Amino acid dipepetide frequency for Murinocardiopsis flavida

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	26.071AlaAla: 26.071 ± 0.22	1.022AlaCys: 1.022 ± 0.024	9.865AlaAsp: 9.865 ± 0.093	10.025AlaGlu: 10.025 ± 0.078	3.837AlaPhe: 3.837 ± 0.051	13.37AlaGly: 13.37 ± 0.09	3.078AlaHis: 3.078 ± 0.045	4.337AlaIle: 4.337 ± 0.048	2.536AlaLys: 2.536 ± 0.043	14.753AlaLeu: 14.753 ± 0.118	2.946AlaMet: 2.946 ± 0.042	1.98AlaAsn: 1.98 ± 0.032	8.152AlaPro: 8.152 ± 0.081	3.466AlaGln: 3.466 ± 0.044	10.626AlaArg: 10.626 ± 0.085	5.579AlaSer: 5.579 ± 0.059	6.717AlaThr: 6.717 ± 0.062	12.857AlaVal: 12.857 ± 0.107	1.909AlaTrp: 1.909 ± 0.03	2.359AlaTyr: 2.359 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.143CysAla: 1.143 ± 0.026	0.088CysCys: 0.088 ± 0.008	0.457CysAsp: 0.457 ± 0.014	0.378CysGlu: 0.378 ± 0.015	0.208CysPhe: 0.208 ± 0.011	0.886CysGly: 0.886 ± 0.024	0.181CysHis: 0.181 ± 0.01	0.153CysIle: 0.153 ± 0.008	0.093CysLys: 0.093 ± 0.006	0.639CysLeu: 0.639 ± 0.017	0.125CysMet: 0.125 ± 0.008	0.111CysAsn: 0.111 ± 0.008	0.443CysPro: 0.443 ± 0.018	0.143CysGln: 0.143 ± 0.008	0.564CysArg: 0.564 ± 0.016	0.36CysSer: 0.36 ± 0.014	0.446CysThr: 0.446 ± 0.015	0.627CysVal: 0.627 ± 0.019	0.104CysTrp: 0.104 ± 0.006	0.182CysTyr: 0.182 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.488AspAla: 8.488 ± 0.077	0.361AspCys: 0.361 ± 0.015	4.276AspAsp: 4.276 ± 0.058	3.448AspGlu: 3.448 ± 0.043	1.612AspPhe: 1.612 ± 0.032	6.423AspGly: 6.423 ± 0.064	1.536AspHis: 1.536 ± 0.026	2.129AspIle: 2.129 ± 0.034	0.976AspLys: 0.976 ± 0.027	6.63AspLeu: 6.63 ± 0.061	0.929AspMet: 0.929 ± 0.024	0.934AspAsn: 0.934 ± 0.025	5.484AspPro: 5.484 ± 0.063	1.496AspGln: 1.496 ± 0.029	5.297AspArg: 5.297 ± 0.054	2.71AspSer: 2.71 ± 0.043	3.586AspThr: 3.586 ± 0.05	4.595AspVal: 4.595 ± 0.052	0.892AspTrp: 0.892 ± 0.021	1.273AspTyr: 1.273 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	6.738GluAla: 6.738 ± 0.07	0.359GluCys: 0.359 ± 0.014	2.808GluAsp: 2.808 ± 0.045	3.314GluGlu: 3.314 ± 0.047	1.678GluPhe: 1.678 ± 0.03	4.207GluGly: 4.207 ± 0.047	1.666GluHis: 1.666 ± 0.031	2.277GluIle: 2.277 ± 0.038	1.188GluLys: 1.188 ± 0.031	6.286GluLeu: 6.286 ± 0.067	0.906GluMet: 0.906 ± 0.02	1.044GluAsn: 1.044 ± 0.022	3.591GluPro: 3.591 ± 0.044	2.152GluGln: 2.152 ± 0.038	5.819GluArg: 5.819 ± 0.06	2.898GluSer: 2.898 ± 0.046	2.7GluThr: 2.7 ± 0.04	4.55GluVal: 4.55 ± 0.045	0.861GluTrp: 0.861 ± 0.02	