Amino acid dipepetide frequency for Hubei sobemo-like virus 13

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.5AlaAla: 3.5 ± 1.371
1.75AlaCys: 1.75 ± 1.882
2.625AlaAsp: 2.625 ± 0.971
1.75AlaGlu: 1.75 ± 0.685
3.5AlaPhe: 3.5 ± 1.701
2.625AlaGly: 2.625 ± 0.971
1.75AlaHis: 1.75 ± 0.947
4.374AlaIle: 4.374 ± 2.125
0.875AlaLys: 0.875 ± 0.843
7.874AlaLeu: 7.874 ± 1.88
0.875AlaMet: 0.875 ± 0.843
2.625AlaAsn: 2.625 ± 0.371
5.249AlaPro: 5.249 ± 2.577
2.625AlaGln: 2.625 ± 2.528
3.5AlaArg: 3.5 ± 2.389
5.249AlaSer: 5.249 ± 2.684
1.75AlaThr: 1.75 ± 0.85
8.749AlaVal: 8.749 ± 2.335
1.75AlaTrp: 1.75 ± 0.947
0.875AlaTyr: 0.875 ± 0.843
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.875CysAsp: 0.875 ± 0.597
1.75CysGlu: 1.75 ± 0.685
0.875CysPhe: 0.875 ± 0.597
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
1.75CysIle: 1.75 ± 1.882
0.0CysLys: 0.0 ± 0.0
1.75CysLeu: 1.75 ± 0.947
0.875CysMet: 0.875 ± 0.941
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
1.75CysSer: 1.75 ± 0.685
0.0CysThr: 0.0 ± 0.0
1.75CysVal: 1.75 ± 1.194
0.875CysTrp: 0.875 ± 0.941
0.875CysTyr: 0.875 ± 0.843
0.0CysXaa: 0.0 ± 0.0
Asp
5.249AspAla: 5.249 ± 3.889
0.875AspCys: 0.875 ± 0.597
5.249AspAsp: 5.249 ± 1.942
5.249AspGlu: 5.249 ± 2.831
0.0AspPhe: 0.0 ± 0.0
1.75AspGly: 1.75 ± 0.685
0.0AspHis: 0.0 ± 0.0
3.5AspIle: 3.5 ± 2.389
3.5AspLys: 3.5 ± 2.226
5.249AspLeu: 5.249 ± 1.463
0.875AspMet: 0.875 ± 0.843
0.0AspAsn: 0.0 ± 0.0
3.5AspPro: 3.5 ± 1.894
1.75AspGln: 1.75 ± 1.882
5.249AspArg: 5.249 ± 3.889
1.75AspSer: 1.75 ± 0.685
5.249AspThr: 5.249 ± 1.077
0.0AspVal: 0.0 ± 0.0
0.875AspTrp: 0.875 ± 0.843
0.875AspTyr: 0.875 ± 0.843
0.0AspXaa: 0.0 ± 0.0
Glu
3.5GluAla: 3.5 ± 1.371
0.0GluCys: 0.0 ± 0.0
2.625GluAsp: 2.625 ± 1.129
1.75GluGlu: 1.75 ± 1.194
2.625GluPhe: 2.625 ± 1.415
2.625GluGly: 2.625 ± 0.971
0.875GluHis: 0.875 ± 0.843
0.875GluIle: 0.875 ± 0.597
0.875GluLys: 0.875 ± 0.843
2.625GluLeu: 2.625 ± 0.971
0.875GluMet: 0.875 ± 0.919
0.0GluAsn: 0.0 ± 0.0
6.124GluPro: 6.124 ± 2.722
2.625GluGln: 2.625 ± 0.971
5.249GluArg: 5.249 ± 2.551
6.124GluSer: 6.124 ± 2.058
1.75GluThr: 1.75 ± 0.685
3.5GluVal: 3.5 ± 2.226
1.75GluTrp: 1.75 ± 0.85
4.374GluTyr: 4.374 ± 2.007
0.0GluXaa: 0.0 ± 0.0
Phe
5.249PheAla: 5.249 ± 1.077
0.0PheCys: 0.0 ± 0.0
5.249PheAsp: 5.249 ± 2.056
0.0PheGlu: 0.0 ± 0.0
1.75PhePhe: 1.75 ± 1.194
1.75PheGly: 1.75 ± 1.685
1.75PheHis: 1.75 ± 1.194
2.625PheIle: 2.625 ± 1.791
0.875PheLys: 0.875 ± 0.843
2.625PheLeu: 2.625 ± 1.691
3.5PheMet: 3.5 ± 1.256
0.875PheAsn: 0.875 ± 0.843
1.75PhePro: 1.75 ± 1.685
3.5PheGln: 3.5 ± 1.256
4.374PheArg: 4.374 ± 1.571
2.625PheSer: 2.625 ± 0.371
1.75PheThr: 1.75 ± 1.194
2.625PheVal: 2.625 ± 1.526
0.875PheTrp: 0.875 ± 0.941
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
4.374GlyAla: 4.374 ± 2.125
1.75GlyCys: 1.75 ± 0.685
2.625GlyAsp: 2.625 ± 2.528
2.625GlyGlu: 2.625 ± 0.971
5.249GlyPhe: 5.249 ± 0.743
4.374GlyGly: 4.374 ± 1.571
0.875GlyHis: 0.875 ± 0.597
2.625GlyIle: 2.625 ± 0.971
3.5GlyLys: 3.5 ± 1.459
2.625GlyLeu: 2.625 ± 0.371
6.999GlyMet: 6.999 ± 1.458
1.75GlyAsn: 1.75 ± 1.194
2.625GlyPro: 2.625 ± 1.129
0.875GlyGln: 0.875 ± 0.597
2.625GlyArg: 2.625 ± 1.415
9.624GlySer: 9.624 ± 4.137
3.5GlyThr: 3.5 ± 1.371
1.75GlyVal: 1.75 ± 1.685
1.75GlyTrp: 1.75 ± 0.685
1.75GlyTyr: 1.75 ± 0.685
0.0GlyXaa: 0.0 ± 0.0
His
0.875HisAla: 0.875 ± 0.597
0.0HisCys: 0.0 ± 0.0
1.75HisAsp: 1.75 ± 0.685
0.875HisGlu: 0.875 ± 0.843
0.875HisPhe: 0.875 ± 0.941
1.75HisGly: 1.75 ± 1.194
0.875HisHis: 0.875 ± 0.843
0.0HisIle: 0.0 ± 0.0
1.75HisLys: 1.75 ± 0.685
6.124HisLeu: 6.124 ± 1.595
0.0HisMet: 0.0 ± 0.0
1.75HisAsn: 1.75 ± 1.194
0.875HisPro: 0.875 ± 0.597
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
1.75HisSer: 1.75 ± 0.685
1.75HisThr: 1.75 ± 0.947
0.875HisVal: 0.875 ± 0.597
0.0HisTrp: 0.0 ± 0.0
0.875HisTyr: 0.875 ± 0.941
0.0HisXaa: 0.0 ± 0.0
Ile
5.249IleAla: 5.249 ± 1.463
0.875IleCys: 0.875 ± 0.597
3.5IleAsp: 3.5 ± 0.986
1.75IleGlu: 1.75 ± 0.85
1.75IlePhe: 1.75 ± 1.194
5.249IleGly: 5.249 ± 1.077
0.0IleHis: 0.0 ± 0.0
3.5IleIle: 3.5 ± 1.593
3.5IleLys: 3.5 ± 1.371
9.624IleLeu: 9.624 ± 3.315
4.374IleMet: 4.374 ± 1.309
0.875IleAsn: 0.875 ± 0.843
5.249IlePro: 5.249 ± 3.583
2.625IleGln: 2.625 ± 1.691
3.5IleArg: 3.5 ± 0.303
2.625IleSer: 2.625 ± 0.371
3.5IleThr: 3.5 ± 1.371
2.625IleVal: 2.625 ± 1.791
4.374IleTrp: 4.374 ± 1.907
2.625IleTyr: 2.625 ± 1.691
0.0IleXaa: 0.0 ± 0.0
Lys
0.875LysAla: 0.875 ± 0.843
0.0LysCys: 0.0 ± 0.0
2.625LysAsp: 2.625 ± 1.415
0.875LysGlu: 0.875 ± 0.597
3.5LysPhe: 3.5 ± 1.371
1.75LysGly: 1.75 ± 0.947
1.75LysHis: 1.75 ± 1.685
3.5LysIle: 3.5 ± 1.593
3.5LysLys: 3.5 ± 1.371
3.5LysLeu: 3.5 ± 0.303
0.875LysMet: 0.875 ± 0.941
1.75LysAsn: 1.75 ± 1.194
3.5LysPro: 3.5 ± 1.459
1.75LysGln: 1.75 ± 0.685
2.625LysArg: 2.625 ± 0.971
2.625LysSer: 2.625 ± 1.526
2.625LysThr: 2.625 ± 0.971
3.5LysVal: 3.5 ± 2.276
0.0LysTrp: 0.0 ± 0.0
0.875LysTyr: 0.875 ± 0.597
0.0LysXaa: 0.0 ± 0.0
Leu
7.874LeuAla: 7.874 ± 2.801
0.875LeuCys: 0.875 ± 0.941
3.5LeuAsp: 3.5 ± 0.303
2.625LeuGlu: 2.625 ± 0.971
7.874LeuPhe: 7.874 ± 2.118
8.749LeuGly: 8.749 ± 3.593
1.75LeuHis: 1.75 ± 0.947
9.624LeuIle: 9.624 ± 2.043
4.374LeuLys: 4.374 ± 1.309
6.124LeuLeu: 6.124 ± 4.242
1.75LeuMet: 1.75 ± 1.882
4.374LeuAsn: 4.374 ± 2.188
2.625LeuPro: 2.625 ± 2.823
6.999LeuGln: 6.999 ± 1.256
9.624LeuArg: 9.624 ± 2.847
8.749LeuSer: 8.749 ± 3.506
5.249LeuThr: 5.249 ± 1.808
8.749LeuVal: 8.749 ± 2.618
0.875LeuTrp: 0.875 ± 0.597
4.374LeuTyr: 4.374 ± 1.006
0.0LeuXaa: 0.0 ± 0.0
Met
4.374MetAla: 4.374 ± 1.006
0.875MetCys: 0.875 ± 0.941
0.875MetAsp: 0.875 ± 0.843
0.0MetGlu: 0.0 ± 0.0
0.875MetPhe: 0.875 ± 0.597
0.875MetGly: 0.875 ± 0.843
0.875MetHis: 0.875 ± 0.597
3.5MetIle: 3.5 ± 1.256
0.875MetLys: 0.875 ± 0.843
4.374MetLeu: 4.374 ± 3.528
0.875MetMet: 0.875 ± 0.941
0.875MetAsn: 0.875 ± 0.843
0.875MetPro: 0.875 ± 0.843
0.0MetGln: 0.0 ± 0.0
4.374MetArg: 4.374 ± 1.309
0.875MetSer: 0.875 ± 0.843
1.75MetThr: 1.75 ± 1.882
1.75MetVal: 1.75 ± 1.882
2.625MetTrp: 2.625 ± 1.691
0.875MetTyr: 0.875 ± 0.597
0.0MetXaa: 0.0 ± 0.0
Asn
0.875AsnAla: 0.875 ± 0.843
0.875AsnCys: 0.875 ± 0.597
0.875AsnAsp: 0.875 ± 0.597
0.875AsnGlu: 0.875 ± 0.597
0.0AsnPhe: 0.0 ± 0.0
1.75AsnGly: 1.75 ± 1.194
0.875AsnHis: 0.875 ± 0.597
4.374AsnIle: 4.374 ± 1.006
0.0AsnLys: 0.0 ± 0.0
3.5AsnLeu: 3.5 ± 1.256
2.625AsnMet: 2.625 ± 0.371
0.0AsnAsn: 0.0 ± 0.0
1.75AsnPro: 1.75 ± 0.85
0.875AsnGln: 0.875 ± 0.843
0.875AsnArg: 0.875 ± 0.597
3.5AsnSer: 3.5 ± 1.894
1.75AsnThr: 1.75 ± 0.85
1.75AsnVal: 1.75 ± 0.85
1.75AsnTrp: 1.75 ± 1.194
0.875AsnTyr: 0.875 ± 0.843
0.0AsnXaa: 0.0 ± 0.0
Pro
2.625ProAla: 2.625 ± 0.971
