Amino acid dipepetide frequency for Geminocystis sp. NIES-3708

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.193AlaAla: 3.193 ± 0.073	0.602AlaCys: 0.602 ± 0.022	3.198AlaAsp: 3.198 ± 0.051	4.019AlaGlu: 4.019 ± 0.074	2.461AlaPhe: 2.461 ± 0.055	3.965AlaGly: 3.965 ± 0.081	0.996AlaHis: 0.996 ± 0.031	6.176AlaIle: 6.176 ± 0.081	4.129AlaLys: 4.129 ± 0.071	6.488AlaLeu: 6.488 ± 0.092	1.377AlaMet: 1.377 ± 0.039	3.484AlaAsn: 3.484 ± 0.074	1.84AlaPro: 1.84 ± 0.046	3.121AlaGln: 3.121 ± 0.058	2.323AlaArg: 2.323 ± 0.054	3.699AlaSer: 3.699 ± 0.069	3.59AlaThr: 3.59 ± 0.074	3.779AlaVal: 3.779 ± 0.066	0.699AlaTrp: 0.699 ± 0.029	1.988AlaTyr: 1.988 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.469CysAla: 0.469 ± 0.021	0.147CysCys: 0.147 ± 0.012	0.557CysAsp: 0.557 ± 0.023	0.539CysGlu: 0.539 ± 0.026	0.497CysPhe: 0.497 ± 0.023	0.719CysGly: 0.719 ± 0.029	0.288CysHis: 0.288 ± 0.016	0.597CysIle: 0.597 ± 0.023	0.394CysLys: 0.394 ± 0.02	1.157CysLeu: 1.157 ± 0.036	0.132CysMet: 0.132 ± 0.011	0.421CysAsn: 0.421 ± 0.019	0.482CysPro: 0.482 ± 0.023	0.641CysGln: 0.641 ± 0.023	0.402CysArg: 0.402 ± 0.022	0.52CysSer: 0.52 ± 0.022	0.426CysThr: 0.426 ± 0.018	0.528CysVal: 0.528 ± 0.025	0.138CysTrp: 0.138 ± 0.019	0.448CysTyr: 0.448 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	2.597AspAla: 2.597 ± 0.056	0.5AspCys: 0.5 ± 0.024	2.618AspAsp: 2.618 ± 0.059	3.112AspGlu: 3.112 ± 0.062	2.704AspPhe: 2.704 ± 0.041	3.17AspGly: 3.17 ± 0.086	0.845AspHis: 0.845 ± 0.03	4.584AspIle: 4.584 ± 0.066	3.184AspLys: 3.184 ± 0.059	6.183AspLeu: 6.183 ± 0.081	0.759AspMet: 0.759 ± 0.026	3.47AspAsn: 3.47 ± 0.067	1.793AspPro: 1.793 ± 0.051	1.845AspGln: 1.845 ± 0.042	2.233AspArg: 2.233 ± 0.052	3.219AspSer: 3.219 ± 0.062	2.553AspThr: 2.553 ± 0.084	2.737AspVal: 2.737 ± 0.059	0.808AspTrp: 0.808 ± 0.03	2.262AspTyr: 2.262 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	4.28GluAla: 4.28 ± 0.072	0.465GluCys: 0.465 ± 0.021	3.199GluAsp: 3.199 ± 0.061	5.082GluGlu: 5.082 ± 0.09	2.467GluPhe: 2.467 ± 0.051	3.65GluGly: 3.65 ± 0.063	0.804GluHis: 0.804 ± 0.027	6.373GluIle: 6.373 ± 0.093	6.03GluLys: 6.03 ± 0.112	6.81GluLeu: 6.81 ± 0.093	1.316GluMet: 1.316 ± 0.04	4.689GluAsn: 4.689 ± 0.085	1.547GluPro: 1.547 ± 0.048	2.688GluGln: 2.688 ± 0.058	2.331GluArg: 2.331 ± 0.055	3.66GluSer: 3.66 ± 0.062	3.599GluThr: 3.599 ± 0.056	3.777GluVal: 3.777 ± 0.064	0.719GluTrp: 0.719 ± 0.027	2.251GluTyr: 