Amino acid dipepetide frequency for Planctomycetaceae bacterium SCGC AG-212-F19

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.02AlaAla: 14.02 ± 0.143	1.269AlaCys: 1.269 ± 0.042	6.628AlaAsp: 6.628 ± 0.079	6.719AlaGlu: 6.719 ± 0.091	3.782AlaPhe: 3.782 ± 0.06	9.772AlaGly: 9.772 ± 0.108	2.077AlaHis: 2.077 ± 0.047	4.563AlaIle: 4.563 ± 0.07	4.917AlaLys: 4.917 ± 0.095	11.527AlaLeu: 11.527 ± 0.126	2.208AlaMet: 2.208 ± 0.044	3.034AlaAsn: 3.034 ± 0.058	5.901AlaPro: 5.901 ± 0.089	4.055AlaGln: 4.055 ± 0.071	7.376AlaArg: 7.376 ± 0.093	5.156AlaSer: 5.156 ± 0.072	5.919AlaThr: 5.919 ± 0.087	8.463AlaVal: 8.463 ± 0.105	1.714AlaTrp: 1.714 ± 0.044	2.353AlaTyr: 2.353 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.037CysAla: 1.037 ± 0.032	0.268CysCys: 0.268 ± 0.02	0.595CysAsp: 0.595 ± 0.023	0.545CysGlu: 0.545 ± 0.024	0.415CysPhe: 0.415 ± 0.021	1.002CysGly: 1.002 ± 0.036	0.442CysHis: 0.442 ± 0.023	0.455CysIle: 0.455 ± 0.02	0.361CysLys: 0.361 ± 0.019	1.241CysLeu: 1.241 ± 0.031	0.208CysMet: 0.208 ± 0.016	0.308CysAsn: 0.308 ± 0.015	0.681CysPro: 0.681 ± 0.028	0.446CysGln: 0.446 ± 0.021	0.926CysArg: 0.926 ± 0.033	0.526CysSer: 0.526 ± 0.023	0.604CysThr: 0.604 ± 0.028	0.713CysVal: 0.713 ± 0.026	0.273CysTrp: 0.273 ± 0.017	0.375CysTyr: 0.375 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	6.08AspAla: 6.08 ± 0.089	0.562AspCys: 0.562 ± 0.024	3.071AspAsp: 3.071 ± 0.058	3.195AspGlu: 3.195 ± 0.056	2.091AspPhe: 2.091 ± 0.043	5.158AspGly: 5.158 ± 0.095	1.292AspHis: 1.292 ± 0.034	2.326AspIle: 2.326 ± 0.046	2.582AspLys: 2.582 ± 0.07	5.863AspLeu: 5.863 ± 0.075	1.029AspMet: 1.029 ± 0.029	1.375AspAsn: 1.375 ± 0.038	3.921AspPro: 3.921 ± 0.065	1.942AspGln: 1.942 ± 0.044	4.198AspArg: 4.198 ± 0.058	2.178AspSer: 2.178 ± 0.045	2.502AspThr: 2.502 ± 0.051	4.011AspVal: 4.011 ± 0.054	1.055AspTrp: 1.055 ± 0.028	1.492AspTyr: 1.492 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.27GluAla: 6.27 ± 0.089	0.505GluCys: 0.505 ± 0.021	2.369GluAsp: 2.369 ± 0.048	3.376GluGlu: 3.376 ± 0.066	1.895GluPhe: 1.895 ± 0.039	3.744GluGly: 3.744 ± 0.055	1.437GluHis: 1.437 ± 0.041	2.52GluIle: 2.52 ± 0.05	3.042GluLys: 3.042 ± 0.061	6.237GluLeu: 6.237 ± 0.087	1.345GluMet: 1.345 ± 0.036	1.382GluAsn: 1.382 ± 0.032	3.212GluPro: 3.212 ± 0.061	2.561GluGln: 2.561 ± 0.056	4.301GluArg: 4.301 ± 0.073	2.371GluSer: 2.371 ± 0.044	2.798GluThr: 2.798 ± 0.055	4.095GluVal: 4.095 ± 0.068	0.833GluTrp: 0.833 ± 0.026	1.366GluTyr: 1.366 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.051PheAla: 4.051 ± 0.064	0.471PheCys: 0.471 ± 0.022	2.409PheAsp: 2.409 ± 0.043	1.765PheGlu: 1.765 ± 0.045	1.4PhePhe: 1.4 ± 0.039	3.197PheGly: 3.197 ± 0.067	0.872PheHis: 0.872 ± 0.026	1.364PheIle: 1.364 ± 0.033	1.191PheLys: 1.191 ± 0.035	3.751PheLeu: 3.751 ± 0.062	0.583PheMet: 0.583 ± 0.023	1.017PheAsn: 1.017 ± 0.035	1.784PhePro: 1.784 ± 0.037	1.329PheGln: 1.329 ± 0.036	2.484PheArg: 2.484 ± 0.053	1.857PheSer: 1.857 ± 0.041	2.098PheThr: 2.098 ± 0.05	2.734PheVal: 2.734 ± 0.05	0.637PheTrp: 0.637 ± 0.024	0.929PheTyr: 0.929 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.296GlyAla: 7.296 ± 0.094	1.103GlyCys: 1.103 ± 0.039	4.16GlyAsp: 4.16 ± 0.069	4.359GlyGlu: 4.359 ± 0.062	3.005GlyPhe: 3.005 ± 0.054	6.9GlyGly: 6.9 ± 0.129	1.939GlyHis: 1.939 ± 0.047	3.684GlyIle: 3.684 ± 0.056	5.216GlyLys: 5.216 ± 0.113	7.921GlyLeu: 7.921 ± 0.111	2.006GlyMet: 2.006 ± 0.048	2.669GlyAsn: 2.669 ± 0.064	4.134GlyPro: 4.134 ± 0.063	3.478GlyGln: 3.478 ± 0.058	5.639GlyArg: 5.639 ± 0.072	4.497GlySer: 4.497 ± 0.071	4.851GlyThr: 4.851 ± 0.101	5.656GlyVal: 5.656 ± 0.07	1.6GlyTrp: 1.6 ± 0.037	2.066GlyTyr: 2.066 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.267HisAla: 2.267 ± 0.043	0.393HisCys: 0.393 ± 0.019	1.26HisAsp: 1.26 ± 0.041	1.181HisGlu: 1.181 ± 0.033	0.959HisPhe: 0.959 ± 0.026	2.019HisGly: 2.019 ± 0.043	0.671HisHis: 0.671 ± 0.023	0.932HisIle: 0.932 ± 0.029	0.744HisLys: 0.744 ± 0.027	2.447HisLeu: 2.447 ± 0.049	0.409HisMet: 0.409 ± 0.02	0.638HisAsn: 0.638 ± 0.023	1.73HisPro: 1.73 ± 0.042	0.868HisGln: 0.868 ± 0.027	1.698HisArg: 1.698 ± 0.04	0.963HisSer: 0.963 ± 0.028	1.105HisThr: 1.105 ± 0.034	1.645HisVal: 1.645 ± 0.041	0.5HisTrp: 0.5 ± 0.022	0.669HisTyr: 0.669 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	4.852IleAla: 4.852 ± 0.068	0.525IleCys: 0.525 ± 0.023	2.917IleAsp: 2.917 ± 0.059	2.467IleGlu: 2.467 ± 0.049	1.359IlePhe: 1.359 ± 0.037	3.632IleGly: 3.632 ± 0.066	1.035IleHis: 1.035 ± 0.031	1.618IleIle: 1.618 ± 0.042	1.665IleLys: 1.665 ± 0.041	3.907IleLeu: 3.907 ± 0.058	0.641IleMet: 0.641 ± 0.027	1.235IleAsn: 1.235 ± 0.039	2.259IlePro: 2.259 ± 0.049	1.448IleGln: 1.448 ± 0.036	3.084IleArg: 3.084 ± 0.057	1.931IleSer: 1.931 ± 0.043	2.313IleThr: 2.313 ± 0.047	3.346IleVal: 3.346 ± 0.063	0.625IleTrp: 0.625 ± 0.026	1.093IleTyr: 1.093 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.371LysAla: 4.371 ± 0.074	0.371LysCys: 0.371 ± 0.02	2.752LysAsp: 2.752 ± 0.07	2.833LysGlu: 2.833 ± 0.061	1.281LysPhe: 1.281 ± 0.036	3.14LysGly: 3.14 ± 0.066	0.895LysHis: 0.895 ± 0.03	1.801LysIle: 1.801 ± 0.041	2.261LysLys: 2.261 ± 0.065	4.584LysLeu: 4.584 ± 0.085	1.154LysMet: 1.154 ± 0.031	1.278LysAsn: 1.278 ± 0.037	3.211LysPro: 3.211 ± 0.067	1.717LysGln: 1.717 ± 0.039	2.488LysArg: 2.488 ± 0.05	1.864LysSer: 1.864 ± 0.039	2.314LysThr: 2.314 ± 0.049	3.109LysVal: 3.109 ± 0.064	0.573LysTrp: 0.573 ± 0.027	0.996LysTyr: 0.996 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	13.889LeuAla: 13.889 ± 0.141	1.172LeuCys: 1.172 ± 0.034	5.931LeuAsp: 5.931 ± 0.067	5.63LeuGlu: 5.63 ± 0.075	3.558LeuPhe: 3.558 ± 0.073	8.277LeuGly: 8.277 ± 0.091	2.339LeuHis: 2.339 ± 0.047	3.991LeuIle: 3.991 ± 0.063	4.133LeuLys: 4.133 ± 0.093	11.324LeuLeu: 11.324 ± 0.14	1.685LeuMet: 1.685 ± 0.037	2.538LeuAsn: 2.538 ± 0.05	6.282LeuPro: 6.282 ± 0.072	3.577LeuGln: 3.577 ± 0.059	7.722LeuArg: 7.722 ± 0.098	4.808LeuSer: 4.808 ± 0.066	6.103LeuThr: 6.103 ± 0.078	7.816LeuVal: 7.816 ± 0.101	1.621LeuTrp: 1.621 ± 0.052	2.218LeuTyr: 2.218 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.26MetAla: 2.26 ± 0.043	0.177MetCys: 0.177 ± 0.014	0.921MetAsp: 0.921 ± 0.031	0.961MetGlu: 0.961 ± 0.027	0.618MetPhe: 0.618 ± 0.022	1.438MetGly: 1.438 ± 0.042	0.462MetHis: 0.462 ± 0.02	0.9MetIle: 0.9 ± 0.031	0.918MetLys: 0.918 ± 0.03	2.161MetLeu: 2.161 ± 0.042	0.443MetMet: 0.443 ± 0.02	0.648MetAsn: 0.648 ± 0.023	1.497MetPro: 1.497 ± 0.042	0.796MetGln: 0.796 ± 0.026	1.395MetArg: 1.395 ± 0.032	1.13MetSer: 1.13 ± 0.031	1.373MetThr: 1.373 ± 0.034	1.406MetVal: 1.406 ± 0.033	0.212MetTrp: 0.212 ± 0.015	0.362MetTyr: 0.362 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.655AsnAla: 2.655 ± 0.053	0.307AsnCys: 0.307 ± 0.016	1.55AsnAsp: 1.55 ± 0.046	1.33AsnGlu: 1.33 ± 0.038	0.997AsnPhe: 0.997 ± 0.028	2.52AsnGly: 2.52 ± 0.06	0.675AsnHis: 0.675 ± 0.026	1.155AsnIle: 1.155 ± 0.037	1.005AsnLys: 1.005 ± 0.038	2.733AsnLeu: 2.733 ± 0.052	0.492AsnMet: 0.492 ± 0.024	0.93AsnAsn: 0.93 ± 0.037	2.145AsnPro: 2.145 ± 0.043	1.085AsnGln: 1.085 ± 0.028	2.007AsnArg: 2.007 ± 0.043	1.191AsnSer: 1.191 ± 0.039	1.324AsnThr: 1.324 ± 0.039	2.024AsnVal: 2.024 ± 0.049	0.511AsnTrp: 0.511 ± 0.02	0.736AsnTyr: 0.736 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.889ProAla: 7.889 ± 0.114	0.5ProCys: 0.5 ± 0.027	4.278ProAsp: 4.278 ± 0.068	4.094ProGlu: 4.094 ± 0.062	2.047ProPhe: 2.047 ± 0.046	5.397ProGly: 5.397 ± 0.075	1.24ProHis: 1.24 ± 0.032	2.461ProIle: 2.461 ± 0.048	2.528ProLys: 2.528 ± 0.062	5.336ProLeu: 5.336 ± 0.077	1.191ProMet: 1.191 ± 0.027	1.679ProAsn: 1.679 ± 0.041	4.446ProPro: 4.446 ± 0.094	2.055ProGln: 2.055 ± 0.044	3.422ProArg: 3.422 ± 0.064	3.002ProSer: 3.002 ± 0.052	3.269ProThr: 3.269 ± 0.061	4.618ProVal: 4.618 ± 0.068	0.909ProTrp: 0.909 ± 0.029	1.237ProTyr: 1.237 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.681GlnAla: 4.681 ± 0.084	0.366GlnCys: 0.366 ± 0.02	1.631GlnAsp: 1.631 ± 0.042	2.096GlnGlu: 2.096 ± 0.048	1.404GlnPhe: 1.404 ± 0.034	2.855GlnGly: 2.855 ± 0.056	0.938GlnHis: 0.938 ± 0.025	1.561GlnIle: 1.561 ± 0.037	1.573GlnLys: 1.573 ± 0.04	4.027GlnLeu: 4.027 ± 0.071	0.818GlnMet: 0.818 ± 0.028	0.866GlnAsn: 0.866 ± 0.026	2.632GlnPro: 2.632 ± 0.054	1.949GlnGln: 1.949 ± 0.046	2.964GlnArg: 2.964 ± 0.053	1.739GlnSer: 1.739 ± 0.038	2.133GlnThr: 2.133 ± 0.046	3.057GlnVal: 3.057 ± 0.056	0.562GlnTrp: 0.562 ± 0.022	0.78GlnTyr: 0.78 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	6.721ArgAla: 6.721 ± 0.089	0.856ArgCys: 0.856 ± 0.029	3.828ArgAsp: 3.828 ± 0.059	4.008ArgGlu: 4.008 ± 0.068	2.849ArgPhe: 2.849 ± 0.053	4.885ArgGly: 4.885 ± 0.066	1.812ArgHis: 1.812 ± 0.049	3.193ArgIle: 3.193 ± 0.058	2.732ArgLys: 2.732 ± 0.055	8.292ArgLeu: 8.292 ± 0.107	1.584ArgMet: 1.584 ± 0.034	1.724ArgAsn: 1.724 ± 0.047	4.122ArgPro: 4.122 ± 0.062	3.315ArgGln: 3.315 ± 0.068	5.912ArgArg: 5.912 ± 0.099	3.332ArgSer: 3.332 ± 0.06	3.457ArgThr: 3.457 ± 0.051	4.827ArgVal: 4.827 ± 0.077	1.371ArgTrp: 1.371 ± 0.04	1.858ArgTyr: 1.858 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.044SerAla: 5.044 ± 0.07	0.577SerCys: 0.577 ± 0.023	2.429SerAsp: 2.429 ± 0.043	2.159SerGlu: 2.159 ± 0.045	1.942SerPhe: 1.942 ± 0.042	4.451SerGly: 4.451 ± 0.076	1.017SerHis: 1.017 ± 0.03	1.972SerIle: 1.972 ± 0.042	1.76SerLys: 1.76 ± 0.041	4.882SerLeu: 4.882 ± 0.069	1.066SerMet: 1.066 ± 0.028	1.316SerAsn: 1.316 ± 0.038	3.312SerPro: 3.312 ± 0.058	1.589SerGln: 1.589 ± 0.038	3.166SerArg: 3.166 ± 0.061	2.649SerSer: 2.649 ± 0.054	2.407SerThr: 2.407 ± 0.049	3.422SerVal: 3.422 ± 0.059	0.879SerTrp: 0.879 ± 0.032	1.234SerTyr: 1.234 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.821ThrAla: 5.821 ± 0.084	0.549ThrCys: 0.549 ± 0.027	3.011ThrAsp: 3.011 ± 0.062	2.64ThrGlu: 2.64 ± 0.048	2.117ThrPhe: 2.117 ± 0.046	5.288ThrGly: 5.288 ± 0.082	1.135ThrHis: 1.135 ± 0.031	2.648ThrIle: 2.648 ± 0.051	1.942ThrLys: 1.942 ± 0.046	5.66ThrLeu: 5.66 ± 0.08	0.976ThrMet: 0.976 ± 0.029	1.476ThrAsn: 1.476 ± 0.034	3.754ThrPro: 3.754 ± 0.056	1.716ThrGln: 1.716 ± 0.044	3.016ThrArg: 3.016 ± 0.05	2.57ThrSer: 2.57 ± 0.056	2.908ThrThr: 2.908 ± 0.066	4.494ThrVal: 4.494 ± 0.076	0.883ThrTrp: 0.883 ± 0.031	1.255ThrTyr: 1.255 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	8.586ValAla: 8.586 ± 0.104	0.923ValCys: 0.923 ± 0.03	3.645ValAsp: 3.645 ± 0.064	4.189ValGlu: 4.189 ± 0.07	2.559ValPhe: 2.559 ± 0.046	5.544ValGly: 5.544 ± 0.076	1.655ValHis: 1.655 ± 0.041	3.358ValIle: 3.358 ± 0.057	2.943ValLys: 2.943 ± 0.059	7.905ValLeu: 7.905 ± 0.099	1.431ValMet: 1.431 ± 0.041	2.031ValAsn: 2.031 ± 0.054	4.389ValPro: 4.389 ± 0.067	2.731ValGln: 2.731 ± 0.055	5.579ValArg: 5.579 ± 0.081	3.556ValSer: 3.556 ± 0.062	4.244ValThr: 4.244 ± 0.073	6.233ValVal: 6.233 ± 0.079	1.201ValTrp: 1.201 ± 0.036	1.833ValTyr: 1.833 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.387TrpAla: 1.387 ± 0.038	0.182TrpCys: 0.182 ± 0.013	1.126TrpAsp: 1.126 ± 0.044	0.86TrpGlu: 0.86 ± 0.029	0.633TrpPhe: 0.633 ± 0.027	1.022TrpGly: 1.022 ± 0.031	0.487TrpHis: 0.487 ± 0.022	0.627TrpIle: 0.627 ± 0.022	0.729TrpLys: 0.729 ± 0.028	2.156TrpLeu: 2.156 ± 0.056	0.371TrpMet: 0.371 ± 0.019	0.55TrpAsn: 0.55 ± 0.025	0.913TrpPro: 0.913 ± 0.029	0.888TrpGln: 0.888 ± 0.027	1.185TrpArg: 1.185 ± 0.038	0.864TrpSer: 0.864 ± 0.029	0.899TrpThr: 0.899 ± 0.028	1.124TrpVal: 1.124 ± 0.03	0.315TrpTrp: 0.315 ± 0.018	0.412TrpTyr: 0.412 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.275TyrAla: 2.275 ± 0.046	0.345TyrCys: 0.345 ± 0.02	1.414TyrAsp: 1.414 ± 0.039	1.254TyrGlu: 1.254 ± 0.036	1.009TyrPhe: 1.009 ± 0.033	1.937TyrGly: 1.937 ± 0.045	0.68TyrHis: 0.68 ± 0.027	0.822TyrIle: 0.822 ± 0.028	0.752TyrLys: 0.752 ± 0.028	2.657TyrLeu: 2.657 ± 0.055	0.436TyrMet: 0.436 ± 0.02	0.678TyrAsn: 0.678 ± 0.026	1.275TyrPro: 1.275 ± 0.035	1.087TyrGln: 1.087 ± 0.032	2.119TyrArg: 2.119 ± 0.047	1.09TyrSer: 1.09 ± 0.037	1.239TyrThr: 1.239 ± 0.04	1.742TyrVal: 1.742 ± 0.038	0.454TyrTrp: 0.454 ± 0.02	0.772TyrTyr: 0.772 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3394 proteins (1134279 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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