0.0ProCys: 0.0 ± 0.0
2.625ProAsp: 2.625 ± 0.371
5.249ProGlu: 5.249 ± 2.056
0.0ProPhe: 0.0 ± 0.0
6.124ProGly: 6.124 ± 1.209
1.75ProHis: 1.75 ± 0.685
1.75ProIle: 1.75 ± 0.85
3.5ProLys: 3.5 ± 2.389
5.249ProLeu: 5.249 ± 0.743
0.875ProMet: 0.875 ± 0.843
0.0ProAsn: 0.0 ± 0.0
1.75ProPro: 1.75 ± 1.194
1.75ProGln: 1.75 ± 0.685
2.625ProArg: 2.625 ± 1.129
2.625ProSer: 2.625 ± 1.129
0.875ProThr: 0.875 ± 0.597
5.249ProVal: 5.249 ± 1.077
0.875ProTrp: 0.875 ± 0.941
2.625ProTyr: 2.625 ± 0.971
0.0ProXaa: 0.0 ± 0.0
Gln
1.75GlnAla: 1.75 ± 1.882
0.0GlnCys: 0.0 ± 0.0
2.625GlnAsp: 2.625 ± 1.129
6.999GlnGlu: 6.999 ± 1.675
0.0GlnPhe: 0.0 ± 0.0
2.625GlnGly: 2.625 ± 0.971
0.0GlnHis: 0.0 ± 0.0
0.0GlnIle: 0.0 ± 0.0
3.5GlnLys: 3.5 ± 1.256
5.249GlnLeu: 5.249 ± 2.055
0.0GlnMet: 0.0 ± 0.0
2.625GlnAsn: 2.625 ± 0.371
1.75GlnPro: 1.75 ± 0.947
3.5GlnGln: 3.5 ± 1.459
3.5GlnArg: 3.5 ± 1.459
1.75GlnSer: 1.75 ± 0.85
2.625GlnThr: 2.625 ± 0.971
6.999GlnVal: 6.999 ± 1.637
0.875GlnTrp: 0.875 ± 0.843
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
1.75ArgAla: 1.75 ± 0.947
0.875ArgCys: 0.875 ± 0.843
2.625ArgAsp: 2.625 ± 0.371
2.625ArgGlu: 2.625 ± 0.971
3.5ArgPhe: 3.5 ± 1.371
3.5ArgGly: 3.5 ± 0.303
1.75ArgHis: 1.75 ± 1.194
6.124ArgIle: 6.124 ± 0.322
3.5ArgLys: 3.5 ± 0.303
11.374ArgLeu: 11.374 ± 5.547
0.0ArgMet: 0.0 ± 0.0
2.625ArgAsn: 2.625 ± 1.129
1.75ArgPro: 1.75 ± 1.194
4.374ArgGln: 4.374 ± 0.871
1.75ArgArg: 1.75 ± 0.685
5.249ArgSer: 5.249 ± 2.551
4.374ArgThr: 4.374 ± 1.907
3.5ArgVal: 3.5 ± 0.303
1.75ArgTrp: 1.75 ± 0.685
3.5ArgTyr: 3.5 ± 0.986
0.0ArgXaa: 0.0 ± 0.0
Ser
3.5SerAla: 3.5 ± 2.389
1.75SerCys: 1.75 ± 0.947
2.625SerAsp: 2.625 ± 1.415
3.5SerGlu: 3.5 ± 1.593
0.875SerPhe: 0.875 ± 0.941
6.999SerGly: 6.999 ± 1.897
1.75SerHis: 1.75 ± 0.85
3.5SerIle: 3.5 ± 0.986
2.625SerLys: 2.625 ± 1.129
13.123SerLeu: 13.123 ± 2.808
2.625SerMet: 2.625 ± 1.691
1.75SerAsn: 1.75 ± 1.194
2.625SerPro: 2.625 ± 0.971
2.625SerGln: 2.625 ± 1.791
6.124SerArg: 6.124 ± 2.917
4.374SerSer: 4.374 ± 2.125
1.75SerThr: 1.75 ± 1.194
4.374SerVal: 4.374 ± 2.058
1.75SerTrp: 1.75 ± 0.85
0.875SerTyr: 0.875 ± 0.941
0.0SerXaa: 0.0 ± 0.0
Thr
5.249ThrAla: 5.249 ± 1.942
0.0ThrCys: 0.0 ± 0.0