1.128GluTyr: 1.128 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.279PheAla: 4.279 ± 0.043	0.267PheCys: 0.267 ± 0.012	2.187PheAsp: 2.187 ± 0.037	1.365PheGlu: 1.365 ± 0.027	0.864PhePhe: 0.864 ± 0.025	3.249PheGly: 3.249 ± 0.041	0.617PheHis: 0.617 ± 0.018	0.848PheIle: 0.848 ± 0.02	0.395PheLys: 0.395 ± 0.013	2.57PheLeu: 2.57 ± 0.042	0.442PheMet: 0.442 ± 0.015	0.506PheAsn: 0.506 ± 0.015	1.38PhePro: 1.38 ± 0.025	0.611PheGln: 0.611 ± 0.019	1.711PheArg: 1.711 ± 0.027	1.448PheSer: 1.448 ± 0.029	2.023PheThr: 2.023 ± 0.035	2.168PheVal: 2.168 ± 0.034	0.421PheTrp: 0.421 ± 0.013	0.564PheTyr: 0.564 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	13.2GlyAla: 13.2 ± 0.09	0.808GlyCys: 0.808 ± 0.022	5.629GlyAsp: 5.629 ± 0.051	5.09GlyGlu: 5.09 ± 0.051	3.042GlyPhe: 3.042 ± 0.041	9.942GlyGly: 9.942 ± 0.107	2.194GlyHis: 2.194 ± 0.041	3.659GlyIle: 3.659 ± 0.044	1.896GlyLys: 1.896 ± 0.038	9.31GlyLeu: 9.31 ± 0.081	2.212GlyMet: 2.212 ± 0.042	1.566GlyAsn: 1.566 ± 0.033	5.75GlyPro: 5.75 ± 0.066	2.257GlyGln: 2.257 ± 0.037	7.845GlyArg: 7.845 ± 0.064	5.172GlySer: 5.172 ± 0.057	6.079GlyThr: 6.079 ± 0.056	7.751GlyVal: 7.751 ± 0.065	1.535GlyTrp: 1.535 ± 0.03	2.379GlyTyr: 2.379 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.804HisAla: 2.804 ± 0.041	0.197HisCys: 0.197 ± 0.011	1.369HisAsp: 1.369 ± 0.024	1.117HisGlu: 1.117 ± 0.027	0.57HisPhe: 0.57 ± 0.018	2.358HisGly: 2.358 ± 0.033	0.581HisHis: 0.581 ± 0.02	0.73HisIle: 0.73 ± 0.019	0.291HisLys: 0.291 ± 0.012	2.379HisLeu: 2.379 ± 0.037	0.353HisMet: 0.353 ± 0.014	0.404HisAsn: 0.404 ± 0.015	1.789HisPro: 1.789 ± 0.035	0.586HisGln: 0.586 ± 0.018	2.221HisArg: 2.221 ± 0.04	0.973HisSer: 0.973 ± 0.024	1.367HisThr: 1.367 ± 0.025	1.623HisVal: 1.623 ± 0.026	0.347HisTrp: 0.347 ± 0.013	0.479HisTyr: 0.479 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	5.775IleAla: 5.775 ± 0.058	0.255IleCys: 0.255 ± 0.01	2.677IleAsp: 2.677 ± 0.038	2.166IleGlu: 2.166 ± 0.04	0.676IlePhe: 0.676 ± 0.02	4.169IleGly: 4.169 ± 0.056	0.54IleHis: 0.54 ± 0.017	1.118IleIle: 1.118 ± 0.028	0.555IleLys: 0.555 ± 0.018	2.58IleLeu: 2.58 ± 0.043	0.508IleMet: 0.508 ± 0.015	0.634IleAsn: 0.634 ± 0.022	1.886IlePro: 1.886 ± 0.033	0.654IleGln: 0.654 ± 0.017	2.335IleArg: 2.335 ± 0.033	1.714IleSer: 1.714 ± 0.031	2.345IleThr: 2.345 ± 0.033	2.905IleVal: 2.905 ± 0.038	0.353IleTrp: 0.353 ± 0.014	0.541IleTyr: 0.541 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	2.257LysAla: 2.257 ± 0.036	0.1LysCys: 0.1 ± 0.007	1.136LysAsp: 1.136 ± 0.032	1.108LysGlu: 1.108 ± 0.027	0.364LysPhe: 0.364 ± 0.013	1.739LysGly: 1.739 ± 0.039	0.357LysHis: 0.357 ± 0.013	0.671LysIle: 0.671 ± 0.02	0.622LysLys: 0.622 ± 0.027	1.468LysLeu: 1.468 ± 0.031	0.282LysMet: 0.282 ± 0.011	0.38LysAsn: 0.38 ± 0.016	1.007LysPro: 1.007 ± 0.022	0.475LysGln: 0.475 ± 0.018	1.397LysArg: 1.397 ± 0.029	1.015LysSer: 1.015 ± 0.024	0.94LysThr: 0.94 ± 0.022	1.478LysVal: 1.478 ± 0.032	0.213LysTrp: 0.213 ± 0.009	0.312LysTyr: 0.312 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	15.485LeuAla: 15.485 ± 0.113	0.795LeuCys: 0.795 ± 0.02	6.813LeuAsp: 6.813 ± 0.061	4.167LeuGlu: 4.167 ± 0.047	2.745LeuPhe: 2.745 ± 0.042	9.372LeuGly: 9.372 ± 0.077	2.277LeuHis: 2.277 ± 0.034	3.598LeuIle: 3.598 ± 0.05	1.575LeuLys: 1.575 ± 0.033	11.245LeuLeu: 11.245 ± 0.096	1.682LeuMet: 1.682 ± 0.028	1.585LeuAsn: 1.585 ± 0.027	6.012LeuPro: 6.012 ± 0.066	1.663LeuGln: 1.663 ± 0.029	8.949LeuArg: 8.949 ± 0.086	5.192LeuSer: 5.192 ± 0.054	6.027LeuThr: 6.027 ± 0.049	8.742LeuVal: 8.742 ± 0.076	1.309LeuTrp: 1.309 ± 0.032	1.727LeuTyr: 1.727 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.671MetAla: 2.671 ± 0.038	0.139MetCys: 0.139 ± 0.008	0.913MetAsp: 0.913 ± 0.021	0.738MetGlu: 0.738 ± 0.019	0.549MetPhe: 0.549 ± 0.014	1.516MetGly: 1.516 ± 0.026	0.392MetHis: 0.392 ± 0.013	0.684MetIle: 0.684 ± 0.02	0.333MetLys: 0.333 ± 0.012	1.825MetLeu: 1.825 ± 0.028	0.322MetMet: 0.322 ± 0.013	0.381MetAsn: 0.381 ± 0.013	1.153MetPro: 1.153 ± 0.023	0.418MetGln: 0.418 ± 0.012	1.683MetArg: 1.683 ± 0.027	1.402MetSer: 1.402 ± 0.028	1.431MetThr: 1.431 ± 0.026	1.502MetVal: 1.502 ± 0.025	0.232MetTrp: 0.232 ± 0.011	0.318MetTyr: 0.318 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.129AsnAla: 2.129 ± 0.036	0.144AsnCys: 0.144 ± 0.007	0.916AsnAsp: 0.916 ± 0.02	0.828AsnGlu: 0.828 ± 0.018	0.404AsnPhe: 0.404 ± 0.013	1.973AsnGly: 1.973 ± 0.037	0.343AsnHis: 0.343 ± 0.014	0.594AsnIle: 0.594 ± 0.018	0.323AsnLys: 0.323 ± 0.014	1.48AsnLeu: 1.48 ± 0.027	0.271AsnMet: 0.271 ± 0.011	0.351AsnAsn: 0.351 ± 0.015	1.276AsnPro: 1.276 ± 0.023	0.432AsnGln: 0.432 ± 0.016	1.255AsnArg: 1.255 ± 0.022	0.792AsnSer: 0.792 ± 0.024	0.977AsnThr: 0.977 ± 0.024	1.269AsnVal: 1.269 ± 0.028	0.249AsnTrp: 0.249 ± 0.011	0.38AsnTyr: 0.38 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	9.195ProAla: 9.195 ± 0.084	0.31ProCys: 0.31 ± 0.011	5.009ProAsp: 5.009 ± 0.059	4.718ProGlu: 4.718 ± 0.051	1.629ProPhe: 1.629 ± 0.028	7.166ProGly: 7.166 ± 0.069	1.391ProHis: 1.391 ± 0.029	1.585ProIle: 1.585 ± 0.029	1.114ProLys: 1.114 ± 0.026	5.223ProLeu: 5.223 ± 0.051	1.212ProMet: 1.212 ± 0.027	0.885ProAsn: 0.885 ± 0.023	4.199ProPro: 4.199 ± 0.067	1.566ProGln: 1.566 ± 0.032	4.263ProArg: 4.263 ± 0.051	2.988ProSer: 2.988 ± 0.037	2.964ProThr: 2.964 ± 0.044	5.21ProVal: 5.21 ± 0.049	0.914ProTrp: 0.914 ± 0.019	1.147ProTyr: 1.147 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.148GlnAla: 3.148 ± 0.046	0.167GlnCys: 0.167 ± 0.009	1.145GlnAsp: 1.145 ± 0.025	1.242GlnGlu: 1.242 ± 0.026	0.583GlnPhe: 0.583 ± 0.016	2.089GlnGly: 2.089 ± 0.035	0.582GlnHis: 0.582 ± 0.017	1.035GlnIle: 1.035 ± 0.022	0.403GlnLys: 0.403 ± 0.016	2.226GlnLeu: 2.226 ± 0.038	0.475GlnMet: 0.475 ± 0.015	0.428GlnAsn: 0.428 ± 0.011	1.418GlnPro: 1.418 ± 0.036	1.029GlnGln: 1.029 ± 0.033	2.481GlnArg: 2.481 ± 0.037	1.159GlnSer: 1.159 ± 0.026	1.13GlnThr: 1.13 ± 0.025	2.251GlnVal: 2.251 ± 0.032	0.491GlnTrp: 0.491 ± 0.015	0.478GlnTyr: 0.478 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.673ArgAla: 10.673 ± 0.1	0.571ArgCys: 0.571 ± 0.018	4.679ArgAsp: 4.679 ± 0.056	4.416ArgGlu: 4.416 ± 0.048	2.507ArgPhe: 2.507 ± 0.038	6.221ArgGly: 6.221 ± 0.059	2.088ArgHis: 2.088 ± 0.029	3.469ArgIle: 3.469 ± 0.04	1.392ArgLys: 1.392 ± 0.027	8.848ArgLeu: 8.848 ± 0.086	1.949ArgMet: 1.949 ± 0.028	1.35ArgAsn: 1.35 ± 0.025	5.305ArgPro: 5.305 ± 0.056	1.932ArgGln: 1.932 ± 0.037	8.39ArgArg: 8.39 ± 0.075	4.466ArgSer: 4.466 ± 0.058	5.156ArgThr: 5.156 ± 0.061	6.166ArgVal: 6.166 ± 0.059	1.323ArgTrp: 1.323 ± 0.025	1.802ArgTyr: 1.802 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	7.115SerAla: 7.115 ± 0.059	0.37SerCys: 0.37 ± 0.015	2.712SerAsp: 2.712 ± 0.038	2.559SerGlu: 2.559 ± 0.042	1.46SerPhe: 1.46 ± 0.032	6.272SerGly: 6.272 ± 0.053	0.902SerHis: 0.902 ± 0.023	1.606SerIle: 1.606 ± 0.029	0.813SerLys: 0.813 ± 0.021	4.514SerLeu: 4.514 ± 0.051	1.034SerMet: 1.034 ± 0.026	0.749SerAsn: 0.749 ± 0.02	3.082SerPro: 3.082 ± 0.047	1.021SerGln: 1.021 ± 0.023	3.394SerArg: 3.394 ± 0.044	2.425SerSer: 2.425 ± 0.037	2.874SerThr: 2.874 ± 0.038	4.054SerVal: 4.054 ± 0.046	0.825SerTrp: 0.825 ± 0.021	1.081SerTyr: 1.081 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	8.79ThrAla: 8.79 ± 0.071	0.351ThrCys: 0.351 ± 0.013	3.404ThrAsp: 3.404 ± 0.036	3.162ThrGlu: 3.162 ± 0.038	1.471ThrPhe: 1.471 ± 0.028	6.508ThrGly: 6.508 ± 0.06	1.062ThrHis: 1.062 ± 0.024	1.822ThrIle: 1.822 ± 0.027	0.953ThrLys: 0.953 ± 0.025	5.275ThrLeu: 5.275 ± 0.05	1.054ThrMet: 1.054 ± 0.024	0.838ThrAsn: 0.838 ± 0.018	3.816ThrPro: 3.816 ± 0.049	1.119ThrGln: 1.119 ± 0.026	4.032ThrArg: 4.032 ± 0.046	2.625ThrSer: 2.625 ± 0.035	3.24ThrThr: 3.24 ± 0.047	5.402ThrVal: 5.402 ± 0.054	0.866ThrTrp: 0.866 ± 0.022	1.021ThrTyr: 1.021 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	11.23ValAla: 11.23 ± 0.092	0.71ValCys: 0.71 ± 0.02	5.019ValAsp: 5.019 ± 0.052	4.593ValGlu: 4.593 ± 0.057	2.606ValPhe: 2.606 ± 0.034	6.777ValGly: 6.777 ± 0.063	2.001ValHis: 2.001 ± 0.033	2.934ValIle: 2.934 ± 0.044	1.299ValLys: 1.299 ± 0.027	9.842ValLeu: 9.842 ± 0.083	1.385ValMet: 1.385 ± 0.026	1.549ValAsn: 1.549 ± 0.031	5.051ValPro: 5.051 ± 0.047	1.922ValGln: 1.922 ± 0.03	7.202ValArg: 7.202 ± 0.06	4.094ValSer: 4.094 ± 0.047	4.685ValThr: 4.685 ± 0.049	7.86ValVal: 7.86 ± 0.072	1.147ValTrp: 1.147 ± 0.024	1.526ValTyr: 1.526 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.744TrpAla: 1.744 ± 0.034	0.145TrpCys: 0.145 ± 0.008	0.806TrpAsp: 0.806 ± 0.021	0.672TrpGlu: 0.672 ± 0.018	0.496TrpPhe: 0.496 ± 0.016	1.091TrpGly: 1.091 ± 0.026	0.369TrpHis: 0.369 ± 0.012	0.555TrpIle: 0.555 ± 0.016	0.252TrpLys: 0.252 ± 0.011	1.767TrpLeu: 1.767 ± 0.032	0.284TrpMet: 0.284 ± 0.011	0.345TrpAsn: 0.345 ± 0.013	0.783TrpPro: 0.783 ± 0.02	0.505TrpGln: 0.505 ± 0.016	1.433TrpArg: 1.433 ± 0.027	0.885TrpSer: 0.885 ± 0.022	0.918TrpThr: 0.918 ± 0.023	0.999TrpVal: 0.999 ± 0.022	0.354TrpTrp: 0.354 ± 0.016	0.275TrpTyr: 0.275 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.552TyrAla: 2.552 ± 0.034	0.171TyrCys: 0.171 ± 0.009	1.258TyrAsp: 1.258 ± 0.027	1.063TyrGlu: 1.063 ± 0.021	0.613TyrPhe: 0.613 ± 0.019	1.988TyrGly: 1.988 ± 0.035	0.38TyrHis: 0.38 ± 0.013	0.58TyrIle: 0.58 ± 0.017	0.312TyrLys: 0.312 ± 0.012	2.103TyrLeu: 2.103 ± 0.035	0.231TyrMet: 0.231 ± 0.01	0.369TyrAsn: 0.369 ± 0.014	1.112TyrPro: 1.112 ± 0.03	0.511TyrGln: 0.511 ± 0.016	1.804TyrArg: 1.804 ± 0.031	0.961TyrSer: 0.961 ± 0.023	1.205TyrThr: 1.205 ± 0.026	1.422TyrVal: 1.422 ± 0.027	0.334TyrTrp: 0.334 ± 0.012	0.419TyrTyr: 0.419 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6614 proteins (2111645 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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