2.251 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	2.832PheAla: 2.832 ± 0.049	0.57PheCys: 0.57 ± 0.024	2.469PheAsp: 2.469 ± 0.05	2.2PheGlu: 2.2 ± 0.041	2.241PhePhe: 2.241 ± 0.055	2.84PheGly: 2.84 ± 0.053	0.724PheHis: 0.724 ± 0.028	3.644PheIle: 3.644 ± 0.072	2.182PheLys: 2.182 ± 0.046	4.658PheLeu: 4.658 ± 0.087	0.788PheMet: 0.788 ± 0.025	2.692PheAsn: 2.692 ± 0.059	1.866PhePro: 1.866 ± 0.047	1.785PheGln: 1.785 ± 0.043	1.667PheArg: 1.667 ± 0.042	3.45PheSer: 3.45 ± 0.061	2.519PheThr: 2.519 ± 0.053	2.237PheVal: 2.237 ± 0.047	0.627PheTrp: 0.627 ± 0.026	1.689PheTyr: 1.689 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	3.878GlyAla: 3.878 ± 0.093	0.72GlyCys: 0.72 ± 0.029	3.37GlyAsp: 3.37 ± 0.073	4.098GlyGlu: 4.098 ± 0.066	3.046GlyPhe: 3.046 ± 0.065	4.688GlyGly: 4.688 ± 0.159	0.972GlyHis: 0.972 ± 0.033	5.773GlyIle: 5.773 ± 0.081	4.821GlyLys: 4.821 ± 0.088	6.004GlyLeu: 6.004 ± 0.091	1.23GlyMet: 1.23 ± 0.039	3.832GlyAsn: 3.832 ± 0.158	0.891GlyPro: 0.891 ± 0.035	2.018GlyGln: 2.018 ± 0.05	2.201GlyArg: 2.201 ± 0.052	3.479GlySer: 3.479 ± 0.105	3.283GlyThr: 3.283 ± 0.126	4.033GlyVal: 4.033 ± 0.082	0.928GlyTrp: 0.928 ± 0.031	2.395GlyTyr: 2.395 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	0.697HisAla: 0.697 ± 0.03	0.254HisCys: 0.254 ± 0.017	0.799HisAsp: 0.799 ± 0.027	0.868HisGlu: 0.868 ± 0.029	0.828HisPhe: 0.828 ± 0.029	1.046HisGly: 1.046 ± 0.033	0.645HisHis: 0.645 ± 0.03	1.168HisIle: 1.168 ± 0.035	0.9HisLys: 0.9 ± 0.031	2.028HisLeu: 2.028 ± 0.052	0.182HisMet: 0.182 ± 0.014	0.947HisAsn: 0.947 ± 0.032	1.044HisPro: 1.044 ± 0.035	1.159HisGln: 1.159 ± 0.037	0.855HisArg: 0.855 ± 0.032	1.121HisSer: 1.121 ± 0.032	0.771HisThr: 0.771 ± 0.028	0.648HisVal: 0.648 ± 0.028	0.316HisTrp: 0.316 ± 0.019	0.706HisTyr: 0.706 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.473IleAla: 6.473 ± 0.083	0.883IleCys: 0.883 ± 0.029	4.824IleAsp: 4.824 ± 0.08	5.685IleGlu: 5.685 ± 0.084	3.885IlePhe: 3.885 ± 0.071	5.031IleGly: 5.031 ± 0.087	1.371IleHis: 1.371 ± 0.04	7.852IleIle: 7.852 ± 0.116	5.706IleLys: 5.706 ± 0.093	8.783IleLeu: 8.783 ± 0.106	1.254IleMet: 1.254 ± 0.031	6.257IleAsn: 6.257 ± 0.107	4.225IlePro: 4.225 ± 0.071	3.121IleGln: 3.121 ± 0.05	3.116IleArg: 3.116 ± 0.06	6.05IleSer: 6.05 ± 0.091	5.269IleThr: 5.269 ± 0.105	4.776IleVal: 4.776 ± 0.067	0.924IleTrp: 0.924 ± 0.029	2.781IleTyr: 2.781 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	4.017LysAla: 4.017 ± 0.085	0.441LysCys: 0.441 ± 0.022	3.139LysAsp: 3.139 ± 0.056	4.648LysGlu: 4.648 ± 0.072	2.285LysPhe: 2.285 ± 0.048	3.394LysGly: 3.394 ± 0.064	0.879LysHis: 0.879 ± 0.031	6.66LysIle: 6.66 ± 0.093	4.543LysLys: 4.543 ± 0.087	6.694LysLeu: 6.694 ± 0.098	1.382LysMet: 1.382 ± 0.037	4.449LysAsn: 4.449 ± 0.079	2.567LysPro: 2.567 ± 0.058	3.18LysGln: 3.18 ± 0.064	2.323LysArg: 2.323 ± 0.052	3.846LysSer: 3.846 ± 0.061	3.825LysThr: 3.825 ± 0.066	3.754LysVal: 3.754 ± 0.062	0.694LysTrp: 0.694 ± 0.027	2.211LysTyr: 2.211 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	7.368LeuAla: 7.368 ± 0.105	0.925LeuCys: 0.925 ± 0.031	5.561LeuAsp: 5.561 ± 0.082	7.72LeuGlu: 7.72 ± 0.125	4.207LeuPhe: 4.207 ± 0.07	6.734LeuGly: 6.734 ± 0.087	1.639LeuHis: 1.639 ± 0.04	9.064LeuIle: 9.064 ± 0.115	7.199LeuLys: 7.199 ± 0.103	10.52LeuLeu: 10.52 ± 0.131	2.12LeuMet: 2.12 ± 0.045	6.1LeuAsn: 6.1 ± 0.096	4.945LeuPro: 4.945 ± 0.067	4.676LeuGln: 4.676 ± 0.069	4.192LeuArg: 4.192 ± 0.076	7.76LeuSer: 7.76 ± 0.097	6.843LeuThr: 6.843 ± 0.094	6.025LeuVal: 6.025 ± 0.076	1.256LeuTrp: 1.256 ± 0.039	2.855LeuTyr: 2.855 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	1.5MetAla: 1.5 ± 0.038	0.133MetCys: 0.133 ± 0.01	0.79MetAsp: 0.79 ± 0.026	1.055MetGlu: 1.055 ± 0.039	0.582MetPhe: 0.582 ± 0.026	1.355MetGly: 1.355 ± 0.04	0.185MetHis: 0.185 ± 0.013	1.639MetIle: 1.639 ± 0.039	1.16MetLys: 1.16 ± 0.031	1.696MetLeu: 1.696 ± 0.041	0.495MetMet: 0.495 ± 0.023	1.068MetAsn: 1.068 ± 0.029	0.707MetPro: 0.707 ± 0.026	0.593MetGln: 0.593 ± 0.025	0.76MetArg: 0.76 ± 0.024	1.34MetSer: 1.34 ± 0.037	1.324MetThr: 1.324 ± 0.035	1.097MetVal: 1.097 ± 0.037	0.162MetTrp: 0.162 ± 0.011	0.378MetTyr: 0.378 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.974AsnAla: 2.974 ± 0.064	0.608AsnCys: 0.608 ± 0.027	2.855AsnAsp: 2.855 ± 0.094	2.714AsnGlu: 2.714 ± 0.053	3.088AsnPhe: 3.088 ± 0.061	3.203AsnGly: 3.203 ± 0.106	1.304AsnHis: 1.304 ± 0.039	5.707AsnIle: 5.707 ± 0.099	3.468AsnLys: 3.468 ± 0.067	7.885AsnLeu: 7.885 ± 0.121	0.98AsnMet: 0.98 ± 0.033	5.044AsnAsn: 5.044 ± 0.122	3.347AsnPro: 3.347 ± 0.071	3.627AsnGln: 3.627 ± 0.073	2.311AsnArg: 2.311 ± 0.044	4.315AsnSer: 4.315 ± 0.09	3.094AsnThr: 3.094 ± 0.079	2.676AsnVal: 2.676 ± 0.061	0.875AsnTrp: 0.875 ± 0.035	2.596AsnTyr: 2.596 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	1.865ProAla: 1.865 ± 0.041	0.327ProCys: 0.327 ± 0.018	2.407ProAsp: 2.407 ± 0.051	3.351ProGlu: 3.351 ± 0.064	1.777ProPhe: 1.777 ± 0.047	1.528ProGly: 1.528 ± 0.043	0.876ProHis: 0.876 ± 0.028	3.256ProIle: 3.256 ± 0.058	2.073ProLys: 2.073 ± 0.048	4.344ProLeu: 4.344 ± 0.071	0.622ProMet: 0.622 ± 0.024	2.361ProAsn: 2.361 ± 0.05	1.654ProPro: 1.654 ± 0.05	2.15ProGln: 2.15 ± 0.053	1.316ProArg: 1.316 ± 0.041	2.743ProSer: 2.743 ± 0.055	2.15ProThr: 2.15 ± 0.047	2.48ProVal: 2.48 ± 0.062	0.499ProTrp: 0.499 ± 0.021	1.369ProTyr: 1.369 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.94GlnAla: 2.94 ± 0.06	0.315GlnCys: 0.315 ± 0.016	2.085GlnAsp: 2.085 ± 0.05	3.889GlnGlu: 3.889 ± 0.077	1.708GlnPhe: 1.708 ± 0.039	3.064GlnGly: 3.064 ± 0.059	0.623GlnHis: 0.623 ± 0.026	3.967GlnIle: 3.967 ± 0.072	3.72GlnLys: 3.72 ± 0.082	4.942GlnLeu: 4.942 ± 0.079	0.809GlnMet: 0.809 ± 0.026	2.684GlnAsn: 2.684 ± 0.054	1.834GlnPro: 1.834 ± 0.043	2.72GlnGln: 2.72 ± 0.065	1.834GlnArg: 1.834 ± 0.047	2.748GlnSer: 2.748 ± 0.049	2.291GlnThr: 2.291 ± 0.047	2.818GlnVal: 2.818 ± 0.049	0.71GlnTrp: 0.71 ± 0.029	1.336GlnTyr: 1.336 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.019ArgAla: 2.019 ± 0.043	0.367ArgCys: 0.367 ± 0.018	1.962ArgAsp: 1.962 ± 0.044	2.751ArgGlu: 2.751 ± 0.058	1.824ArgPhe: 1.824 ± 0.041	2.274ArgGly: 2.274 ± 0.049	0.8ArgHis: 0.8 ± 0.028	3.113ArgIle: 3.113 ± 0.05	2.444ArgLys: 2.444 ± 0.051	4.514ArgLeu: 4.514 ± 0.071	0.721ArgMet: 0.721 ± 0.026	2.076ArgAsn: 2.076 ± 0.048	1.315ArgPro: 1.315 ± 0.041	2.332ArgGln: 2.332 ± 0.045	1.881ArgArg: 1.881 ± 0.053	2.176ArgSer: 2.176 ± 0.042	1.719ArgThr: 1.719 ± 0.037	2.264ArgVal: 2.264 ± 0.051	0.572ArgTrp: 0.572 ± 0.024	1.55ArgTyr: 1.55 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	3.931SerAla: 3.931 ± 0.069	0.622SerCys: 0.622 ± 0.03	3.208SerAsp: 3.208 ± 0.061	3.902SerGlu: 3.902 ± 0.064	3.017SerPhe: 3.017 ± 0.054	4.304SerGly: 4.304 ± 0.118	1.284SerHis: 1.284 ± 0.032	5.159SerIle: 5.159 ± 0.073	3.458SerLys: 3.458 ± 0.065	7.771SerLeu: 7.771 ± 0.084	1.169SerMet: 1.169 ± 0.034	3.83SerAsn: 3.83 ± 0.076	2.773SerPro: 2.773 ± 0.039	3.464SerGln: 3.464 ± 0.057	2.48SerArg: 2.48 ± 0.045	4.683SerSer: 4.683 ± 0.091	3.271SerThr: 3.271 ± 0.075	3.526SerVal: 3.526 ± 0.061	0.85SerTrp: 0.85 ± 0.028	2.211SerTyr: 2.211 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	3.749ThrAla: 3.749 ± 0.063	0.442ThrCys: 0.442 ± 0.022	2.699ThrAsp: 2.699 ± 0.06	3.544ThrGlu: 3.544 ± 0.063	2.318ThrPhe: 2.318 ± 0.049	3.953ThrGly: 3.953 ± 0.133	0.863ThrHis: 0.863 ± 0.029	5.246ThrIle: 5.246 ± 0.097	3.198ThrLys: 3.198 ± 0.059	5.994ThrLeu: 5.994 ± 0.109	0.872ThrMet: 0.872 ± 0.028	3.106ThrAsn: 3.106 ± 0.085	2.773ThrPro: 2.773 ± 0.063	2.424ThrGln: 2.424 ± 0.049	1.972ThrArg: 1.972 ± 0.051	3.272ThrSer: 3.272 ± 0.064	3.259ThrThr: 3.259 ± 0.084	3.448ThrVal: 3.448 ± 0.076	0.63ThrTrp: 0.63 ± 0.027	1.725ThrTyr: 1.725 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	3.995ValAla: 3.995 ± 0.071	0.574ValCys: 0.574 ± 0.026	3.008ValAsp: 3.008 ± 0.062	3.809ValGlu: 3.809 ± 0.067	2.394ValPhe: 2.394 ± 0.047	3.769ValGly: 3.769 ± 0.075	0.717ValHis: 0.717 ± 0.027	5.118ValIle: 5.118 ± 0.078	4.019ValLys: 4.019 ± 0.07	5.129ValLeu: 5.129 ± 0.058	1.147ValMet: 1.147 ± 0.029	3.677ValAsn: 3.677 ± 0.075	1.777ValPro: 1.777 ± 0.042	1.778ValGln: 1.778 ± 0.047	2.117ValArg: 2.117 ± 0.046	3.78ValSer: 3.78 ± 0.071	3.664ValThr: 3.664 ± 0.063	3.497ValVal: 3.497 ± 0.071	0.543ValTrp: 0.543 ± 0.022	1.759ValTyr: 1.759 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.678TrpAla: 0.678 ± 0.026	0.164TrpCys: 0.164 ± 0.01	0.613TrpAsp: 0.613 ± 0.028	0.917TrpGlu: 0.917 ± 0.04	0.578TrpPhe: 0.578 ± 0.026	0.874TrpGly: 0.874 ± 0.03	0.324TrpHis: 0.324 ± 0.019	0.878TrpIle: 0.878 ± 0.027	0.634TrpLys: 0.634 ± 0.031	1.762TrpLeu: 1.762 ± 0.047	0.247TrpMet: 0.247 ± 0.014	0.615TrpAsn: 0.615 ± 0.023	0.132TrpPro: 0.132 ± 0.011	1.249TrpGln: 1.249 ± 0.049	0.604TrpArg: 0.604 ± 0.022	0.662TrpSer: 0.662 ± 0.023	0.514TrpThr: 0.514 ± 0.025	0.653TrpVal: 0.653 ± 0.026	0.193TrpTrp: 0.193 ± 0.016	0.399TrpTyr: 0.399 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.675TyrAla: 1.675 ± 0.041	0.442TyrCys: 0.442 ± 0.022	1.815TyrAsp: 1.815 ± 0.045	1.832TyrGlu: 1.832 ± 0.043	1.774TyrPhe: 1.774 ± 0.039	2.099TyrGly: 2.099 ± 0.049	0.841TyrHis: 0.841 ± 0.029	2.291TyrIle: 2.291 ± 0.05	1.669TyrLys: 1.669 ± 0.046	4.345TyrLeu: 4.345 ± 0.073	0.417TyrMet: 0.417 ± 0.023	1.867TyrAsn: 1.867 ± 0.047	1.635TyrPro: 1.635 ± 0.035	2.468TyrGln: 2.468 ± 0.056	1.758TyrArg: 1.758 ± 0.044	2.391TyrSer: 2.391 ± 0.049	1.522TyrThr: 1.522 ± 0.042	1.519TyrVal: 1.519 ± 0.035	0.547TyrTrp: 0.547 ± 0.024	1.418TyrTyr: 1.418 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3607 proteins (1128004 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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