2.625ThrAsp: 2.625 ± 1.526
5.249ThrGlu: 5.249 ± 1.463
1.75ThrPhe: 1.75 ± 1.194
4.374ThrGly: 4.374 ± 2.986
3.5ThrHis: 3.5 ± 1.701
2.625ThrIle: 2.625 ± 1.415
1.75ThrLys: 1.75 ± 1.194
6.124ThrLeu: 6.124 ± 1.595
0.0ThrMet: 0.0 ± 0.0
2.625ThrAsn: 2.625 ± 1.526
0.875ThrPro: 0.875 ± 0.597
0.875ThrGln: 0.875 ± 0.843
4.374ThrArg: 4.374 ± 1.309
0.875ThrSer: 0.875 ± 0.597
4.374ThrThr: 4.374 ± 0.575
1.75ThrVal: 1.75 ± 1.194
0.875ThrTrp: 0.875 ± 0.941
1.75ThrTyr: 1.75 ± 1.882
0.0ThrXaa: 0.0 ± 0.0
Val
4.374ValAla: 4.374 ± 1.006
1.75ValCys: 1.75 ± 0.685
4.374ValAsp: 4.374 ± 4.213
5.249ValGlu: 5.249 ± 2.056
5.249ValPhe: 5.249 ± 1.808
4.374ValGly: 4.374 ± 2.125
0.0ValHis: 0.0 ± 0.0
5.249ValIle: 5.249 ± 1.808
3.5ValLys: 3.5 ± 2.226
5.249ValLeu: 5.249 ± 2.055
1.75ValMet: 1.75 ± 1.048
1.75ValAsn: 1.75 ± 0.85
4.374ValPro: 4.374 ± 0.575
4.374ValGln: 4.374 ± 2.506
0.875ValArg: 0.875 ± 0.597
4.374ValSer: 4.374 ± 0.575
3.5ValThr: 3.5 ± 0.303
6.124ValVal: 6.124 ± 0.322
0.0ValTrp: 0.0 ± 0.0
5.249ValTyr: 5.249 ± 1.463
0.0ValXaa: 0.0 ± 0.0
Trp
0.875TrpAla: 0.875 ± 0.941
0.875TrpCys: 0.875 ± 0.597
0.875TrpAsp: 0.875 ± 0.843
1.75TrpGlu: 1.75 ± 0.85
0.875TrpPhe: 0.875 ± 0.597
0.0TrpGly: 0.0 ± 0.0
2.625TrpHis: 2.625 ± 0.371
2.625TrpIle: 2.625 ± 1.129
0.0TrpLys: 0.0 ± 0.0
1.75TrpLeu: 1.75 ± 0.947
0.0TrpMet: 0.0 ± 0.0
1.75TrpAsn: 1.75 ± 1.882
0.875TrpPro: 0.875 ± 0.941
1.75TrpGln: 1.75 ± 0.685
0.875TrpArg: 0.875 ± 0.597
2.625TrpSer: 2.625 ± 1.415
1.75TrpThr: 1.75 ± 0.85
2.625TrpVal: 2.625 ± 1.691
0.875TrpTrp: 0.875 ± 0.843
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.75TyrAla: 1.75 ± 1.194
0.0TyrCys: 0.0 ± 0.0
0.0TyrAsp: 0.0 ± 0.0
0.875TyrGlu: 0.875 ± 0.597
2.625TyrPhe: 2.625 ± 1.415
2.625TyrGly: 2.625 ± 1.691
0.0TyrHis: 0.0 ± 0.0
5.249TyrIle: 5.249 ± 1.463
0.0TyrLys: 0.0 ± 0.0
2.625TyrLeu: 2.625 ± 1.526
1.75TyrMet: 1.75 ± 1.882
1.75TyrAsn: 1.75 ± 1.194
0.0TyrPro: 0.0 ± 0.0
3.5TyrGln: 3.5 ± 1.256
4.374TyrArg: 4.374 ± 0.575
0.0TyrSer: 0.0 ± 0.0
1.75TyrThr: 1.75 ± 0.685
3.5TyrVal: 3.5 ± 0.303
0.875TyrTrp: 0.875 ± 0.843
0.875TyrTyr: 0.875 ± 0.843
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1144 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski