCys: 0.31 ± 0.156
3.281ProAsp: 3.281 ± 0.375
4.89ProGlu: 4.89 ± 0.668
2.105ProPhe: 2.105 ± 0.362
4.519ProGly: 4.519 ± 0.491
1.3ProHis: 1.3 ± 0.279
2.6ProIle: 2.6 ± 0.332
2.909ProLys: 2.909 ± 0.571
3.343ProLeu: 3.343 ± 0.385
1.238ProMet: 1.238 ± 0.277
2.29ProAsn: 2.29 ± 0.423
2.6ProPro: 2.6 ± 0.5
1.981ProGln: 1.981 ± 0.462
2.909ProArg: 2.909 ± 0.511
2.228ProSer: 2.228 ± 0.329
3.714ProThr: 3.714 ± 0.391
4.085ProVal: 4.085 ± 0.477
1.362ProTrp: 1.362 ± 0.362
1.362ProTyr: 1.362 ± 0.337
0.0ProXaa: 0.0 ± 0.0
Gln
4.643GlnAla: 4.643 ± 0.641
0.371GlnCys: 0.371 ± 0.119
1.609GlnAsp: 1.609 ± 0.37
2.167GlnGlu: 2.167 ± 0.386
1.548GlnPhe: 1.548 ± 0.322
2.847GlnGly: 2.847 ± 0.463
0.929GlnHis: 0.929 ± 0.204
2.228GlnIle: 2.228 ± 0.403
1.733GlnLys: 1.733 ± 0.361
3.219GlnLeu: 3.219 ± 0.713
0.867GlnMet: 0.867 ± 0.201
1.176GlnAsn: 1.176 ± 0.227
1.052GlnPro: 1.052 ± 0.304
1.795GlnGln: 1.795 ± 0.437
2.228GlnArg: 2.228 ± 0.326
1.795GlnSer: 1.795 ± 0.351
2.105GlnThr: 2.105 ± 0.345
2.538GlnVal: 2.538 ± 0.295
0.681GlnTrp: 0.681 ± 0.181
1.052GlnTyr: 1.052 ± 0.23
0.0GlnXaa: 0.0 ± 0.0
Arg
5.757ArgAla: 5.757 ± 0.681
1.052ArgCys: 1.052 ± 0.278
3.652ArgAsp: 3.652 ± 0.477
4.581ArgGlu: 4.581 ± 0.609
2.352ArgPhe: 2.352 ± 0.48
3.466ArgGly: 3.466 ± 0.496
1.424ArgHis: 1.424 ± 0.312
4.085ArgIle: 4.085 ± 0.472
3.281ArgLys: 3.281 ± 0.347
5.323ArgLeu: 5.323 ± 0.625
1.981ArgMet: 1.981 ± 0.337
2.105ArgAsn: 2.105 ± 0.328
2.228ArgPro: 2.228 ± 0.355
1.671ArgGln: 1.671 ± 0.344
5.571ArgArg: 5.571 ± 0.633
2.847ArgSer: 2.847 ± 0.412
2.662ArgThr: 2.662 ± 0.438
4.89ArgVal: 4.89 ± 0.518
1.3ArgTrp: 1.3 ± 0.28
2.352ArgTyr: 2.352 ± 0.426
0.0ArgXaa: 0.0 ± 0.0
Ser
4.581SerAla: 4.581 ± 0.46
0.371SerCys: 0.371 ± 0.16
3.652SerAsp: 3.652 ± 0.457
3.281SerGlu: 3.281 ± 0.47
2.105SerPhe: 2.105 ± 0.419
5.2SerGly: 5.2 ± 0.674
0.619SerHis: 0.619 ± 0.16
2.167SerIle: 2.167 ± 0.318
2.6SerLys: 2.6 ± 0.481
4.581SerLeu: 4.581 ± 0.587
0.929SerMet: 0.929 ± 0.224
1.238SerAsn: 1.238 ± 0.255
3.033SerPro: 3.033 ± 0.336
2.29SerGln: 2.29 ± 0.403
3.652SerArg: 3.652 ± 0.46
2.724SerSer: 2.724 ± 0.368
3.838SerThr: 3.838 ± 0.402
3.59SerVal: 3.59 ± 0.44
1.3SerTrp: 1.3 ± 0.296
1.671SerTyr: 1.671 ± 0.272
0.0SerXaa: 0.0 ± 0.0
Thr
5.509ThrAla: 5.509 ± 0.46
0.557ThrCys: 0.557 ± 0.174
4.395ThrAsp: 4.395 ± 0.515
3.962ThrGlu: 3.962 ± 0.525
2.228ThrPhe: 2.228 ± 0.324
5.881ThrGly: 5.881 ± 0.543
1.362ThrHis: 1.362 ± 0.313
2.662ThrIle: 2.662 ± 0.418
2.909ThrLys: 2.909 ± 0.433
4.704ThrLeu: 4.704 ± 0.594
1.424ThrMet: 1.424 ± 0.302
1.424ThrAsn: 1.424 ± 0.309
4.643ThrPro: 4.643 ± 0.674
2.167ThrGln: 2.167 ± 0.433
2.228ThrArg: 2.228 ± 0.412
2.6ThrSer: 2.6 ± 0.462
3.466ThrThr: 3.466 ± 0.631
4.457ThrVal: 4.457 ± 0.58
1.114ThrTrp: 1.114 ± 0.274
1.733ThrTyr: 1.733 ± 0.288
0.0ThrXaa: 0.0 ± 0.0
Val
7.676ValAla: 7.676 ± 0.827
0.867ValCys: 0.867 ± 0.262
5.509ValAsp: 5.509 ± 0.713
4.085ValGlu: 4.085 ± 0.456
1.857ValPhe: 1.857 ± 0.355
4.952ValGly: 4.952 ± 0.535
1.671ValHis: 1.671 ± 0.364
4.147ValIle: 4.147 ± 0.57
3.466ValLys: 3.466 ± 0.437
5.076ValLeu: 5.076 ± 0.555
1.548ValMet: 1.548 ± 0.297
2.786ValAsn: 2.786 ± 0.45
3.528ValPro: 3.528 ± 0.516
1.981ValGln: 1.981 ± 0.376
5.262ValArg: 5.262 ± 0.602
4.457ValSer: 4.457 ± 0.563
4.085ValThr: 4.085 ± 0.703
5.447ValVal: 5.447 ± 0.618
1.3ValTrp: 1.3 ± 0.256
2.105ValTyr: 2.105 ± 0.372
0.0ValXaa: 0.0 ± 0.0
Trp
1.362TrpAla: 1.362 ± 0.311
0.371TrpCys: 0.371 ± 0.153
1.238TrpAsp: 1.238 ± 0.305
1.3TrpGlu: 1.3 ± 0.242
0.619TrpPhe: 0.619 ± 0.17
1.424TrpGly: 1.424 ± 0.367
0.619TrpHis: 0.619 ± 0.198
1.238TrpIle: 1.238 ± 0.264
0.681TrpLys: 0.681 ± 0.239
1.424TrpLeu: 1.424 ± 0.365
0.495TrpMet: 0.495 ± 0.184
0.743TrpAsn: 0.743 ± 0.177
0.805TrpPro: 0.805 ± 0.291
1.052TrpGln: 1.052 ± 0.291
0.867TrpArg: 0.867 ± 0.204
1.238TrpSer: 1.238 ± 0.315
1.3TrpThr: 1.3 ± 0.279
1.3TrpVal: 1.3 ± 0.228
0.495TrpTrp: 0.495 ± 0.212
0.743TrpTyr: 0.743 ± 0.248
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.786TyrAla: 2.786 ± 0.461
0.124TyrCys: 0.124 ± 0.085
2.414TyrAsp: 2.414 ± 0.352
1.857TyrGlu: 1.857 ± 0.356
0.681TyrPhe: 0.681 ± 0.181
2.228TyrGly: 2.228 ± 0.353
0.248TyrHis: 0.248 ± 0.131
1.733TyrIle: 1.733 ± 0.306
0.743TyrLys: 0.743 ± 0.269
3.095TyrLeu: 3.095 ± 0.415
0.929TyrMet: 0.929 ± 0.273
1.176TyrAsn: 1.176 ± 0.252
1.795TyrPro: 1.795 ± 0.351
1.176TyrGln: 1.176 ± 0.263
2.043TyrArg: 2.043 ± 0.32
1.548TyrSer: 1.548 ± 0.336
2.043TyrThr: 2.043 ± 0.313
1.919TyrVal: 1.919 ± 0.376
0.619TyrTrp: 0.619 ± 0.2
1.052TyrTyr: 1.052 ± 0.325
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 98 proteins (16156 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski