Amino acid dipepetide frequency for Veillonellaceae bacterium DNF00626

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.731AlaAla: 6.731 ± 0.165
0.939AlaCys: 0.939 ± 0.052
4.284AlaAsp: 4.284 ± 0.104
5.138AlaGlu: 5.138 ± 0.115
3.111AlaPhe: 3.111 ± 0.087
6.329AlaGly: 6.329 ± 0.128
1.491AlaHis: 1.491 ± 0.059
5.725AlaIle: 5.725 ± 0.132
5.482AlaLys: 5.482 ± 0.117
7.627AlaLeu: 7.627 ± 0.152
2.408AlaMet: 2.408 ± 0.079
2.572AlaAsn: 2.572 ± 0.096
2.178AlaPro: 2.178 ± 0.075
2.387AlaGln: 2.387 ± 0.096
2.976AlaArg: 2.976 ± 0.084
3.318AlaSer: 3.318 ± 0.088
3.855AlaThr: 3.855 ± 0.103
6.39AlaVal: 6.39 ± 0.135
0.708AlaTrp: 0.708 ± 0.044
2.753AlaTyr: 2.753 ± 0.084
0.0AlaXaa: 0.0 ± 0.0
Cys
0.752CysAla: 0.752 ± 0.042
0.175CysCys: 0.175 ± 0.021
0.677CysAsp: 0.677 ± 0.038
0.623CysGlu: 0.623 ± 0.039
0.539CysPhe: 0.539 ± 0.034
1.006CysGly: 1.006 ± 0.044
0.389CysHis: 0.389 ± 0.03
0.808CysIle: 0.808 ± 0.041
0.604CysLys: 0.604 ± 0.033
0.946CysLeu: 0.946 ± 0.052
0.3CysMet: 0.3 ± 0.027
0.377CysAsn: 0.377 ± 0.029
0.492CysPro: 0.492 ± 0.041
0.321CysGln: 0.321 ± 0.025
0.602CysArg: 0.602 ± 0.036
0.556CysSer: 0.556 ± 0.034
0.585CysThr: 0.585 ± 0.037
0.66CysVal: 0.66 ± 0.04
0.096CysTrp: 0.096 ± 0.015
0.467CysTyr: 0.467 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
4.001AspAla: 4.001 ± 0.101
0.535AspCys: 0.535 ± 0.04
2.984AspAsp: 2.984 ± 0.08
4.128AspGlu: 4.128 ± 0.097
2.453AspPhe: 2.453 ± 0.082
4.973AspGly: 4.973 ± 0.236
0.879AspHis: 0.879 ± 0.04
5.055AspIle: 5.055 ± 0.117
4.322AspLys: 4.322 ± 0.111
4.444AspLeu: 4.444 ± 0.11
1.937AspMet: 1.937 ± 0.066
2.222AspAsn: 2.222 ± 0.089
1.743AspPro: 1.743 ± 0.065
1.204AspGln: 1.204 ± 0.05
2.214AspArg: 2.214 ± 0.072
2.703AspSer: 2.703 ± 0.076
3.057AspThr: 3.057 ± 0.08
4.332AspVal: 4.332 ± 0.103
0.541AspTrp: 0.541 ± 0.036
2.164AspTyr: 2.164 ± 0.072
0.0AspXaa: 0.0 ± 0.0
Glu
5.355GluAla: 5.355 ± 0.129
0.544GluCys: 0.544 ± 0.032
3.663GluAsp: 3.663 ± 0.101
6.163GluGlu: 6.163 ± 0.165
2.197GluPhe: 2.197 ± 0.07
4.632GluGly: 4.632 ± 0.111
1.183GluHis: 1.183 ± 0.055
5.854GluIle: 5.854 ± 0.13
7.25GluLys: 7.25 ± 0.157
5.561GluLeu: 5.561 ± 0.114
2.189GluMet: 2.189 ± 0.072
3.982GluAsn: 3.982 ± 0.094
1.533GluPro: 1.533 ± 0.062
2.081GluGln: 2.081 ± 0.073
3.372GluArg: 3.372 ± 0.105
3.259GluSer: 3.259 ± 0.087
3.536GluThr: 3.536 ± 0.097
4.142GluVal: 4.142 ± 0.107
0.766GluTrp: 0.766 ± 0.042
2.208GluTyr: 2.208 ± 0.074
0.0GluXaa: 0.0 ± 0.0
Phe
2.599PheAla: 2.599 ± 0.086
0.594PheCys: 0.594 ± 0.037
2.395PheAsp: 2.395 ± 0.077
1.791PheGlu: 1.791 ± 0.062
1.989PhePhe: 1.989 ± 0.087
2.939PheGly: 2.939 ± 0.08
1.175PheHis: 1.175 ± 0.05
3.493PheIle: 3.493 ± 0.107
1.779PheLys: 1.779 ± 0.065
4.23PheLeu: 4.23 ± 0.127
1.237PheMet: 1.237 ± 0.054
1.422PheAsn: 1.422 ± 0.067
1.533PhePro: 1.533 ± 0.058
1.018PheGln: 1.018 ± 0.046
1.783PheArg: 1.783 ± 0.062
2.751PheSer: 2.751 ± 0.089
2.372PheThr: 2.372 ± 0.07
2.458PheVal: 2.458 ± 0.085
0.423PheTrp: 0.423 ± 0.029
1.685PheTyr: 1.685 ± 0.065
0.0PheXaa: 0.0 ± 0.0
Gly
5.834GlyAla: 5.834 ± 0.133
0.835GlyCys: 0.835 ± 0.04
4.257GlyAsp: 4.257 ± 0.103
4.909GlyGlu: 4.909 ± 0.128
2.81GlyPhe: 2.81 ± 0.078
5.571GlyGly: 5.571 ± 0.165
1.779GlyHis: 1.779 ± 0.061
6.452GlyIle: 6.452 ± 0.126
6.773GlyLys: 6.773 ± 0.192
6.15GlyLeu: 6.15 ± 0.136
2.445GlyMet: 2.445 ± 0.079
3.643GlyAsn: 3.643 ± 0.156
1.554GlyPro: 1.554 ± 0.056
2.405GlyGln: 2.405 ± 0.097
3.203GlyArg: 3.203 ± 0.097
4.001GlySer: 4.001 ± 0.123
4.99GlyThr: 4.99 ± 0.137
5.492GlyVal: 5.492 ± 0.122
0.604GlyTrp: 0.604 ± 0.04
2.791GlyTyr: 2.791 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
1.481HisAla: 1.481 ± 0.06
0.262HisCys: 0.262 ± 0.024
1.156HisAsp: 1.156 ± 0.057
1.362HisGlu: 1.362 ± 0.051
0.979HisPhe: 0.979 ± 0.051
1.535HisGly: 1.535 ± 0.065
0.616HisHis: 0.616 ± 0.039
1.983HisIle: 1.983 ± 0.078
1.187HisLys: 1.187 ± 0.056
1.951HisLeu: 1.951 ± 0.066
0.708HisMet: 0.708 ± 0.039
0.752HisAsn: 0.752 ± 0.04
0.989HisPro: 0.989 ± 0.042
0.685HisGln: 0.685 ± 0.041
0.95HisArg: 0.95 ± 0.041
1.07HisSer: 1.07 ± 0.046
1.148HisThr: 1.148 ± 0.048
1.749HisVal: 1.749 ± 0.062
0.258HisTrp: 0.258 ± 0.025
0.779HisTyr: 0.779 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
5.567IleAla: 5.567 ± 0.124
1.152IleCys: 1.152 ± 0.055
4.322IleAsp: 4.322 ± 0.116
4.715IleGlu: 4.715 ± 0.104
3.397IlePhe: 3.397 ± 0.117
6.177IleGly: 6.177 ± 0.152
1.962IleHis: 1.962 ± 0.071
5.79IleIle: 5.79 ± 0.14
4.909IleLys: 4.909 ± 0.114
7.052IleLeu: 7.052 ± 0.18
1.983IleMet: 1.983 ± 0.078
3.191IleAsn: 3.191 ± 0.103
3.405IlePro: 3.405 ± 0.09
2.416IleGln: 2.416 ± 0.076
3.543IleArg: 3.543 ± 0.085
5.669IleSer: 5.669 ± 0.118
4.463IleThr: 4.463 ± 0.109
4.811IleVal: 4.811 ± 0.134
0.619IleTrp: 0.619 ± 0.034
2.801IleTyr: 2.801 ± 0.092
0.0IleXaa: 0.0 ± 0.0
Lys
5.771LysAla: 5.771 ± 0.135
0.487LysCys: 0.487 ± 0.032
5.098LysAsp: 5.098 ± 0.202
8.008LysGlu: 8.008 ± 0.145
1.756LysPhe: 1.756 ± 0.053
5.348LysGly: 5.348 ± 0.138
1.129LysHis: 1.129 ± 0.046
5.038LysIle: 5.038 ± 0.106
7.45LysLys: 7.45 ± 0.157
5.136LysLeu: 5.136 ± 0.096
2.451LysMet: 2.451 ± 0.083
4.432LysAsn: 4.432 ± 0.119
2.035LysPro: 2.035 ± 0.077
2.237LysGln: 2.237 ± 0.076
3.159LysArg: 3.159 ± 0.093
3.757LysSer: 3.757 ± 0.096
3.997LysThr: 3.997 ± 0.111
4.828LysVal: 4.828 ± 0.124
0.744LysTrp: 0.744 ± 0.043
2.649LysTyr: 2.649 ± 0.079
0.0LysXaa: 0.0 ± 0.0
Leu
7.131LeuAla: 7.131 ± 0.157
1.168LeuCys: 1.168 ± 0.051
4.224LeuAsp: 4.224 ± 0.106
4.819LeuGlu: 4.819 ± 0.128
4.134LeuPhe: 4.134 ± 0.141
6.025LeuGly: 6.025 ± 0.126
2.037LeuHis: 2.037 ± 0.07
5.821LeuIle: 5.821 ± 0.142
5.967LeuLys: 5.967 ± 0.122
8.083LeuLeu: 8.083 ± 0.222
2.441LeuMet: 2.441 ± 0.086
3.353LeuAsn: 3.353 ± 0.093
3.649LeuPro: 3.649 ± 0.093
2.839LeuGln: 2.839 ± 0.079
3.917LeuArg: 3.917 ± 0.091
6.517LeuSer: 6.517 ± 0.137
5.202LeuThr: 5.202 ± 0.12
5.075LeuVal: 5.075 ± 0.12
0.916LeuTrp: 0.916 ± 0.047
3.007LeuTyr: 3.007 ± 0.093
0.0LeuXaa: 0.0 ± 0.0
Met
2.909MetAla: 2.909 ± 0.081
0.217MetCys: 0.217 ± 0.021
1.635MetAsp: 1.635 ± 0.06
2.276MetGlu: 2.276 ± 0.088
0.816MetPhe: 0.816 ± 0.043
2.133MetGly: 2.133 ± 0.079
0.494MetHis: 0.494 ± 0.032
2.312MetIle: 2.312 ± 0.08
2.972MetLys: 2.972 ± 0.084
2.176MetLeu: 2.176 ± 0.082
1.018MetMet: 1.018 ± 0.05
1.793MetAsn: 1.793 ± 0.055
1.064MetPro: 1.064 ± 0.054
0.908MetGln: 0.908 ± 0.047
1.281MetArg: 1.281 ± 0.06
1.731MetSer: 1.731 ± 0.066
1.964MetThr: 1.964 ± 0.057
1.937MetVal: 1.937 ± 0.073
0.19MetTrp: 0.19 ± 0.022
0.931MetTyr: 0.931 ± 0.047
0.0MetXaa: 0.0 ± 0.0
Asn
3.111AsnAla: 3.111 ± 0.096
0.469AsnCys: 0.469 ± 0.033
2.345AsnAsp: 2.345 ± 0.077
2.98AsnGlu: 2.98 ± 0.083
1.489AsnPhe: 1.489 ± 0.054
3.72AsnGly: 3.72 ± 0.151
1.1AsnHis: 1.1 ± 0.045
3.72AsnIle: 3.72 ± 0.107
3.449AsnLys: 3.449 ± 0.122
3.403AsnLeu: 3.403 ± 0.078
1.268AsnMet: 1.268 ± 0.053
1.956AsnAsn: 1.956 ± 0.085
1.854AsnPro: 1.854 ± 0.066
1.631AsnGln: 1.631 ± 0.068
1.983AsnArg: 1.983 ± 0.057
2.358AsnSer: 2.358 ± 0.087
2.322AsnThr: 2.322 ± 0.07
2.978AsnVal: 2.978 ± 0.101
0.367AsnTrp: 0.367 ± 0.032
1.679AsnTyr: 1.679 ± 0.067
0.0AsnXaa: 0.0 ± 0.0
Pro
2.378ProAla: 2.378 ± 0.076
0.381ProCys: 0.381 ± 0.028
2.085ProAsp: 2.085 ± 0.064
2.749ProGlu: 2.749 ± 0.082
1.633ProPhe: 1.633 ± 0.062
2.651ProGly: 2.651 ± 0.087
0.775ProHis: 0.775 ± 0.044
2.395ProIle: 2.395 ± 0.081
2.151ProLys: 2.151 ± 0.069
3.116ProLeu: 3.116 ± 0.102
0.987ProMet: 0.987 ± 0.042
1.227ProAsn: 1.227 ± 0.058
1.029ProPro: 1.029 ± 0.056
0.939ProGln: 0.939 ± 0.043
1.012ProArg: 1.012 ± 0.048
1.749ProSer: 1.749 ± 0.061
1.804ProThr: 1.804 ± 0.071
2.862ProVal: 2.862 ± 0.078
0.381ProTrp: 0.381 ± 0.026
1.377ProTyr: 1.377 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
2.387GlnAla: 2.387 ± 0.087
0.252GlnCys: 0.252 ± 0.024
1.516GlnAsp: 1.516 ± 0.065
2.303GlnGlu: 2.303 ± 0.073
0.991GlnPhe: 0.991 ± 0.046
2.181GlnGly: 2.181 ± 0.072
0.5GlnHis: 0.5 ± 0.034
2.364GlnIle: 2.364 ± 0.072
2.787GlnLys: 2.787 ± 0.081
2.512GlnLeu: 2.512 ± 0.088
1.16GlnMet: 1.16 ± 0.053
1.587GlnAsn: 1.587 ± 0.076
0.825GlnPro: 0.825 ± 0.045
0.996GlnGln: 0.996 ± 0.07
1.385GlnArg: 1.385 ± 0.062
1.599GlnSer: 1.599 ± 0.064
1.433GlnThr: 1.433 ± 0.059
2.151GlnVal: 2.151 ± 0.07
0.337GlnTrp: 0.337 ± 0.029
0.993GlnTyr: 0.993 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
2.914ArgAla: 2.914 ± 0.102
0.452ArgCys: 0.452 ± 0.032
2.197ArgAsp: 2.197 ± 0.083
3.228ArgGlu: 3.228 ± 0.102
1.704ArgPhe: 1.704 ± 0.061
2.743ArgGly: 2.743 ± 0.08
1.018ArgHis: 1.018 ± 0.047
3.488ArgIle: 3.488 ± 0.086
3.436ArgLys: 3.436 ± 0.096
3.97ArgLeu: 3.97 ± 0.115
1.533ArgMet: 1.533 ± 0.053
2.174ArgAsn: 2.174 ± 0.072
1.408ArgPro: 1.408 ± 0.067
1.51ArgGln: 1.51 ± 0.056
2.414ArgArg: 2.414 ± 0.082
2.058ArgSer: 2.058 ± 0.074
2.116ArgThr: 2.116 ± 0.069
2.72ArgVal: 2.72 ± 0.083
0.487ArgTrp: 0.487 ± 0.036
1.718ArgTyr: 1.718 ± 0.066
0.0ArgXaa: 0.0 ± 0.0
Ser
4.142SerAla: 4.142 ± 0.084
0.598SerCys: 0.598 ± 0.039
3.38SerAsp: 3.38 ± 0.092
3.307SerGlu: 3.307 ± 0.087
2.593SerPhe: 2.593 ± 0.077
4.796SerGly: 4.796 ± 0.132
1.32SerHis: 1.32 ± 0.043
4.261SerIle: 4.261 ± 0.09
3.172SerLys: 3.172 ± 0.098
5.348SerLeu: 5.348 ± 0.131
1.699SerMet: 1.699 ± 0.06
1.949SerAsn: 1.949 ± 0.07
1.885SerPro: 1.885 ± 0.07
1.627SerGln: 1.627 ± 0.064
2.416SerArg: 2.416 ± 0.075
3.197SerSer: 3.197 ± 0.096
2.866SerThr: 2.866 ± 0.088
4.386SerVal: 4.386 ± 0.113
0.562SerTrp: 0.562 ± 0.04
2.31SerTyr: 2.31 ± 0.066
0.0SerXaa: 0.0 ± 0.0
Thr
4.624ThrAla: 4.624 ± 0.109
0.539ThrCys: 0.539 ± 0.036
3.116ThrAsp: 3.116 ± 0.077
3.586ThrGlu: 3.586 ± 0.095
2.12ThrPhe: 2.12 ± 0.072
4.934ThrGly: 4.934 ± 0.112
1.118ThrHis: 1.118 ± 0.045
4.299ThrIle: 4.299 ± 0.111
3.765ThrLys: 3.765 ± 0.095
4.969ThrLeu: 4.969 ± 0.1
1.552ThrMet: 1.552 ± 0.066
2.312ThrAsn: 2.312 ± 0.076
2.38ThrPro: 2.38 ± 0.082
1.406ThrGln: 1.406 ± 0.06
1.858ThrArg: 1.858 ± 0.067
2.701ThrSer: 2.701 ± 0.085
3.168ThrThr: 3.168 ± 0.107
4.792ThrVal: 4.792 ± 0.138
0.66ThrTrp: 0.66 ± 0.037
2.039ThrTyr: 2.039 ± 0.073
0.0ThrXaa: 0.0 ± 0.0
Val
5.604ValAla: 5.604 ± 0.144
0.846ValCys: 0.846 ± 0.043
3.67ValAsp: 3.67 ± 0.094
4.322ValGlu: 4.322 ± 0.097
2.67ValPhe: 2.67 ± 0.073
5.096ValGly: 5.096 ± 0.143
1.42ValHis: 1.42 ± 0.057
5.548ValIle: 5.548 ± 0.118
4.911ValLys: 4.911 ± 0.117
5.742ValLeu: 5.742 ± 0.138
2.093ValMet: 2.093 ± 0.073
3.216ValAsn: 3.216 ± 0.105
2.576ValPro: 2.576 ± 0.088
1.829ValGln: 1.829 ± 0.067
2.889ValArg: 2.889 ± 0.083
4.459ValSer: 4.459 ± 0.094
4.58ValThr: 4.58 ± 0.128
4.988ValVal: 4.988 ± 0.124
0.569ValTrp: 0.569 ± 0.036
2.453ValTyr: 2.453 ± 0.065
0.0ValXaa: 0.0 ± 0.0
Trp
0.637TrpAla: 0.637 ± 0.046
0.123TrpCys: 0.123 ± 0.017
0.521TrpAsp: 0.521 ± 0.034
0.604TrpGlu: 0.604 ± 0.037
0.389TrpPhe: 0.389 ± 0.028
0.694TrpGly: 0.694 ± 0.04
0.242TrpHis: 0.242 ± 0.022
0.8TrpIle: 0.8 ± 0.051
0.908TrpLys: 0.908 ± 0.048
0.779TrpLeu: 0.779 ± 0.051
0.314TrpMet: 0.314 ± 0.025
0.583TrpAsn: 0.583 ± 0.038
0.231TrpPro: 0.231 ± 0.022
0.498TrpGln: 0.498 ± 0.032
0.46TrpArg: 0.46 ± 0.03
0.504TrpSer: 0.504 ± 0.031
0.475TrpThr: 0.475 ± 0.034
0.467TrpVal: 0.467 ± 0.034
0.146TrpTrp: 0.146 ± 0.017
0.362TrpTyr: 0.362 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.474TyrAla: 2.474 ± 0.076
0.406TyrCys: 0.406 ± 0.028
2.368TyrAsp: 2.368 ± 0.083
2.458TyrGlu: 2.458 ± 0.074
1.893TyrPhe: 1.893 ± 0.072
3.014TyrGly: 3.014 ± 0.082
0.975TyrHis: 0.975 ± 0.045
2.737TyrIle: 2.737 ± 0.086
2.237TyrLys: 2.237 ± 0.071
3.132TyrLeu: 3.132 ± 0.088
1.031TyrMet: 1.031 ± 0.051
1.437TyrAsn: 1.437 ± 0.064
1.318TyrPro: 1.318 ± 0.057
1.325TyrGln: 1.325 ± 0.059
1.872TyrArg: 1.872 ± 0.059
1.858TyrSer: 1.858 ± 0.065
2.006TyrThr: 2.006 ± 0.066
2.262TyrVal: 2.262 ± 0.067
0.362TyrTrp: 0.362 ± 0.034
1.427TyrTyr: 1.427 ± 0.067
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1608 proteins (480156 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski